ATE46163T1 - Verfahren zur dealkylierung von alkaloiden und zwischenprodukte. - Google Patents

Verfahren zur dealkylierung von alkaloiden und zwischenprodukte.

Info

Publication number: ATE46163T1
Authority: AT; Austria
Prior art keywords: dealkylation; alkaloids; formula; processes; see diagramm
Prior art date: 1984-05-25

Application number

AT85400996T

Other languages

English (en)

Inventor

Christian Mazet De L Esco Hoff

Cabanette

Christian Vergely

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-25

Filing date

1985-05-21

Publication date

1989-09-15

1985-05-21 Application filed by Sanofi Sa filed Critical Sanofi Sa

1989-09-15 Application granted granted Critical

1989-09-15 Publication of ATE46163T1 publication Critical patent/ATE46163T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

AT85400996T 1984-05-25 1985-05-21 Verfahren zur dealkylierung von alkaloiden und zwischenprodukte. ATE46163T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8408273A FR2564838B1 (fr)	1984-05-25	1984-05-25	Procede de dealkylation d'alcaloides et intermediaires
EP85400996A EP0164290B1 (de)	1984-05-25	1985-05-21	Verfahren zur Dealkylierung von Alkaloiden und Zwischenprodukte

Publications (1)

Publication Number	Publication Date
ATE46163T1 true ATE46163T1 (de)	1989-09-15

Family

ID=9304425

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT85400996T ATE46163T1 (de)	1984-05-25	1985-05-21	Verfahren zur dealkylierung von alkaloiden und zwischenprodukte.

Country Status (12)

Country	Link
EP (1)	EP0164290B1 (de)
JP (1)	JPS60258183A (de)
AT (1)	ATE46163T1 (de)
AU (1)	AU577379B2 (de)
CA (1)	CA1244825A (de)
DE (1)	DE3572819D1 (de)
DK (1)	DK160048C (de)
ES (1)	ES8603893A1 (de)
FR (1)	FR2564838B1 (de)
NO (1)	NO164981C (de)
NZ (1)	NZ212193A (de)
PT (1)	PT80519B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4795813A (en) *	1981-08-17	1989-01-03	The Florida Board Of Regents On Behalf Of The Florida State University	Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US6067749A (en) *	1996-07-11	2000-05-30	Tasmanian Alkaloids Pty. Ltd.	Papaver somniferum strain with high concentration of thebaine and oripavine
GB2471801B (en) *	2006-05-25	2011-02-16	Alpharma	Process useful in the preparation of morphine antagonists
GB2444052A (en) *	2006-05-25	2008-05-28	Alpharma Aps	Processes of preparing morphinan derivatives such as naltrexone and naloxone comprising O- and N-demethylation and reductive alkylation steps
GB2471802B (en) *	2006-05-25	2011-02-16	Alpharma	Chemical process
US8962841B2 (en)	2007-06-29	2015-02-24	Brock University	Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
US7999104B2 (en)	2007-06-29	2011-08-16	Brock University	Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids
US8101757B2 (en) *	2007-12-17	2012-01-24	Mallinckrodt Llc	Processes for the preparation of normorphinan salts
US9131649B2 (en)	2008-03-07	2015-09-15	Tasmanian Alkaloids Pty. Ltd	Papaver somniferum strain with high concentration of thebaine
JP2011516464A (ja) *	2008-03-31	2011-05-26	サン・ファーマシューティカル・インダストリーズ・リミテッド	モルフィナン類似体の改良された調製方法
TWI471289B (zh)	2010-06-11	2015-02-01	Rhodes Technologies	使三級胺進行ｎ－脫烷反應之方法
CA2936749C (en)	2010-06-11	2019-07-09	Rhodes Technologies	Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
JP6121988B2 (ja)	2011-05-06	2017-04-26	ブロックユニバーシティ	金属触媒ｎ−脱メチル化／官能基化および分子内基移動によるモルヒネ類似体の調製のための方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4141807A (en) *	1977-03-01	1979-02-27	Stauffer Chemical Company	Photopolymerizable composition stabilized with nitrogen-containing aromatic compounds
DE2727805A1 (de) *	1977-06-21	1979-01-04	Goedecke Ag	Verfahren zur herstellung von oxynormorphon
US4390699A (en) *	1981-07-16	1983-06-28	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	6-Keto-morphinans belonging to the 14-hydroxy-series
US4472253A (en) *	1981-08-17	1984-09-18	The Florida Board Of Regents On Behalf Of The Florida State University	Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
DE3381560D1 (de) *	1982-09-24	1990-06-21	Poudres & Explosifs Ste Nale	Vinylcarmabate und herstellungsverfahren.

1984
- 1984-05-25 FR FR8408273A patent/FR2564838B1/fr not_active Expired
1985
- 1985-05-21 ES ES543338A patent/ES8603893A1/es not_active Expired
- 1985-05-21 DE DE8585400996T patent/DE3572819D1/de not_active Expired
- 1985-05-21 EP EP85400996A patent/EP0164290B1/de not_active Expired
- 1985-05-21 AT AT85400996T patent/ATE46163T1/de not_active IP Right Cessation
- 1985-05-22 DK DK227685A patent/DK160048C/da not_active IP Right Cessation
- 1985-05-22 CA CA000482102A patent/CA1244825A/en not_active Expired
- 1985-05-23 PT PT80519A patent/PT80519B/pt not_active IP Right Cessation
- 1985-05-24 NO NO852091A patent/NO164981C/no unknown
- 1985-05-24 NZ NZ212193A patent/NZ212193A/xx unknown
- 1985-05-24 JP JP60113016A patent/JPS60258183A/ja active Pending
- 1985-05-24 AU AU42843/85A patent/AU577379B2/en not_active Ceased

Also Published As

Publication number	Publication date
CA1244825A (en)	1988-11-15
DK227685A (da)	1985-11-26
DE3572819D1 (en)	1989-10-12
NZ212193A (en)	1988-10-28
AU4284385A (en)	1985-11-28
FR2564838B1 (fr)	1986-11-07
NO164981C (no)	1990-12-05
DK160048C (da)	1991-06-17
ES543338A0 (es)	1986-01-01
DK160048B (da)	1991-01-21
PT80519B (pt)	1988-01-22
JPS60258183A (ja)	1985-12-20
EP0164290B1 (de)	1989-09-06
PT80519A (fr)	1985-06-01
FR2564838A1 (fr)	1985-11-29
NO852091L (no)	1985-11-26
NO164981B (no)	1990-08-27
DK227685D0 (da)	1985-05-22
EP0164290A1 (de)	1985-12-11
AU577379B2 (en)	1988-09-22
ES8603893A1 (es)	1986-01-01

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Legal Events

Date	Code	Title	Description
1990-04-15	UEP	Publication of translation of european patent specification
1994-02-15	REN	Ceased due to non-payment of the annual fee