DK227685A - Fremgangsmaade til dealkylering af 14-hydroxy-morphinanalkaloider og mellemprodukter til anvendelse ved fremgangsmaaden - Google Patents

Fremgangsmaade til dealkylering af 14-hydroxy-morphinanalkaloider og mellemprodukter til anvendelse ved fremgangsmaaden Download PDF

Info

Publication number: DK227685A
Authority: DK; Denmark
Prior art keywords: procedure; hydroxy; formula; morphinalalkaloids; dealkyling
Prior art date: 1984-05-25

Application number

DK227685A

Other languages

English (en)

Other versions

DK160048B (da

DK227685D0 (da

DK160048C (da

Inventor

Christian Hoff

Christian Vergely

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-25

Filing date

1985-05-22

Publication date

1985-11-26

1985-05-22 Application filed by Sanofi Sa filed Critical Sanofi Sa

1985-05-22 Publication of DK227685D0 publication Critical patent/DK227685D0/da

1985-11-26 Publication of DK227685A publication Critical patent/DK227685A/da

1991-01-21 Publication of DK160048B publication Critical patent/DK160048B/da

1991-06-17 Application granted granted Critical

1991-06-17 Publication of DK160048C publication Critical patent/DK160048C/da

Links

238000000034 method Methods 0.000 title abstract 3
239000000543 intermediate Substances 0.000 title 1
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
BLUMEJOOWLSPSE-OWCLPIDISA-N (1S,9R,10S)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-trien-10-ol Chemical class C1CCC[C@@]2(O)[C@]3([H])NCC[C@@]21C1=CC=CC=C1C3 BLUMEJOOWLSPSE-OWCLPIDISA-N 0.000 abstract 1
KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000020335 dealkylation Effects 0.000 abstract 1
238000006900 dealkylation reaction Methods 0.000 abstract 1
RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 abstract 1
229910052739 hydrogen Chemical group 0.000 abstract 1
239000001257 hydrogen Chemical group 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

DK227685A 1984-05-25 1985-05-22 Fremgangsmaade til dealkylering af 14-hydroxy-morphinanalkaloider DK160048C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8408273		1984-05-25
FR8408273A FR2564838B1 (fr)	1984-05-25	1984-05-25	Procede de dealkylation d'alcaloides et intermediaires

Publications (4)

Publication Number	Publication Date
DK227685D0 DK227685D0 (da)	1985-05-22
DK227685A true DK227685A (da)	1985-11-26
DK160048B DK160048B (da)	1991-01-21
DK160048C DK160048C (da)	1991-06-17

Family

ID=9304425

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK227685A DK160048C (da)	1984-05-25	1985-05-22	Fremgangsmaade til dealkylering af 14-hydroxy-morphinanalkaloider

Country Status (12)

Country	Link
EP (1)	EP0164290B1 (da)
JP (1)	JPS60258183A (da)
AT (1)	ATE46163T1 (da)
AU (1)	AU577379B2 (da)
CA (1)	CA1244825A (da)
DE (1)	DE3572819D1 (da)
DK (1)	DK160048C (da)
ES (1)	ES8603893A1 (da)
FR (1)	FR2564838B1 (da)
NO (1)	NO164981C (da)
NZ (1)	NZ212193A (da)
PT (1)	PT80519B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4795813A (en) *	1981-08-17	1989-01-03	The Florida Board Of Regents On Behalf Of The Florida State University	Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US6067749A (en)	1996-07-11	2000-05-30	Tasmanian Alkaloids Pty. Ltd.	Papaver somniferum strain with high concentration of thebaine and oripavine
GB2471801B (en) *	2006-05-25	2011-02-16	Alpharma	Process useful in the preparation of morphine antagonists
GB2471803B (en) *	2006-05-25	2011-02-16	Alpharma	Chemical process
GB2471802B (en) *	2006-05-25	2011-02-16	Alpharma	Chemical process
US7999104B2 (en)	2007-06-29	2011-08-16	Brock University	Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids
US8962841B2 (en)	2007-06-29	2015-02-24	Brock University	Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
US8101757B2 (en) *	2007-12-17	2012-01-24	Mallinckrodt Llc	Processes for the preparation of normorphinan salts
US9131649B2 (en)	2008-03-07	2015-09-15	Tasmanian Alkaloids Pty. Ltd	Papaver somniferum strain with high concentration of thebaine
KR20110014974A (ko) *	2008-03-31	2011-02-14	썬 파마슈티컬 인더스트리스 리미티드	모르피난 유사체의 개선된 제조 방법
CA2802294C (en)	2010-06-11	2016-05-10	Rhodes Technologies	Process for n-dealkylation of tertiary amines
EP2580201B1 (en)	2010-06-11	2017-08-02	Rhodes Technologies	Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
CN103619847A (zh) *	2011-05-06	2014-03-05	布鲁克大学	通过金属催化n-脱甲基化/官能化以及分子内基团转移制备吗啡类似物的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4141807A (en) *	1977-03-01	1979-02-27	Stauffer Chemical Company	Photopolymerizable composition stabilized with nitrogen-containing aromatic compounds
DE2727805A1 (de) *	1977-06-21	1979-01-04	Goedecke Ag	Verfahren zur herstellung von oxynormorphon
US4390699A (en) *	1981-07-16	1983-06-28	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	6-Keto-morphinans belonging to the 14-hydroxy-series
US4472253A (en) *	1981-08-17	1984-09-18	The Florida Board Of Regents On Behalf Of The Florida State University	Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
FR2533561B1 (fr) *	1982-09-24	1986-07-25	Poudres & Explosifs Ste Nale	Procede de preparation des carbamates vinyliques et nouveaux carbamates vinyliques

1984
- 1984-05-25 FR FR8408273A patent/FR2564838B1/fr not_active Expired
1985
- 1985-05-21 EP EP85400996A patent/EP0164290B1/fr not_active Expired
- 1985-05-21 ES ES543338A patent/ES8603893A1/es not_active Expired
- 1985-05-21 DE DE8585400996T patent/DE3572819D1/de not_active Expired
- 1985-05-21 AT AT85400996T patent/ATE46163T1/de not_active IP Right Cessation
- 1985-05-22 CA CA000482102A patent/CA1244825A/en not_active Expired
- 1985-05-22 DK DK227685A patent/DK160048C/da not_active IP Right Cessation
- 1985-05-23 PT PT80519A patent/PT80519B/pt not_active IP Right Cessation
- 1985-05-24 NO NO852091A patent/NO164981C/no unknown
- 1985-05-24 JP JP60113016A patent/JPS60258183A/ja active Pending
- 1985-05-24 NZ NZ212193A patent/NZ212193A/xx unknown
- 1985-05-24 AU AU42843/85A patent/AU577379B2/en not_active Ceased

Also Published As

Publication number	Publication date
NZ212193A (en)	1988-10-28
CA1244825A (en)	1988-11-15
PT80519A (fr)	1985-06-01
AU4284385A (en)	1985-11-28
ES543338A0 (es)	1986-01-01
FR2564838A1 (fr)	1985-11-29
AU577379B2 (en)	1988-09-22
EP0164290A1 (fr)	1985-12-11
DK160048B (da)	1991-01-21
EP0164290B1 (fr)	1989-09-06
DK227685D0 (da)	1985-05-22
DE3572819D1 (en)	1989-10-12
ES8603893A1 (es)	1986-01-01
NO164981B (no)	1990-08-27
JPS60258183A (ja)	1985-12-20
DK160048C (da)	1991-06-17
ATE46163T1 (de)	1989-09-15
NO164981C (no)	1990-12-05
NO852091L (no)	1985-11-26
FR2564838B1 (fr)	1986-11-07
PT80519B (pt)	1988-01-22

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Legal Events

Date	Code	Title	Description
1994-01-24	PBP	Patent lapsed