ATE466873T1 - Verfahren zur herstellung eines rekombinanten peptids aus spinnengift, und das peptid enthaltende analgetische zusammensetzung - Google Patents

Verfahren zur herstellung eines rekombinanten peptids aus spinnengift, und das peptid enthaltende analgetische zusammensetzung

Info

Publication number: ATE466873T1
Authority: AT; Austria
Prior art keywords: peptide; gsmtx4; producing; recombinant; present
Prior art date: 2005-10-18

Application number

AT06799316T

Other languages

English (en)

Inventor

Uhtaek Oh

Byung Moon Kim

Seung Pyo Park

Heung Sik Na

Original Assignee

Seoul Nat Univ Ind Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-18

Filing date

2006-10-18

Publication date

2010-05-15

2005-10-18 Priority claimed from KR1020050098082A external-priority patent/KR100761790B1/ko

2006-01-06 Priority claimed from KR1020060001918A external-priority patent/KR100761792B1/ko

2006-10-18 Application filed by Seoul Nat Univ Ind Foundation filed Critical Seoul Nat Univ Ind Foundation

2010-05-15 Application granted granted Critical

2010-05-15 Publication of ATE466873T1 publication Critical patent/ATE466873T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
230000000202 analgesic effect Effects 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 3
239000000203 mixture Substances 0.000 title abstract 3
239000002708 spider venom Substances 0.000 title abstract 2
101000623875 Grammostola rosea M-theraphotoxin-Gr1a Proteins 0.000 abstract 4
WVDNTWXIIKNMHY-UHFFFAOYSA-N GsMTx4 Chemical compound O=C1NC(CC=2C3=CC=CC=C3NC=2)C(=O)NC(CC=2C3=CC=CC=C3NC=2)C(=O)NC(CCCCN)C(=O)NC(C(NC(CC(N)=O)C(=O)N2CCCC2C(=O)NC(CC(N)=O)C(=O)NC(CC(O)=O)C(=O)NC(CC(O)=O)C(=O)NC(CCCCN)C(=O)NC(CSSCC(NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CC=2C=CC=CC=2)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CO)NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CO)C(=O)NC(CC=3C=CC=CC=3)C(N)=O)C(=O)N3)=O)CSSCC2NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C2CCCN2C(=O)C(CCCNC(N)=N)NC(=O)C3CSSCC(NC(=O)CN)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC1CC1=CC=CC=C1 WVDNTWXIIKNMHY-UHFFFAOYSA-N 0.000 abstract 4
108010025188 Alcohol oxidase Proteins 0.000 abstract 2
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
206010019280 Heart failures Diseases 0.000 abstract 1
102000004310 Ion Channels Human genes 0.000 abstract 1
108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
IXKSXJFAGXLQOQ-XISFHERQSA-N WHWLQLKPGQPMY Chemical compound C([C@@H](C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)C1=CNC=N1 IXKSXJFAGXLQOQ-XISFHERQSA-N 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000013613 expression plasmid Substances 0.000 abstract 1
239000013612 plasmid Substances 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
210000005253 yeast cell Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Mycology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Insects & Arthropods (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Physics & Mathematics (AREA)
Tropical Medicine & Parasitology (AREA)
Toxicology (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT06799316T 2005-10-18 2006-10-18 Verfahren zur herstellung eines rekombinanten peptids aus spinnengift, und das peptid enthaltende analgetische zusammensetzung ATE466873T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
KR1020050098082A KR100761790B1 (ko)	2005-10-18	2005-10-18	ＧｓＭＴｘ4 유전자를 포함하는 효모 발현용 재조합플라스미드 및 이를 이용한 칠레산 타란툴라 거미독펩타이드 ＧｓＭＴｘ4의 생산 방법
KR1020060001918A KR100761792B1 (ko)	2006-01-06	2006-01-06	ＧｓＭＴｘ4 펩타이드 및 그 유도체를 유효성분으로함유하는 통증치료용 조성물
PCT/KR2006/004242 WO2007046634A1 (en)	2005-10-18	2006-10-18	Method for preparing recombinant peptide from spider venom and analgesic composition containing the peptide

Publications (1)

Publication Number	Publication Date
ATE466873T1 true ATE466873T1 (de)	2010-05-15

Family

ID=37962693

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06799316T ATE466873T1 (de)	2005-10-18	2006-10-18	Verfahren zur herstellung eines rekombinanten peptids aus spinnengift, und das peptid enthaltende analgetische zusammensetzung

Country Status (5)

Country	Link
US (2)	US20090023183A1 (de)
EP (1)	EP1948679B1 (de)
AT (1)	ATE466873T1 (de)
DE (1)	DE602006014186D1 (de)
WO (1)	WO2007046634A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0605484A8 (pt) *	2006-11-21	2017-03-07	Fund Amparo Pesquisa Estado Minas Gerais Fapemig	Toxina ph(alfa)1b, cdna do gene da toxina ph(alfa)1b, composições farmacêuticas contendo a toxina ph(alfa)1b, processo para sua obtenção, processo para obtenção do cdna, e produto
HK1213683A1 (zh)	2012-10-04	2016-07-08	Nanoco Technologies Ltd	使用量子点的照明标识
US9551718B2 (en)	2014-06-20	2017-01-24	The Royal Institution For The Advancement Of Learning/Mcgill University	TMEM120A ion channel modulator
WO2017068388A2 (pt) *	2015-09-18	2017-04-27	Universidade Federal De Minas Gerais - Ufmg	Uso do peptideo sintetico pntx-19 para tratamento de dor
CN106632603B (zh) *	2016-12-09	2019-05-17	唐琼瑶	一组肽及其药物组合物和应用
MX2019011917A (es)	2017-04-04	2020-01-09	Univ Baylor	Toxinas mosquitocidas dirigidas.
CN113214376B (zh) *	2021-03-30	2023-09-19	青岛大学	一种新的合成蜈蚣毒素RhTx和蜘蛛毒素GsMTx4的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2180537T3 (es) *	1991-08-14	2003-02-16	Procter & Gamble Pharma	Nuevas ureas 4-oxociclicas, utilizables como agentes antiarritmicos o antifibrilantes.
KR0127776B1 (ko) *	1994-10-11	1997-12-29	허영섭	신규한 단백질 분해효소의 cDNA 서열 및 그로 부터 유래된 단백질
US5756663A (en) *	1996-01-03	1998-05-26	Zeneca Limited	Antiarrhythmic peptide from venom of spider Grammostola spatulata
US7125847B1 (en) *	2000-04-07	2006-10-24	The Research Foundation Of State University Of New York At Buffalo	Mechanically activated channel blocker

2006
- 2006-10-18 DE DE602006014186T patent/DE602006014186D1/de active Active
- 2006-10-18 EP EP06799316A patent/EP1948679B1/de not_active Not-in-force
- 2006-10-18 WO PCT/KR2006/004242 patent/WO2007046634A1/en not_active Ceased
- 2006-10-18 AT AT06799316T patent/ATE466873T1/de not_active IP Right Cessation
- 2006-10-18 US US12/090,664 patent/US20090023183A1/en not_active Abandoned
2010
- 2010-10-19 US US12/907,475 patent/US20120015886A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20090023183A1 (en)	2009-01-22
WO2007046634A1 (en)	2007-04-26
DE602006014186D1 (de)	2010-06-17
EP1948679A4 (de)	2009-06-17
EP1948679B1 (de)	2010-05-05
US20120015886A1 (en)	2012-01-19
EP1948679A1 (de)	2008-07-30

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Legal Events

Date	Code	Title	Description
2010-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties