DK227685A - Fremgangsmaade til dealkylering af 14-hydroxy-morphinanalkaloider og mellemprodukter til anvendelse ved fremgangsmaaden - Google Patents

Fremgangsmaade til dealkylering af 14-hydroxy-morphinanalkaloider og mellemprodukter til anvendelse ved fremgangsmaaden Download PDF

Info

Publication number: DK227685A
Authority: DK; Denmark
Prior art keywords: procedure; hydroxy; formula; morphinalalkaloids; dealkyling
Prior art date: 1984-05-25

Application number

DK227685A

Other languages

English (en)

Other versions

DK160048B (da

DK227685D0 (da

DK160048C (da

Inventor

Christian Hoff

Christian Vergely

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-25

Filing date

1985-05-22

Publication date

1985-11-26

1985-05-22 Application filed by Sanofi Sa filed Critical Sanofi Sa

1985-05-22 Publication of DK227685D0 publication Critical patent/DK227685D0/da

1985-11-26 Publication of DK227685A publication Critical patent/DK227685A/da

1991-01-21 Publication of DK160048B publication Critical patent/DK160048B/da

1991-06-17 Application granted granted Critical

1991-06-17 Publication of DK160048C publication Critical patent/DK160048C/da

Links

238000000034 method Methods 0.000 title abstract 3
239000000543 intermediate Substances 0.000 title 1
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
BLUMEJOOWLSPSE-OWCLPIDISA-N (1S,9R,10S)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-trien-10-ol Chemical class C1CCC[C@@]2(O)[C@]3([H])NCC[C@@]21C1=CC=CC=C1C3 BLUMEJOOWLSPSE-OWCLPIDISA-N 0.000 abstract 1
KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000020335 dealkylation Effects 0.000 abstract 1
238000006900 dealkylation reaction Methods 0.000 abstract 1
RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 abstract 1
229910052739 hydrogen Chemical group 0.000 abstract 1
239000001257 hydrogen Chemical group 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

DK227685A 1984-05-25 1985-05-22 Fremgangsmaade til dealkylering af 14-hydroxy-morphinanalkaloider DK160048C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8408273A FR2564838B1 (fr)	1984-05-25	1984-05-25	Procede de dealkylation d'alcaloides et intermediaires
FR8408273		1984-05-25

Publications (4)

Publication Number	Publication Date
DK227685D0 DK227685D0 (da)	1985-05-22
DK227685A true DK227685A (da)	1985-11-26
DK160048B DK160048B (da)	1991-01-21
DK160048C DK160048C (da)	1991-06-17

Family

ID=9304425

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK227685A DK160048C (da)	1984-05-25	1985-05-22	Fremgangsmaade til dealkylering af 14-hydroxy-morphinanalkaloider

Country Status (12)

Country	Link
EP (1)	EP0164290B1 (da)
JP (1)	JPS60258183A (da)
AT (1)	ATE46163T1 (da)
AU (1)	AU577379B2 (da)
CA (1)	CA1244825A (da)
DE (1)	DE3572819D1 (da)
DK (1)	DK160048C (da)
ES (1)	ES543338A0 (da)
FR (1)	FR2564838B1 (da)
NO (1)	NO164981C (da)
NZ (1)	NZ212193A (da)
PT (1)	PT80519B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4795813A (en) *	1981-08-17	1989-01-03	The Florida Board Of Regents On Behalf Of The Florida State University	Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US6067749A (en)	1996-07-11	2000-05-30	Tasmanian Alkaloids Pty. Ltd.	Papaver somniferum strain with high concentration of thebaine and oripavine
GB2444052A (en) *	2006-05-25	2008-05-28	Alpharma Aps	Processes of preparing morphinan derivatives such as naltrexone and naloxone comprising O- and N-demethylation and reductive alkylation steps
GB2471801B (en) *	2006-05-25	2011-02-16	Alpharma	Process useful in the preparation of morphine antagonists
GB2471802B (en) *	2006-05-25	2011-02-16	Alpharma	Chemical process
US8962841B2 (en)	2007-06-29	2015-02-24	Brock University	Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
US7999104B2 (en) *	2007-06-29	2011-08-16	Brock University	Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids
CN101896488A (zh) *	2007-12-17	2010-11-24	马林克罗特公司	制备去甲吗啡喃盐的方法
US9131649B2 (en)	2008-03-07	2015-09-15	Tasmanian Alkaloids Pty. Ltd	Papaver somniferum strain with high concentration of thebaine
AU2009233315B2 (en) *	2008-03-31	2013-08-29	Sun Pharmaceutical Industries Ltd.	An improved process for the preparation of morphinane analogues
EP2580201B1 (en)	2010-06-11	2017-08-02	Rhodes Technologies	Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
TWI471289B (zh)	2010-06-11	2015-02-01	Rhodes Technologies	使三級胺進行ｎ－脫烷反應之方法
KR20140047609A (ko)	2011-05-06	2014-04-22	브럭 유니버시티	금속 촉매된 n-탈메틸화/기능화 및 분자내 기 전이를 통한 모르핀 아날로그의 제조 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4141807A (en) *	1977-03-01	1979-02-27	Stauffer Chemical Company	Photopolymerizable composition stabilized with nitrogen-containing aromatic compounds
DE2727805A1 (de) *	1977-06-21	1979-01-04	Goedecke Ag	Verfahren zur herstellung von oxynormorphon
US4390699A (en) *	1981-07-16	1983-06-28	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	6-Keto-morphinans belonging to the 14-hydroxy-series
US4472253A (en) *	1981-08-17	1984-09-18	The Florida Board Of Regents On Behalf Of The Florida State University	Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
FR2533561B1 (fr) *	1982-09-24	1986-07-25	Poudres & Explosifs Ste Nale	Procede de preparation des carbamates vinyliques et nouveaux carbamates vinyliques

1984
- 1984-05-25 FR FR8408273A patent/FR2564838B1/fr not_active Expired
1985
- 1985-05-21 ES ES543338A patent/ES543338A0/es active Granted
- 1985-05-21 AT AT85400996T patent/ATE46163T1/de not_active IP Right Cessation
- 1985-05-21 EP EP85400996A patent/EP0164290B1/fr not_active Expired
- 1985-05-21 DE DE8585400996T patent/DE3572819D1/de not_active Expired
- 1985-05-22 CA CA000482102A patent/CA1244825A/en not_active Expired
- 1985-05-22 DK DK227685A patent/DK160048C/da not_active IP Right Cessation
- 1985-05-23 PT PT80519A patent/PT80519B/pt not_active IP Right Cessation
- 1985-05-24 NO NO852091A patent/NO164981C/no unknown
- 1985-05-24 AU AU42843/85A patent/AU577379B2/en not_active Ceased
- 1985-05-24 JP JP60113016A patent/JPS60258183A/ja active Pending
- 1985-05-24 NZ NZ212193A patent/NZ212193A/xx unknown

Also Published As

Publication number	Publication date
NO164981C (no)	1990-12-05
CA1244825A (en)	1988-11-15
AU4284385A (en)	1985-11-28
ATE46163T1 (de)	1989-09-15
DE3572819D1 (en)	1989-10-12
PT80519A (fr)	1985-06-01
NO164981B (no)	1990-08-27
AU577379B2 (en)	1988-09-22
PT80519B (pt)	1988-01-22
JPS60258183A (ja)	1985-12-20
DK160048B (da)	1991-01-21
NZ212193A (en)	1988-10-28
FR2564838A1 (fr)	1985-11-29
ES8603893A1 (es)	1986-01-01
DK227685D0 (da)	1985-05-22
ES543338A0 (es)	1986-01-01
FR2564838B1 (fr)	1986-11-07
EP0164290A1 (fr)	1985-12-11
EP0164290B1 (fr)	1989-09-06
NO852091L (no)	1985-11-26
DK160048C (da)	1991-06-17

Similar Documents

Publication	Publication Date	Title
DK227685A (da)	1985-11-26	Fremgangsmaade til dealkylering af 14-hydroxy-morphinanalkaloider og mellemprodukter til anvendelse ved fremgangsmaaden
ES8704473A1 (es)	1987-04-01	Procedimiento para la produccion de derivados de la 13-beta-milbemicina
FI852974L (fi)	1986-02-04	Nya n-hydroxylgruppen skyddande grupper och framstaellningsfoerfarande foer 3-acylamino-1-hydroxi-2-azetidinoner.
ATE158798T1 (de)	1997-10-15	Verfahren zur herstellung von optisch aktiven zyklobutannukleosiden
ATE21105T1 (de)	1986-08-15	7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
DK0402339T3 (da)	1994-10-31	Fremgangsmåde til fremstilling af carbonatestere
SE9000790L (sv)	1991-09-07	Mellanprodukter vid stereokontrollerat acetoxi-azetidinon-foerfarande
DK154639C (da)	1989-05-08	Fremgangsmaade til fremstilling af monochlormethylketoner
ES543432A0 (es)	1986-07-16	Procedimiento para preparar esteres de acido 2-cloropropio- nico
ATE130840T1 (de)	1995-12-15	Verfahren zur herstellung von optisch-aktivem zyklobutanon, ein zwischenprodukt in der synthese von optisch-aktiven zyklobutanonnukleosiden.
DK0399748T3 (da)	1996-02-12	Fremgangsmåde til fremstilling af 2-oxindol-1-carboxamider
DK342383A (da)	1984-03-11	Fremgangsmaade til fremstilling af 4-amino-5-dialkoxymethylpyrimidinderivater
ES552838A0 (es)	1987-06-01	Procedimiento para preparar esteres de acido 2-isocianato-2,3-deshidrocarboxilico
ES8507494A1 (es)	1985-09-16	Procedimiento de obtencion de 2, 6-dimetil-4-(3'-nitrofenil)-1, 4-dihidropiridin-3, 5-dicarboxilato de 2-n-propoxietilo
ES2075285T3 (es)	1995-10-01	Procedimiento mejorado para la sintesis de alfa-(metileno sustituido con dialquilamino)-beta-oxo-propanonitrilos sustituidos.
FI890886A0 (fi)	1989-02-24	Kristallin n-(s-3-metylheptanoyl) -d-gamma-glutamyl-glycyl-d-alanin och foerfaranden foer dess framstaellning samt mellanprodukter.
JPS5448743A (en)	1979-04-17	Preparation of benzoin ether
ATE26259T1 (de)	1987-04-15	Verfahren zur herstellung von 3-cyano-4aminoacetophenonen.
ES2140384T3 (es)	2000-03-01	Intermedios para 1-carbacefalosporinas y procedimiento para su preparacion.
ES477768A1 (es)	1980-06-16	Un procedimiento para la preparacion de 1 alfa-oxido de aci-do penicilinico.
JPS56147769A (en)	1981-11-16	Preparation of n-substituted piperidinol derivative

Legal Events

Date	Code	Title	Description
1994-01-24	PBP	Patent lapsed