ATE468341T1 - Thienopyrazole - Google Patents

Thienopyrazole

Info

Publication number
ATE468341T1
ATE468341T1 AT04779049T AT04779049T ATE468341T1 AT E468341 T1 ATE468341 T1 AT E468341T1 AT 04779049 T AT04779049 T AT 04779049T AT 04779049 T AT04779049 T AT 04779049T AT E468341 T1 ATE468341 T1 AT E468341T1
Authority
AT
Austria
Prior art keywords
thienopyrazoles
itk
inhibition
modulated
compounds
Prior art date
Application number
AT04779049T
Other languages
English (en)
Inventor
John Jurcak
Matthieu Barrague
Timothy Gillespy
Michael Edwards
Kwon Musick
Philip Weintraub
Yan Du
Ramalinga Dharanipragada
Ashfaq Parkar
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of ATE468341T1 publication Critical patent/ATE468341T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT04779049T 2003-09-08 2004-07-23 Thienopyrazole ATE468341T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50115903P 2003-09-08 2003-09-08
PCT/US2004/023814 WO2005026175A1 (en) 2003-09-08 2004-07-23 Thienopyrazoles

Publications (1)

Publication Number Publication Date
ATE468341T1 true ATE468341T1 (de) 2010-06-15

Family

ID=34312256

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04779049T ATE468341T1 (de) 2003-09-08 2004-07-23 Thienopyrazole

Country Status (29)

Country Link
US (2) US7518000B2 (de)
JP (1) JP4879739B2 (de)
KR (1) KR20060069490A (de)
CN (1) CN100398545C (de)
AT (1) ATE468341T1 (de)
AU (1) AU2004272507B2 (de)
BR (1) BRPI0414215A (de)
CA (1) CA2538032C (de)
CR (1) CR8255A (de)
DE (1) DE602004027288D1 (de)
DK (1) DK1682553T3 (de)
EC (1) ECSP066411A (de)
ES (1) ES2345257T3 (de)
HR (1) HRP20100398T1 (de)
IL (1) IL173916A (de)
MA (1) MA28038A1 (de)
ME (1) MEP20908A (de)
MX (1) MXPA06001827A (de)
MY (1) MY144339A (de)
NO (1) NO20061626L (de)
NZ (1) NZ545421A (de)
OA (1) OA13252A (de)
PT (1) PT1682553E (de)
RS (2) RS51846B (de)
RU (1) RU2358978C2 (de)
TN (1) TNSN06058A1 (de)
TW (1) TWI352705B (de)
WO (1) WO2005026175A1 (de)
ZA (1) ZA200601947B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006101454A1 (en) * 2005-03-21 2006-09-28 S*Bio Pte Ltd Benzothiophene derivatives: preparation and pharmaceutical applications
WO2007076228A2 (en) * 2005-12-20 2007-07-05 Boehringer Ingelheim International Gmbh 2-(ih-thieno [3,2-c] pyrazol-3yl)-ih-indole derivatives and related compounds as tec kinase inhibitors for the treatment of inflammations and immunological disorders
EP2151433A1 (de) 2008-08-05 2010-02-10 Institut Pasteur Alkoxypyrazole und Verfahren zu ihrer Herstellung
EP2151434A1 (de) 2008-08-05 2010-02-10 Institut Pasteur Allkoxypyrazole und Verfahren zu ihrer Herstellung
US8299070B2 (en) * 2009-11-25 2012-10-30 Japan Tobacco Inc. Indole compounds and pharmaceutical use thereof
US20130158066A1 (en) * 2011-12-20 2013-06-20 Hoffmann-La Roche Inc. 4-azaindole inhibitors of crac
WO2013153539A1 (en) 2012-04-13 2013-10-17 Glenmark Pharmaceuticals S.A. Tricyclic compounds as tec kinase inhibitors
CN103467481B (zh) * 2012-06-07 2016-08-31 上海汇伦生命科技有限公司 二氢吡啶类化合物、其组合物、制备方法和用途
TW201414734A (zh) 2012-07-10 2014-04-16 Takeda Pharmaceutical 氮雜吲哚衍生物
WO2014041518A1 (en) * 2012-09-14 2014-03-20 Glenmark Pharmaceuticals S.A. Thienopyrrole derivatives as itk inhibitors
CN103720694A (zh) * 2012-10-11 2014-04-16 韩冰 一类治疗脑性瘫痪的化合物及其用途
CN103772391A (zh) * 2012-10-23 2014-05-07 杨子娇 一类治疗房角狭窄的化合物及其用途
KR101571590B1 (ko) * 2012-11-21 2015-11-25 주식회사 두산 유기 화합물 및 이를 이용하는 유기 전계 발광 소자
JP2016538270A (ja) 2013-10-25 2016-12-08 ファーマサイクリックス エルエルシー 移植片対宿主病を処置し予防する方法
WO2015106012A1 (en) 2014-01-09 2015-07-16 Takeda Pharmaceutical Company Limited Azaindole derivatives
WO2016010108A1 (ja) * 2014-07-18 2016-01-21 塩野義製薬株式会社 含窒素複素環誘導体およびそれらを含有する医薬組成物
MA45973A (fr) 2015-08-31 2019-06-26 Pharmacyclics Llc Combinaisons d'inhibiteurs de btk pour le traitement du myélome multiple
JP2019532997A (ja) 2016-11-03 2019-11-14 ジュノー セラピューティクス インコーポレイテッド Ｔ細胞療法とｂｔｋ阻害剤との併用療法
KR20210044736A (ko) 2018-05-03 2021-04-23 주노 쎄러퓨티크스 인코퍼레이티드 키메라 항원 수용체(ｃａｒ) ｔ세포 요법과 키나제 억제제의 조합요법
WO2023139248A1 (en) * 2022-01-21 2023-07-27 Ecole Polytechnique Federale De Lausanne (Epfl) Inhibitors of acyl protein thioesterases against microbial infections
WO2023220655A1 (en) 2022-05-11 2023-11-16 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
WO2024123175A1 (en) 2022-12-06 2024-06-13 Erasmus University Medical Center Rotterdam Compositions for treating immune checkpoint blockade therapy resistant cancers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654307A (en) * 1994-01-25 1997-08-05 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US6462036B1 (en) * 1998-11-06 2002-10-08 Basf Aktiengesellschaft Tricyclic pyrazole derivatives
US6297238B1 (en) * 1999-04-06 2001-10-02 Basf Aktiengesellschaft Therapeutic agents
DK1194425T3 (da) * 1999-06-23 2005-11-21 Aventis Pharma Gmbh Substituerede benzimidazoler
YU54202A (sh) * 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
WO2003024969A1 (en) * 2001-09-14 2003-03-27 Merck & Co., Inc. Tyrosine kinase inhibitors
FR2831536A1 (fr) * 2001-10-26 2003-05-02 Aventis Pharma Sa Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr
BR0213562A (pt) * 2001-10-26 2004-08-31 Aventis Pharma Inc Benzimidazóis e análogos e seu uso como inibidores de cinases de proteìna

Also Published As

Publication number Publication date
MXPA06001827A (es) 2006-05-31
RS51846B (sr) 2012-02-29
RU2006111470A (ru) 2007-10-27
BRPI0414215A (pt) 2006-11-07
CN100398545C (zh) 2008-07-02
CR8255A (es) 2006-07-14
US20070254937A1 (en) 2007-11-01
AU2004272507B2 (en) 2011-05-12
DK1682553T3 (da) 2010-08-23
CN1849322A (zh) 2006-10-18
US7928231B2 (en) 2011-04-19
TW200519118A (en) 2005-06-16
AU2004272507A1 (en) 2005-03-24
MEP20908A (en) 2010-06-10
ES2345257T3 (es) 2010-09-20
US20100056514A1 (en) 2010-03-04
NZ545421A (en) 2010-03-26
ECSP066411A (es) 2006-09-18
CA2538032A1 (en) 2005-03-24
JP2007505038A (ja) 2007-03-08
IL173916A (en) 2011-07-31
OA13252A (en) 2007-01-31
HRP20100398T1 (hr) 2010-09-30
JP4879739B2 (ja) 2012-02-22
HK1095587A1 (zh) 2007-05-11
KR20060069490A (ko) 2006-06-21
NO20061626L (no) 2006-04-10
WO2005026175A1 (en) 2005-03-24
DE602004027288D1 (en) 2010-07-01
ZA200601947B (en) 2007-05-30
TNSN06058A1 (en) 2007-10-03
RS20060162A (sr) 2008-06-05
TWI352705B (en) 2011-11-21
RU2358978C2 (ru) 2009-06-20
MY144339A (en) 2011-08-29
PT1682553E (pt) 2010-07-29
CA2538032C (en) 2011-01-11
MA28038A1 (fr) 2006-07-03
IL173916A0 (en) 2006-07-05
US7518000B2 (en) 2009-04-14

Similar Documents

Publication Publication Date Title
DK1682553T3 (da) Thienopyrazoler
EA200801291A1 (ru) Карбониламинопирролопиразолы в качестве эффективных ингибиторов киназ
CY1111599T1 (el) Αναστολεις κινασης θειενοπυριδινης και φουροπυριδινης
CL2004000778A1 (es) Compuestos derivados de heterociclos de 5 miembros, inhibidores de la porteina tirosina fosfatasa 1b (ptp1b); composiciones farmaceuticas, utiles para tratar hipertension, obesidad, diabetes, hiperlipidemia.
MXPA05010711A (es) Compuestos y composiciones novedosos como inhibidores de proteina-quinasa.
SV2005002148A (es) "compuestos moduladores de la actividad c-kit y usos de los mismos"
DK1347971T3 (da) Thiazolylinhibitorer af tyrosinkinaser fra Tec-familien
SE0301700D0 (sv) Novel compounds
ATE554087T1 (de) Neue kinaseinhibitoren
MEP52808A (en) Aminoheteroaryl compounds as protein kinase inhibitors
UA91002C2 (ru) 7-фенилалкилзамещенные 2-хинолиноны и 2-хиноксалиноны как ингибиторы поле(адф-рибоза)полимеразы
BRPI0509369A (pt) azaindóis úteis como inibidores de jak e outras proteìna cinases
ATE430747T1 (de) 2-pyrimidinyl-pyrazolopyridin-erbb- kinaseinhibitoren
DE60314603D1 (de) Zusammensetzungen brauchbar als protein-kinase- inhibitoren
ATE466580T1 (de) Azolylaminoazine als proteinkinasehemmer
DK1318992T3 (da) Imidazolderivater som Raf-kinaseinhibitorer
NO20071915L (no) Diaminotriazolforbindelser nyttige som proteinkinaseinhibitorer
EA200800546A1 (ru) Бензимидазолтиофеновые соединения в качестве ингибиторов polo-подобных киназ (plk)
PA8601901A1 (es) Pirazoles como inhibidores de factor de necrosis tumoral
DK1423384T3 (da) Pyridinderivater som Raf kinaseinhibitorer
CL2008000021A1 (es) Compuestos derivados de 2,4-dianilinopirimidinas, inhibidores de proteinas cinasas; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades inflamatorias, diabetes y cancer.
EA200700848A1 (ru) Ингибиторы pi3-гамма-киназы для лечения анемии
EA200601176A1 (ru) 3-цианохинолиновые производные с антипролиферативной активностью
BRPI0410704A (pt) uso de inibidor c-abl- tirosina quinase, pdgf-r- tirosina quinase, ou c-kit-tirosina quinase no tratamento da diabete
NO20081818L (no) Arylsulfonylkromaner som 5-HT6-inhibitorer - indolylmaleimidderivater som protein kinaseinhibitorer

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1682553

Country of ref document: EP