ES543338A0 - Procedimiento de desalquilacion de alcaloides e intermedia- rios - Google Patents

Procedimiento de desalquilacion de alcaloides e intermedia- rios

Info

Publication number: ES543338A0
Authority: ES; Spain
Prior art keywords: formula; desalquilation; alkaloid; procedure; see diagramm
Prior art date: 1984-05-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES543338A

Other languages

English (en)

Other versions

ES8603893A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi SA

Original Assignee

Sanofi SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-25

Filing date

1985-05-21

Publication date

1986-01-01

1985-05-21 Application filed by Sanofi SA filed Critical Sanofi SA

1986-01-01 Publication of ES543338A0 publication Critical patent/ES543338A0/es

1986-01-01 Publication of ES8603893A1 publication Critical patent/ES8603893A1/es

Status Expired legal-status Critical Current

Links

238000000034 method Methods 0.000 title abstract 2
229930013930 alkaloid Natural products 0.000 title 1
150000003797 alkaloid derivatives Chemical class 0.000 title 1
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
BLUMEJOOWLSPSE-OWCLPIDISA-N (1S,9R,10S)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-trien-10-ol Chemical class C1CCC[C@@]2(O)[C@]3([H])NCC[C@@]21C1=CC=CC=C1C3 BLUMEJOOWLSPSE-OWCLPIDISA-N 0.000 abstract 1
KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000020335 dealkylation Effects 0.000 abstract 1
238000006900 dealkylation reaction Methods 0.000 abstract 1
RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 abstract 1
229910052739 hydrogen Chemical group 0.000 abstract 1
239000001257 hydrogen Chemical group 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Saccharide Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

ES543338A 1984-05-25 1985-05-21 Procedimiento de desalquilacion de alcaloides e intermedia- rios Expired ES8603893A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8408273A FR2564838B1 (fr)	1984-05-25	1984-05-25	Procede de dealkylation d'alcaloides et intermediaires

Publications (2)

Publication Number	Publication Date
ES543338A0 true ES543338A0 (es)	1986-01-01
ES8603893A1 ES8603893A1 (es)	1986-01-01

Family

ID=9304425

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES543338A Expired ES8603893A1 (es)	1984-05-25	1985-05-21	Procedimiento de desalquilacion de alcaloides e intermedia- rios

Country Status (12)

Country	Link
EP (1)	EP0164290B1 (es)
JP (1)	JPS60258183A (es)
AT (1)	ATE46163T1 (es)
AU (1)	AU577379B2 (es)
CA (1)	CA1244825A (es)
DE (1)	DE3572819D1 (es)
DK (1)	DK160048C (es)
ES (1)	ES8603893A1 (es)
FR (1)	FR2564838B1 (es)
NO (1)	NO164981C (es)
NZ (1)	NZ212193A (es)
PT (1)	PT80519B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4795813A (en) *	1981-08-17	1989-01-03	The Florida Board Of Regents On Behalf Of The Florida State University	Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US6067749A (en)	1996-07-11	2000-05-30	Tasmanian Alkaloids Pty. Ltd.	Papaver somniferum strain with high concentration of thebaine and oripavine
GB2471803B (en) *	2006-05-25	2011-02-16	Alpharma	Chemical process
GB2438400A (en) *	2006-05-25	2007-11-28	Alpharma Aps	N-Demethylation of 14-hydroxy morphinans with alpha-chloroethyl chloroformate
GB2438401A (en) *	2006-05-25	2007-11-28	Alpharma Aps	Preparation of morphinan derivatives comprising N-demethylation, reductive amination and O-demethylation steps
US7999104B2 (en) *	2007-06-29	2011-08-16	Brock University	Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids
US8962841B2 (en)	2007-06-29	2015-02-24	Brock University	Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
AU2008338971B2 (en) *	2007-12-17	2013-08-29	SpecGx LLC	Processes for the preparation of normorphinan salts
US9131649B2 (en)	2008-03-07	2015-09-15	Tasmanian Alkaloids Pty. Ltd	Papaver somniferum strain with high concentration of thebaine
WO2009122436A2 (en) *	2008-03-31	2009-10-08	Sun Pharmaceutical Industries Ltd.	An improved process for the preparation of morphinane analogues
JP2013529595A (ja)	2010-06-11	2013-07-22	ローズテクノロジーズ	第３級アミンのｎ−脱アルキル化方法
ES2645725T3 (es)	2010-06-11	2017-12-07	Rhodes Technologies	Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
CN103619847A (zh) *	2011-05-06	2014-03-05	布鲁克大学	通过金属催化n-脱甲基化/官能化以及分子内基团转移制备吗啡类似物的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4141807A (en) *	1977-03-01	1979-02-27	Stauffer Chemical Company	Photopolymerizable composition stabilized with nitrogen-containing aromatic compounds
DE2727805A1 (de) *	1977-06-21	1979-01-04	Goedecke Ag	Verfahren zur herstellung von oxynormorphon
US4390699A (en) *	1981-07-16	1983-06-28	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	6-Keto-morphinans belonging to the 14-hydroxy-series
US4472253A (en) *	1981-08-17	1984-09-18	The Florida Board Of Regents On Behalf Of The Florida State University	Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
ATE52768T1 (de) *	1982-09-24	1990-06-15	Poudres & Explosifs Ste Nale	Vinylcarmabate und herstellungsverfahren.

1984
- 1984-05-25 FR FR8408273A patent/FR2564838B1/fr not_active Expired
1985
- 1985-05-21 DE DE8585400996T patent/DE3572819D1/de not_active Expired
- 1985-05-21 ES ES543338A patent/ES8603893A1/es not_active Expired
- 1985-05-21 AT AT85400996T patent/ATE46163T1/de not_active IP Right Cessation
- 1985-05-21 EP EP85400996A patent/EP0164290B1/fr not_active Expired
- 1985-05-22 CA CA000482102A patent/CA1244825A/en not_active Expired
- 1985-05-22 DK DK227685A patent/DK160048C/da not_active IP Right Cessation
- 1985-05-23 PT PT80519A patent/PT80519B/pt not_active IP Right Cessation
- 1985-05-24 AU AU42843/85A patent/AU577379B2/en not_active Ceased
- 1985-05-24 JP JP60113016A patent/JPS60258183A/ja active Pending
- 1985-05-24 NO NO852091A patent/NO164981C/no unknown
- 1985-05-24 NZ NZ212193A patent/NZ212193A/xx unknown

Also Published As

Publication number	Publication date
NO164981C (no)	1990-12-05
AU4284385A (en)	1985-11-28
DK160048C (da)	1991-06-17
ES8603893A1 (es)	1986-01-01
DK160048B (da)	1991-01-21
PT80519B (pt)	1988-01-22
DK227685D0 (da)	1985-05-22
ATE46163T1 (de)	1989-09-15
NZ212193A (en)	1988-10-28
CA1244825A (en)	1988-11-15
FR2564838A1 (fr)	1985-11-29
AU577379B2 (en)	1988-09-22
PT80519A (fr)	1985-06-01
DE3572819D1 (en)	1989-10-12
FR2564838B1 (fr)	1986-11-07
DK227685A (da)	1985-11-26
EP0164290A1 (fr)	1985-12-11
NO164981B (no)	1990-08-27
EP0164290B1 (fr)	1989-09-06
JPS60258183A (ja)	1985-12-20
NO852091L (no)	1985-11-26

Legal Events

Date	Code	Title	Description
1997-05-01	FD1A	Patent lapsed	Effective date: 19970303

Publication	Publication Date	Title
NO164981C (no)	1990-12-05	Fremgangsmaate for fremstilling av dealkylerte 14-hydroksy-morfinan-alkaloider.
FI852974A0 (fi)	1985-08-01	Nya n-hydroxylgruppen skyddande grupper och framstaellningsfoerfarande foer 3-acylamino-1-hydroxi-2-azetidinoner.
ATE158798T1 (de)	1997-10-15	Verfahren zur herstellung von optisch aktiven zyklobutannukleosiden
AU643489B2 (en)	1993-11-18	Antibacterial agents - II
ATE21105T1 (de)	1986-08-15	7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
KR840001175A (ko)	1984-03-28	[3H]-이미다조 [5,1-d]-1,2,3,5- 테트라진-4-온 유도체의 제조방법
CA1273957C (es)	1990-09-11
DK0402339T3 (da)	1994-10-31	Fremgangsmåde til fremstilling af carbonatestere
SE8501679L (sv)	1985-10-07	Stereokontrollerat acetoxiazetidinon-forfarande
ES8801274A1 (es)	1988-01-01	Un metodo para preparar eteres alcoximetilicos y esteres alcoximetilicos de derivados de guanina.
IT1149846B (it)	1986-12-10	Processo per la sintesi di 1-ammino-3-p(b-metossi-etil)-fenosi-2-propanolo
CA1273347C (es)	1990-08-28
SG76447A1 (en)	2000-11-21	Novel benzyl and benzhydryl alcohols
GB8907008D0 (en)	1989-05-10	Intermediates useful for the synthesis for delphinidin chloride
MX160068A (es)	1989-11-17	Composicion de poliolefina estable a la degradacion y metodo para su obtencion
ATE34389T1 (de)	1988-06-15	Verfahren zur herstellung von chiralen blactamen.
JPS55133325A (en)	1980-10-17	Manufacture of pentadienol
DE3260782D1 (en)	1984-10-25	Method for the preparation of 1,1'-diacetals