ATE463483T1 - 6-substituierte isochinolinderivate als rock-1- inhibitoren - Google Patents

6-substituierte isochinolinderivate als rock-1- inhibitoren

Info

Publication number
ATE463483T1
ATE463483T1 AT07802697T AT07802697T ATE463483T1 AT E463483 T1 ATE463483 T1 AT E463483T1 AT 07802697 T AT07802697 T AT 07802697T AT 07802697 T AT07802697 T AT 07802697T AT E463483 T1 ATE463483 T1 AT E463483T1
Authority
AT
Austria
Prior art keywords
alkyl
halogen
isoquinoline derivatives
rock
substituted isoquinoline
Prior art date
Application number
AT07802697T
Other languages
English (en)
Inventor
Peter Ray
Steven Laats
John Morphy
Brad Sherborne
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Application granted granted Critical
Publication of ATE463483T1 publication Critical patent/ATE463483T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT07802697T 2006-08-18 2007-08-17 6-substituierte isochinolinderivate als rock-1- inhibitoren ATE463483T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06119142 2006-08-18
PCT/EP2007/058593 WO2008020081A1 (en) 2006-08-18 2007-08-17 6-substituted isoquinoline derivatives as rock-1 inhibitors

Publications (1)

Publication Number Publication Date
ATE463483T1 true ATE463483T1 (de) 2010-04-15

Family

ID=37062542

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07802697T ATE463483T1 (de) 2006-08-18 2007-08-17 6-substituierte isochinolinderivate als rock-1- inhibitoren

Country Status (10)

Country Link
US (1) US7893088B2 (de)
EP (1) EP2054389B1 (de)
JP (1) JP5341758B2 (de)
CN (1) CN101522633B (de)
AT (1) ATE463483T1 (de)
CA (1) CA2660489A1 (de)
DE (1) DE602007005811D1 (de)
ES (1) ES2341809T3 (de)
MX (1) MX2009001804A (de)
WO (1) WO2008020081A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1899322B1 (de) * 2005-06-28 2009-09-02 Sanofi-Aventis Isochinolinderivate als inhibitoren von rho-kinase
PT1910333E (pt) 2005-07-26 2013-08-01 Sanofi Sa Derivados de isoquinolona substituída com piperidinilo como inibidores da rho-cinase
HRP20110839T1 (hr) * 2005-07-26 2011-12-31 Sanofi Derivati cikloheksaminizokinolona kao inhibitori rho-kinaze
ATE502027T1 (de) * 2006-12-27 2011-04-15 Sanofi Aventis Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren
JP5421783B2 (ja) * 2006-12-27 2014-02-19 サノフイ Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体
KR20090094338A (ko) 2006-12-27 2009-09-04 사노피-아벤티스 치환된 이소퀴놀린 및 이소퀴놀리논 유도체
AU2007338410B2 (en) * 2006-12-27 2012-08-16 Sanofi-Aventis Cycloalkylamine substituted isoquinoline derivatives
BRPI0720710A2 (pt) * 2006-12-27 2014-12-23 Sanofi Aventis Derivados de isoquinolona e isoquinolinona substituídos com cicloalquilamina
CN101595094B (zh) * 2006-12-27 2013-02-20 塞诺菲-安万特股份有限公司 环烷基胺取代的异喹诺酮衍生物
EP2102164B1 (de) * 2006-12-27 2010-12-01 Sanofi-Aventis Cycloalkylaminsubstituierte isochinolin- und isochinolinonderivate
PE20110059A1 (es) * 2008-06-24 2011-02-15 Sanofi Aventis Isoquinolinas e isoquinolinonas sustituidas en calidad de inhibidores de la rho-quinasa
SI2303845T1 (sl) * 2008-06-24 2013-12-31 Sanofi Bi- in policiklični substituirani izokinolin in izokinolinski derivati kot inhibitorji rho-kinaze
PL2313374T3 (pl) * 2008-06-24 2014-03-31 Sanofi Sa 6-podstawione izochinoliny i izochinolinony
WO2009158587A1 (en) * 2008-06-26 2009-12-30 Inspire Pharmaceuticals, Inc. Method for treating pulmonary diseases using rho kinase inhibitor compounds
FR3017868A1 (fr) * 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN112969694B (zh) 2018-11-09 2023-06-13 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其用途
US20230095341A1 (en) * 2020-01-29 2023-03-30 Georgetown University Compositions and methods for treating neurodegenerative, myodegenerative, and lysosomal storage disorders
CN111440150B (zh) * 2020-05-12 2021-04-06 中国药科大学 一种一氧化氮供体型法舒地尔衍生物及其制备方法和用途
EP4504909A4 (de) * 2022-04-05 2026-06-17 Univ Washington Verfahren zur verbesserung der lebensfähigkeit von zellen von kardiomyozyten

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1403255A4 (de) 2001-06-12 2005-04-06 Sumitomo Pharma Rho-kinase-inhibitoren
AU2003281623B8 (en) 2002-07-22 2009-06-11 Asahi Kasei Pharma Corporation 5-substituted isoquinoline derivative
CA2502583A1 (en) 2002-09-12 2004-03-25 Kirin Beer Kabushiki Kaisha Isoquinoline derivatives having kinase inhibitory activity and medicament containing the same
UY29198A1 (es) 2004-11-09 2006-05-31 Cancer Rec Tech Ltd Derivados sustituidos de quinazolinona y derivados sustituidos de quinazolina-2, 4-diona, composiciones conteniéndolos, procedimientos de preparación y aplicaciones
HRP20110839T1 (hr) 2005-07-26 2011-12-31 Sanofi Derivati cikloheksaminizokinolona kao inhibitori rho-kinaze
US7618985B2 (en) * 2005-12-08 2009-11-17 N.V. Organon Isoquinoline derivatives

Also Published As

Publication number Publication date
DE602007005811D1 (de) 2010-05-20
ES2341809T3 (es) 2010-06-28
US7893088B2 (en) 2011-02-22
EP2054389A1 (de) 2009-05-06
CA2660489A1 (en) 2008-02-21
CN101522633A (zh) 2009-09-02
CN101522633B (zh) 2012-05-09
JP2010501480A (ja) 2010-01-21
US20080045566A1 (en) 2008-02-21
MX2009001804A (es) 2009-02-26
WO2008020081A1 (en) 2008-02-21
JP5341758B2 (ja) 2013-11-13
EP2054389B1 (de) 2010-04-07

Similar Documents

Publication Publication Date Title
DE602007005811D1 (de) 6-substituierte isochinolinderivate als rock-1-inhibitoren
TW200738682A (en) Isoquinoline derivatives
PE20091466A1 (es) Derivados de 4,5-dihidro-oxazol-2-il-amina
MX2009004920A (es) Nuevos derivados de aminopirimidina como inhibidores de plk1.
HUP0402454A2 (hu) Szubsztituált kinazolinszármazékok mint az aurora kinázok inhibitorai, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
MX2011009146A (es) Sales de adicion de aminas que contienen grupos hidroxilo y/o carboxilicos con derivados de acido aminonicotinico como inhibidores de dhodh.
TW200833675A (en) Nicotinamide derivatives
MX2009006024A (es) Derivados de heteroaril piridopirimidona sustituidos.
TW200833686A (en) Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors
ES2530943T3 (es) Derivados de la cromenona con actividad antitumoral
EP1724262A4 (de) 1-(2h)-isochinolonderivat
MX2010000658A (es) Derivados de pirimidina 934.
MX2015008971A (es) Derivados de pirimidina pirido- o pirrolo-fusionados como inhibidores de autotaxina para tratar dolor.
HRP20090151T3 (en) Indozolone derivatives as 11b-hsd1 inhibitors
EA022420B1 (ru) Гетероциклические ингибиторы глутаминилциклазы (qc, ec 2.3.2.5)
ATE545647T1 (de) 5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivat
ATE435223T1 (de) Pyrimidin-, chinazolin-, pteridin- und triazinderivate
MY169179A (en) Novel piperidine compound or salt thereof
JOP20200208A1 (ar) مشتقات 2، 4-داي أمينو كوينازولين والاستخدامات الطبية لها
WO2012044531A8 (en) Novel piperazine analogs with substituted heteroaryl groups as broad-spectrum influenza antivirals
HRP20080493T3 (hr) Supstituirani kinolinski derivati kao mitotski inhibitori kinezina
TW200716531A (en) Cyclohexanesulfonyl derivatives as GLYT1 inhibitors to treat schizophrenia
TW200616979A (en) Non-nucleoside reverse transcriptase inhibitors
NO20075617L (no) 4-fenyl-5-okso-1,4,5,6,7,8-heksahydrokinolinderivater for behandling av infertilitet
ATE512142T1 (de) Pyrimidin- und chinazolinderivate als modulatoren der somatostatin-rezeptor aktivität

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties