ATE469884T1 - Indolinverbindung und deren medizinische verwendung - Google Patents

Indolinverbindung und deren medizinische verwendung

Info

Publication number
ATE469884T1
ATE469884T1 AT03764206T AT03764206T ATE469884T1 AT E469884 T1 ATE469884 T1 AT E469884T1 AT 03764206 T AT03764206 T AT 03764206T AT 03764206 T AT03764206 T AT 03764206T AT E469884 T1 ATE469884 T1 AT E469884T1
Authority
AT
Austria
Prior art keywords
indoline compound
medical use
compound
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
AT03764206T
Other languages
English (en)
Inventor
Shouji Kamiya
Miho Ukai
Kenji Takahashi
Tadatsugu Tarumi
Masavasu Kasai
Akihisa Yoshimi
Hiroaki Shirahase
Original Assignee
Kyoto Pharma Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharma Ind filed Critical Kyoto Pharma Ind
Application granted granted Critical
Publication of ATE469884T1 publication Critical patent/ATE469884T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
AT03764206T 2002-07-17 2003-07-16 Indolinverbindung und deren medizinische verwendung ATE469884T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002208878 2002-07-17
PCT/JP2003/009012 WO2004007450A1 (ja) 2002-07-17 2003-07-16 新規インドリン化合物およびその医薬用途

Publications (1)

Publication Number Publication Date
ATE469884T1 true ATE469884T1 (de) 2010-06-15

Family

ID=30112861

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03764206T ATE469884T1 (de) 2002-07-17 2003-07-16 Indolinverbindung und deren medizinische verwendung

Country Status (21)

Country Link
US (1) US7429612B2 (de)
EP (1) EP1541553B1 (de)
JP (1) JP4485357B2 (de)
CN (1) CN100349868C (de)
AT (1) ATE469884T1 (de)
AU (1) AU2003252638B8 (de)
BR (1) BR0312734A (de)
CA (1) CA2492669A1 (de)
CO (1) CO5690574A2 (de)
DE (1) DE60332851D1 (de)
DK (1) DK1541553T3 (de)
IL (1) IL166313A0 (de)
MX (1) MXPA05000749A (de)
NO (1) NO20050834L (de)
NZ (1) NZ538226A (de)
PL (1) PL374919A1 (de)
RS (1) RS20050127A (de)
RU (1) RU2318808C2 (de)
TW (1) TWI285196B (de)
WO (1) WO2004007450A1 (de)
ZA (1) ZA200501297B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011076931A1 (de) 2011-06-03 2012-12-06 Basf Se Wässrige Lösung, enthaltend Acrylsäure und deren konjugierte Base
JP2018052818A (ja) * 2015-01-28 2018-04-05 武田薬品工業株式会社 スルホンアミド化合物

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013404A (en) * 1970-12-06 1977-03-22 American Cyanamid Company Method of dyeing hair with indolines, indoles and indazoles
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
US4803218A (en) * 1982-09-29 1989-02-07 Mcneilab, Inc. 3-aminoalkyl-1H-indole-5-urea and amide derivatives
US4956372A (en) * 1987-10-02 1990-09-11 Kyorin Pharmaceutical Co., Ltd. Cyclic anthranilic acid derivatives and process for their preparation
US5227492A (en) 1988-01-20 1993-07-13 Yamanouchi Pharmaceutical Co., Ltd. Diurea derivatives useful as medicaments and processes for the preparation thereof
JPH02117651A (ja) 1988-01-20 1990-05-02 Yamanouchi Pharmaceut Co Ltd ジウレア誘導体及びその製造法
CN1021819C (zh) * 1988-01-20 1993-08-18 山之内制药株式会社 作为药物有用的双脲衍生物的制备方法
US5166429A (en) * 1988-01-20 1992-11-24 Yamanouchi Pharmaceutical Co., Ltd. Diurea derivatives useful as medicaments and processes for the preparation thereof
IE892088L (en) * 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use
JPH0753714B2 (ja) 1988-07-12 1995-06-07 武田薬品工業株式会社 Ａｃａｔ阻害剤、キノリン誘導体及びその製造法
US5153226A (en) 1989-08-31 1992-10-06 Warner-Lambert Company Acat inhibitors for treating hypocholesterolemia
CA2037669A1 (en) 1990-03-12 1991-09-13 Noriki Ito Urea derivatives and salts thereof, pharmaceutical compositions containing the same, and methods for producing the same
US5258405A (en) * 1990-03-12 1993-11-02 Yamanouchi Pharmaceutical Co., Ltd. Urea derivatives and salts thereof in method for inhibiting the ACAT enzyme
JPH0466568A (ja) 1990-06-29 1992-03-02 Takeda Chem Ind Ltd 中枢性抗酸化剤化合物
US5143919A (en) * 1990-08-17 1992-09-01 Takeda Chemical Industries, Ltd. Thienopyridine derivatives and their pharmaceutical use
JP3086295B2 (ja) 1990-08-17 2000-09-11 武田薬品工業株式会社 チエノピリジン誘導体、その製造法およびａｃａｔ阻害剤
US5256782A (en) * 1990-08-17 1993-10-26 Takeda Chemical Industries, Ltd. Thienopyridine derivatives which are intermediates
IL100915A (en) * 1991-02-19 1996-03-31 Erba Carlo Spa Disubstituted ureas and thioureas their preparation and pharmaceutical compositions containing them
FR2673625B1 (fr) * 1991-03-08 1993-05-07 Adir Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2674522B1 (fr) 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.
IL101785A0 (en) 1991-05-10 1992-12-30 Fujisawa Pharmaceutical Co Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
CA2121391A1 (en) 1993-04-28 1994-10-29 Atsuyuki Kojima Indoloylguanidine derivatives
US6169107B1 (en) * 1993-04-28 2001-01-02 Sumitomo Pharmaceutical Co., Ltd. Indoloylguanidine derivatives
JP3720395B2 (ja) * 1994-09-20 2005-11-24 京都薬品工業株式会社 新規ヘテロ環誘導体、その製造方法およびその医薬用途
CA2160600A1 (en) 1994-10-18 1996-04-19 Masahumi Kitano Indoloylguanidine derivatives
JPH08208602A (ja) 1994-10-18 1996-08-13 Sumitomo Pharmaceut Co Ltd インドロイルグアニジン誘導体
US5767129A (en) * 1995-08-24 1998-06-16 Warner-Lambert Company Substituted quinolines and isoquinolines as calcium channel blockers, their preparation and the use thereof
ATE210116T1 (de) * 1995-10-05 2001-12-15 Kyoto Pharma Ind Neue heterozyklische derivate und ihre medizinische anwendung
EP0793140B1 (de) 1996-03-04 2000-08-09 Fuji Photo Film Co., Ltd. Verarbeitungszusammensetzung für lichtempfindliches photographisches Silberhalogenidmaterial, Entwickler und Verarbeitungsverfahren unter dessen Verwendung
JP2002047269A (ja) 2000-08-01 2002-02-12 Kyoto Pharmaceutical Industries Ltd ヘテロ環化合物の製造方法およびその中間体
JP2002302481A (ja) 2001-02-02 2002-10-18 Sankyo Co Ltd インドリン誘導体と製造法
EP1631546A1 (de) * 2003-04-25 2006-03-08 H. Lundbeck A/S Substituierte indolin- und indolderivate

Also Published As

Publication number Publication date
CN100349868C (zh) 2007-11-21
US20060128787A1 (en) 2006-06-15
DE60332851D1 (de) 2010-07-15
AU2003252638A1 (en) 2004-02-02
RS20050127A (sr) 2007-06-04
WO2004007450A1 (ja) 2004-01-22
IL166313A0 (en) 2006-01-15
RU2318808C2 (ru) 2008-03-10
AU2003252638B8 (en) 2009-03-05
TWI285196B (en) 2007-08-11
ZA200501297B (en) 2006-10-25
RU2005104238A (ru) 2005-08-27
EP1541553B1 (de) 2010-06-02
JPWO2004007450A1 (ja) 2005-11-10
JP4485357B2 (ja) 2010-06-23
US7429612B2 (en) 2008-09-30
NO20050834L (no) 2005-04-15
NZ538226A (en) 2006-08-31
CA2492669A1 (en) 2004-01-22
AU2003252638B2 (en) 2009-02-05
CO5690574A2 (es) 2006-10-31
EP1541553A1 (de) 2005-06-15
BR0312734A (pt) 2005-04-26
PL374919A1 (en) 2005-11-14
CN1681781A (zh) 2005-10-12
TW200407304A (en) 2004-05-16
EP1541553A4 (de) 2007-04-11
MXPA05000749A (es) 2005-04-28
DK1541553T3 (da) 2010-09-20
HK1083839A1 (zh) 2006-07-14

Similar Documents

Publication Publication Date Title
NO331013B1 (no) Nye forbindelser som er anti-inflammasjons, immunomodulerende og anti-proliferative midler, anvendelse av forbindelsene samt farmasoytisk preparat
DE602004008098D1 (de) Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren
NO20050828L (no) lndol-3-svovelderivater
DE60330407D1 (de) Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung
ATE413388T1 (de) Muskarin antagonisten
SE0104250D0 (sv) Heterocyclic compounds
NO20040881L (no) Orale antidiabetes midler.
ATE303384T1 (de) 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
SE0302573D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
ECSP055809A (es) Inhibidores 4-oxo-1-(3-fenil sustituido)-1,4-dihidro-1,8-naftiridina-3-carboxamida de la fosfodiesterasa-4
BRPI0417858A (pt) composto, composição farmacêutica, e, uso de uma composição farmacêutica
MXPA05006889A (es) Compuestos aromaticos como agentes anti-inflamatorios, inmunomoduladores y anti-proliferativos.
DE602004031410D1 (de) Inden derivate als pharmazeutika
SE0203303D0 (sv) Novel Compounds
NO20052182L (no) Nye forbindelser
NO20060146L (no) Benzimidazolderivater, sammensetninger som inneholder slike, fremstilling derav og anvendelse derav
SE0302570D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0203300D0 (sv) Novel Compounds
SE0300105D0 (sv) Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof
CY1108238T1 (el) Μεθοδος συνθεσης της περινδοπριλης και των φαρμακευτικως αποδεκτων αλατων της
SE0302572D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
GB0212410D0 (en) Organic compounds
MY139613A (en) Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders
ATE469884T1 (de) Indolinverbindung und deren medizinische verwendung
ATE374751T1 (de) 3,4-dihydro-1h-chinolin-2-onderivate als norepinephrin-wiederaufnahme-hemmern

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties