ATE463483T1 - 6-substituierte isochinolinderivate als rock-1- inhibitoren - Google Patents

6-substituierte isochinolinderivate als rock-1- inhibitoren

Info

Publication number
ATE463483T1
ATE463483T1 AT07802697T AT07802697T ATE463483T1 AT E463483 T1 ATE463483 T1 AT E463483T1 AT 07802697 T AT07802697 T AT 07802697T AT 07802697 T AT07802697 T AT 07802697T AT E463483 T1 ATE463483 T1 AT E463483T1
Authority
AT
Austria
Prior art keywords
alkyl
halogen
isoquinoline derivatives
rock
substituted isoquinoline
Prior art date
Application number
AT07802697T
Other languages
English (en)
Inventor
Peter Ray
Steven Laats
John Morphy
Brad Sherborne
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Application granted granted Critical
Publication of ATE463483T1 publication Critical patent/ATE463483T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT07802697T 2006-08-18 2007-08-17 6-substituierte isochinolinderivate als rock-1- inhibitoren ATE463483T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06119142 2006-08-18
PCT/EP2007/058593 WO2008020081A1 (en) 2006-08-18 2007-08-17 6-substituted isoquinoline derivatives as rock-1 inhibitors

Publications (1)

Publication Number Publication Date
ATE463483T1 true ATE463483T1 (de) 2010-04-15

Family

ID=37062542

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07802697T ATE463483T1 (de) 2006-08-18 2007-08-17 6-substituierte isochinolinderivate als rock-1- inhibitoren

Country Status (10)

Country Link
US (1) US7893088B2 (de)
EP (1) EP2054389B1 (de)
JP (1) JP5341758B2 (de)
CN (1) CN101522633B (de)
AT (1) ATE463483T1 (de)
CA (1) CA2660489A1 (de)
DE (1) DE602007005811D1 (de)
ES (1) ES2341809T3 (de)
MX (1) MX2009001804A (de)
WO (1) WO2008020081A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101213187B (zh) 2005-06-28 2012-06-06 塞诺菲-安万特股份有限公司 作为rho-激酶抑制剂的异喹啉衍生物
CA2615577C (en) 2005-07-26 2014-09-09 Sanofi-Aventis Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors
RS52241B (sr) * 2005-07-26 2012-10-31 Sanofi Derivati cikloheksilamin izohinolona kao inhibitori rho-kinaze
RU2468011C2 (ru) 2006-12-27 2012-11-27 Санофи-Авентис Замещенные циклоалкиламином производные изохинолина и изохинолинона
BRPI0720986A2 (pt) 2006-12-27 2014-03-11 Sanofi Aventis Derivados de isoquinolina e isoquinolinona substituídos
NZ577980A (en) * 2006-12-27 2012-01-12 Sanofi Aventis Cycloalkylamine substituted isoquinolone derivatives
MX2009005964A (es) * 2006-12-27 2009-06-15 Sanofi Aventis Derivados de isoquinolina sustituidos con cicloalquilamina.
JP5421783B2 (ja) 2006-12-27 2014-02-19 サノフイ Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体
MY148902A (en) * 2006-12-27 2013-06-14 Sanofi Aventis Substituted isoquinolines and their use as rho-kinase inhibitors
PT2125744E (pt) * 2006-12-27 2011-07-01 Sanofi Aventis Derivados de isoquinolona e isoquinolinona substituídos com cicloalquilamina
MY153615A (en) * 2008-06-24 2015-02-27 Sanofi Aventis 6-substituted isoquinolines and isoquinolinones
CA2728137C (en) * 2008-06-24 2016-10-18 Sanofi-Aventis Substituted isoquinolines and isoquinolinones as rho kinase inhibitors
MY153756A (en) * 2008-06-24 2015-03-13 Sanofi Aventis Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as rho kinase inhibitors
WO2009158587A1 (en) * 2008-06-26 2009-12-30 Inspire Pharmaceuticals, Inc. Method for treating pulmonary diseases using rho kinase inhibitor compounds
FR3017868A1 (fr) * 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN112969694B (zh) * 2018-11-09 2023-06-13 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其用途
EP4096666A4 (de) * 2020-01-29 2024-05-22 Georgetown University Zusammensetzungen und verfahren zur behandlung von neurodegenerativen, neuroentwicklungs-, myodegenerativen und lysosomalen speicherkrankheiten
CN111440150B (zh) * 2020-05-12 2021-04-06 中国药科大学 一种一氧化氮供体型法舒地尔衍生物及其制备方法和用途
JP2025511730A (ja) * 2022-04-05 2025-04-16 ユニヴァーシティ オブ ワシントン 心筋細胞の細胞生存能を向上させるための方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100833A1 (en) 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Rho KINASE INHIBITORS
EP1541559A4 (de) 2002-07-22 2007-08-22 Asahi Kasei Pharma Corp 5-substituiertes isochinolinderivat
AU2003264427A1 (en) 2002-09-12 2004-04-30 Kirin Beer Kabushiki Kaisha Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same
UY29198A1 (es) 2004-11-09 2006-05-31 Cancer Rec Tech Ltd Derivados sustituidos de quinazolinona y derivados sustituidos de quinazolina-2, 4-diona, composiciones conteniéndolos, procedimientos de preparación y aplicaciones
RS52241B (sr) 2005-07-26 2012-10-31 Sanofi Derivati cikloheksilamin izohinolona kao inhibitori rho-kinaze
US7618985B2 (en) 2005-12-08 2009-11-17 N.V. Organon Isoquinoline derivatives

Also Published As

Publication number Publication date
DE602007005811D1 (de) 2010-05-20
EP2054389B1 (de) 2010-04-07
JP2010501480A (ja) 2010-01-21
CA2660489A1 (en) 2008-02-21
ES2341809T3 (es) 2010-06-28
EP2054389A1 (de) 2009-05-06
US7893088B2 (en) 2011-02-22
CN101522633B (zh) 2012-05-09
MX2009001804A (es) 2009-02-26
JP5341758B2 (ja) 2013-11-13
WO2008020081A1 (en) 2008-02-21
CN101522633A (zh) 2009-09-02
US20080045566A1 (en) 2008-02-21

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