ATE462702T1 - Für die behandlung von entzündlichen krankheiten nützliche beta-carboline - Google Patents

Für die behandlung von entzündlichen krankheiten nützliche beta-carboline

Info

Publication number: ATE462702T1
Authority: AT; Austria
Prior art keywords: beta; inflammatory diseases; treatment; useful; carbolines
Prior art date: 2004-04-09

Application number

AT05779267T

Other languages

English (en)

Inventor

Michael Hepperle

Julie Liu

Francois Soucy

Raman Prakash

Jeremy Little

Paul Fleming

Dominic Reynolds

Geraldine Harriman

Original Assignee

Millennium Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-04-09

Filing date

2005-04-08

Publication date

2010-04-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35045213&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE462702(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-04-08 Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc

2010-04-15 Application granted granted Critical

2010-04-15 Publication of ATE462702T1 publication Critical patent/ATE462702T1/de

Links

208000027866 inflammatory disease Diseases 0.000 title abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical class N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Immunology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Dermatology (AREA)
Biotechnology (AREA)
AIDS & HIV (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)

AT05779267T 2004-04-09 2005-04-08 Für die behandlung von entzündlichen krankheiten nützliche beta-carboline ATE462702T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US56089204P	2004-04-09	2004-04-09
PCT/US2005/013812 WO2005111037A1 (en)	2004-04-09	2005-04-08	Beta-carbolines useful for treating inflammatory disease

Publications (1)

Publication Number	Publication Date
ATE462702T1 true ATE462702T1 (de)	2010-04-15

Family

ID=35045213

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05779267T ATE462702T1 (de)	2004-04-09	2005-04-08	Für die behandlung von entzündlichen krankheiten nützliche beta-carboline

Country Status (23)

Country	Link
US (1)	US7951801B2 (de)
EP (2)	EP1735311B1 (de)
JP (1)	JP2007532582A (de)
KR (1)	KR20070014166A (de)
CN (1)	CN1976931A (de)
AT (1)	ATE462702T1 (de)
AU (1)	AU2005243188A1 (de)
BR (1)	BRPI0509660A (de)
CA (1)	CA2561859A1 (de)
CR (1)	CR8696A (de)
DE (1)	DE602005020263D1 (de)
EA (1)	EA010546B1 (de)
EC (1)	ECSP066986A (de)
IL (1)	IL178435A0 (de)
MA (1)	MA28567B1 (de)
MX (1)	MXPA06011545A (de)
NO (1)	NO20064894L (de)
RS (1)	RS20060584A (de)
TN (1)	TNSN06321A1 (de)
TW (1)	TW200539880A (de)
UA (1)	UA88638C2 (de)
WO (1)	WO2005111037A1 (de)
ZA (1)	ZA200608956B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200630337A (en) *	2004-10-14	2006-09-01	Euro Celtique Sa	Piperidinyl compounds and the use thereof
WO2007110449A1 (en) *	2006-03-29	2007-10-04	Euro-Celtique S.A.	Benzenesulfonamide compounds and their use
WO2007118854A1 (en) *	2006-04-13	2007-10-25	Euro-Celtique S.A.	Benzenesulfonamide compounds and the use thereof
US8791264B2 (en) *	2006-04-13	2014-07-29	Purdue Pharma L.P.	Benzenesulfonamide compounds and their use as blockers of calcium channels
AR063275A1 (es) *	2006-10-12	2009-01-14	Epix Delaware Inc	Compuestos de carboxamida, una composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la activacion de ccr2.
WO2008124118A1 (en)	2007-04-09	2008-10-16	Purdue Pharma L.P.	Benzenesulfonyl compounds and the use therof
WO2009040659A2 (en) *	2007-09-28	2009-04-02	Purdue Pharma L.P.	Benzenesulfonamide compounds and the use thereof
US20090137579A1 (en) *	2007-10-23	2009-05-28	Millennium Pharmaceuticals, Inc.	Mesylate salt of an IKK inhibitor
US20090131422A1 (en) *	2007-10-23	2009-05-21	Millennium Pharmaceuticals, Inc.	Salts of an IKK inhibitor
BRPI0820701A2 (pt)	2007-12-11	2015-06-16	Cytopathfinder Inc	Composto de carboxamida e seu uso como agonistas do receptor de quimiocina
ES2693247T3 (es)	2010-07-06	2018-12-10	Ono Pharmaceutical Co., Ltd.	Derivado de tetrahidrocarbolina
WO2012127885A1 (ja)	2011-03-18	2012-09-27	小野薬品工業株式会社	テトラヒドロカルボリン誘導体
CN102416014B (zh) *	2011-09-13	2012-11-21	河南中医学院	一种生物碱类成分组合物在制备抗甲型h1n1流感病毒药物中的应用
WO2017067670A1 (en)	2015-10-23	2017-04-27	Pharmathen S.A.	A novel process for the preparation of tryptamines and derivatives thereof
AU2017225912B2 (en)	2016-03-03	2022-02-17	Bill Elliot Cham	Glycoalkaloid combinations and various uses thereof
US11117893B2 (en) *	2018-09-24	2021-09-14	Union University	Methods for preparation of substituted pyridines and related novel compounds
WO2022223022A1 (zh) *	2021-04-23	2022-10-27	四川海思科制药有限公司	一种并环杂环衍生物及其在医药上的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2242402T3 (es)	1998-08-12	2005-11-01	Pfizer Products Inc.	Inhibidores de tace.
DE19951360A1 (de)	1999-10-26	2001-05-03	Aventis Pharma Gmbh	Substituierte Indole
HK1054039B (zh) *	2000-03-15	2010-04-16	萨诺费－阿文蒂斯德国有限公司	取代的β-咔啉
EP1268477B1 (de) *	2000-03-15	2010-04-21	Sanofi-Aventis Deutschland GmbH	Substituierte beta-carboline mit ikb-kinase hemmender wirkung
ATE363473T1 (de)	2001-09-19	2007-06-15	Pharmacia Corp	Substituierte pyrazoloverbindungen zur behandlung von entzündungen
US9248124B2 (en)	2001-11-07	2016-02-02	Millennium Pharmaceuticals, Inc.	Use of inhibitors of IκB kinase for the treatment of cancer
BRPI0409263A (pt)	2003-04-09	2006-03-28	Millennium Pharm Inc	composto; composição farmacêutica; método para tratar uma doença mediada por ikk e método para inibir ikk em um paciente que dele necessita

2005
- 2005-04-08 BR BRPI0509660-0A patent/BRPI0509660A/pt not_active IP Right Cessation
- 2005-04-08 EP EP05779267A patent/EP1735311B1/de not_active Expired - Lifetime
- 2005-04-08 MX MXPA06011545A patent/MXPA06011545A/es not_active Application Discontinuation
- 2005-04-08 TW TW094111190A patent/TW200539880A/zh unknown
- 2005-04-08 JP JP2007507578A patent/JP2007532582A/ja active Pending
- 2005-04-08 WO PCT/US2005/013812 patent/WO2005111037A1/en not_active Ceased
- 2005-04-08 UA UAA200611756A patent/UA88638C2/ru unknown
- 2005-04-08 EA EA200601884A patent/EA010546B1/ru not_active IP Right Cessation
- 2005-04-08 US US11/101,998 patent/US7951801B2/en not_active Expired - Lifetime
- 2005-04-08 EP EP10003450A patent/EP2206713A1/de not_active Withdrawn
- 2005-04-08 AT AT05779267T patent/ATE462702T1/de not_active IP Right Cessation
- 2005-04-08 AU AU2005243188A patent/AU2005243188A1/en not_active Withdrawn
- 2005-04-08 DE DE602005020263T patent/DE602005020263D1/de not_active Expired - Fee Related
- 2005-04-08 KR KR1020067023401A patent/KR20070014166A/ko not_active Ceased
- 2005-04-08 CA CA002561859A patent/CA2561859A1/en not_active Abandoned
- 2005-04-08 RS RSP-2006/0584A patent/RS20060584A/sr unknown
- 2005-04-08 CN CNA2005800190147A patent/CN1976931A/zh active Pending
2006
- 2006-10-04 IL IL178435A patent/IL178435A0/en unknown
- 2006-10-06 TN TNP2006000321A patent/TNSN06321A1/en unknown
- 2006-10-19 CR CR8696A patent/CR8696A/es unknown
- 2006-10-26 NO NO20064894A patent/NO20064894L/no not_active Application Discontinuation
- 2006-10-27 ZA ZA200608956A patent/ZA200608956B/en unknown
- 2006-11-02 MA MA29431A patent/MA28567B1/fr unknown
- 2006-11-09 EC EC2006006986A patent/ECSP066986A/es unknown

Also Published As

Publication number	Publication date
TW200539880A (en)	2005-12-16
CN1976931A (zh)	2007-06-06
AU2005243188A1 (en)	2005-11-24
EA200601884A1 (ru)	2007-04-27
ECSP066986A (es)	2006-12-29
IL178435A0 (en)	2007-02-11
WO2005111037A1 (en)	2005-11-24
CR8696A (es)	2007-08-28
RS20060584A (sr)	2008-08-07
EP1735311B1 (de)	2010-03-31
US20050239781A1 (en)	2005-10-27
MXPA06011545A (es)	2007-03-26
JP2007532582A (ja)	2007-11-15
BRPI0509660A (pt)	2007-10-09
EA010546B1 (ru)	2008-10-30
CA2561859A1 (en)	2005-11-24
US7951801B2 (en)	2011-05-31
MA28567B1 (fr)	2007-05-02
EP2206713A1 (de)	2010-07-14
ZA200608956B (en)	2008-06-25
DE602005020263D1 (de)	2010-05-12
KR20070014166A (ko)	2007-01-31
UA88638C2 (ru)	2009-11-10
EP1735311A1 (de)	2006-12-27
NO20064894L (no)	2007-01-03
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Publication	Publication Date	Title
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EA200700175A1 (ru)	2007-08-31	Композиции и способы лечения воспалительных заболеваний
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EA201170344A1 (ru)	2011-08-30	Азаиндольные ингибиторы iap
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DE602004006118D1 (de)	2007-06-06	2,3,4,5-TETRAHYDROBENZOiFöi1,4öOXAZEPIN-5-CARBONSÄUREAMID DERIVATE ALS GAMMA-SECRETASE INHIBITOREN ZUR BEHANDLUNG VON ALZHEIMER
DE602004021363D1 (de)	2009-07-16	Imidazotriazin verbindungen zur behandlung von krebserkrankungen
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