ATE466860T1 - Cgrp-rezeptorantagonisten - Google Patents

Cgrp-rezeptorantagonisten

Info

Publication number
ATE466860T1
ATE466860T1 AT04750028T AT04750028T ATE466860T1 AT E466860 T1 ATE466860 T1 AT E466860T1 AT 04750028 T AT04750028 T AT 04750028T AT 04750028 T AT04750028 T AT 04750028T AT E466860 T1 ATE466860 T1 AT E466860T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
cgrp receptor
cgrp
compounds
diseases
Prior art date
Application number
AT04750028T
Other languages
English (en)
Inventor
Christopher Burgey
Daniel Paone
Anthony Shaw
Theresa WILLIAMS
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE466860T1 publication Critical patent/ATE466860T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT04750028T 2003-04-15 2004-04-09 Cgrp-rezeptorantagonisten ATE466860T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46410903P 2003-04-15 2003-04-15
PCT/US2004/011254 WO2004091514A2 (en) 2003-04-15 2004-04-09 Cgrp receptor antagonists

Publications (1)

Publication Number Publication Date
ATE466860T1 true ATE466860T1 (de) 2010-05-15

Family

ID=33300105

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04750028T ATE466860T1 (de) 2003-04-15 2004-04-09 Cgrp-rezeptorantagonisten

Country Status (9)

Country Link
US (1) US7205292B2 (de)
EP (1) EP1615914B1 (de)
JP (1) JP4705908B2 (de)
CN (1) CN100572379C (de)
AT (1) ATE466860T1 (de)
AU (1) AU2004229518B2 (de)
CA (1) CA2522024A1 (de)
DE (1) DE602004027021D1 (de)
WO (1) WO2004091514A2 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220862B2 (en) 2002-06-05 2007-05-22 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
US7842808B2 (en) 2002-06-05 2010-11-30 Bristol-Myers Squibb Company Anti-migraine spirocycles
JO2355B1 (en) * 2003-04-15 2006-12-12 ميرك شارب اند دوم كوربوريشن Hereditary calcitonin polypeptide receptor antagonists
US7476665B2 (en) * 2003-06-26 2009-01-13 Merck & Co., Inc. Benzodiazepine CGRP receptor antagonists
EP1641781B1 (de) * 2003-06-26 2013-03-06 Merck Sharp & Dohme Corp. Benzodiazepin-CGRP-Rezeptor-Antagonisten
TW200524601A (en) 2003-12-05 2005-08-01 Bristol Myers Squibb Co Heterocyclic anti-migraine agents
CN101124217A (zh) * 2004-01-29 2008-02-13 默克公司 Cgrp受体拮抗剂
TW200533398A (en) 2004-03-29 2005-10-16 Bristol Myers Squibb Co Novel therapeutic agents for the treatment of migraine
EA200602045A1 (ru) * 2004-05-19 2007-06-29 Басф Акциенгезельшафт 2-замещённые пиримидины
US7659264B2 (en) * 2004-10-07 2010-02-09 Merck Sharp & Dohme Corp. CGRP receptor antagonists
US7384930B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384931B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7449586B2 (en) 2004-12-03 2008-11-11 Bristol-Myers Squibb Company Processes for the preparation of CGRP-receptor antagonists and intermediates thereof
EP1856100B1 (de) * 2005-01-18 2010-05-05 Merck Sharp & Dohme Corp. Cgrp-rezeptorantagonisten
EP1861399B1 (de) * 2005-03-14 2011-12-14 Merck Sharp & Dohme Corp. Cgrp-rezeptorantagonisten
US7834007B2 (en) 2005-08-25 2010-11-16 Bristol-Myers Squibb Company CGRP antagonists
US8168592B2 (en) 2005-10-21 2012-05-01 Amgen Inc. CGRP peptide antagonists and conjugates
SI3045182T1 (en) 2005-11-14 2018-08-31 Teva Pharmaceuticals International Gmbh An antibody to a peptide-associated peptide antagonist to calcitonin for treating a headache in aggregates
EP2013213B1 (de) 2006-05-02 2011-07-27 Bristol-Myers Squibb Company Verbindungen mit eingeschränkter konformation als cgrp rezeptor antagonisten.
US7470680B2 (en) 2006-05-03 2008-12-30 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
WO2007133491A1 (en) * 2006-05-09 2007-11-22 Merck & Co., Inc. Substituted spirocyclic cgrp receptor antagonists
WO2008070014A2 (en) * 2006-12-04 2008-06-12 Neurogen Corporation Biaryl ketone-substituted piperidines
KR101304150B1 (ko) 2008-03-04 2013-09-05 라브리스 바이올로직스 인코포레이티드 만성 통증의 치료 방법
BR112012004464B8 (pt) 2009-08-28 2021-05-25 Labrys Biologics Inc uso de um anticorpo antagonista anti-cgrp para preparar uma composição farmacêutica para tratar e/ou prevenir dor visceral e/ou um ou mais sintomas de dor visceral, em que a dor visceral está associada á cistite intersticial (ic), e dita composição farmacêutica
EA033109B1 (ru) 2011-05-20 2019-08-30 Олдербайо Холдингз Ллк Способы ингибирования, профилактики или лечения диареи и/или поддержания соответствующих уровней электролитов и жидкости в толстой кишке субъекта, подвергающегося связанному с диареей состоянию, с помощью антитела против cgrp или фрагмента антитела против cgrp
CN108014334B (zh) 2011-05-20 2021-11-30 H.伦德贝克公司 抗cgrp抗体和抗体片段用于在有需要的受试者中预防或抑制畏光或厌光的用途
PT3495392T (pt) 2011-05-20 2021-09-22 H Lundbeck As Composições anti-cgrp e a sua utilização
US20170114122A1 (en) 2015-10-23 2017-04-27 Alderbio Holdings Llc Regulation of glucose metabolism using anti-cgrp antibodies
MX378344B (es) 2014-03-21 2025-03-10 Teva Pharmaceuticals Int Gmbh Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos.
US10556945B2 (en) 2014-03-21 2020-02-11 Teva Pharmaceuticals International Gmbh Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
CN108349894A (zh) * 2015-11-06 2018-07-31 第三共株式会社 除去二甲氧基苄基的方法
SMT202600087T1 (it) 2016-09-23 2026-03-09 Teva Pharmaceuticals Int Gmbh Trattamento dell’emicrania refrattaria
EP3366286A1 (de) 2017-02-22 2018-08-29 Johannes Keller Verbindungen zur behandlung von sepsis
CR20210373A (es) 2019-01-08 2021-08-19 H Lundbeck As Tratamiento agudo y tratamiento rápido de la cefalea usando anticuerpos anti-cgrp
GEAP202515803A (en) 2019-05-02 2025-06-10 H Lundbeck As Treatment of headache using anti-cgrp antibodies
KR20210124867A (ko) 2020-04-06 2021-10-15 하. 룬드벡 아크티에셀스카브 항-cgrp 항체를 사용하는 편두통 관련 성가심 증상 (mbs) 의 치료

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA76475B (en) * 1975-03-10 1977-08-31 Ciba Geigy Ag Indolyalkylpiperidines
JPH08505120A (ja) * 1992-07-29 1996-06-04 メルク シヤープ エンド ドーム リミテツド ベンゾジアゼピン誘導体
US5661163A (en) 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
AUPO284396A0 (en) * 1996-10-08 1996-10-31 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
JPH11209356A (ja) * 1997-04-21 1999-08-03 Takeda Chem Ind Ltd 縮合環化合物、その製造法及び剤
JP2002525371A (ja) * 1998-09-30 2002-08-13 メルク シャープ エンド ドーム リミテッド Ｃｇｒｐリガンドとしてのベンゾイミダゾリニルピペリジン
DE19963868A1 (de) * 1999-12-30 2001-07-12 Boehringer Ingelheim Pharma Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US7164024B2 (en) * 2001-04-20 2007-01-16 Banyu Pharmaceutical Co., Ltd. Benzimidazolone derivatives
WO2002099388A2 (en) * 2001-06-07 2002-12-12 Merck & Co., Inc. Benzodiazepine bradykinin antagonists
WO2003037890A2 (en) * 2001-11-01 2003-05-08 Icagen, Inc. Piperidines
SE0104250D0 (sv) * 2001-12-14 2001-12-14 Astrazeneca Ab Heterocyclic compounds
SE0104248D0 (sv) * 2001-12-14 2001-12-14 Astrazeneca Ab Method of treatment
JO2355B1 (en) * 2003-04-15 2006-12-12 ميرك شارب اند دوم كوربوريشن Hereditary calcitonin polypeptide receptor antagonists
EP1641781B1 (de) * 2003-06-26 2013-03-06 Merck Sharp & Dohme Corp. Benzodiazepin-CGRP-Rezeptor-Antagonisten
US7476665B2 (en) * 2003-06-26 2009-01-13 Merck & Co., Inc. Benzodiazepine CGRP receptor antagonists
CN101124217A (zh) * 2004-01-29 2008-02-13 默克公司 Cgrp受体拮抗剂

Also Published As

Publication number Publication date
EP1615914B1 (de) 2010-05-05
CN1802369A (zh) 2006-07-12
CN100572379C (zh) 2009-12-23
AU2004229518A1 (en) 2004-10-28
CA2522024A1 (en) 2004-10-28
WO2004091514A3 (en) 2005-09-15
EP1615914A4 (de) 2008-03-12
DE602004027021D1 (de) 2010-06-17
JP4705908B2 (ja) 2011-06-22
JP2007525450A (ja) 2007-09-06
US20060194783A1 (en) 2006-08-31
WO2004091514A2 (en) 2004-10-28
EP1615914A2 (de) 2006-01-18
AU2004229518B2 (en) 2010-02-18
US7205292B2 (en) 2007-04-17

Similar Documents

Publication Publication Date Title
DE602004027021D1 (de) Cgrp-rezeptorantagonisten
NO20072435L (no) CGRP-reseptorantagonister
TW200505903A (en) CGRP receptor antagonists
DE602005020655D1 (de) Carboxamid-spirolactam-cgrp-rezeptor-antagonisten
DE602004013563D1 (de) Rantagonisten
WO2005013894A3 (en) Benzodiazepine cgrp receptor antagonists
ATE537170T1 (de) Cgrp-rezeptorantagonisten
WO2005000807A3 (en) Benzodiazepine cgrp receptor antagonists
EP1605936A4 (de) Aryl-spirohydantoin-cgrp-rezeptor-antagonisten
EP1606286A4 (de) Benzodiazepinspirohydantoine als cgrp-rezeptorantagonisten
ATE535514T1 (de) Carboxamid-spirohydantoin-cgrp-rezeptor- antagonisten
EP1794133A4 (de) Arylspirolactamverbindungen als antagonisten des cgrp-rezeptors
EP1797073A4 (de) Bicyclische anilidspirolactame als antagonisten des cgrp-rezeptors
ATE503755T1 (de) Cgrp-rezeptorantagonisten
EP1794146A4 (de) Tricyclische anilid-spirohydantoin-cgrp-rezeptorantagonisten
WO2006041830A3 (en) Cgrp receptor antagonists
ATE365733T1 (de) Zusammensetzungen brauchbar als protein-kinase- inhibitoren
ATE507880T1 (de) Cgrp-rezeptorantagonisten
ATE466853T1 (de) Cgrp-rezeptorantagonisten

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties