ATE466593T1 - Neue pflanzenviruspartikel und verfahren zu deren inaktivierung - Google Patents
Neue pflanzenviruspartikel und verfahren zu deren inaktivierungInfo
- Publication number
- ATE466593T1 ATE466593T1 AT06852018T AT06852018T ATE466593T1 AT E466593 T1 ATE466593 T1 AT E466593T1 AT 06852018 T AT06852018 T AT 06852018T AT 06852018 T AT06852018 T AT 06852018T AT E466593 T1 ATE466593 T1 AT E466593T1
- Authority
- AT
- Austria
- Prior art keywords
- inactivation
- virus particles
- virus
- plant virus
- particles
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 7
- 239000002245 particle Substances 0.000 title abstract 6
- 230000002779 inactivation Effects 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 229960005486 vaccine Drugs 0.000 abstract 2
- 230000010354 integration Effects 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/07—Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/18011—Comoviridae
- C12N2770/18061—Methods of inactivation or attenuation
- C12N2770/18063—Methods of inactivation or attenuation by chemical treatment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74219705P | 2005-12-02 | 2005-12-02 | |
| PCT/US2006/046160 WO2008085147A2 (en) | 2005-12-02 | 2006-12-01 | Novel plant virus particles and methods of inactivation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE466593T1 true ATE466593T1 (de) | 2010-05-15 |
Family
ID=39609166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06852018T ATE466593T1 (de) | 2005-12-02 | 2006-12-01 | Neue pflanzenviruspartikel und verfahren zu deren inaktivierung |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20070128213A1 (de) |
| EP (1) | EP1996711B1 (de) |
| JP (1) | JP2009524699A (de) |
| KR (1) | KR20080091759A (de) |
| CN (1) | CN101495137A (de) |
| AT (1) | ATE466593T1 (de) |
| AU (1) | AU2006351933A1 (de) |
| BR (1) | BRPI0619089A2 (de) |
| CA (1) | CA2632245A1 (de) |
| DE (1) | DE602006014215D1 (de) |
| MX (1) | MX2008007005A (de) |
| WO (1) | WO2008085147A2 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2477650B8 (de) * | 2009-09-18 | 2019-10-09 | FRAUNHOFER USA Inc. | Virusähnliche partikel, die fusionsproteine bestehend aus targetproteinen und coatproteinen von pflanzenviren enthalten |
| WO2014059021A1 (en) | 2012-10-09 | 2014-04-17 | Case Western Reserve University | Rod-shaped plant virus nanoparticles as imaging agent platforms |
| WO2014113203A1 (en) | 2013-01-17 | 2014-07-24 | Case Western Reserve University | Viral nanoparticle multimers |
| US11998594B2 (en) | 2014-04-02 | 2024-06-04 | Case Western Reserve University | Anti-cancer plant virus particles linked to HER2 antigens |
| US9925281B2 (en) | 2014-08-05 | 2018-03-27 | Case Western Reserve University | Coated plant virus imaging agents |
| US12465624B2 (en) | 2018-05-08 | 2025-11-11 | Case Western Reserve University | Cancer immunotherapy using virus particles and immune checkpoint therapy |
| US11617787B2 (en) | 2014-11-07 | 2023-04-04 | Case Western Reserve University | Cancer immunotherapy using virus particles |
| EP3215520B1 (de) | 2014-11-07 | 2022-01-05 | Case Western Reserve University | Krebsimmuntherapie unter verwendung von viruspartikeln |
| EP3313527B1 (de) | 2015-06-29 | 2021-02-24 | Case Western Reserve University | Pflanzenviruspartikel mit wirkstoff gegen krebs |
| EP3322485B1 (de) | 2015-07-16 | 2020-07-01 | Case Western Reserve University | Pflanzenviruspartikel zur freisetzung von antimitotika |
| US12599141B2 (en) | 2016-06-03 | 2026-04-14 | Case Western Reserve University | Rod-shaped plant viral nanoparticles or virus-like particles for agricultural applications |
| EP3487527A4 (de) | 2016-07-21 | 2020-03-11 | Case Western Reserve University | Pflanzenvirus- oder virusähnliche partikelkonstrukte |
| EP3535283A4 (de) | 2016-11-03 | 2020-08-12 | Case Western Reserve University | Schmelzverarbeitete virale nanopartikelkonstrukte |
| US12433840B2 (en) | 2016-11-03 | 2025-10-07 | Case Western Reserve University | Melt processed viral nanoparticle constructs |
| US11590183B2 (en) | 2017-03-10 | 2023-02-28 | Case Western Reserve University | Cancer immunotherapy using virus particles |
| WO2018213587A1 (en) | 2017-05-17 | 2018-11-22 | Case Western Reserve University | Anticancer trail-targeted plant virus particles |
| US11739301B2 (en) | 2017-10-27 | 2023-08-29 | Case Western Reserve University | Tymovirus virus and virus-like particles as nanocarriers for imaging and therapeutic agents |
| US11390853B2 (en) | 2019-04-26 | 2022-07-19 | Case Western Reserve University | Freeze dried viral nanoparticle constructs |
| US11896676B2 (en) | 2019-08-07 | 2024-02-13 | Case Western Reserve University | Targeting cancer cells and tissue using filamentous plant virus particles |
| US12203073B2 (en) | 2019-12-20 | 2025-01-21 | Case Western Reserve University | Plant viral RNA delivery nanoparticles and uses thereof |
| US11529430B2 (en) | 2019-12-20 | 2022-12-20 | Case Western Reserve University | Polydopamine decorated tobacco mosaic theranostic virus nanoparticles |
| WO2023102483A1 (en) * | 2021-12-01 | 2023-06-08 | The Regents Of The University Of Michigan | Immunogens targeting anthrax |
| WO2023111224A1 (en) | 2021-12-15 | 2023-06-22 | Diamante Srl | Apparatus for determining administrative form of a composition of an engineered virus-based nanoparticle for a treatment of an autoimmune condition |
| WO2025165878A1 (en) * | 2024-01-29 | 2025-08-07 | Flagship Pioneering Innovations Vii, Llc | Methods of delivering therapeutic agents to target tissues and organs |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19923027C2 (de) * | 1999-05-19 | 2002-09-19 | Aventis Behring Gmbh | Verfahren zur Inaktivierung von Viren |
| US7928290B2 (en) * | 2004-02-27 | 2011-04-19 | Dow Agrosciences Llc | Viral capsid fusion peptide expressing plant cells |
-
2006
- 2006-12-01 BR BRPI0619089-8A patent/BRPI0619089A2/pt not_active IP Right Cessation
- 2006-12-01 CA CA002632245A patent/CA2632245A1/en not_active Abandoned
- 2006-12-01 US US11/607,405 patent/US20070128213A1/en not_active Abandoned
- 2006-12-01 EP EP06852018A patent/EP1996711B1/de not_active Not-in-force
- 2006-12-01 KR KR1020087013044A patent/KR20080091759A/ko not_active Withdrawn
- 2006-12-01 JP JP2008553230A patent/JP2009524699A/ja active Pending
- 2006-12-01 WO PCT/US2006/046160 patent/WO2008085147A2/en not_active Ceased
- 2006-12-01 AU AU2006351933A patent/AU2006351933A1/en not_active Abandoned
- 2006-12-01 AT AT06852018T patent/ATE466593T1/de not_active IP Right Cessation
- 2006-12-01 MX MX2008007005A patent/MX2008007005A/es not_active Application Discontinuation
- 2006-12-01 CN CNA2006800452055A patent/CN101495137A/zh active Pending
- 2006-12-01 DE DE602006014215T patent/DE602006014215D1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2632245A1 (en) | 2007-06-02 |
| CN101495137A (zh) | 2009-07-29 |
| WO2008085147A3 (en) | 2008-12-18 |
| AU2006351933A1 (en) | 2008-07-17 |
| MX2008007005A (es) | 2009-03-04 |
| US20070128213A1 (en) | 2007-06-07 |
| BRPI0619089A2 (pt) | 2011-09-13 |
| EP1996711B1 (de) | 2010-05-05 |
| KR20080091759A (ko) | 2008-10-14 |
| EP1996711A2 (de) | 2008-12-03 |
| JP2009524699A (ja) | 2009-07-02 |
| DE602006014215D1 (de) | 2010-06-17 |
| WO2008085147A2 (en) | 2008-07-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE466593T1 (de) | Neue pflanzenviruspartikel und verfahren zu deren inaktivierung | |
| JOP20130186B1 (ar) | تنقية الجزيئات الشبيهة بالفيروسات | |
| SG10201903538YA (en) | Modified virus-like particles of cmv | |
| Banzhoff et al. | MF59®‐adjuvanted vaccines for seasonal and pandemic influenza prophylaxis | |
| MX392585B (es) | Particulas similares al virus de la influenza quimericas que comprenden hemaglutinina. | |
| MX2010003202A (es) | Metodo para producir virus de la gripe. | |
| MY161965A (en) | New influenza virus immunizing epitope | |
| TN2009000557A1 (en) | Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant | |
| CA2817005A1 (en) | Rabies glycoprotein virus-like particles (vlps) | |
| WO2013063366A3 (en) | Methods for screening viral like particles and identifying neutralizing epitopes and related vaccines, constructs, and libraries | |
| MX2021006342A (es) | Mutantes de virus de influenza y usos para los mismos. | |
| MX349119B (es) | Vacuna de virus de dengue inactivado. | |
| NO20090177L (no) | Vaksiner for malaria | |
| WO2014150822A3 (en) | Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use | |
| JP2009225809A5 (de) | ||
| MY163972A (en) | Attenuated recombinant newcastle disease virus and vaccine containing the same | |
| CA2839668C (en) | Epitope and its use of hepatitis b virus surface antigen | |
| PH12020500414A1 (en) | Method for producing influenza ha split vaccine | |
| RU2010129770A (ru) | Вакцина против гриппа и способ ее получения | |
| WO2018066999A3 (en) | Chimeric enterovirus virus-like particles | |
| ATE547116T1 (de) | Kombinationsimpfstoff | |
| WO2022261297A3 (en) | Broadly reactive viral antigens as immunogens, compositions and methods of use thereof | |
| EA201270794A8 (ru) | Маркерная вакцина против классической чумы свиней | |
| TW200734463A (en) | Marked bovine viral diarrhea virus vaccines | |
| MX2023011129A (es) | Mutantes del virus de la influenza b y usos de los mismos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |