|
US4196265A
(en)
|
1977-06-15 |
1980-04-01 |
The Wistar Institute |
Method of producing antibodies
|
|
US4469797A
(en)
|
1982-09-23 |
1984-09-04 |
Miles Laboratories, Inc. |
Digoxigenin immunogens, antibodies, labeled conjugates, and related derivatives
|
|
US5082658A
(en)
|
1984-01-16 |
1992-01-21 |
Genentech, Inc. |
Gamma interferon-interleukin-2 synergism
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
US5679543A
(en)
|
1985-08-29 |
1997-10-21 |
Genencor International, Inc. |
DNA sequences, vectors and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US4935233A
(en)
|
1985-12-02 |
1990-06-19 |
G. D. Searle And Company |
Covalently linked polypeptide cell modulators
|
|
US5359035A
(en)
|
1985-12-21 |
1994-10-25 |
Hoechst Aktiengesellschaft |
Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF)
|
|
US4954617A
(en)
|
1986-07-07 |
1990-09-04 |
Trustees Of Dartmouth College |
Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes
|
|
US5019368A
(en)
|
1989-02-23 |
1991-05-28 |
Cancer Biologics, Inc. |
Detection of necrotic malignant tissue and associated therapy
|
|
EP0307434B2
(de)
|
1987-03-18 |
1998-07-29 |
Scotgen Biopharmaceuticals, Inc. |
Geänderte antikörper
|
|
US5091513A
(en)
|
1987-05-21 |
1992-02-25 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
AU612370B2
(en)
|
1987-05-21 |
1991-07-11 |
Micromet Ag |
Targeted multifunctional proteins
|
|
DE3853740T2
(de)
|
1987-06-10 |
1995-11-09 |
Dana Farber Cancer Inst Inc |
Bifunktionelle Antikörperkonstruktionen und Verfahren zur selektiven Tötung von Zellbeständen.
|
|
US5064646A
(en)
|
1988-08-02 |
1991-11-12 |
The University Of Maryland |
Novel infectious bursal disease virus
|
|
ATE88900T1
(de)
|
1987-09-02 |
1993-05-15 |
Ciba Geigy Ag |
Konjugate von interferon alpha mit immunglobulinen.
|
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
DE3850542T2
(de)
|
1987-09-23 |
1994-11-24 |
Bristol Myers Squibb Co |
Antikörper-Heterokonjugate zur Töting von HIV-infizierten Zellen.
|
|
PT88641B
(pt)
|
1987-10-02 |
1993-04-30 |
Genentech Inc |
Metodo para a preparacao de uma variante de adesao
|
|
US5714585A
(en)
|
1987-10-26 |
1998-02-03 |
Sterling Winthrop, Inc. |
Antibodies that are immunoreactive with interleukin-7
|
|
ZA887773B
(en)
*
|
1987-10-26 |
1989-07-26 |
Immunex Corp |
Interleukin-7
|
|
WO1989006692A1
(en)
|
1988-01-12 |
1989-07-27 |
Genentech, Inc. |
Method of treating tumor cells by inhibiting growth factor receptor function
|
|
CA1341588C
(en)
|
1988-01-26 |
2009-01-06 |
Michel Revel |
Human ifn-beta2/i1-6, its purification and use
|
|
US5120525A
(en)
|
1988-03-29 |
1992-06-09 |
Immunomedics, Inc. |
Radiolabeled antibody cytotoxic therapy of cancer
|
|
DE3812605A1
(de)
|
1988-04-15 |
1990-06-07 |
Leskovar Peter Dipl Ing Dr Hab |
Immunregulative stoffe und stoffgemische zur aktiven beeinflussung des krankheitsverlaufes
|
|
IE62463B1
(en)
|
1988-07-07 |
1995-02-08 |
Res Dev Foundation |
Immunoconjugates for cancer diagnosis and therapy
|
|
US5601819A
(en)
|
1988-08-11 |
1997-02-11 |
The General Hospital Corporation |
Bispecific antibodies for selective immune regulation and for selective immune cell binding
|
|
US5242824A
(en)
|
1988-12-22 |
1993-09-07 |
Oncogen |
Monoclonal antibody to human carcinomas
|
|
US5116964A
(en)
|
1989-02-23 |
1992-05-26 |
Genentech, Inc. |
Hybrid immunoglobulins
|
|
US5225538A
(en)
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
|
US6750329B1
(en)
|
1989-05-05 |
2004-06-15 |
Research Development Foundation |
Antibody delivery system for biological response modifiers
|
|
ZA902949B
(en)
|
1989-05-05 |
1992-02-26 |
Res Dev Foundation |
A novel antibody delivery system for biological response modifiers
|
|
US5399346A
(en)
|
1989-06-14 |
1995-03-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Gene therapy
|
|
EP0479909B1
(de)
|
1989-06-29 |
1996-10-30 |
Medarex, Inc. |
Bispezifische reagenzien für die aids-therapie
|
|
EP0406857B1
(de)
|
1989-07-07 |
1995-05-24 |
Takeda Chemical Industries, Ltd. |
Proteine und deren Herstellung
|
|
DE69030579T2
(de)
|
1989-09-20 |
1997-11-13 |
Abbott Lab |
Verfahren zur herstellung von fusionsproteinen
|
|
US5314995A
(en)
|
1990-01-22 |
1994-05-24 |
Oncogen |
Therapeutic interleukin-2-antibody based fusion proteins
|
|
JPH07507440A
(ja)
|
1990-03-02 |
1995-08-24 |
レプリゲン・コーポレーション |
結合親和性を高めた抗体構築物
|
|
AU654811B2
(en)
|
1990-03-20 |
1994-11-24 |
Trustees Of Columbia University In The City Of New York, The |
Chimeric antibodies with receptor binding ligands in place of their constant region
|
|
US5349053A
(en)
|
1990-06-01 |
1994-09-20 |
Protein Design Labs, Inc. |
Chimeric ligand/immunoglobulin molecules and their uses
|
|
US7253264B1
(en)
|
1990-06-28 |
2007-08-07 |
Sanofi-Arentideutschland GmbH |
Immunoglobulin fusion proteins, their production and use
|
|
ATE169030T1
(de)
*
|
1990-06-28 |
1998-08-15 |
Hoechst Ag |
Fusionsproteine mit immunglobulinanteilen, ihre herstellung und verwendung
|
|
WO1992002240A2
(en)
|
1990-07-27 |
1992-02-20 |
Repligen Corporation |
Novel methods and compositions for treatment of angiogenic diseases
|
|
ATE218889T1
(de)
|
1990-11-09 |
2002-06-15 |
Stephen D Gillies |
Cytokine immunokonjugate
|
|
WO1992008801A1
(en)
|
1990-11-09 |
1992-05-29 |
Abbott Laboratories |
Bridging antibody fusion constructs
|
|
US5650150A
(en)
|
1990-11-09 |
1997-07-22 |
Gillies; Stephen D. |
Recombinant antibody cytokine fusion proteins
|
|
CA2095852C
(en)
|
1990-12-05 |
2001-05-08 |
Uffe Lovborg |
Proteins with changed epitopes and methods for the production thereof
|
|
US5709859A
(en)
|
1991-01-24 |
1998-01-20 |
Bristol-Myers Squibb Company |
Mixed specificity fusion proteins
|
|
GB9105245D0
(en)
|
1991-03-12 |
1991-04-24 |
Lynxvale Ltd |
Binding molecules
|
|
US6072039A
(en)
|
1991-04-19 |
2000-06-06 |
Rohm And Haas Company |
Hybrid polypeptide comparing a biotinylated avidin binding polypeptide fused to a polypeptide of interest
|
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
|
WO1993003157A1
(en)
|
1991-07-29 |
1993-02-18 |
Dana Farber Cancer Institute |
Plasmids for the rapid preparation of modified proteins
|
|
ATE173763T1
(de)
|
1991-08-30 |
1998-12-15 |
Hutchinson Fred Cancer Res |
Hybride cytokine
|
|
US20020037558A1
(en)
|
1991-10-23 |
2002-03-28 |
Kin-Ming Lo |
E.coli produced immunoglobulin constructs
|
|
US6627615B1
(en)
|
1991-12-17 |
2003-09-30 |
The Regents Of The University Of California |
Methods and compositions for in vivo gene therapy
|
|
DK0615451T3
(da)
|
1992-05-26 |
2006-04-24 |
Immunex Corp |
Hidtil ukendt cytokin der binder til CD30
|
|
WO1993024640A2
(en)
|
1992-06-04 |
1993-12-09 |
The Regents Of The University Of California |
Methods and compositions for in vivo gene therapy
|
|
US5614184A
(en)
|
1992-07-28 |
1997-03-25 |
New England Deaconess Hospital |
Recombinant human erythropoietin mutants and therapeutic methods employing them
|
|
CA2142007C
(en)
|
1992-08-11 |
2007-10-30 |
Robert Glen Urban |
Immunomodulatory peptides
|
|
DE4228839A1
(de)
|
1992-08-29 |
1994-03-03 |
Behringwerke Ag |
Verfahren zum Nachweis und zur Bestimmung von Mediatoren
|
|
WO1994025609A1
(en)
|
1993-04-28 |
1994-11-10 |
Hybritech Incorporated |
Method for creating optimized regulatory regions affecting protein expression and protein trafficking
|
|
US5554512A
(en)
|
1993-05-24 |
1996-09-10 |
Immunex Corporation |
Ligands for flt3 receptors
|
|
GB9316989D0
(en)
|
1993-08-16 |
1993-09-29 |
Lynxvale Ltd |
Binding molecules
|
|
WO1995021258A1
(en)
|
1994-02-01 |
1995-08-10 |
United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Fusion proteins that include antibody and nonantibody portions
|
|
CA2190101A1
(en)
|
1994-05-13 |
1995-11-23 |
Donald Leonard Nicholas Cardy |
Improvements in or relating to peptide delivery
|
|
CU22615A1
(es)
|
1994-06-30 |
2000-02-10 |
Centro Inmunologia Molecular |
Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos
|
|
HUT76369A
(en)
|
1994-07-29 |
1997-08-28 |
Smithkline Beecham Corp |
Novel soluble protein compounds
|
|
US5541087A
(en)
|
1994-09-14 |
1996-07-30 |
Fuji Immunopharmaceuticals Corporation |
Expression and export technology of proteins as immunofusins
|
|
ES2167391T3
(es)
|
1994-09-16 |
2002-05-16 |
Merck Patent Gmbh |
Inmunoconjugados ii.
|
|
EP1621206A1
(de)
|
1994-12-12 |
2006-02-01 |
Beth Israel Deaconess Medical Center, Inc. |
Chimäre Zytokine und ihre Verwendung
|
|
US6485726B1
(en)
|
1995-01-17 |
2002-11-26 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
|
US6086875A
(en)
|
1995-01-17 |
2000-07-11 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of immunogens
|
|
JP3342873B2
(ja)
|
1995-03-10 |
2002-11-11 |
ジェネンテク・インコーポレイテッド |
ｇａｓ６による受容体活性化
|
|
US6281010B1
(en)
|
1995-06-05 |
2001-08-28 |
The Trustees Of The University Of Pennsylvania |
Adenovirus gene therapy vehicle and cell line
|
|
AU5985996A
(en)
|
1995-06-07 |
1997-01-15 |
Osteosa Inc. |
Osteoclast growth regulatory factor
|
|
AU5893796A
(en)
|
1995-06-07 |
1996-12-30 |
Novo Nordisk A/S |
Modification of polypeptides
|
|
GB9511935D0
(en)
|
1995-06-13 |
1995-08-09 |
Smithkline Beecham Plc |
Novel compound
|
|
US6620413B1
(en)
|
1995-12-27 |
2003-09-16 |
Genentech, Inc. |
OB protein-polymer chimeras
|
|
RU2178307C2
(ru)
|
1995-12-27 |
2002-01-20 |
Джинентех Инк. |
Производные ов-протеина
|
|
US5723125A
(en)
|
1995-12-28 |
1998-03-03 |
Tanox Biosystems, Inc. |
Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
|
|
US6750334B1
(en)
|
1996-02-02 |
2004-06-15 |
Repligen Corporation |
CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
|
|
WO1997030089A1
(en)
|
1996-02-13 |
1997-08-21 |
Regents Of The University Of California |
Novel antibody-cytokine fusion protein, and methods of making and using the same
|
|
US5756541A
(en)
|
1996-03-11 |
1998-05-26 |
Qlt Phototherapeutics Inc |
Vision through photodynamic therapy of the eye
|
|
AU2527397A
(en)
|
1996-03-13 |
1997-10-01 |
Protein Design Labs, Inc. |
Fas ligand fusion proteins and their uses
|
|
ATE279947T1
(de)
|
1996-03-18 |
2004-11-15 |
Univ Texas |
Immunglobulinähnliche domäne mit erhöhten halbwertszeiten
|
|
WO1997043316A1
(en)
|
1996-05-10 |
1997-11-20 |
Beth Israel Deaconess Medical Center, Inc. |
Physiologically active molecules with extended half-lives and methods of using same
|
|
CA2258593A1
(en)
|
1996-07-02 |
1998-01-08 |
Abraham Nudelman |
Retinoyloxy(substituted)alkylene butyrates useful for the treatment of cancer and other proliferative diseases
|
|
EP0826696B1
(de)
|
1996-09-03 |
2002-05-29 |
GSF-Forschungszentrum für Umwelt und Gesundheit GmbH |
Verwendung bi-und trispezifischer Antikörper zur Induktion einer Tumorimmunität
|
|
CA2275183A1
(en)
|
1996-12-20 |
1998-07-02 |
Amgen Inc. |
Ob fusion protein compositions and methods
|
|
US6737057B1
(en)
|
1997-01-07 |
2004-05-18 |
The University Of Tennessee Research Corporation |
Compounds, compositions and methods for the endocytic presentation of immunosuppressive factors
|
|
US6100387A
(en)
|
1997-02-28 |
2000-08-08 |
Genetics Institute, Inc. |
Chimeric polypeptides containing chemokine domains
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
CN1202862C
(zh)
|
1997-04-17 |
2005-05-25 |
安姆根有限公司 |
包含具有抗体Fc链的稳定、有活性人OB蛋白的结合物的组合物及方法
|
|
WO1998052976A1
(en)
|
1997-05-21 |
1998-11-26 |
Biovation Limited |
Method for the production of non-immunogenic proteins
|
|
GB9712892D0
(en)
|
1997-06-20 |
1997-08-20 |
Eclagen Ltd |
Identification of mhc binding peptides
|
|
AU8182298A
(en)
|
1997-07-10 |
1999-02-08 |
Beth Israel Deaconess Medical Center |
Recombinant erythropoietin / immunoglobulin fusion proteins
|
|
CN1269805A
(zh)
|
1997-07-14 |
2000-10-11 |
博尔德生物技术公司 |
生长激素和相关蛋白的衍生物
|
|
PT1037927E
(pt)
|
1997-12-08 |
2004-10-29 |
Emd Lexigen Res Ct Corp |
Proteinas de fusao heterodimericas uteis para imunoterapia de abordagem selectiva e estimulacao imunologica geral
|
|
US20030105294A1
(en)
|
1998-02-25 |
2003-06-05 |
Stephen Gillies |
Enhancing the circulating half life of antibody-based fusion proteins
|
|
CN1204147C
(zh)
|
1998-02-25 |
2005-06-01 |
利思进药品公司 |
提高以抗体为基础的融合蛋白的循环半衰期的方法
|
|
ATE329622T1
(de)
*
|
1998-04-15 |
2006-07-15 |
Lexigen Pharm Corp |
Steigerung der antikörper-zytokin- fusionsproteinmediierten immunantwort durch mitverabreichung mit einem angiogeneseinhibitor
|
|
RU2217168C2
(ru)
|
1998-04-17 |
2003-11-27 |
Лексиген Фармасьютикэлс Корпорейшн |
Усиление иммунных ответов, опосредованных белками, слитыми из антитела и цитокина, посредством совместного введения ингибитора простагландина
|
|
WO1999054484A1
(en)
|
1998-04-20 |
1999-10-28 |
The Regents Of The University Of California |
Modified immunoglobulin molecules and methods for use thereof
|
|
EP1088888A4
(de)
|
1998-05-14 |
2005-03-16 |
Merck Patent Gmbh |
Fusionierte proteine
|
|
EP1105427A2
(de)
|
1998-08-17 |
2001-06-13 |
Abgenix, Inc. |
Herstellung von modifizierten molekülen mit mit erhöhten halbwertszeiten
|
|
ATE462725T1
(de)
|
1998-08-25 |
2010-04-15 |
Merck Patent Gmbh |
Expression und export von angiostatin und endostatin als immunofusins
|
|
US6646113B1
(en)
|
1998-09-17 |
2003-11-11 |
The Trustees Of The University Of Pennsylvania |
Nucleic acid molecule encoding human survival of motor neuron-interacting protein 1 (SIP1) deletion mutants
|
|
US6335176B1
(en)
|
1998-10-16 |
2002-01-01 |
Pharmacopeia, Inc. |
Incorporation of phosphorylation sites
|
|
EP1051432B1
(de)
|
1998-12-08 |
2007-01-24 |
Biovation Limited |
Verfahren zur verminderung der immunogenität von proteinen
|
|
BR0007414A
(pt)
|
1999-01-07 |
2001-10-16 |
Lexigen Pharm Corp |
Expressão e exportação de proteìnas antiobesidade como proteìnas de fusão fc
|
|
WO2000067761A1
(en)
|
1999-05-06 |
2000-11-16 |
Wake Forest University |
Compositions and methods for identifying antigens which elicit an immune response
|
|
KR20020018197A
(ko)
|
1999-05-19 |
2002-03-07 |
추후보정 |
Ｆｃ 융합 단백질로서의 인터페론-알파 단백질의 발현 및분비
|
|
SK782002A3
(en)
|
1999-07-21 |
2003-08-05 |
Lexigen Pharm Corp |
FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
|
US7067110B1
(en)
|
1999-07-21 |
2006-06-27 |
Emd Lexigen Research Center Corp. |
Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
|
BR0013231A
(pt)
|
1999-08-09 |
2002-07-23 |
Lexigen Pharm Corp |
Complexos citocina-anticorpo múltiplos
|
|
EP1228214A2
(de)
|
1999-11-12 |
2002-08-07 |
MERCK PATENT GmbH |
Erythropoietinformen mit verbesserten eigenschaften
|
|
JP5179689B2
(ja)
|
2000-02-11 |
2013-04-10 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
抗体ベース融合タンパク質の循環系内半減期の増強
|
|
PT1257297E
(pt)
|
2000-02-24 |
2006-12-29 |
Philogen Spa |
Composições e método para tratamento da angiogénese em lesões patológicas
|
|
AU2001263149A1
(en)
|
2000-05-12 |
2001-11-26 |
Neose Technologies, Inc. |
In vitro fucosylation recombinant glycopeptides
|
|
JP5390055B2
(ja)
|
2000-06-29 |
2014-01-15 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
免疫サイトカインの取り込み増強剤との併用治療による抗体−サイトカイン融合タンパク質媒介免疫応答の増強
|
|
MXPA03006294A
(es)
|
2001-01-18 |
2003-09-16 |
Merck Patent Gmbh |
Proteinas de fusion disfuncionales con actividad glucocerebrosidasa.
|
|
AU2002256624B2
(en)
|
2001-02-19 |
2007-12-06 |
Merck Patent Gmbh |
Method for identification of T-cell epitopes and use for preparing molecules with reduced immunogenicity
|
|
PL362324A1
(en)
|
2001-02-19 |
2004-10-18 |
Merck Patent Gmbh |
Artificial fusion proteins with reduced immunogenicity
|
|
HUP0303428A2
(hu)
|
2001-03-07 |
2004-01-28 |
Merck Patent Gmbh. |
Expressziós eljárás hibrid izotípusú antitestcsoportot tartalmazó fehérjékhez
|
|
WO2002079415A2
(en)
|
2001-03-30 |
2002-10-10 |
Lexigen Pharmaceuticals Corp. |
Reducing the immunogenicity of fusion proteins
|
|
DE10119338A1
(de)
|
2001-04-20 |
2002-10-24 |
Clariant Gmbh |
Verwendung von Copolymerisaten auf Basis von Acrylamidoalkylsulfonsäuren als Verdicker in Zubereitungen enthaltend organische Lösemittel
|
|
KR100900166B1
(ko)
|
2001-05-03 |
2009-06-02 |
메르크 파텐트 게엠베하 |
재조합 종양 특이적 항체 및 이들의 용도
|
|
WO2003015697A2
(en)
|
2001-08-13 |
2003-02-27 |
University Of Southern California |
Interleukin-2 mutants with reduced toxicity
|
|
ATE542137T1
(de)
|
2001-12-04 |
2012-02-15 |
Merck Patent Gmbh |
Immunocytokine mit modulierter selektivität
|
|
WO2003077834A2
(en)
|
2002-03-15 |
2003-09-25 |
The Brigham And Women's Hospital, Inc. |
Central airway administration for systemic delivery of therapeutics
|
|
CN100432105C
(zh)
|
2002-12-17 |
2008-11-12 |
默克专利有限公司 |
与gd2结合的小鼠14.18抗体的人源化抗体(h14.18)以及其与il-2的融合
|
|
US20050069521A1
(en)
|
2003-08-28 |
2005-03-31 |
Emd Lexigen Research Center Corp. |
Enhancing the circulating half-life of interleukin-2 proteins
|
|
PT1699822E
(pt)
|
2003-12-30 |
2008-07-30 |
Merck Patent Gmbh |
Proteínas de fusão de il-7
|
|
BRPI0417916A
(pt)
|
2003-12-31 |
2007-04-10 |
Merck Patent Gmbh |
proteìna de fusão de fc-eritropoietina com farmacocinética melhorada
|
|
AU2005206277B2
(en)
|
2004-01-22 |
2011-06-23 |
Merck Patent Gmbh |
Anti-cancer antibodies with reduced complement fixation
|
|
US7670595B2
(en)
|
2004-06-28 |
2010-03-02 |
Merck Patent Gmbh |
Fc-interferon-beta fusion proteins
|
|
RU2437893C2
(ru)
|
2004-12-09 |
2011-12-27 |
Мерк Патент Гмбх |
Варианты il-7 со сниженной иммуногенностью
|