ATE466868T1 - Zusammensetzungen und verfahren zur trennung von fusionsproteinen - Google Patents

Zusammensetzungen und verfahren zur trennung von fusionsproteinen

Info

Publication number
ATE466868T1
ATE466868T1 AT06779979T AT06779979T ATE466868T1 AT E466868 T1 ATE466868 T1 AT E466868T1 AT 06779979 T AT06779979 T AT 06779979T AT 06779979 T AT06779979 T AT 06779979T AT E466868 T1 ATE466868 T1 AT E466868T1
Authority
AT
Austria
Prior art keywords
compositions
methods
fusion proteins
separating fusion
separating
Prior art date
Application number
AT06779979T
Other languages
English (en)
Inventor
Sujeong Kim
Jong-Mook Kim
Song Shan Xu
Original Assignee
Viromed Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viromed Co Ltd filed Critical Viromed Co Ltd
Application granted granted Critical
Publication of ATE466868T1 publication Critical patent/ATE466868T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5431—IL-11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
AT06779979T 2005-04-20 2006-04-20 Zusammensetzungen und verfahren zur trennung von fusionsproteinen ATE466868T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67287905P 2005-04-20 2005-04-20
PCT/IB2006/002378 WO2006126102A2 (en) 2005-04-20 2006-04-20 Compositions and methods for fusion protein separation

Publications (1)

Publication Number Publication Date
ATE466868T1 true ATE466868T1 (de) 2010-05-15

Family

ID=37452418

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06779979T ATE466868T1 (de) 2005-04-20 2006-04-20 Zusammensetzungen und verfahren zur trennung von fusionsproteinen

Country Status (8)

Country Link
US (2) US7585943B2 (de)
EP (1) EP1871785B1 (de)
JP (1) JP4897792B2 (de)
KR (1) KR101312339B1 (de)
CN (1) CN101287748B (de)
AT (1) ATE466868T1 (de)
DE (1) DE602006014126D1 (de)
WO (1) WO2006126102A2 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101287748B (zh) * 2005-04-20 2013-03-27 百疗医株式会社 一种融合蛋白的组成及其分离方法
EP1908779B1 (de) * 2005-07-15 2013-01-09 Beijing Northland Biotech Co. Ltd. Thymosin-beta-4-derivate und verwendung davon
US20080069796A1 (en) * 2006-07-31 2008-03-20 Kim Jong-Mook Low Dose Treatment with an Interleukin-11 Analog
US8206837B2 (en) * 2007-01-12 2012-06-26 Terumo Kabushiki Kaisha Interventional medical device
US8563521B2 (en) * 2007-06-21 2013-10-22 Technische Universitat Munchen Biological active proteins having increased in vivo and/or in vitro stability
DK2205618T3 (en) * 2007-09-26 2017-02-20 Intrexon Corp SYNTHETIC 5 'NON-TRANSLATED REGIONS, EXPRESSION VECTORS AND PROCEDURES FOR INCREASING TRANSGENIC EXPRESSION
KR100980457B1 (ko) 2008-06-27 2010-09-07 한국생명공학연구원 대장균에서 활성형 인간 인터루킨-6의 생산 및 정제방법
KR101292740B1 (ko) * 2008-08-25 2013-08-05 주식회사 바이오폴리메드 인터루킨-11 유사체를 포함하는 생체중합체 결합체
KR101016766B1 (ko) 2009-01-15 2011-02-25 한국과학기술연구원 티오레독신이 융합된 단백질 발현용 플라스미드 및 이를 이용한 목적 단백질의 생산방법
CN102262158A (zh) * 2010-05-27 2011-11-30 戴国祯 重组融合蛋白质在快速诊断检测中的直接应用
WO2011151721A1 (en) 2010-06-04 2011-12-08 Lupin Limited Process for production of fusion proteins using truncated e. coli thioredoxin
WO2011151716A1 (en) 2010-06-04 2011-12-08 Lupin Limited Process for the purification of recombinant human il-11
AU2011287360A1 (en) * 2010-08-05 2013-02-21 Council Of Scientific & Industrial Research Protein fusion constructs possessing thrombolytic and anticoagulant properties
CN102161700A (zh) * 2011-01-19 2011-08-24 温州医学院 一种新型人白细胞介素-11
US8580922B2 (en) 2011-03-04 2013-11-12 Shire Human Genetic Therapies, Inc. Peptide linkers for polypeptide compositions and methods for using same
BR112013022557A2 (pt) * 2011-03-04 2017-08-01 Shire Human Genetic Therapies ligantes de peptídeo composições de polipeptídeo e métodos para uso dos mesmos
KR20140036905A (ko) * 2012-09-18 2014-03-26 삼성전자주식회사 이중특이 항체를 포함하는 단백질 복합체
WO2014084432A1 (ko) * 2012-11-30 2014-06-05 경상대학교 산학협력단 헬리코박터 파일로리 발현 벡터
WO2014197816A1 (en) * 2013-06-06 2014-12-11 Massachusetts Institute Of Technology Stimulus responsive nanocomplexes and methods of use thereof
EP3036252A1 (de) * 2013-08-21 2016-06-29 Cadila Healthcare Limited Reinigungsverfahren für pth
KR101814048B1 (ko) 2014-01-28 2018-01-02 (주)에이피테크놀로지 대량 생산이 가능하도록 개선된 경구투여용 트롬보포이에틴 및 이의 대량 생산공정
WO2016089782A1 (en) 2014-12-01 2016-06-09 Pfenex Inc. Fusion partners for peptide production
CN104437411A (zh) * 2014-12-15 2015-03-25 武汉大学 可逆组装和分解的Strep-tag多肽标记的生物分子衍生化基质及其应用
CN106884030A (zh) * 2015-12-16 2017-06-23 丰益(上海)生物技术研发中心有限公司 提高含纤维素结合域的融合蛋白的发酵产量的方法
JP6758889B2 (ja) * 2016-04-07 2020-09-23 シスメックス株式会社 標的タンパク質の精製方法
WO2020113403A1 (en) * 2018-12-04 2020-06-11 Beijing Percans Oncology Co. Ltd. Cytokine fusion proteins
JP7534215B2 (ja) 2018-01-24 2024-08-14 ベイジン パーカンズ オンコロジー カンパニー リミテッド サイトカイン融合タンパク質
KR102140531B1 (ko) * 2018-08-07 2020-08-04 (주)휴온스 Gly-Tβ4의 제조방법
WO2020221153A1 (zh) * 2019-04-28 2020-11-05 广州市雷德生物科技有限公司 一种促进蛋白二聚体形成的拉链扣结构及其应用
CN110484551B (zh) * 2019-07-29 2021-04-02 因之彩生物科技（武汉）有限公司 金属硫蛋白表达载体及其应用
CN115003328A (zh) * 2019-10-22 2022-09-02 西奈山伊坎医学院 重组神经氨酸酶及其用途
CN111909947B (zh) * 2020-08-04 2022-06-07 辽宁省海洋水产科学研究院 一种仿刺参β-胸腺素的制备及应用
CN112946041B (zh) * 2021-02-06 2022-07-22 自然资源部第一海洋研究所 一种基于融合蛋白传感器的重金属离子检测方法
CN115078728B (zh) * 2021-03-11 2024-10-22 盛禾(中国)生物制药有限公司 一种融合蛋白的快速分析方法
CN114644715B (zh) * 2022-03-04 2024-08-20 苏州红冠庄国药股份有限公司 一种igfbp-3和igf-1的融合蛋白及复合物制备方法
CN118638209A (zh) * 2024-06-20 2024-09-13 上海唯科生物制药有限公司 一种重组肿瘤坏死因子的生产方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0185426B1 (ko) * 1991-06-24 1999-04-01 로버트 피. 블랙버언 씨형 간염 바이러스 폴리펩티드
US5820866A (en) 1994-03-04 1998-10-13 National Jewish Center For Immunology And Respiratory Medicine Product and process for T cell regulation
JP3828214B2 (ja) * 1996-11-08 2006-10-04 株式会社クラレ ペプチドおよびその塩
US6551795B1 (en) * 1998-02-18 2003-04-22 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
DE19822823A1 (de) * 1998-05-20 2000-02-10 Basf Ag Neue Peptidfragmente zur Reinigung von Proteinen
EP1573024A4 (de) 2001-04-10 2007-08-29 Agensys Inc Nukleinsäuren und diesen entprechende, für die behandlung und den nachweis verschiedener krebserkrankungen geeignete proteine
WO2002083860A2 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nucleic acid and corresponding protein entitled 151p3d4 useful in treatment and detection of cancer
US7034134B2 (en) * 2001-04-26 2006-04-25 Bristol-Myers Squibb Company Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29
FR2831170B1 (fr) * 2001-10-19 2004-03-19 Inst Nat Sante Rech Med Proteines c modifiees activables directement par la thrombine
JP2005533855A (ja) 2002-07-24 2005-11-10 インターツェル・アクチェンゲゼルシャフト 病原性ウイルスからの別のリーディングフレームによりコードされる抗原
US20040210036A1 (en) * 2003-04-15 2004-10-21 Nanogen, Inc. Peptide substrate libraries
WO2005007090A2 (en) * 2003-07-03 2005-01-27 President And Fellows Of Harvard College Inhibitors of the map kinase pathway
JP2005049164A (ja) * 2003-07-31 2005-02-24 Shimadzu Corp ペプチドの高感度測定又は定量のためのラベル化試薬及び方法
US20050187147A1 (en) 2003-09-22 2005-08-25 Newman Michael J. Compositions and methods for increasing drug efficiency
CN1666995A (zh) * 2004-03-11 2005-09-14 许日山 一种经切割后能产生多种有效成分的前体蛋白
WO2006038208A2 (en) 2004-07-12 2006-04-13 Medical Research Fund Of Tel Aviv Sourasky Medical Center Agents capable of downregulating an msf-a - dependent hif-1α and use thereof in cancer treatment
EP1786451A4 (de) * 2004-08-06 2009-07-22 Sopherion Therapeutics Inc Antiangiogene peptide und verfahren zu ihrer verwendung
CN101287748B (zh) * 2005-04-20 2013-03-27 百疗医株式会社 一种融合蛋白的组成及其分离方法

Also Published As

Publication number Publication date
EP1871785A4 (de) 2009-03-18
DE602006014126D1 (de) 2010-06-17
US8106158B2 (en) 2012-01-31
JP4897792B2 (ja) 2012-03-14
US7585943B2 (en) 2009-09-08
JP2008539696A (ja) 2008-11-20
KR101312339B1 (ko) 2013-09-27
WO2006126102A8 (en) 2008-05-15
EP1871785B1 (de) 2010-05-05
US20060276625A1 (en) 2006-12-07
EP1871785A2 (de) 2008-01-02
US20080171852A9 (en) 2008-07-17
HK1125387A1 (en) 2009-08-07
US20100285526A1 (en) 2010-11-11
CN101287748A (zh) 2008-10-15
CN101287748B (zh) 2013-03-27
WO2006126102A2 (en) 2006-11-30
KR20080002845A (ko) 2008-01-04

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