CR9053A - Uso de 2-fenil-1,2-etanodiol-(id) carbamatos para tratar epileptogenesis y epilepsia - Google Patents
Uso de 2-fenil-1,2-etanodiol-(id) carbamatos para tratar epileptogenesis y epilepsiaInfo
- Publication number
- CR9053A CR9053A CR9053A CR9053A CR9053A CR 9053 A CR9053 A CR 9053A CR 9053 A CR9053 A CR 9053A CR 9053 A CR9053 A CR 9053A CR 9053 A CR9053 A CR 9053A
- Authority
- CR
- Costa Rica
- Prior art keywords
- phenyl
- group
- epilepsy
- alkyl
- ethanodiol
- Prior art date
Links
- 206010015037 epilepsy Diseases 0.000 title abstract 2
- 230000008579 epileptogenesis Effects 0.000 title abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Esta invencion se refiere a metodos para prevenir, tratar, revertir, inhibir o detener la epilepsia y epiletogenesis en un sujeto, que comprende administrar al sujeto en necesidad del mismo una cantidad terapeuticamente efectiva de un compuesto seleccionado del grupo que consiste en la formula (I) y formula (II), o un sal o ester farmaceuticamente aceptable del mismo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61027604P | 2004-09-16 | 2004-09-16 | |
| US69862505P | 2005-07-12 | 2005-07-12 | |
| US70724205P | 2005-08-11 | 2005-08-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR9053A true CR9053A (es) | 2009-10-30 |
Family
ID=36087909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR9053A CR9053A (es) | 2004-09-16 | 2007-04-13 | Uso de 2-fenil-1,2-etanodiol-(id) carbamatos para tratar epileptogenesis y epilepsia |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20060194873A1 (es) |
| JP (1) | JP2008513466A (es) |
| KR (1) | KR20070057939A (es) |
| CN (1) | CN101056629B (es) |
| AT (1) | ATE464044T1 (es) |
| AU (1) | AU2005287174B2 (es) |
| BR (1) | BRPI0515374A (es) |
| CA (1) | CA2580640A1 (es) |
| CO (1) | CO6382111A2 (es) |
| CR (1) | CR9053A (es) |
| DE (1) | DE602005020667D1 (es) |
| DK (1) | DK1809273T3 (es) |
| EA (1) | EA200700642A1 (es) |
| ES (1) | ES2342185T3 (es) |
| HR (1) | HRP20100304T1 (es) |
| IL (1) | IL181910A0 (es) |
| MX (1) | MX2007003278A (es) |
| NO (1) | NO20071921L (es) |
| NZ (1) | NZ553813A (es) |
| PT (1) | PT1809273E (es) |
| RS (1) | RS51269B (es) |
| WO (1) | WO2006033947A2 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1202720A4 (en) * | 1999-08-10 | 2004-02-25 | Uab Research Foundation | USE OF GABA AGONISTS FOR THE TREATMENT OF SPASTIC DISEASES, CONVULSIONS AND EPILEPSY |
| BRPI0516112A (pt) * | 2004-10-15 | 2008-08-26 | Janssen Pharmaceutica Nv | métodos para neuroproteção |
| PE20070325A1 (es) * | 2005-06-29 | 2007-05-12 | Alza Corp | Formas de dosificacion oral que comprenden compuestos derivados de carbamato |
| US20070021500A1 (en) * | 2005-07-12 | 2007-01-25 | Twyman Roy E | Methods for neuroprotection |
| US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
| ES2531118T5 (es) | 2006-06-15 | 2022-06-14 | Ucb Pharma Gmbh | Composición farmacéutica que comprende lacosamida y levetiracetamo para uso en el tratamiento de la epilepsia |
| MX2009003755A (es) * | 2006-10-06 | 2009-07-10 | Janssen Pharmaceutica Nv | Cristal novedoso de (s)-(+)-2-(2-clorofenil)-2-hidroxietil carbamato. |
| WO2008054984A1 (en) * | 2006-10-31 | 2008-05-08 | Janssen Pharmaceutica, N.V. | Treatment of pervasive developmental disorders |
| US9018253B2 (en) | 2010-07-02 | 2015-04-28 | Bio-Pharm Solutions Co., Ltd. | Phenylcarbamate compound and muscle relaxant containing the same |
| US8609849B1 (en) | 2010-11-30 | 2013-12-17 | Fox Chase Chemical Diversity Center, Inc. | Hydroxylated sulfamides exhibiting neuroprotective action and their method of use |
| EP2797879B1 (en) | 2011-12-27 | 2018-12-26 | Bio-Pharm Solutions Co., Ltd. | Phenyl carbamate compounds for use in alleviating or treating pain and neuropathic pain |
| US9907776B2 (en) * | 2013-03-12 | 2018-03-06 | Bio-Pharm Solutions, Co., Ltd. | Phenyl carbamate compound and a composition for preventing or treating a psychiatric disorder comprising the same |
| ES2998534T3 (en) | 2013-03-12 | 2025-02-20 | Bio Pharm Solutions Co Ltd | Phenyl carbamate compounds for use in preventing or treating pediatric epilesy |
| JP6807941B2 (ja) * | 2016-02-29 | 2021-01-06 | バイオ−ファーム ソリューションズ カンパニー リミテッド | スルファメート誘導体化合物、その製造方法および用途 |
| CN106053510A (zh) * | 2016-05-16 | 2016-10-26 | 山东省分析测试中心 | 一种基于氢核磁共振快速测定普瑞巴林原料药纯度的方法 |
| KR102421006B1 (ko) * | 2016-05-19 | 2022-07-14 | 에스케이바이오팜 주식회사 | 두통의 예방학적 치료를 위한 카바메이트 화합물의 용도 |
| WO2022031099A1 (ko) * | 2020-08-06 | 2022-02-10 | 에스케이바이오팜 주식회사 | 카바메이트 화합물을 포함하는 경구용 고형 제제 및 이의 제조방법 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3313692A (en) * | 1958-04-21 | 1967-04-11 | Armour Pharma | Method of inducing calming and muscle relaxation with carbamates |
| US3265728A (en) * | 1962-07-18 | 1966-08-09 | Armour Pharma | Substituted phenethyl carbamates |
| US5698588A (en) * | 1996-01-16 | 1997-12-16 | Yukong Limited | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
| US20010034365A1 (en) * | 1996-01-16 | 2001-10-25 | Choi Yong Moon | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
| US6104956A (en) * | 1996-05-31 | 2000-08-15 | Board Of Trustees Of Southern Illinois University | Methods of treating traumatic brain injury by vagus nerve stimulation |
| DK1156798T3 (da) * | 1999-02-09 | 2003-11-03 | Univ Virginia | Felbamat-afledte forbindelser |
| AU778896B2 (en) * | 1999-07-26 | 2004-12-23 | Sk Biopharmaceuticals Co., Ltd. | Transnasal anticonvulsive compositions and modulated process |
| EP1368021B1 (en) * | 2001-02-27 | 2007-11-14 | Ortho-Mcneil Pharmaceutical, Inc. | Carbamate compounds for use in preventing or treating bipolar disorder |
| PT1383489E (pt) * | 2001-02-27 | 2007-06-21 | Ortho Mcneil Pharm Inc | Compostos carbamato para utilização na prevenção ou tratamento de distúrbios neurodegenerativos |
| CA2439475C (en) * | 2001-02-27 | 2010-05-18 | Carlos R. Plata-Salaman | Carbamate compounds for use in preventing or treating bipolar disorder |
-
2005
- 2005-09-15 EA EA200700642A patent/EA200700642A1/ru unknown
- 2005-09-15 CN CN2005800387418A patent/CN101056629B/zh not_active Expired - Fee Related
- 2005-09-15 ES ES05810288T patent/ES2342185T3/es not_active Expired - Lifetime
- 2005-09-15 CA CA002580640A patent/CA2580640A1/en not_active Abandoned
- 2005-09-15 KR KR1020077008402A patent/KR20070057939A/ko not_active Ceased
- 2005-09-15 DE DE602005020667T patent/DE602005020667D1/de not_active Expired - Lifetime
- 2005-09-15 MX MX2007003278A patent/MX2007003278A/es active IP Right Grant
- 2005-09-15 PT PT05810288T patent/PT1809273E/pt unknown
- 2005-09-15 RS RSP-2010/0264A patent/RS51269B/sr unknown
- 2005-09-15 HR HR20100304T patent/HRP20100304T1/hr unknown
- 2005-09-15 US US11/227,247 patent/US20060194873A1/en not_active Abandoned
- 2005-09-15 AT AT05810288T patent/ATE464044T1/de active
- 2005-09-15 BR BRPI0515374-3A patent/BRPI0515374A/pt not_active IP Right Cessation
- 2005-09-15 NZ NZ553813A patent/NZ553813A/en not_active IP Right Cessation
- 2005-09-15 JP JP2007532446A patent/JP2008513466A/ja active Pending
- 2005-09-15 DK DK05810288.0T patent/DK1809273T3/da active
- 2005-09-15 WO PCT/US2005/032861 patent/WO2006033947A2/en not_active Ceased
- 2005-09-15 AU AU2005287174A patent/AU2005287174B2/en not_active Expired - Fee Related
-
2007
- 2007-03-13 IL IL181910A patent/IL181910A0/en unknown
- 2007-03-29 CO CO07031825A patent/CO6382111A2/es not_active Application Discontinuation
- 2007-04-13 CR CR9053A patent/CR9053A/es not_active Application Discontinuation
- 2007-04-16 NO NO20071921A patent/NO20071921L/no not_active Application Discontinuation
- 2007-11-15 US US11/940,710 patent/US20110152362A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070057939A (ko) | 2007-06-07 |
| EA200700642A1 (ru) | 2007-10-26 |
| AU2005287174B2 (en) | 2012-01-12 |
| CO6382111A2 (es) | 2012-02-15 |
| CA2580640A1 (en) | 2006-03-30 |
| RS51269B (sr) | 2010-12-31 |
| WO2006033947A3 (en) | 2006-06-29 |
| BRPI0515374A (pt) | 2008-07-22 |
| HRP20100304T1 (hr) | 2010-09-30 |
| US20110152362A1 (en) | 2011-06-23 |
| NO20071921L (no) | 2007-06-12 |
| US20060194873A1 (en) | 2006-08-31 |
| MX2007003278A (es) | 2007-10-08 |
| AU2005287174A1 (en) | 2006-03-30 |
| CN101056629B (zh) | 2012-01-11 |
| PT1809273E (pt) | 2010-05-10 |
| WO2006033947A2 (en) | 2006-03-30 |
| DK1809273T3 (da) | 2010-08-02 |
| ES2342185T3 (es) | 2010-07-02 |
| JP2008513466A (ja) | 2008-05-01 |
| HK1105583A1 (en) | 2008-02-22 |
| IL181910A0 (en) | 2007-07-04 |
| ATE464044T1 (de) | 2010-04-15 |
| DE602005020667D1 (de) | 2010-05-27 |
| CN101056629A (zh) | 2007-10-17 |
| NZ553813A (en) | 2010-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal (granting procedure) |