ATE465729T1 - Cis-imidazoline als mdm2-hemmer - Google Patents
Cis-imidazoline als mdm2-hemmerInfo
- Publication number
- ATE465729T1 ATE465729T1 AT04736392T AT04736392T ATE465729T1 AT E465729 T1 ATE465729 T1 AT E465729T1 AT 04736392 T AT04736392 T AT 04736392T AT 04736392 T AT04736392 T AT 04736392T AT E465729 T1 ATE465729 T1 AT E465729T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazoline
- cis
- mdm2 inhibitors
- mdm2
- peptide
- Prior art date
Links
- 239000012819 MDM2-Inhibitor Substances 0.000 title 1
- 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 abstract 1
- 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47956303P | 2003-06-17 | 2003-06-17 | |
| PCT/EP2004/006211 WO2005002575A1 (en) | 2003-06-17 | 2004-06-09 | Cis-imidazolines as mdm2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE465729T1 true ATE465729T1 (de) | 2010-05-15 |
Family
ID=33563798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04736392T ATE465729T1 (de) | 2003-06-17 | 2004-06-09 | Cis-imidazoline als mdm2-hemmer |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1643989B1 (de) |
| JP (2) | JP4643570B2 (de) |
| KR (1) | KR100748424B1 (de) |
| CN (1) | CN100562316C (de) |
| AT (1) | ATE465729T1 (de) |
| AU (1) | AU2004253245B2 (de) |
| BR (1) | BRPI0411597A (de) |
| CA (1) | CA2528096C (de) |
| DE (1) | DE602004026873D1 (de) |
| ES (1) | ES2341449T3 (de) |
| MX (1) | MXPA05013465A (de) |
| RU (1) | RU2354649C2 (de) |
| WO (1) | WO2005002575A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100129331A (ko) * | 2005-12-01 | 2010-12-08 | 에프. 호프만-라 로슈 아게 | 항암제로서 사용하기 위한 ｐ53 및 ｍｄｍ2 단백질 간 상호작용의 저해제로서의 2,4,5-트리페닐 이미다졸린 유도체 |
| EP2103619A4 (de) * | 2006-12-14 | 2011-11-23 | Daiichi Sankyo Co Ltd | Imidazothiazolderivate |
| WO2009151069A1 (ja) | 2008-06-12 | 2009-12-17 | 第一三共株式会社 | ４，７－ジアザスピロ［２．５］オクタン環構造を有するイミダゾチアゾール誘導体 |
| CN102356085A (zh) | 2009-01-16 | 2012-02-15 | 第一三共株式会社 | 具有脯氨酸环结构的咪唑并噻唑衍生物 |
| AU2010288534A1 (en) * | 2009-08-26 | 2012-03-15 | Novartis Ag | Tetra-substituted heteroaryl compounds and their use as MDM2 and/or MDM4 modulators |
| US20140328893A1 (en) | 2011-10-11 | 2014-11-06 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Nutlin compounds for use in the treatment of pulmonary hypertension |
| EP2935263B1 (de) * | 2012-12-20 | 2018-12-05 | Merck Sharp & Dohme Corp. | Substituierte imidazopyridine als hdm2 inhibitoren |
| JP6130248B2 (ja) * | 2013-07-04 | 2017-05-17 | 公益財団法人微生物化学研究会 | 新規化合物キノフラシン類、その製造方法、及びその用途、並びに新規微生物 |
| TWI652264B (zh) * | 2013-09-26 | 2019-03-01 | 東麗股份有限公司 | Cyclic amine derivatives and their medical uses |
| CN118436801A (zh) | 2016-05-20 | 2024-08-06 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02101065A (ja) * | 1988-10-06 | 1990-04-12 | Tanabe Seiyaku Co Ltd | イミダゾリン誘導体及びその製法 |
| CA2030158A1 (en) * | 1989-11-22 | 1991-05-23 | Nahed K. Ahmed | Cancer treatments |
| US5182268A (en) * | 1989-11-22 | 1993-01-26 | Marion Merrell Dow, Inc. | Pharmaceutical composition comprising daunorubicin potentiated with 2,4,5-tri (4-methoxyphenyl)-4,5-dihydroimidazole |
| EP0947511A1 (de) * | 1998-03-30 | 1999-10-06 | F. Hoffmann-La Roche Ag | Phenoxy-Essigsäurederivate und Phenoxymetyl-Tetrazolderivate mit antitumoraler Wirkung |
| WO2000019994A1 (en) * | 1998-10-02 | 2000-04-13 | Board Of Trustees Of The University Of Illinois | Estrogen receptor ligands |
| GB2351082A (en) * | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Synthesis of Cyclic Substituted Amidines |
| CN100486969C (zh) * | 2001-12-18 | 2009-05-13 | 霍夫曼-拉罗奇有限公司 | 顺式-2,4,5-三苯基-咪唑啉及其在肿瘤治疗中的应用 |
| PL370909A1 (en) * | 2001-12-18 | 2005-05-30 | F.Hoffmann-La Roche Ag | Cis-imidazolines as mdm2 inhibitors |
-
2004
- 2004-06-09 AU AU2004253245A patent/AU2004253245B2/en not_active Ceased
- 2004-06-09 CA CA2528096A patent/CA2528096C/en not_active Expired - Fee Related
- 2004-06-09 JP JP2006515863A patent/JP4643570B2/ja not_active Expired - Fee Related
- 2004-06-09 BR BRPI0411597-0A patent/BRPI0411597A/pt not_active IP Right Cessation
- 2004-06-09 KR KR1020057024165A patent/KR100748424B1/ko not_active Expired - Fee Related
- 2004-06-09 EP EP04736392A patent/EP1643989B1/de not_active Expired - Lifetime
- 2004-06-09 MX MXPA05013465A patent/MXPA05013465A/es active IP Right Grant
- 2004-06-09 ES ES04736392T patent/ES2341449T3/es not_active Expired - Lifetime
- 2004-06-09 DE DE602004026873T patent/DE602004026873D1/de not_active Expired - Lifetime
- 2004-06-09 RU RU2006100732/04A patent/RU2354649C2/ru not_active IP Right Cessation
- 2004-06-09 WO PCT/EP2004/006211 patent/WO2005002575A1/en not_active Ceased
- 2004-06-09 AT AT04736392T patent/ATE465729T1/de active
- 2004-06-09 CN CNB200480016900XA patent/CN100562316C/zh not_active Expired - Fee Related
-
2010
- 2010-07-09 JP JP2010156419A patent/JP2010280666A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005002575A1 (en) | 2005-01-13 |
| RU2354649C2 (ru) | 2009-05-10 |
| KR20060023992A (ko) | 2006-03-15 |
| BRPI0411597A (pt) | 2006-08-29 |
| CN1805742A (zh) | 2006-07-19 |
| KR100748424B1 (ko) | 2007-08-10 |
| EP1643989B1 (de) | 2010-04-28 |
| CN100562316C (zh) | 2009-11-25 |
| CA2528096A1 (en) | 2005-01-13 |
| DE602004026873D1 (de) | 2010-06-10 |
| RU2006100732A (ru) | 2007-07-27 |
| AU2004253245A1 (en) | 2005-01-13 |
| ES2341449T3 (es) | 2010-06-21 |
| EP1643989A1 (de) | 2006-04-12 |
| AU2004253245B2 (en) | 2010-02-11 |
| MXPA05013465A (es) | 2006-03-09 |
| JP4643570B2 (ja) | 2011-03-02 |
| JP2010280666A (ja) | 2010-12-16 |
| CA2528096C (en) | 2011-09-13 |
| JP2006527713A (ja) | 2006-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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