MA28567B1 - Utilisation de beta-carbolines pour le traitement de maladies inflammatoires - Google Patents

Utilisation de beta-carbolines pour le traitement de maladies inflammatoires

Info

Publication number: MA28567B1
Authority: MA; Morocco
Prior art keywords: beta; inflammatory diseases; carbolines; treatment; compounds
Prior art date: 2004-04-09

Application number

MA29431A

Other languages

English (en)

Inventor

Michael E Hepperle

Julie Fields Liu

Francois Soucy

Raman Prakash

Jeremy D Little

Paul E Fleming

Dominic Reynolds

Geraldine C B Harriman

Original Assignee

Millennium Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-04-09

Filing date

2006-11-02

Publication date

2007-05-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35045213&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA28567(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-11-02 Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc

2007-05-02 Publication of MA28567B1 publication Critical patent/MA28567B1/fr

Links

208000027866 inflammatory disease Diseases 0.000 title abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
AIFRHYZBTHREPW-UHFFFAOYSA-N β-carboline Chemical class N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P33/06—Antimalarials
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- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Hematology (AREA)
Transplantation (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)

MA29431A 2004-04-09 2006-11-02 Utilisation de beta-carbolines pour le traitement de maladies inflammatoires MA28567B1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US56089204P	2004-04-09	2004-04-09

Publications (1)

Publication Number	Publication Date
MA28567B1 true MA28567B1 (fr)	2007-05-02

Family

ID=35045213

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA29431A MA28567B1 (fr)	2004-04-09	2006-11-02	Utilisation de beta-carbolines pour le traitement de maladies inflammatoires

Country Status (23)

Country	Link
US (1)	US7951801B2 (fr)
EP (2)	EP1735311B1 (fr)
JP (1)	JP2007532582A (fr)
KR (1)	KR20070014166A (fr)
CN (1)	CN1976931A (fr)
AT (1)	ATE462702T1 (fr)
AU (1)	AU2005243188A1 (fr)
BR (1)	BRPI0509660A (fr)
CA (1)	CA2561859A1 (fr)
CR (1)	CR8696A (fr)
DE (1)	DE602005020263D1 (fr)
EA (1)	EA010546B1 (fr)
EC (1)	ECSP066986A (fr)
IL (1)	IL178435A0 (fr)
MA (1)	MA28567B1 (fr)
MX (1)	MXPA06011545A (fr)
NO (1)	NO20064894L (fr)
RS (1)	RS20060584A (fr)
TN (1)	TNSN06321A1 (fr)
TW (1)	TW200539880A (fr)
UA (1)	UA88638C2 (fr)
WO (1)	WO2005111037A1 (fr)
ZA (1)	ZA200608956B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200630337A (en) *	2004-10-14	2006-09-01	Euro Celtique Sa	Piperidinyl compounds and the use thereof
WO2007110449A1 (fr) *	2006-03-29	2007-10-04	Euro-Celtique S.A.	Composés de benzènesulfonamide et utilisation de ceux-ci
WO2007118853A1 (fr) *	2006-04-13	2007-10-25	Euro-Celtique S.A.	Benzènesulfonamides et leur emploi en tant qu'agents bloquants des canaux calcium
TW200812963A (en) *	2006-04-13	2008-03-16	Euro Celtique Sa	Benzenesulfonamide compounds and the use thereof
WO2008045564A2 (fr) *	2006-10-12	2008-04-17	Epix Delaware, Inc.	Composés de carboxamide et leur utilisation
US8399486B2 (en)	2007-04-09	2013-03-19	Purdue Pharma L.P.	Benzenesulfonyl compounds and the use thereof
US8765736B2 (en) *	2007-09-28	2014-07-01	Purdue Pharma L.P.	Benzenesulfonamide compounds and the use thereof
WO2009054965A1 (fr) *	2007-10-23	2009-04-30	Millennium Pharmaceuticals, Inc.	Sel de n-(6-chloro-9h-pyrido[3,4-b]indol-8-yl)-4-[2-(2,6-diméthyl-4-morpholinyl)-2-oxoéthyl]-6,6-diméthylmorpholinecarboxamide
WO2009054970A1 (fr) *	2007-10-23	2009-04-30	Millennium Pharmaceuticals, Inc.	Sel mésylate d'un inhibiteur d'ikk
BRPI0820701A2 (pt)	2007-12-11	2015-06-16	Cytopathfinder Inc	Composto de carboxamida e seu uso como agonistas do receptor de quimiocina
JP5821848B2 (ja)	2010-07-06	2015-11-24	小野薬品工業株式会社	テトラヒドロカルボリン誘導体
TW201309698A (zh)	2011-03-18	2013-03-01	Ono Pharmaceutical Co	四氫咔啉衍生物
CN102416014B (zh) *	2011-09-13	2012-11-21	河南中医学院	一种生物碱类成分组合物在制备抗甲型h1n1流感病毒药物中的应用
WO2017067670A1 (fr)	2015-10-23	2017-04-27	Pharmathen S.A.	Nouveau procédé de préparation de tryptamines et de leurs dérivés
CN108883123B (zh)	2016-03-03	2022-04-19	B·E·查姆	配糖生物碱组合及其各种用途
US11117893B2 (en) *	2018-09-24	2021-09-14	Union University	Methods for preparation of substituted pyridines and related novel compounds
WO2022223022A1 (fr) *	2021-04-23	2022-10-27	四川海思科制药有限公司	Dérivé hétérocyclique à cycles fusionnés et son application médicale

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU4925099A (en)	1998-08-12	2000-03-06	Pfizer Products Inc.	Tace inhibitors
DE19951360A1 (de)	1999-10-26	2001-05-03	Aventis Pharma Gmbh	Substituierte Indole
EP1268477B1 (fr) *	2000-03-15	2010-04-21	Sanofi-Aventis Deutschland GmbH	Beta-carbolines substituees ayant une activite inhibitrice de l'ikb-kinase
KR100826817B1 (ko) *	2000-03-15	2008-05-02	사노피-아벤티스 도이칠란트 게엠베하	치환된 베타-카볼린
ES2286275T3 (es)	2001-09-19	2007-12-01	Pharmacia Corporation	Compuestos de pirazolo sustituidos para el tratamiento de la inflamacion.
WO2003039545A2 (fr)	2001-11-07	2003-05-15	Millennium Pharmaceuticals, Inc.	Utilisation d'inhibiteurs de i$g(k)b kinase pour traiter le cancer
RS20050832A (sr) *	2003-04-09	2007-12-31	Millennium Pharmaceuticals Inc.,	Beta-karbolini koji su korisni u tretiranju inflamatornih bolesti

2005
- 2005-04-08 DE DE602005020263T patent/DE602005020263D1/de not_active Expired - Fee Related
- 2005-04-08 BR BRPI0509660-0A patent/BRPI0509660A/pt not_active IP Right Cessation
- 2005-04-08 CA CA002561859A patent/CA2561859A1/fr not_active Abandoned
- 2005-04-08 AT AT05779267T patent/ATE462702T1/de not_active IP Right Cessation
- 2005-04-08 KR KR1020067023401A patent/KR20070014166A/ko not_active Ceased
- 2005-04-08 AU AU2005243188A patent/AU2005243188A1/en not_active Withdrawn
- 2005-04-08 UA UAA200611756A patent/UA88638C2/ru unknown
- 2005-04-08 CN CNA2005800190147A patent/CN1976931A/zh active Pending
- 2005-04-08 RS RSP-2006/0584A patent/RS20060584A/sr unknown
- 2005-04-08 EP EP05779267A patent/EP1735311B1/fr not_active Expired - Lifetime
- 2005-04-08 JP JP2007507578A patent/JP2007532582A/ja active Pending
- 2005-04-08 US US11/101,998 patent/US7951801B2/en not_active Expired - Lifetime
- 2005-04-08 EP EP10003450A patent/EP2206713A1/fr not_active Withdrawn
- 2005-04-08 EA EA200601884A patent/EA010546B1/ru not_active IP Right Cessation
- 2005-04-08 MX MXPA06011545A patent/MXPA06011545A/es not_active Application Discontinuation
- 2005-04-08 WO PCT/US2005/013812 patent/WO2005111037A1/fr not_active Ceased
- 2005-04-08 TW TW094111190A patent/TW200539880A/zh unknown
2006
- 2006-10-04 IL IL178435A patent/IL178435A0/en unknown
- 2006-10-06 TN TNP2006000321A patent/TNSN06321A1/en unknown
- 2006-10-19 CR CR8696A patent/CR8696A/es unknown
- 2006-10-26 NO NO20064894A patent/NO20064894L/no not_active Application Discontinuation
- 2006-10-27 ZA ZA200608956A patent/ZA200608956B/en unknown
- 2006-11-02 MA MA29431A patent/MA28567B1/fr unknown
- 2006-11-09 EC EC2006006986A patent/ECSP066986A/es unknown

Also Published As

Publication number	Publication date
WO2005111037A1 (fr)	2005-11-24
JP2007532582A (ja)	2007-11-15
KR20070014166A (ko)	2007-01-31
CN1976931A (zh)	2007-06-06
ZA200608956B (en)	2008-06-25
UA88638C2 (ru)	2009-11-10
US20050239781A1 (en)	2005-10-27
US7951801B2 (en)	2011-05-31
CR8696A (es)	2007-08-28
EA200601884A1 (ru)	2007-04-27
DE602005020263D1 (de)	2010-05-12
NO20064894L (no)	2007-01-03
EP1735311A1 (fr)	2006-12-27
AU2005243188A1 (en)	2005-11-24
CA2561859A1 (fr)	2005-11-24
EA010546B1 (ru)	2008-10-30
EP2206713A1 (fr)	2010-07-14
BRPI0509660A (pt)	2007-10-09
ATE462702T1 (de)	2010-04-15
EP1735311B1 (fr)	2010-03-31
MXPA06011545A (es)	2007-03-26
ECSP066986A (es)	2006-12-29
RS20060584A (sr)	2008-08-07
IL178435A0 (en)	2007-02-11
TW200539880A (en)	2005-12-16
TNSN06321A1 (en)	2008-02-22

Publication	Publication Date	Title
MA28567B1 (fr)	2007-05-02	Utilisation de beta-carbolines pour le traitement de maladies inflammatoires
EA200700175A1 (ru)	2007-08-31	Композиции и способы лечения воспалительных заболеваний
MA29935B1 (fr)	2008-11-03	Inhibiteurs de l'activite de akt
EA200900802A1 (ru)	2010-04-30	Способы и композиции для лечения амилоидных заболеваний
DE602006018057D1 (de)	2010-12-16	Substituierte chinolone und verwendungsverfahren
TW200605886A (en)	2006-02-16	Indazoles useful in treating cardiovascular diseases
SE0301700D0 (sv)	2003-06-10	Novel compounds
EA200501771A1 (ru)	2006-06-30	Лиганды каннабиноидных рецепторов и их применения
ATE548039T1 (de)	2012-03-15	Kondensierte heteroarylpyridyl- und phenylbenzensulfonamide als ccr2-modulatoren zur behandlung von entzündungen
ATE544748T1 (de)	2012-02-15	Zusammensetzungen und verfahren für die behandlung von zellproliferationserkrankungen
UA85559C2 (en)	2009-02-10	Aminobenzophenone compounds
ATE437861T1 (de)	2009-08-15	2-(amino-substituierte)-4-arylpyramidine und verwandte verbindungen, die sich für die behandlung von entzündlichen krankheiten eignen
NO20053792L (no)	2005-08-10	Heterocykly-3-sulfonylindazoler som 5-hydroksytryptamin-6 ligander
ATE312096T1 (de)	2005-12-15	Neue verbindungen
EA201170344A1 (ru)	2011-08-30	Азаиндольные ингибиторы iap
EP1804787A4 (fr)	2009-01-14	Composition flavonoide pour le traitement des maladies bucco-dentaires
UA90698C2 (en)	2010-05-25	Triazole substituted aminobenzophenone compounds
SE0302304D0 (sv)	2003-08-27	Novel compounds
FR2860154B1 (fr)	2006-02-03	Composition pour le traitement de la mauvaise haleine
DE602005015963D1 (de)	2009-09-24	Estergebundene makrolide, die sich für die behandlung von mikrobiellen infektionen eignen
NO20055563L (no)	2005-11-24	Midler for behandlingen av lavere abdominale lidelser
MX2007010484A (es)	2007-10-15	Moleculas y metodos para usarlas para tratar enfermedades asociadas con mcp-1/ccr2.
ATE514679T1 (de)	2011-07-15	Biarylcarboxyarylamide als modulatoren des vanilloid-1-rezeptors
TW200716561A (en)	2007-05-01	P38 inhibitors and methods of use thereof
FR2873037B1 (fr)	2008-04-11	Methodes et compositions pour le traitement de cancers