ATE464390T1 - Verfahren zur herstellung von insulinverbindungen - Google Patents

Verfahren zur herstellung von insulinverbindungen

Info

Publication number: ATE464390T1
Authority: AT; Austria
Prior art keywords: insulin compounds; producing insulin; compounds; insulin; ester
Prior art date: 2001-11-19

Application number

AT02779247T

Other languages

English (en)

Inventor

Are Bogsnes

Ingun Christiansen

Per Balschmidt

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-19

Filing date

2002-11-15

Publication date

2010-04-15

2002-11-15 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2010-04-15 Application granted granted Critical

2010-04-15 Publication of ATE464390T1 publication Critical patent/ATE464390T1/de

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
-1 amino acid ester Chemical class 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
230000007030 peptide scission Effects 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Wood Science & Technology (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Pharmacology & Pharmacy (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Obesity (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Emergency Medicine (AREA)
General Engineering & Computer Science (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT02779247T 2001-11-19 2002-11-15 Verfahren zur herstellung von insulinverbindungen ATE464390T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA200101716		2001-11-19
PCT/DK2002/000765 WO2003044210A2 (en)	2001-11-19	2002-11-15	Process for preparing insulin compounds

Publications (1)

Publication Number	Publication Date
ATE464390T1 true ATE464390T1 (de)	2010-04-15

Family

ID=8160841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02779247T ATE464390T1 (de)	2001-11-19	2002-11-15	Verfahren zur herstellung von insulinverbindungen

Country Status (15)

Country	Link
EP (1)	EP1448786B1 (de)
JP (1)	JP4404631B2 (de)
KR (1)	KR100925381B1 (de)
CN (1)	CN100424179C (de)
AT (1)	ATE464390T1 (de)
AU (1)	AU2002342597A1 (de)
BR (1)	BR0213583A (de)
CA (1)	CA2464616C (de)
DE (1)	DE60236014D1 (de)
ES (1)	ES2344448T3 (de)
HU (1)	HU228934B1 (de)
IL (2)	IL161358A0 (de)
PL (1)	PL210437B1 (de)
RU (1)	RU2376379C2 (de)
WO (1)	WO2003044210A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102006031962A1 (de) *	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Amidiertes Insulin Glargin
DE102006031955A1 (de)	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
TW200902708A (en) *	2007-04-23	2009-01-16	Wyeth Corp	Methods of protein production using anti-senescence compounds
PT3228320T (pt)	2008-10-17	2020-03-26	Sanofi Aventis Deutschland	Combinação de uma insulina e de um agonista do glp-1
KR101853606B1 (ko)	2009-07-06	2018-05-03	사노피-아벤티스 도이칠란트 게엠베하	메티오닌을 함유하는 수성 인슐린 제제
PL2464655T3 (pl) *	2009-08-11	2017-08-31	Biocon Limited	Procesy chromatograficzne
KR101337322B1 (ko)	2009-11-13	2013-12-06	사노피-아벤티스 도이칠란트 게엠베하	Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물
DK2498802T3 (en)	2009-11-13	2015-04-13	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a GLP-1 agonist, insulin and a methionine
ES2606554T3 (es)	2010-08-30	2017-03-24	Sanofi-Aventis Deutschland Gmbh	Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
PL2750699T3 (pl)	2011-08-29	2015-12-31	Sanofi Aventis Deutschland	Kombinacja farmaceutyczna do stosowania w kontroli glikemii u pacjentów z cukrzycą typu 2
AR087744A1 (es)	2011-09-01	2014-04-16	Sanofi Aventis Deutschland	Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
CN102703552B (zh) *	2012-05-15	2014-10-29	山东阿华生物药业有限公司	重组人胰岛素的制备方法及其产品
CN102816819B (zh) *	2012-08-13	2014-10-29	山东阿华生物药业有限公司	提高人胰岛素前体融合蛋白酶切转换成b30缺苏氨酸人胰岛素产率的方法
CN103305581B (zh) *	2013-07-04	2015-05-27	珠海联邦制药股份有限公司	一种重组人胰岛素的制备方法
CN105849273B (zh) *	2013-12-23	2020-01-14	拜康研究有限公司	人胰岛素甲酯的生产方法
AU2015359376B2 (en)	2014-12-12	2021-09-09	Sanofi-Aventis Deutschland Gmbh	Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
EP3341405A4 (de) *	2015-09-24	2019-05-01	Hanmi Pharm. Co., Ltd.	Verfahren zur insulinproduktion

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4343898A (en)	1980-02-11	1982-08-10	Novo Industri A/S	Process for preparing esters of human insulin
EP0088117B1 (de)	1981-09-15	1986-09-24	Nordisk Insulinlaboratorium	Verfahren zur herstellung von menschlichem insulin oder b-30-estern davon
DE3262052D1 (en)	1981-08-10	1985-03-07	Nordisk Insulinlab	Process for the enzymatic preparation of human insulin
DK149824C (da)	1982-01-22	1987-03-16	Carlsberg Biotechnology Ltd	Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner
WO1983002772A1 (en)	1982-02-08	1983-08-18	Robin Ewart Offord	An improved method for preparing human insulin from non-human insulin
DK347086D0 (da)	1986-07-21	1986-07-21	Novo Industri As	Novel peptides
PH25772A (en)	1985-08-30	1991-10-18	Novo Industri As	Insulin analogues, process for their preparation
IL84110A (en) *	1986-10-14	1992-11-15	Lilly Co Eli	Process for transforming a human insulin precursor to a human insulin
DE3880346T2 (de)	1987-02-25	1993-07-29	Novonordisk As	Insulinderivate.
SI0792290T1 (en)	1993-09-17	2001-12-31	Novo Nordisk As	Acylated insulin
US6011007A (en)	1993-09-17	2000-01-04	Novo Nordisk A/S	Acylated insulin
RU2141531C1 (ru) *	1999-05-26	1999-11-20	Российское акционерное общество открытого типа "Биопрепарат"	Способ получения рекомбинантного инсулина человека
CA2392844A1 (en)	1999-12-29	2001-07-12	Novo Nordisk A/S	Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
JP4773023B2 (ja)	1999-12-29	2011-09-14	ノボノルディスクアクティーゼルスカブ	インスリン前駆体及びインスリン前駆体類似体の製造方法
CA2409347C (en)	2000-04-14	2010-03-30	Frank T. Robb	Enhanced protein thermostability and temperature resistance
WO2002079254A1 (en)	2001-03-29	2002-10-10	Janoff Edward N	Human monoclonal antibodies against capsular polysaccharides of streptococcus pneumoniae

2002
- 2002-11-15 RU RU2004118503/13A patent/RU2376379C2/ru not_active IP Right Cessation
- 2002-11-15 EP EP02779247A patent/EP1448786B1/de not_active Expired - Lifetime
- 2002-11-15 CN CNB028229622A patent/CN100424179C/zh not_active Expired - Lifetime
- 2002-11-15 WO PCT/DK2002/000765 patent/WO2003044210A2/en not_active Ceased
- 2002-11-15 JP JP2003545831A patent/JP4404631B2/ja not_active Expired - Lifetime
- 2002-11-15 BR BR0213583-3A patent/BR0213583A/pt not_active Application Discontinuation
- 2002-11-15 PL PL369447A patent/PL210437B1/pl unknown
- 2002-11-15 IL IL16135802A patent/IL161358A0/xx unknown
- 2002-11-15 AU AU2002342597A patent/AU2002342597A1/en not_active Abandoned
- 2002-11-15 KR KR1020047007129A patent/KR100925381B1/ko not_active Expired - Fee Related
- 2002-11-15 AT AT02779247T patent/ATE464390T1/de not_active IP Right Cessation
- 2002-11-15 ES ES02779247T patent/ES2344448T3/es not_active Expired - Lifetime
- 2002-11-15 HU HU0500037A patent/HU228934B1/hu not_active IP Right Cessation
- 2002-11-15 CA CA2464616A patent/CA2464616C/en not_active Expired - Fee Related
- 2002-11-15 DE DE60236014T patent/DE60236014D1/de not_active Expired - Lifetime
2004
- 2004-04-14 IL IL161358A patent/IL161358A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU2002342597A8 (en)	2003-06-10
CN1589328A (zh)	2005-03-02
JP4404631B2 (ja)	2010-01-27
WO2003044210A2 (en)	2003-05-30
KR100925381B1 (ko)	2009-11-09
RU2376379C2 (ru)	2009-12-20
AU2002342597A1 (en)	2003-06-10
DE60236014D1 (de)	2010-05-27
EP1448786A2 (de)	2004-08-25
IL161358A (en)	2011-05-31
IL161358A0 (en)	2004-09-27
PL369447A1 (en)	2005-04-18
JP2005509687A (ja)	2005-04-14
PL210437B1 (pl)	2012-01-31
EP1448786B1 (de)	2010-04-14
KR20050044855A (ko)	2005-05-13
CN100424179C (zh)	2008-10-08
CA2464616A1 (en)	2003-05-30
HUP0500037A2 (hu)	2005-03-29
ES2344448T3 (es)	2010-08-27
BR0213583A (pt)	2004-08-24
CA2464616C (en)	2012-07-24
RU2004118503A (ru)	2005-06-10
WO2003044210A3 (en)	2004-03-25
HUP0500037A3 (en)	2010-01-28
HU228934B1 (hu)	2013-06-28

Legal Events

Date	Code	Title	Description
2010-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60236014D1 (de)	2010-05-27	Verfahren zur herstellung von insulinverbindungen
ATE461270T1 (de)	2010-04-15	Verfahren zur herstellung von l-aminosäuren
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ATE206407T1 (de)	2001-10-15	Verfahren zur herstellung von hiv proteasinhibitoren
ATE458066T1 (de)	2010-03-15	Verfahren zur herstellung von substituierten carbonsäureestern mittels enzymatischer hydrolyse
DE50311645D1 (de)	2009-08-13	Verfahren zur enzymatischen Herstellung enantiomerenangereicherter Beta-Aminosäuren
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DE69528160D1 (de)	2002-10-17	Verfahren zur herstellung von 5,7 dichlor-4-hydroxychinolin
WO2004081220A3 (en)	2005-01-27	A process for enzymatically resolving an enantiomeric mixture of alpha-hydroxy acids
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DE60103565D1 (de)	2004-07-01	Verfahren zur herstellung von 2-methoxy-4-methyl-6-methylamino-1,3,5-triazin
ATE317842T1 (de)	2006-03-15	Verfahren zur herstellung von 2-halo-6- nitrobenzoesäuren