ATE46155T1 - Fluorcumarine als antilymphoedema-mittel. - Google Patents

Fluorcumarine als antilymphoedema-mittel.

Info

Publication number
ATE46155T1
ATE46155T1 AT85115883T AT85115883T ATE46155T1 AT E46155 T1 ATE46155 T1 AT E46155T1 AT 85115883 T AT85115883 T AT 85115883T AT 85115883 T AT85115883 T AT 85115883T AT E46155 T1 ATE46155 T1 AT E46155T1
Authority
AT
Austria
Prior art keywords
sub
hydrogen
fluorine
agent
fluorcumarine
Prior art date
Application number
AT85115883T
Other languages
English (en)
Inventor
Carmelo A Gandolfi
Odoardo Tofanetti
Silvano Spinelli
Piervitto Cipolla
Sergio Tognella
Original Assignee
Boehringer Biochemia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Biochemia Srl filed Critical Boehringer Biochemia Srl
Application granted granted Critical
Publication of ATE46155T1 publication Critical patent/ATE46155T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
AT85115883T 1984-12-21 1985-12-12 Fluorcumarine als antilymphoedema-mittel. ATE46155T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB08432464A GB2168696B (en) 1984-12-21 1984-12-21 Fluoro coumarins as antilymphoedema agents
EP85115883A EP0185319B1 (de) 1984-12-21 1985-12-12 Fluorcumarine als Antilymphoedema-Mittel

Publications (1)

Publication Number Publication Date
ATE46155T1 true ATE46155T1 (de) 1989-09-15

Family

ID=10571633

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85115883T ATE46155T1 (de) 1984-12-21 1985-12-12 Fluorcumarine als antilymphoedema-mittel.

Country Status (7)

Country Link
US (1) US4749798A (de)
EP (1) EP0185319B1 (de)
JP (1) JPS61180781A (de)
AT (1) ATE46155T1 (de)
AU (1) AU599893B2 (de)
DE (1) DE3572812D1 (de)
GB (1) GB2168696B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278186A (en) * 1990-02-10 1994-01-11 Takeda Chemical Industries, Ltd. Chromene derivatives, their production and use
DE4111861A1 (de) * 1991-04-11 1992-10-15 Schwabe Willmar Gmbh & Co Benzopyranone, verfahren zu ihrer herstellung und verwendung
US6124477A (en) * 1996-06-27 2000-09-26 Bioavailability Systems, Llc Anti-first-pass effect compounds
US5830912A (en) * 1996-11-15 1998-11-03 Molecular Probes, Inc. Derivatives of 6,8-difluoro-7-hydroxycoumarin
EP0975617B1 (de) * 1997-04-16 2003-11-05 The University of New Mexico Inhibitoren der cholesterolesterase
ES2199457T3 (es) * 1997-08-26 2004-02-16 Bioavailability Systems, L.L.C. Compuestos que inhiben el efecto del primer paso.
US6248776B1 (en) 1997-08-26 2001-06-19 Bioavailability Systems, L.L.C. Anti-first-pass effect compounds
ATE304847T1 (de) * 2001-12-04 2005-10-15 Mac Pharma S A S Verwendung von cumarin oder seines hydroxy- derivats zur behandlung von mittelschwerem oder schwerem gefäss- und/oder lymphödem
US20070298132A1 (en) * 2002-05-03 2007-12-27 Pharmchem Inc. Berberine as a selective lung cancer agent
WO2006078833A2 (en) * 2005-01-21 2006-07-27 Janssen Pharmaceutica N.V. Novel coumarin derivatives as ion channel openers
ES2398939T3 (es) 2008-02-22 2013-03-22 Actelion Pharmaceuticals Ltd. Derivados de oxazolidinona

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1110848A (en) * 1965-06-18 1968-04-24 Stauffer Chemical Co Control of growth of fungi and bacteria
BE788200A (fr) * 1971-09-03 1973-02-28 Lonza Ag Procede de fabrication de 4-halogenomethylcoumarines et nouveaux composes ainsi obtenus
US4701456A (en) * 1984-09-19 1987-10-20 Warner-Lambert Company Aminoalkoxybenzopyranones as antipsychotic and anxiolytic agents

Also Published As

Publication number Publication date
GB2168696B (en) 1989-01-11
DE3572812D1 (en) 1989-10-12
GB8432464D0 (en) 1985-02-06
JPS61180781A (ja) 1986-08-13
EP0185319A3 (en) 1987-04-29
US4749798A (en) 1988-06-07
GB2168696A (en) 1986-06-25
EP0185319B1 (de) 1989-09-06
AU5154985A (en) 1986-06-26
EP0185319A2 (de) 1986-06-25
AU599893B2 (en) 1990-08-02

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties