ATE464910T1 - Humane cd80-mutante und zusammensetzungen und methoden zu deren herstellung und verwendung - Google Patents

Humane cd80-mutante und zusammensetzungen und methoden zu deren herstellung und verwendung

Info

Publication number
ATE464910T1
ATE464910T1 AT00926416T AT00926416T ATE464910T1 AT E464910 T1 ATE464910 T1 AT E464910T1 AT 00926416 T AT00926416 T AT 00926416T AT 00926416 T AT00926416 T AT 00926416T AT E464910 T1 ATE464910 T1 AT E464910T1
Authority
AT
Austria
Prior art keywords
methods
compositions
mutant
human
production
Prior art date
Application number
AT00926416T
Other languages
English (en)
Inventor
Rafick Sekaly
Mark Holterman
David Weiner
Michael Agadjanyan
Original Assignee
Univ Pennsylvania
Univ Montreal
Inst Rech S Cliniques De Montr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania, Univ Montreal, Inst Rech S Cliniques De Montr filed Critical Univ Pennsylvania
Application granted granted Critical
Publication of ATE464910T1 publication Critical patent/ATE464910T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AT00926416T 1999-04-30 2000-04-27 Humane cd80-mutante und zusammensetzungen und methoden zu deren herstellung und verwendung ATE464910T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13176499P 1999-04-30 1999-04-30
PCT/US2000/011310 WO2000066162A1 (en) 1999-04-30 2000-04-27 Mutant human cd80 and compositions for and methods of making and using the same

Publications (1)

Publication Number Publication Date
ATE464910T1 true ATE464910T1 (de) 2010-05-15

Family

ID=22450922

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00926416T ATE464910T1 (de) 1999-04-30 2000-04-27 Humane cd80-mutante und zusammensetzungen und methoden zu deren herstellung und verwendung

Country Status (13)

Country Link
US (2) US7446189B1 (de)
EP (1) EP1173204B1 (de)
JP (1) JP2002542800A (de)
KR (2) KR100903710B1 (de)
CN (1) CN1196495C (de)
AT (1) ATE464910T1 (de)
AU (1) AU779395B2 (de)
BR (1) BR0010155A (de)
CA (1) CA2369747A1 (de)
DE (1) DE60044247D1 (de)
IL (2) IL145795A0 (de)
MX (1) MXPA01011079A (de)
WO (1) WO2000066162A1 (de)

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CN110325205B (zh) 2016-12-22 2023-08-15 库尔生物制药有限公司 T细胞调节性多聚体多肽及其使用方法
US11851471B2 (en) 2017-01-09 2023-12-26 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
KR20240005989A (ko) 2017-03-15 2024-01-12 큐 바이오파마, 인크. 면역 반응을 조절하는 방법
MX2019010887A (es) 2017-03-16 2019-10-15 Alpine Immune Sciences Inc Proteinas inmunomoduladoras de cb80 variante y usos de estas.
WO2019139896A1 (en) 2018-01-09 2019-07-18 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
WO2020219896A1 (en) * 2019-04-26 2020-10-29 Beijing Xuanyi Pharmasciences Co., Ltd. Cd80 variant proteins and uses thereof
CN117660331A (zh) 2019-11-20 2024-03-08 吉爱希公司 用于培养自然杀手细胞的组合物及使用其来生产自然杀手细胞的方法
IL296209A (en) 2020-05-12 2022-11-01 Cue Biopharma Inc Multimeric t-cell modulatory polypeptides and methods of using them
JP2023541366A (ja) 2020-09-09 2023-10-02 キュー バイオファーマ， インコーポレイテッド １型真性糖尿病（ｔ１ｄ）を治療するためのｍｈｃクラスｉｉ ｔ細胞調節多量体ポリペプチド及びその使用方法

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Also Published As

Publication number Publication date
WO2000066162A9 (en) 2002-01-10
AU4494700A (en) 2000-11-17
US7446189B1 (en) 2008-11-04
KR100903710B1 (ko) 2009-06-19
EP1173204B1 (de) 2010-04-21
JP2002542800A (ja) 2002-12-17
DE60044247D1 (de) 2010-06-02
IL145795A (en) 2010-02-17
MXPA01011079A (es) 2002-07-22
US8202847B2 (en) 2012-06-19
CN1196495C (zh) 2005-04-13
EP1173204A1 (de) 2002-01-23
IL145795A0 (en) 2002-07-25
CA2369747A1 (en) 2000-11-09
KR20080052690A (ko) 2008-06-11
WO2000066162A1 (en) 2000-11-09
CN1384758A (zh) 2002-12-11
AU779395B2 (en) 2005-01-20
US20110002956A1 (en) 2011-01-06
KR20020047032A (ko) 2002-06-21
EP1173204A4 (de) 2003-11-05
BR0010155A (pt) 2002-01-15

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