ATE468848T1 - In organischen lösemitteln lösliche biologisch abbaubare poly (alkylenoxid)- poly (p-dioxanon) blockcopolymere sowie diese enthaltende zusammensetzung zur arzneistoffverabreichung - Google Patents

In organischen lösemitteln lösliche biologisch abbaubare poly (alkylenoxid)- poly (p-dioxanon) blockcopolymere sowie diese enthaltende zusammensetzung zur arzneistoffverabreichung

Info

Publication number
ATE468848T1
ATE468848T1 AT00946497T AT00946497T ATE468848T1 AT E468848 T1 ATE468848 T1 AT E468848T1 AT 00946497 T AT00946497 T AT 00946497T AT 00946497 T AT00946497 T AT 00946497T AT E468848 T1 ATE468848 T1 AT E468848T1
Authority
AT
Austria
Prior art keywords
poly
dioxanone
organic solvents
alkylene oxide
compositions containing
Prior art date
Application number
AT00946497T
Other languages
English (en)
Inventor
Min-Hyo Seo
In-Ja Choi
Original Assignee
Samyang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Corp filed Critical Samyang Corp
Application granted granted Critical
Publication of ATE468848T1 publication Critical patent/ATE468848T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
AT00946497T 1999-07-20 2000-07-18 In organischen lösemitteln lösliche biologisch abbaubare poly (alkylenoxid)- poly (p-dioxanon) blockcopolymere sowie diese enthaltende zusammensetzung zur arzneistoffverabreichung ATE468848T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019990029269A KR20010010393A (ko) 1999-07-20 1999-07-20 소수성 고분자와 친수성 고분자의 생분해성 블록 공중합체 및이를 포함하는 약물 전달체 조성물
PCT/KR2000/000779 WO2001005379A1 (en) 1999-07-20 2000-07-18 BIODEGRADABLE POLY(ALKYLENE OXIDE)-POLY(p-DIOXANONE) BLOCK COPOLYMER SOLUBLE IN ORGANIC SOLVENTS, AND DRUG DELIVERY COMPOSITION COMPRISING SAME

Publications (1)

Publication Number Publication Date
ATE468848T1 true ATE468848T1 (de) 2010-06-15

Family

ID=19602907

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00946497T ATE468848T1 (de) 1999-07-20 2000-07-18 In organischen lösemitteln lösliche biologisch abbaubare poly (alkylenoxid)- poly (p-dioxanon) blockcopolymere sowie diese enthaltende zusammensetzung zur arzneistoffverabreichung

Country Status (14)

Country Link
US (1) US6599519B1 (de)
EP (1) EP1196149B1 (de)
JP (1) JP3955759B2 (de)
KR (2) KR20010010393A (de)
CN (1) CN1205248C (de)
AT (1) ATE468848T1 (de)
AU (1) AU758838B2 (de)
BR (1) BRPI0012588B8 (de)
CA (1) CA2379672C (de)
DE (1) DE60044459D1 (de)
MX (1) MXPA02000600A (de)
NZ (1) NZ517035A (de)
WO (1) WO2001005379A1 (de)
ZA (1) ZA200200462B (de)

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WO2002085337A1 (en) 2001-04-20 2002-10-31 The University Of British Columbia Micellar drug delivery systems for hydrophobic drugs
US7473433B2 (en) 2000-12-21 2009-01-06 Nektar Therapeutics Pulmonary delivery of polyene antifungal agents
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
US6362308B1 (en) * 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
WO2002043580A2 (en) * 2000-10-27 2002-06-06 Epic Therapeutics, Inc. Production of microspheres
GB0029750D0 (en) * 2000-12-06 2001-01-17 Laporte Performance Chemicals Alkylene oxide-lactone copolymers
KR100773078B1 (ko) * 2001-06-21 2007-11-02 주식회사 삼양사 결정성이 높은 난용성 약물을 함유하는 고분자 미셀형약물 조성물
US7049285B2 (en) * 2001-10-31 2006-05-23 Myung-Ok Park Biocompatible polymers including peptide spacer
JP4290381B2 (ja) * 2002-04-11 2009-07-01 学校法人 聖マリアンナ医科大学 ピリドンカルボン酸化合物含有エマルション
PT1532985T (pt) 2002-06-25 2017-01-20 Takeda Pharmaceuticals Co Processo de produção de uma composição de libertação sustentada
KR100502840B1 (ko) * 2002-09-04 2005-07-21 학교법인 포항공과대학교 약물 담지능력이 우수한 블록 공중합체 미셀 조성물
US20040225077A1 (en) * 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
EP1661556A4 (de) * 2003-08-20 2010-05-19 Ajinomoto Kk Medizinisches präparat mit verbesserten auflösungseigenschaften
KR100597845B1 (ko) 2004-12-29 2006-07-10 호남석유화학 주식회사 폴리파라다이옥산온의 제조방법
EP1960469B1 (de) * 2005-12-06 2016-07-13 Covidien LP Biologisch absorbierbare verbindungen und diese enthaltende zusammensetzungen
WO2008038944A1 (en) * 2006-09-26 2008-04-03 Samyang Corporation Submicron nanoparticle of poorly water soluble camptothecin derivatives and process for preparation thereof
EP1920765A1 (de) * 2006-11-07 2008-05-14 Medigene AG Single-Pass Verfahren zur Liposomherstellung
US20120231053A1 (en) 2009-10-21 2012-09-13 Nippon Kayaku Kabushiki Kaisha Block Copolymer For Intraperitoneal Administration Containing Anti-Cancer Agent, Micelle Preparation Thereof, And Cancer Therapeutic Agent Comprising The Micelle Preparation As Active Ingredient
WO2011119995A2 (en) 2010-03-26 2011-09-29 Cerulean Pharma Inc. Formulations and methods of use
KR101335624B1 (ko) * 2011-02-08 2013-12-02 이화여자대학교 산학협력단 졸-겔 전이 키토산-폴리머 복합체 및 그의 용도
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
RS62297B1 (sr) 2011-11-23 2021-09-30 Therapeuticsmd Inc Prirodne kombinovane hormonske supstitucione formulacije i terapije
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
WO2014018075A1 (en) 2012-07-23 2014-01-30 Crayola, Llc Dissolvable films and methods of using the same
US20150202313A1 (en) * 2012-08-31 2015-07-23 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Macromolecular Prodrugs for Hard Tissue and Methods of Use Thereof
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
WO2014179615A2 (en) * 2013-05-01 2014-11-06 Dae Won Park Biodegradable copolymers, systems including the copolymers, and methods of forming and using same
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
KR101501217B1 (ko) 2014-07-17 2015-03-10 최명 필러용 폴리디옥사논 입자의 제조방법
CN107208120B (zh) 2014-12-09 2021-11-23 斯威特沃特能源公司 快速预处理
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
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US11179466B2 (en) * 2016-12-14 2021-11-23 Samyang Holdings Corporation Amphiphilic block copolymer composition having enhanced micelle stability, and pharmaceutical composition comprising same
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US10981955B2 (en) * 2017-08-11 2021-04-20 Ferring B.V. Method of manufacturing a pharmaceutical composition
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Also Published As

Publication number Publication date
JP2003504393A (ja) 2003-02-04
NZ517035A (en) 2003-07-25
AU6024700A (en) 2001-02-05
KR20020008815A (ko) 2002-01-31
JP3955759B2 (ja) 2007-08-08
EP1196149A1 (de) 2002-04-17
EP1196149B1 (de) 2010-05-26
DE60044459D1 (de) 2010-07-08
CN1361684A (zh) 2002-07-31
ZA200200462B (en) 2003-03-26
EP1196149A4 (de) 2004-04-21
WO2001005379A1 (en) 2001-01-25
BR0012588A (pt) 2002-04-09
CA2379672A1 (en) 2001-01-25
BR0012588B1 (pt) 2013-02-19
AU758838B2 (en) 2003-04-03
US6599519B1 (en) 2003-07-29
MXPA02000600A (es) 2002-07-02
KR20010010393A (ko) 2001-02-05
KR100431491B1 (ko) 2004-05-14
CN1205248C (zh) 2005-06-08
BRPI0012588B8 (pt) 2021-05-25
CA2379672C (en) 2005-03-22

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