ATE469122T1 - Mtp-inhibierende tetrahydronaphthalin-1- carbonsäurederivate - Google Patents

Mtp-inhibierende tetrahydronaphthalin-1- carbonsäurederivate

Info

Publication number: ATE469122T1
Authority: AT; Austria
Prior art keywords: carboxylic acid; acid derivatives; mtp; compounds; tetrahydronaphthaline
Prior art date: 2006-10-24

Application number

AT07821653T

Other languages

English (en)

Inventor

Lieven Meerpoel

Leo Jacobus Jozef Backx

Holte Peter Ten

Guuske Frederike Busscher

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-24

Filing date

2007-10-22

Publication date

2010-06-15

2007-10-22 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2010-06-15 Application granted granted Critical

2010-06-15 Publication of ATE469122T1 publication Critical patent/ATE469122T1/de

Links

VDLWTJCSPSUGOA-UHFFFAOYSA-N 1,2,3,4-tetrahydronaphthalene-1-carboxylic acid Chemical class C1=CC=C2C(C(=O)O)CCCC2=C1 VDLWTJCSPSUGOA-UHFFFAOYSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 3
101150102415 Apob gene Proteins 0.000 abstract 1
201000001320 Atherosclerosis Diseases 0.000 abstract 1
208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
206010033645 Pancreatitis Diseases 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
208000006575 hypertriglyceridemia Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Obesity (AREA)
Hematology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Pyrrole Compounds (AREA)
Hydrogenated Pyridines (AREA)

AT07821653T 2006-10-24 2007-10-22 Mtp-inhibierende tetrahydronaphthalin-1- carbonsäurederivate ATE469122T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06122820		2006-10-24
PCT/EP2007/061289 WO2008049808A1 (en)	2006-10-24	2007-10-22	Mtp inhibiting tetrahydro-naphthalene-1-carboxylic acid derivatives

Publications (1)

Publication Number	Publication Date
ATE469122T1 true ATE469122T1 (de)	2010-06-15

Family

ID=37726924

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07821653T ATE469122T1 (de)	2006-10-24	2007-10-22	Mtp-inhibierende tetrahydronaphthalin-1- carbonsäurederivate

Country Status (15)

Country	Link
US (1)	US8158783B2 (de)
EP (1)	EP2076487B1 (de)
JP (1)	JP5525261B2 (de)
KR (1)	KR101387459B1 (de)
CN (1)	CN101528671B (de)
AT (1)	ATE469122T1 (de)
AU (1)	AU2007310927B2 (de)
BR (1)	BRPI0717314A2 (de)
CA (1)	CA2664143C (de)
DE (1)	DE602007006833D1 (de)
EA (1)	EA017376B1 (de)
ES (1)	ES2346014T3 (de)
IL (1)	IL198333A (de)
MX (1)	MX2009004387A (de)
WO (1)	WO2008049808A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JO2653B1 (en)	2006-10-24	2012-06-17	شركة جانسين فارماسوتيكا ان. في	Tetrahydroflavin 1-carboxylic acid substituted with pyridine or pyrazine inhibit MTB
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US8933024B2 (en)	2010-06-18	2015-01-13	Sanofi	Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
CA2960277A1 (en) *	2014-09-10	2016-03-17	Epizyme, Inc.	Substituted pyrrolidine carboxamide compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5595872A (en)	1992-03-06	1997-01-21	Bristol-Myers Squibb Company	Nucleic acids encoding microsomal trigyceride transfer protein
US5739135A (en) *	1993-09-03	1998-04-14	Bristol-Myers Squibb Company	Inhibitors of microsomal triglyceride transfer protein and method
WO1996040640A1 (en)	1995-06-07	1996-12-19	Pfizer Inc.	BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION
TR199901180T2 (xx) *	1996-11-27	1999-08-23	Pfizer Inc.	Apo B-Salg�lama/MTP inhibit�r amidler.
CA2291630A1 (en) *	1997-05-30	1998-12-03	Tetsutaro Niizato	Nitrogen-containing heterocyclic compounds and therapeutic agents for hyperlipidemia comprising the same
GB9826412D0 (en) *	1998-12-03	1999-01-27	Glaxo Group Ltd	Chemical compounds
DE19963235A1 (de)	1999-12-27	2001-07-05	Boehringer Ingelheim Pharma	Substituierte Piperazinderivate, ihre Herstellung und ihre Verwendung als Arzneimittel
GB0013346D0 (en)	2000-06-01	2000-07-26	Glaxo Group Ltd	Therapeutic benzamide derivatives
FR2816940A1 (fr)	2000-11-23	2002-05-24	Lipha	Derives de 4-(biphenylcarbonylamino)-piperidine, compositions les contenant et leur utilisation
FR2871463B1 (fr) *	2004-06-11	2006-09-22	Merck Sante Soc Par Actions Si	Derives a structure aroyl-o-piperidine, leurs procedes de preparation, les compositions pharmaceutiques qui les contiennent et leurs applications en therapeutique
JO2653B1 (en)	2006-10-24	2012-06-17	شركة جانسين فارماسوتيكا ان. في	Tetrahydroflavin 1-carboxylic acid substituted with pyridine or pyrazine inhibit MTB

2007
- 2007-10-22 JP JP2009533801A patent/JP5525261B2/ja not_active Expired - Fee Related
- 2007-10-22 CA CA2664143A patent/CA2664143C/en not_active Expired - Fee Related
- 2007-10-22 US US12/446,581 patent/US8158783B2/en not_active Expired - Fee Related
- 2007-10-22 EP EP07821653A patent/EP2076487B1/de active Active
- 2007-10-22 AT AT07821653T patent/ATE469122T1/de not_active IP Right Cessation
- 2007-10-22 BR BRPI0717314-8A2A patent/BRPI0717314A2/pt not_active IP Right Cessation
- 2007-10-22 CN CN2007800392631A patent/CN101528671B/zh not_active Expired - Fee Related
- 2007-10-22 ES ES07821653T patent/ES2346014T3/es active Active
- 2007-10-22 EA EA200970399A patent/EA017376B1/ru not_active IP Right Cessation
- 2007-10-22 WO PCT/EP2007/061289 patent/WO2008049808A1/en not_active Ceased
- 2007-10-22 DE DE602007006833T patent/DE602007006833D1/de active Active
- 2007-10-22 MX MX2009004387A patent/MX2009004387A/es active IP Right Grant
- 2007-10-22 AU AU2007310927A patent/AU2007310927B2/en not_active Ceased
- 2007-10-22 KR KR1020097007793A patent/KR101387459B1/ko not_active Expired - Fee Related
2009
- 2009-04-23 IL IL198333A patent/IL198333A/en active IP Right Grant

Also Published As

Publication number	Publication date
EA200970399A1 (ru)	2009-10-30
US20100016291A1 (en)	2010-01-21
MX2009004387A (es)	2009-05-08
US8158783B2 (en)	2012-04-17
ES2346014T3 (es)	2010-10-07
KR101387459B1 (ko)	2014-05-14
WO2008049808A1 (en)	2008-05-02
KR20090076919A (ko)	2009-07-13
HK1137011A1 (en)	2010-07-16
JP2010507616A (ja)	2010-03-11
IL198333A (en)	2013-03-24
CA2664143C (en)	2015-12-01
CN101528671A (zh)	2009-09-09
IL198333A0 (en)	2010-02-17
EA017376B1 (ru)	2012-12-28
AU2007310927B2 (en)	2012-01-12
EP2076487A1 (de)	2009-07-08
BRPI0717314A2 (pt)	2014-01-21
EP2076487B1 (de)	2010-05-26
JP5525261B2 (ja)	2014-06-18
DE602007006833D1 (de)	2010-07-08
AU2007310927A1 (en)	2008-05-02
CN101528671B (zh)	2013-03-13
CA2664143A1 (en)	2008-05-02

Legal Events

Date	Code	Title	Description
2010-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
MX2009004386A (es)	2009-05-08	Compuestos inhibidores de proteina de transferencia de trigliceridos microsomales de acido tetrahidro-naftalen-1-carboxil ico sustituidos con piperidina o piperazina.
JO2537B1 (en)	2010-09-05	Aryl-pyridine or pyrezinate compounds replaced with heterogeneous pentagonal rings used as inhibitors of MTB proteins
EA201190235A1 (ru)	2012-05-30	Замещенные 1-цианоэтилгетероциклилкарбоксамидные соединения 750
EA201270560A1 (ru)	2012-09-28	Спиропиперидиновые соединения и их фармацевтическое применение для лечения диабета
MX2010002461A (es)	2010-03-26	(carboxilalquilenfenil)feniloxamidas, metodo para su produccion y uso de las mismas como medicamento.
NO20091620L (no)	2009-07-09	Boronsyre og estere som inhibitorer av fettsyreamidhydrolaser
MX2010002419A (es)	2010-03-30	(ciclopropilfenil) feniloxamidas, metodo para su produccion y uso como un medicamento.
EA201001682A1 (ru)	2011-06-30	Производные фенил- и бензодиоксинилзамещенных индазолов
CY1109842T1 (el)	2014-09-10	Αναστολεις της αφυδρογονασης 11-β-υδροξυστεροειδων i
ATE524450T1 (de)	2011-09-15	5-phenyl-isoxazol-3-carboxamid-derivate als trpv1-modulatoren
PT2323972E (pt)	2013-10-09	Compostos de tetraciclina substituídos com c7-flúor
ATE500222T1 (de)	2011-03-15	Benzamid- und heteroarenderivate als cetp- inhibitoren
MX2010008051A (es)	2010-08-10	Nuevos derivados de fluoroglicosidos aromaticos, productos farmaceuticos que comprenden dichos compuestos y uso de los mismos.
IN2012DN02502A (de)	2015-08-28
EA201071180A1 (ru)	2011-04-29	Конденсированные циклические соединения и их применение
EA200970170A1 (ru)	2009-06-30	Производные 4-триметиламмоний-3-аминобутирата и 4-триметилфосфоний-3-аминобутирата как ингибиторы срт
HRP20050103B1 (hr)	2013-09-30	N-aril supstituirani bifenilkarboksamidi kao inhibitori sekrecije apolipoproteina b
MY148406A (en)	2013-04-30	4-[(3-fluorophenoxy)phenylmethyl] piperidine methanesulfonate: uses, process of synthesis and pharmaceutical compositions
UA107831C2 (en)	2015-02-25	Composition for combating plant diseases and its application
WO2010132670A3 (en)	2010-12-29	Pentacycline compounds
DE602007006833D1 (de)	2010-07-08	Mtp-inhibierende tetrahydronaphthalin-1-carbonsäurederivate
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