ATE466868T1 - Zusammensetzungen und verfahren zur trennung von fusionsproteinen - Google Patents
Zusammensetzungen und verfahren zur trennung von fusionsproteinenInfo
- Publication number
- ATE466868T1 ATE466868T1 AT06779979T AT06779979T ATE466868T1 AT E466868 T1 ATE466868 T1 AT E466868T1 AT 06779979 T AT06779979 T AT 06779979T AT 06779979 T AT06779979 T AT 06779979T AT E466868 T1 ATE466868 T1 AT E466868T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- methods
- fusion proteins
- separating fusion
- separating
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 2
- 108020001507 fusion proteins Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5431—IL-11
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57581—Thymosin; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67287905P | 2005-04-20 | 2005-04-20 | |
| PCT/IB2006/002378 WO2006126102A2 (en) | 2005-04-20 | 2006-04-20 | Compositions and methods for fusion protein separation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE466868T1 true ATE466868T1 (de) | 2010-05-15 |
Family
ID=37452418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06779979T ATE466868T1 (de) | 2005-04-20 | 2006-04-20 | Zusammensetzungen und verfahren zur trennung von fusionsproteinen |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7585943B2 (de) |
| EP (1) | EP1871785B1 (de) |
| JP (1) | JP4897792B2 (de) |
| KR (1) | KR101312339B1 (de) |
| CN (1) | CN101287748B (de) |
| AT (1) | ATE466868T1 (de) |
| DE (1) | DE602006014126D1 (de) |
| WO (1) | WO2006126102A2 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1871785B1 (de) * | 2005-04-20 | 2010-05-05 | Viromed Co., Ltd | Zusammensetzungen und verfahren zur trennung von fusionsproteinen |
| KR100984635B1 (ko) * | 2005-07-15 | 2010-10-01 | 주식회사 바이오톡스텍 | 티모신 β4 유도체 및 이의 용도 |
| US20080069796A1 (en) * | 2006-07-31 | 2008-03-20 | Kim Jong-Mook | Low Dose Treatment with an Interleukin-11 Analog |
| US8206837B2 (en) * | 2007-01-12 | 2012-06-26 | Terumo Kabushiki Kaisha | Interventional medical device |
| HRP20110368T1 (hr) * | 2007-06-21 | 2011-06-30 | Technische Universitt Mnchen | Biološki aktivni proteini s povećanom stabilnošću in vivo i/ili in vitro |
| ES2614402T3 (es) * | 2007-09-26 | 2017-05-31 | Intrexon Corporation | 5'UTR sintéticas, vectores de expresión y métodos para aumentar la expresión transgénica |
| KR100980457B1 (ko) | 2008-06-27 | 2010-09-07 | 한국생명공학연구원 | 대장균에서 활성형 인간 인터루킨-6의 생산 및 정제방법 |
| MX2011002055A (es) * | 2008-08-25 | 2011-03-30 | Viromed Co Ltd | Conjugados de biopolimeros que contienen un analogo de interleucina-11. |
| KR101016766B1 (ko) | 2009-01-15 | 2011-02-25 | 한국과학기술연구원 | 티오레독신이 융합된 단백질 발현용 플라스미드 및 이를 이용한 목적 단백질의 생산방법 |
| CN102262158A (zh) * | 2010-05-27 | 2011-11-30 | 戴国祯 | 重组融合蛋白质在快速诊断检测中的直接应用 |
| WO2011151716A1 (en) | 2010-06-04 | 2011-12-08 | Lupin Limited | Process for the purification of recombinant human il-11 |
| WO2011151721A1 (en) | 2010-06-04 | 2011-12-08 | Lupin Limited | Process for production of fusion proteins using truncated e. coli thioredoxin |
| WO2012017310A2 (en) * | 2010-08-05 | 2012-02-09 | Council Of Scientific & Industrial Research | Protein fusion constructs possessing thrombolytic and anticoagulant properties |
| CN102161700A (zh) * | 2011-01-19 | 2011-08-24 | 温州医学院 | 一种新型人白细胞介素-11 |
| EP2680879B1 (de) * | 2011-03-04 | 2021-01-06 | Shire Human Genetic Therapies, Inc. | Peptidlinker für polypeptidzusammensetzungen und anwendungsverfahren dafür |
| US8580922B2 (en) | 2011-03-04 | 2013-11-12 | Shire Human Genetic Therapies, Inc. | Peptide linkers for polypeptide compositions and methods for using same |
| KR20140036905A (ko) * | 2012-09-18 | 2014-03-26 | 삼성전자주식회사 | 이중특이 항체를 포함하는 단백질 복합체 |
| WO2014084432A1 (ko) * | 2012-11-30 | 2014-06-05 | 경상대학교 산학협력단 | 헬리코박터 파일로리 발현 벡터 |
| US20140364368A1 (en) * | 2013-06-06 | 2014-12-11 | Massachusetts Institute Of Technology | Stimulus responsive nanocomplexes and methods of use thereof |
| HK1223378A1 (zh) * | 2013-08-21 | 2017-07-28 | Cadila Healthcare Limited | 用於pth的纯化方法 |
| KR101814048B1 (ko) | 2014-01-28 | 2018-01-02 | (주)에이피테크놀로지 | 대량 생산이 가능하도록 개선된 경구투여용 트롬보포이에틴 및 이의 대량 생산공정 |
| US10118956B2 (en) | 2014-12-01 | 2018-11-06 | Pfenex Inc. | Fusion partners for peptide production |
| CN104437411A (zh) * | 2014-12-15 | 2015-03-25 | 武汉大学 | 可逆组装和分解的Strep-tag多肽标记的生物分子衍生化基质及其应用 |
| CN106884030A (zh) * | 2015-12-16 | 2017-06-23 | 丰益(上海)生物技术研发中心有限公司 | 提高含纤维素结合域的融合蛋白的发酵产量的方法 |
| JP6758889B2 (ja) * | 2016-04-07 | 2020-09-23 | シスメックス株式会社 | 標的タンパク質の精製方法 |
| CN112105632A (zh) | 2018-01-24 | 2020-12-18 | 北京智康博药肿瘤医学研究有限公司 | 细胞因子融合蛋白 |
| WO2020113403A1 (en) * | 2018-12-04 | 2020-06-11 | Beijing Percans Oncology Co. Ltd. | Cytokine fusion proteins |
| KR102140531B1 (ko) * | 2018-08-07 | 2020-08-04 | (주)휴온스 | Gly-Tβ4의 제조방법 |
| CN114805598A (zh) * | 2019-04-28 | 2022-07-29 | 广州市雷德生物科技有限公司 | 促进蛋白二聚体形成的拉链扣结构及其应用 |
| CN110484551B (zh) * | 2019-07-29 | 2021-04-02 | 因之彩生物科技（武汉）有限公司 | 金属硫蛋白表达载体及其应用 |
| US20220403358A1 (en) * | 2019-10-22 | 2022-12-22 | Icahn School Of Medicine At Mount Sinai | Recombinant neuraminidase and uses thereof |
| CN111909947B (zh) * | 2020-08-04 | 2022-06-07 | 辽宁省海洋水产科学研究院 | 一种仿刺参β-胸腺素的制备及应用 |
| CN112946041B (zh) * | 2021-02-06 | 2022-07-22 | 自然资源部第一海洋研究所 | 一种基于融合蛋白传感器的重金属离子检测方法 |
| CN115078728B (zh) * | 2021-03-11 | 2024-10-22 | 盛禾(中国)生物制药有限公司 | 一种融合蛋白的快速分析方法 |
| CN114644715B (zh) * | 2022-03-04 | 2024-08-20 | 苏州红冠庄国药股份有限公司 | 一种igfbp-3和igf-1的融合蛋白及复合物制备方法 |
| CN118638209A (zh) * | 2024-06-20 | 2024-09-13 | 上海唯科生物制药有限公司 | 一种重组肿瘤坏死因子的生产方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU227547B1 (en) | 1991-06-24 | 2011-08-29 | Novartis Vaccines & Diagnostic | Hepatitis c virus (hcv) polypeptides |
| US5820866A (en) | 1994-03-04 | 1998-10-13 | National Jewish Center For Immunology And Respiratory Medicine | Product and process for T cell regulation |
| JP3828214B2 (ja) * | 1996-11-08 | 2006-10-04 | 株式会社クラレ | ペプチドおよびその塩 |
| US6551795B1 (en) * | 1998-02-18 | 2003-04-22 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics |
| DE19822823A1 (de) * | 1998-05-20 | 2000-02-10 | Basf Ag | Neue Peptidfragmente zur Reinigung von Proteinen |
| EP2280030A3 (de) * | 2001-04-10 | 2011-06-15 | Agensys, Inc. | Nukleinsäuren und zugehörige Proteine für die Behandlung und den Nachweis von Krebs |
| CA2443147A1 (en) * | 2001-04-10 | 2002-10-24 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 184p1e2 useful in treatment and detection of cancer |
| US7034134B2 (en) * | 2001-04-26 | 2006-04-25 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29 |
| FR2831170B1 (fr) * | 2001-10-19 | 2004-03-19 | Inst Nat Sante Rech Med | Proteines c modifiees activables directement par la thrombine |
| WO2004011650A2 (en) | 2002-07-24 | 2004-02-05 | Intercell Ag | Antigens encoded by alternative reading frame from pathogenic viruses |
| US20040210036A1 (en) * | 2003-04-15 | 2004-10-21 | Nanogen, Inc. | Peptide substrate libraries |
| WO2005007090A2 (en) * | 2003-07-03 | 2005-01-27 | President And Fellows Of Harvard College | Inhibitors of the map kinase pathway |
| JP2005049164A (ja) * | 2003-07-31 | 2005-02-24 | Shimadzu Corp | ペプチドの高感度測定又は定量のためのラベル化試薬及び方法 |
| US20050187147A1 (en) * | 2003-09-22 | 2005-08-25 | Newman Michael J. | Compositions and methods for increasing drug efficiency |
| CN1666995A (zh) * | 2004-03-11 | 2005-09-14 | 许日山 | 一种经切割后能产生多种有效成分的前体蛋白 |
| EP1765378B1 (de) | 2004-07-12 | 2014-04-16 | Medical Research Fund of Tel Aviv Sourasky Medical Center | Mittel zur down-regulierung eines msf-a-abhängigen hif-1a und seine verwendung bei der behandlung von krebs |
| CA2575622A1 (en) * | 2004-08-06 | 2006-02-09 | Sopherion Therapeutics, Inc. | Anti-angiogenic peptides and methods of use thereof |
| EP1871785B1 (de) * | 2005-04-20 | 2010-05-05 | Viromed Co., Ltd | Zusammensetzungen und verfahren zur trennung von fusionsproteinen |
-
2006
- 2006-04-20 EP EP06779979A patent/EP1871785B1/de not_active Not-in-force
- 2006-04-20 AT AT06779979T patent/ATE466868T1/de not_active IP Right Cessation
- 2006-04-20 US US11/407,336 patent/US7585943B2/en active Active
- 2006-04-20 DE DE602006014126T patent/DE602006014126D1/de active Active
- 2006-04-20 JP JP2008507200A patent/JP4897792B2/ja not_active Expired - Fee Related
- 2006-04-20 KR KR1020077024073A patent/KR101312339B1/ko active Active
- 2006-04-20 CN CN2006800220541A patent/CN101287748B/zh active Active
- 2006-04-20 WO PCT/IB2006/002378 patent/WO2006126102A2/en not_active Ceased
-
2009
- 2009-04-28 US US12/431,687 patent/US8106158B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP4897792B2 (ja) | 2012-03-14 |
| HK1125387A1 (en) | 2009-08-07 |
| KR20080002845A (ko) | 2008-01-04 |
| KR101312339B1 (ko) | 2013-09-27 |
| US7585943B2 (en) | 2009-09-08 |
| EP1871785A4 (de) | 2009-03-18 |
| US20080171852A9 (en) | 2008-07-17 |
| CN101287748A (zh) | 2008-10-15 |
| CN101287748B (zh) | 2013-03-27 |
| WO2006126102A8 (en) | 2008-05-15 |
| EP1871785B1 (de) | 2010-05-05 |
| US20100285526A1 (en) | 2010-11-11 |
| US8106158B2 (en) | 2012-01-31 |
| US20060276625A1 (en) | 2006-12-07 |
| WO2006126102A2 (en) | 2006-11-30 |
| EP1871785A2 (de) | 2008-01-02 |
| JP2008539696A (ja) | 2008-11-20 |
| DE602006014126D1 (de) | 2010-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |