ATE464044T1 - Verwendung von 2-phenyl-1,2-ethanediol- (di)carbamaten zur behandlung von epileptogenese - Google Patents
Verwendung von 2-phenyl-1,2-ethanediol- (di)carbamaten zur behandlung von epileptogeneseInfo
- Publication number
- ATE464044T1 ATE464044T1 AT05810288T AT05810288T ATE464044T1 AT E464044 T1 ATE464044 T1 AT E464044T1 AT 05810288 T AT05810288 T AT 05810288T AT 05810288 T AT05810288 T AT 05810288T AT E464044 T1 ATE464044 T1 AT E464044T1
- Authority
- AT
- Austria
- Prior art keywords
- phenyl
- group
- alkyl
- epileptogenesis
- ethanediol
- Prior art date
Links
- 230000008579 epileptogenesis Effects 0.000 title abstract 2
- PWMWNFMRSKOCEY-UHFFFAOYSA-N 1-Phenyl-1,2-ethanediol Chemical compound OCC(O)C1=CC=CC=C1 PWMWNFMRSKOCEY-UHFFFAOYSA-N 0.000 title 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61027604P | 2004-09-16 | 2004-09-16 | |
| US69862505P | 2005-07-12 | 2005-07-12 | |
| US70724205P | 2005-08-11 | 2005-08-11 | |
| PCT/US2005/032861 WO2006033947A2 (en) | 2004-09-16 | 2005-09-15 | Use of 2-phenyl-1, 2-ethanediol- (di) carbamates for treating epileptogenesis and epilepsy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE464044T1 true ATE464044T1 (de) | 2010-04-15 |
Family
ID=36087909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05810288T ATE464044T1 (de) | 2004-09-16 | 2005-09-15 | Verwendung von 2-phenyl-1,2-ethanediol- (di)carbamaten zur behandlung von epileptogenese |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20060194873A1 (de) |
| JP (1) | JP2008513466A (de) |
| KR (1) | KR20070057939A (de) |
| CN (1) | CN101056629B (de) |
| AT (1) | ATE464044T1 (de) |
| AU (1) | AU2005287174B2 (de) |
| BR (1) | BRPI0515374A (de) |
| CA (1) | CA2580640A1 (de) |
| CO (1) | CO6382111A2 (de) |
| CR (1) | CR9053A (de) |
| DE (1) | DE602005020667D1 (de) |
| DK (1) | DK1809273T3 (de) |
| EA (1) | EA200700642A1 (de) |
| ES (1) | ES2342185T3 (de) |
| HR (1) | HRP20100304T1 (de) |
| IL (1) | IL181910A0 (de) |
| MX (1) | MX2007003278A (de) |
| NO (1) | NO20071921L (de) |
| NZ (1) | NZ553813A (de) |
| PT (1) | PT1809273E (de) |
| RS (1) | RS51269B (de) |
| WO (1) | WO2006033947A2 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1202720A4 (de) * | 1999-08-10 | 2004-02-25 | Uab Research Foundation | Verwendung von gaba-agonisten zur behandlung von spastischen erkrankungen, konvulsionen und epilepsie |
| BRPI0516112A (pt) * | 2004-10-15 | 2008-08-26 | Janssen Pharmaceutica Nv | métodos para neuroproteção |
| PE20070325A1 (es) * | 2005-06-29 | 2007-05-12 | Alza Corp | Formas de dosificacion oral que comprenden compuestos derivados de carbamato |
| US20070021500A1 (en) * | 2005-07-12 | 2007-01-25 | Twyman Roy E | Methods for neuroprotection |
| US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
| EA019757B1 (ru) | 2006-06-15 | 2014-06-30 | ЮСиБи ФАРМА ГМБХ | Фармацевтическая композиция с синергетическим противосудорожным эффектом |
| US7632963B2 (en) * | 2006-10-06 | 2009-12-15 | Janssen Pharmaceutica Nv | Crystal of (S)-(+)-2-(2-chlorophenyl)-2-hydroxy-ethyl carbamate |
| JP2010508354A (ja) * | 2006-10-31 | 2010-03-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 広汎性発達障害の処置 |
| US9018253B2 (en) | 2010-07-02 | 2015-04-28 | Bio-Pharm Solutions Co., Ltd. | Phenylcarbamate compound and muscle relaxant containing the same |
| US8609849B1 (en) | 2010-11-30 | 2013-12-17 | Fox Chase Chemical Diversity Center, Inc. | Hydroxylated sulfamides exhibiting neuroprotective action and their method of use |
| RU2632659C2 (ru) | 2011-12-27 | 2017-10-09 | Байо-Фарм Солюшнс Ко., Лтд. | Фенилкарбаматные соединения для применения в предупреждении или лечении эпилепсии |
| JP6062077B2 (ja) * | 2013-03-12 | 2017-01-18 | バイオ−ファーム ソリューションズ カンパニー リミテッド | 小児てんかん及びてんかん関連症侯群の予防又は治療用フェニルカルバメート化合物｛ｐｈｅｎｙｌｃａｒｂａｍａｔｅｃｏｍｐｏｕｎｄｓｆｏｒｕｓｅｉｎｐｒｅｖｅｎｔｉｎｇｏｒｔｒｅａｔｉｎｇｐｅｄｉａｔｒｉｃｅｐｉｌｅｓｙａｎｄｅｐｉｌｅｓｙ−ｒｅｌａｔｅｄｓｙｎｄｒｏｍｅｓ｝ |
| WO2014142547A1 (en) * | 2013-03-12 | 2014-09-18 | Bio-Pharm Solutions Co., Ltd. | Phenyl carbamate compound and a composition for neuroprotection comprising the same |
| CN109071424B (zh) * | 2016-02-29 | 2022-01-14 | 生物药品解决方案有限公司 | 氨基磺酸酯衍生物化合物、其制备方法及用途 |
| CN106053510A (zh) * | 2016-05-16 | 2016-10-26 | 山东省分析测试中心 | 一种基于氢核磁共振快速测定普瑞巴林原料药纯度的方法 |
| KR102421006B1 (ko) * | 2016-05-19 | 2022-07-14 | 에스케이바이오팜 주식회사 | 두통의 예방학적 치료를 위한 카바메이트 화합물의 용도 |
| JP2023536341A (ja) * | 2020-08-06 | 2023-08-24 | エスケー バイオファーマスティカルズ カンパニー リミテッド | カルバメート化合物を含む経口用固形製剤及びその製造方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3313692A (en) * | 1958-04-21 | 1967-04-11 | Armour Pharma | Method of inducing calming and muscle relaxation with carbamates |
| US3265728A (en) * | 1962-07-18 | 1966-08-09 | Armour Pharma | Substituted phenethyl carbamates |
| US20010034365A1 (en) * | 1996-01-16 | 2001-10-25 | Choi Yong Moon | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
| US5698588A (en) * | 1996-01-16 | 1997-12-16 | Yukong Limited | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
| AU3304997A (en) * | 1996-05-31 | 1998-01-05 | Southern Illinois University | Methods of modulating aspects of brain neural plasticity by vagus nerve stimulation |
| JP2002536409A (ja) * | 1999-02-09 | 2002-10-29 | ユニバーシティ オブ バージニア パテント ファウンデーション | フェルバメートから誘導される化合物 |
| CA2379365C (en) * | 1999-07-26 | 2009-11-17 | Sk Corporation | Transnasal anticonvulsive compositions and modulated process |
| DE60223506T2 (de) * | 2001-02-27 | 2008-09-18 | Ortho-Mcneil Pharmaceutical, Inc. | Carbamatverbindungen zur vorbeugung oder behandlung bipolarer erkrankungen |
| DE60220043T2 (de) * | 2001-02-27 | 2008-01-10 | Ortho-Mcneil Pharmaceutical, Inc. | Carbamatverbindungen zur vorbeugung oder behandlung von neurodegenerativen störungen |
| HUP0303243A3 (en) * | 2001-02-27 | 2012-07-30 | Ortho Mcneil Pharm Inc | Carbamate compounds for use in preventing and treating bipolar disorder |
-
2005
- 2005-09-15 PT PT05810288T patent/PT1809273E/pt unknown
- 2005-09-15 NZ NZ553813A patent/NZ553813A/en not_active IP Right Cessation
- 2005-09-15 CN CN2005800387418A patent/CN101056629B/zh not_active Expired - Fee Related
- 2005-09-15 CA CA002580640A patent/CA2580640A1/en not_active Abandoned
- 2005-09-15 AT AT05810288T patent/ATE464044T1/de active
- 2005-09-15 ES ES05810288T patent/ES2342185T3/es not_active Expired - Lifetime
- 2005-09-15 HR HR20100304T patent/HRP20100304T1/hr unknown
- 2005-09-15 US US11/227,247 patent/US20060194873A1/en not_active Abandoned
- 2005-09-15 JP JP2007532446A patent/JP2008513466A/ja active Pending
- 2005-09-15 RS RSP-2010/0264A patent/RS51269B/sr unknown
- 2005-09-15 DK DK05810288.0T patent/DK1809273T3/da active
- 2005-09-15 AU AU2005287174A patent/AU2005287174B2/en not_active Expired - Fee Related
- 2005-09-15 WO PCT/US2005/032861 patent/WO2006033947A2/en not_active Ceased
- 2005-09-15 DE DE602005020667T patent/DE602005020667D1/de not_active Expired - Lifetime
- 2005-09-15 KR KR1020077008402A patent/KR20070057939A/ko not_active Ceased
- 2005-09-15 EA EA200700642A patent/EA200700642A1/ru unknown
- 2005-09-15 BR BRPI0515374-3A patent/BRPI0515374A/pt not_active IP Right Cessation
- 2005-09-15 MX MX2007003278A patent/MX2007003278A/es active IP Right Grant
-
2007
- 2007-03-13 IL IL181910A patent/IL181910A0/en unknown
- 2007-03-29 CO CO07031825A patent/CO6382111A2/es not_active Application Discontinuation
- 2007-04-13 CR CR9053A patent/CR9053A/es not_active Application Discontinuation
- 2007-04-16 NO NO20071921A patent/NO20071921L/no not_active Application Discontinuation
- 2007-11-15 US US11/940,710 patent/US20110152362A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EA200700642A1 (ru) | 2007-10-26 |
| CO6382111A2 (es) | 2012-02-15 |
| AU2005287174B2 (en) | 2012-01-12 |
| DK1809273T3 (da) | 2010-08-02 |
| US20110152362A1 (en) | 2011-06-23 |
| MX2007003278A (es) | 2007-10-08 |
| WO2006033947A2 (en) | 2006-03-30 |
| CA2580640A1 (en) | 2006-03-30 |
| PT1809273E (pt) | 2010-05-10 |
| HK1105583A1 (en) | 2008-02-22 |
| BRPI0515374A (pt) | 2008-07-22 |
| JP2008513466A (ja) | 2008-05-01 |
| DE602005020667D1 (de) | 2010-05-27 |
| KR20070057939A (ko) | 2007-06-07 |
| NZ553813A (en) | 2010-09-30 |
| ES2342185T3 (es) | 2010-07-02 |
| US20060194873A1 (en) | 2006-08-31 |
| CR9053A (es) | 2009-10-30 |
| CN101056629B (zh) | 2012-01-11 |
| RS51269B (sr) | 2010-12-31 |
| NO20071921L (no) | 2007-06-12 |
| IL181910A0 (en) | 2007-07-04 |
| HRP20100304T1 (hr) | 2010-09-30 |
| CN101056629A (zh) | 2007-10-17 |
| WO2006033947A3 (en) | 2006-06-29 |
| AU2005287174A1 (en) | 2006-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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