ATE466000T1 - Fluoreszente pyrazinderivate und verfahren zu deren anwendung bei der bewertung der nierenfunktion - Google Patents
Fluoreszente pyrazinderivate und verfahren zu deren anwendung bei der bewertung der nierenfunktionInfo
- Publication number
- ATE466000T1 ATE466000T1 AT05855315T AT05855315T ATE466000T1 AT E466000 T1 ATE466000 T1 AT E466000T1 AT 05855315 T AT05855315 T AT 05855315T AT 05855315 T AT05855315 T AT 05855315T AT E466000 T1 ATE466000 T1 AT E466000T1
- Authority
- AT
- Austria
- Prior art keywords
- derivative
- spectral energy
- pyrazine derivatives
- formulas
- pyrazine
- Prior art date
Links
- 230000003907 kidney function Effects 0.000 title abstract 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical class C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 1
- 150000003216 pyrazines Chemical class 0.000 abstract 4
- 230000003595 spectral effect Effects 0.000 abstract 4
- 125000006575 electron-withdrawing group Chemical group 0.000 abstract 1
- 230000006870 function Effects 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
- C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J2219/12—Processes employing electromagnetic waves
- B01J2219/1203—Incoherent waves
- B01J2219/1206—Microwaves
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63861104P | 2004-12-23 | 2004-12-23 | |
| PCT/US2005/046732 WO2006071759A2 (en) | 2004-12-23 | 2005-12-22 | Fluorescent pyrazine derivatives and methods of using the same in assessing renal function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE466000T1 true ATE466000T1 (de) | 2010-05-15 |
Family
ID=36570361
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05855315T ATE466000T1 (de) | 2004-12-23 | 2005-12-22 | Fluoreszente pyrazinderivate und verfahren zu deren anwendung bei der bewertung der nierenfunktion |
| AT07013568T ATE522510T1 (de) | 2004-12-23 | 2005-12-22 | Fluoreszierende pyrazin-derivate und verwendungsverfahren dafür bei der überprüfung der nierenfunktion |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07013568T ATE522510T1 (de) | 2004-12-23 | 2005-12-22 | Fluoreszierende pyrazin-derivate und verwendungsverfahren dafür bei der überprüfung der nierenfunktion |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US8778309B2 (de) |
| EP (4) | EP2039688A1 (de) |
| JP (1) | JP2008525487A (de) |
| CN (2) | CN101087767A (de) |
| AT (2) | ATE466000T1 (de) |
| AU (1) | AU2005322114A1 (de) |
| CA (1) | CA2592021A1 (de) |
| DE (1) | DE602005020981D1 (de) |
| ES (2) | ES2375395T3 (de) |
| IL (1) | IL183962A0 (de) |
| WO (1) | WO2006071759A2 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005322114A1 (en) | 2004-12-23 | 2006-07-06 | Mallinckrodt Llc | Fluorescent pyrazine derivatives and methods of using the same in assessing renal function |
| CA2616147A1 (en) | 2006-02-24 | 2007-09-20 | Mallinckrodt Inc. | Process for using optical agents |
| EP2038261A2 (de) * | 2006-06-22 | 2009-03-25 | Mallinckrodt Inc. | Pyrazinderivate mit erweiterter konjugation und anwendung |
| CA2628661A1 (en) * | 2006-06-22 | 2007-12-27 | Mallinckrodt Inc. | Pyrazine derivatives and uses thereof in renal monitoring |
| JP2010520238A (ja) * | 2007-03-01 | 2010-06-10 | マリンクロット インコーポレイテッド | 統合された光活性低分子および統合された光活性低分子使用 |
| CA2641297A1 (en) * | 2008-07-11 | 2010-01-11 | Richard B. Dorshow | Pyrazine derivatives, methods of use, and methods for preparing same |
| WO2010121003A1 (en) | 2009-04-16 | 2010-10-21 | Mallinckrodt Inc. | Pyrazine derivatives for optical imaging and therapy |
| WO2010129258A2 (en) | 2009-04-27 | 2010-11-11 | Mallinckrodt Inc. | Tissue sealant compositions, vascular closure devices, and uses thereof |
| WO2011031955A2 (en) * | 2009-09-11 | 2011-03-17 | Mallinckrodt Inc. | Optical monitoring of leukemia |
| DE102011012674B3 (de) * | 2011-02-28 | 2012-04-26 | Ldiamon As | Verfahren und Nachweisvorrichtung zur Bestimmung eines Nierenfunktionsparameters |
| US11077211B2 (en) | 2013-11-11 | 2021-08-03 | Medibeacon Inc. | Compositions and methods for assessing gut function |
| MX388576B (es) | 2016-06-07 | 2025-03-20 | Jacobio Pharmaceuticals Co Ltd | Derivados heterociclicos novedosos utiles como inhibidores de shp2. |
| EP4302834A3 (de) | 2016-07-12 | 2024-07-17 | Revolution Medicines, Inc. | 2,5-disubstituierte 3-methyl pyrazine und 2,5,6-trisubstituierte 3-methylpyrazine als allosterische shp2-inhibitoren |
| CN106543089A (zh) * | 2016-11-04 | 2017-03-29 | 山东铂源药业有限公司 | 一种达沙替尼中间体的合成方法 |
| KR20190110588A (ko) | 2017-01-23 | 2019-09-30 | 레볼루션 메디슨즈, 인크. | 알로스테릭 shp2 억제제로서의 피리딘 화합물 |
| JP7240319B2 (ja) | 2017-01-23 | 2023-03-15 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
| CA3051963A1 (en) | 2017-01-30 | 2018-08-02 | Medibeacon Inc. | Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections |
| EA202190196A1 (ru) | 2017-03-23 | 2021-08-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| TW201930292A (zh) | 2017-10-12 | 2019-08-01 | 美商銳新醫藥公司 | 作為變構ｓｈｐ２抑制劑的吡啶、吡嗪和三嗪化合物 |
| IL269617B2 (en) | 2017-10-27 | 2024-09-01 | Medibeacon Inc | Compositions and systems for renal function determination |
| WO2019084425A1 (en) * | 2017-10-27 | 2019-05-02 | Medibeacon Inc. | METHODS FOR EVALUATING RENAL FUNCTION |
| RU2746503C1 (ru) | 2017-11-20 | 2021-04-14 | Медибикон Инк. | Способ получения и анализа флуоресцентных соединений в плазме |
| JP7361693B2 (ja) | 2017-12-15 | 2023-10-16 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての多環式化合物 |
| US20210393623A1 (en) | 2018-09-26 | 2021-12-23 | Jacobio Pharmaceuticals Co., Ltd. | Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors |
| CN115844391A (zh) | 2019-01-16 | 2023-03-28 | 麦迪贝肯有限公司 | 两件式传感器组件及其使用方法 |
| EP3917378B8 (de) | 2019-01-28 | 2025-04-23 | MediBeacon Inc. | Systeme und verfahren zur häuslichen transdermalen gfr-überwachung |
| CN110144050B (zh) * | 2019-06-28 | 2021-06-29 | 西北大学 | 一种具有MnO4-检测功能的稀土铕配位聚合物及其制备方法 |
| EP4041235A4 (de) * | 2019-10-10 | 2024-11-20 | Medibeacon Inc. | Anodische oxidation von 5-aminouracil |
| US20240025864A1 (en) * | 2020-11-09 | 2024-01-25 | Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. | Method for preparing 3,6-diaminopyrazine-2,5-dicarboxylic acid and synthetic intermediate thereof |
| WO2023016483A1 (zh) * | 2021-08-11 | 2023-02-16 | 杭州中美华东制药有限公司 | 制备作为荧光示踪剂的吡嗪羧酸类衍生物的方法 |
| USD1051738S1 (en) | 2023-01-06 | 2024-11-19 | Medibeacon Inc. | Sensor ring |
| USD1052412S1 (en) | 2023-01-06 | 2024-11-26 | Medibeacon Inc. | Sensor |
| WO2024191532A2 (en) * | 2023-03-16 | 2024-09-19 | Alj Creative Works, Llc | Programmable drug-device microneedle system for the delivery and monitoring of diabetes and obesity medications |
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| IL39114A0 (en) * | 1971-04-13 | 1972-05-30 | Du Pont | Novel cyanopyrazines carbamoyl diaminopyrazines,and 3,5-diaminopyrazinoic acid,and their preparation |
| US3814757A (en) | 1971-04-13 | 1974-06-04 | Du Pont | Diamino substituted dicyano pyrazines and process |
| US3948895A (en) | 1971-09-28 | 1976-04-06 | E. I. Du Pont De Nemours And Company | Synthesis of 3,5-diaminopyrazinoic acid from 3,5-diamino-2,6-dicyanopyrazine and intermediates |
| US3808209A (en) | 1972-07-14 | 1974-04-30 | Du Pont | Tetraaminopyrazine,2,3,5-triamino-6-nitropyrazine,2,6-diamino-3,5-dinitropyrazine |
| US4517186A (en) * | 1982-09-30 | 1985-05-14 | Merck & Co., Inc. | 2-Amino-3,5-dicyano-6-(substituted)pyrazine antimicrobial compounds |
| WO1988001264A1 (en) | 1986-08-13 | 1988-02-25 | Nippon Soda Co., Ltd. | 2,3-diaminoacrylonitrile derivatives |
| JPH0249775A (ja) | 1988-05-19 | 1990-02-20 | Nippon Soda Co Ltd | ６員環又は７員環を有する複素環化合物及びその製造方法 |
| JPH0217163A (ja) | 1988-07-05 | 1990-01-22 | Nippon Soda Co Ltd | ジアミノマレオニトリル及びジアミノアクリロニトリル誘導体の製造方法 |
| JPH0269457A (ja) | 1988-09-06 | 1990-03-08 | Nippon Soda Co Ltd | ピロール誘導体及びその製造法 |
| US5145610A (en) * | 1989-11-27 | 1992-09-08 | E. I. Du Pont De Nemours And Company | Organic optical elements and nonlinear optical devices |
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| EP0579835A4 (en) | 1991-11-12 | 1994-06-01 | Nippon Soda Co | Wavelength conversion material for agriculture |
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| JPH07278456A (ja) * | 1994-04-12 | 1995-10-24 | Nippon Soda Co Ltd | 蛍光着色剤 |
| JPH09143168A (ja) | 1995-11-22 | 1997-06-03 | Nippon Soda Co Ltd | ２，３−ジアミノアクリロニトリル誘導体および３，６−ジアミノ−２，５−ピラジンジカルボニトリルの製造方法 |
| JP3845848B2 (ja) | 1996-01-25 | 2006-11-15 | 日本曹達株式会社 | ２，３−ジアミノアクリロニトリル誘導体の製造方法 |
| JPH09249773A (ja) * | 1996-03-19 | 1997-09-22 | Nippon Soda Co Ltd | 波長変換能を有するポリオレフィン系樹脂組成物、その組成物用マスターバッチおよびその組成物を含む農業用フイルム |
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| WO2000010983A1 (en) | 1998-08-20 | 2000-03-02 | Abbott Laboratories | Process for preparing regiospecific substituted pyrazine isomers |
| US6440389B1 (en) | 2000-07-19 | 2002-08-27 | The General Hospital Corporation | Fluorescent agents for real-time measurement of organ function |
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| AU2005322114A1 (en) | 2004-12-23 | 2006-07-06 | Mallinckrodt Llc | Fluorescent pyrazine derivatives and methods of using the same in assessing renal function |
-
2005
- 2005-12-22 AU AU2005322114A patent/AU2005322114A1/en not_active Abandoned
- 2005-12-22 US US11/721,186 patent/US8778309B2/en active Active
- 2005-12-22 CN CNA2005800446810A patent/CN101087767A/zh active Pending
- 2005-12-22 JP JP2007548504A patent/JP2008525487A/ja active Pending
- 2005-12-22 AT AT05855315T patent/ATE466000T1/de not_active IP Right Cessation
- 2005-12-22 ES ES07013568T patent/ES2375395T3/es not_active Expired - Lifetime
- 2005-12-22 CN CN201010122903A patent/CN101812027A/zh active Pending
- 2005-12-22 ES ES05855315T patent/ES2345209T3/es not_active Expired - Lifetime
- 2005-12-22 EP EP08017332A patent/EP2039688A1/de not_active Withdrawn
- 2005-12-22 WO PCT/US2005/046732 patent/WO2006071759A2/en not_active Ceased
- 2005-12-22 AT AT07013568T patent/ATE522510T1/de not_active IP Right Cessation
- 2005-12-22 EP EP09011710A patent/EP2135863A1/de not_active Withdrawn
- 2005-12-22 CA CA002592021A patent/CA2592021A1/en not_active Abandoned
- 2005-12-22 DE DE602005020981T patent/DE602005020981D1/de not_active Expired - Lifetime
- 2005-12-22 EP EP05855315A patent/EP1836175B1/de not_active Expired - Lifetime
- 2005-12-22 EP EP07013568A patent/EP1854790B1/de not_active Expired - Lifetime
-
2007
- 2007-06-14 IL IL183962A patent/IL183962A0/en unknown
-
2013
- 2013-10-07 US US14/047,733 patent/US9376399B2/en not_active Expired - Lifetime
-
2016
- 2016-06-10 US US15/178,720 patent/US10617687B2/en active Active
- 2016-06-10 US US15/178,799 patent/US20170298030A9/en not_active Abandoned
-
2022
- 2022-01-03 US US17/646,818 patent/US20220127237A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1854790A1 (de) | 2007-11-14 |
| ATE522510T1 (de) | 2011-09-15 |
| WO2006071759A3 (en) | 2006-09-14 |
| US20160280665A1 (en) | 2016-09-29 |
| CA2592021A1 (en) | 2006-07-06 |
| ES2375395T3 (es) | 2012-02-29 |
| US9376399B2 (en) | 2016-06-28 |
| DE602005020981D1 (de) | 2010-06-10 |
| US20220127237A1 (en) | 2022-04-28 |
| US20090010851A1 (en) | 2009-01-08 |
| EP2135863A1 (de) | 2009-12-23 |
| IL183962A0 (en) | 2007-10-31 |
| US20170298030A9 (en) | 2017-10-19 |
| WO2006071759A2 (en) | 2006-07-06 |
| CN101087767A (zh) | 2007-12-12 |
| US10617687B2 (en) | 2020-04-14 |
| EP2039688A1 (de) | 2009-03-25 |
| AU2005322114A1 (en) | 2006-07-06 |
| US8778309B2 (en) | 2014-07-15 |
| EP1836175B1 (de) | 2010-04-28 |
| EP1854790B1 (de) | 2011-08-31 |
| CN101812027A (zh) | 2010-08-25 |
| US20140039191A1 (en) | 2014-02-06 |
| US20160280666A1 (en) | 2016-09-29 |
| JP2008525487A (ja) | 2008-07-17 |
| ES2345209T3 (es) | 2010-09-17 |
| EP1836175A2 (de) | 2007-09-26 |
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