ATE469968T1 - Verfahren und mittel zur überwachung und modulation des gen-silencing - Google Patents
Verfahren und mittel zur überwachung und modulation des gen-silencingInfo
- Publication number
- ATE469968T1 ATE469968T1 AT03707900T AT03707900T ATE469968T1 AT E469968 T1 ATE469968 T1 AT E469968T1 AT 03707900 T AT03707900 T AT 03707900T AT 03707900 T AT03707900 T AT 03707900T AT E469968 T1 ATE469968 T1 AT E469968T1
- Authority
- AT
- Austria
- Prior art keywords
- monitoring
- gene silencing
- modulating gene
- gene
- modulating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/825—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving pigment biosynthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8262—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield involving plant development
- C12N15/827—Flower development or morphology, e.g. flowering promoting factor [FPF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Mold Materials And Core Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36385202P | 2002-03-14 | 2002-03-14 | |
| PCT/AU2003/000293 WO2003076620A1 (en) | 2002-03-14 | 2003-03-12 | Methods and means for monitoring and modulating gene silencing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE469968T1 true ATE469968T1 (de) | 2010-06-15 |
Family
ID=27805294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03707900T ATE469968T1 (de) | 2002-03-14 | 2003-03-12 | Verfahren und mittel zur überwachung und modulation des gen-silencing |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20030175783A1 (de) |
| EP (1) | EP1490489B1 (de) |
| JP (1) | JP2006503548A (de) |
| CN (1) | CN1643147B (de) |
| AT (1) | ATE469968T1 (de) |
| AU (1) | AU2003212089B2 (de) |
| CA (1) | CA2478910C (de) |
| DE (1) | DE60332820D1 (de) |
| ES (1) | ES2346645T3 (de) |
| WO (1) | WO2003076620A1 (de) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL145778A0 (en) * | 1999-04-21 | 2002-07-25 | American Home Prod | Methods and compositions for inhibiting the function of polynucleotide sequences |
| US7485715B2 (en) * | 1999-06-18 | 2009-02-03 | Ceres, Inc. | Sequence-determined DNA encoding AP2 domain polypeptides |
| US7479555B2 (en) * | 1999-07-21 | 2009-01-20 | Ceres, Inc. | Polynucleotides having a nucleotide sequence that encodes a polypeptide having MOV34 family activity |
| GB9918061D0 (en) * | 1999-07-30 | 1999-10-06 | Univ Bath | Modified plants |
| DE10212892A1 (de) * | 2002-03-20 | 2003-10-09 | Basf Plant Science Gmbh | Konstrukte und Verfahren zur Regulation der Genexpression |
| US20050059044A1 (en) * | 2003-06-03 | 2005-03-17 | Graham Michael Wayne | Double-stranded nucleic acid |
| AU2004243347B2 (en) * | 2003-06-03 | 2009-04-09 | Benitec Australia Limited | Double-stranded nucleic acid |
| US20050081261A1 (en) * | 2003-10-14 | 2005-04-14 | Pennell Roger I. | Methods and compositions for altering seed phenotypes |
| ATE508190T1 (de) * | 2004-03-05 | 2011-05-15 | Benitec Inc | Mehrfachpromotor-expressionskassetten zurgleichzeitigen zuführung von rnai-agentien |
| US7429692B2 (en) * | 2004-10-14 | 2008-09-30 | Ceres, Inc. | Sucrose synthase 3 promoter from rice and uses thereof |
| NZ582988A (en) | 2004-10-21 | 2011-07-29 | Venganza Inc | Methods and materials for conferring resistance to pests and pathogens of plants |
| WO2008069878A2 (en) | 2006-10-27 | 2008-06-12 | Ceres, Inc. | Modulating lignin in plants |
| WO2007087601A2 (en) * | 2006-01-25 | 2007-08-02 | Ceres, Inc. | Modulating plant protein levels |
| US9758790B2 (en) | 2004-12-08 | 2017-09-12 | Ceres, Inc. | Modulating the level of components within plants |
| WO2007050625A1 (en) * | 2005-10-25 | 2007-05-03 | Ceres, Inc. | Modulation of triterpenoid content in plants |
| WO2007089610A1 (en) * | 2006-01-26 | 2007-08-09 | Ceres, Inc. | Modulating plant oil levels |
| US7795503B2 (en) * | 2005-02-22 | 2010-09-14 | Ceres, Inc. | Modulating plant alkaloids |
| US7312376B2 (en) * | 2005-04-20 | 2007-12-25 | Ceres, Inc. | Regulatory regions from Papaveraceae |
| US8124839B2 (en) * | 2005-06-08 | 2012-02-28 | Ceres, Inc. | Identification of terpenoid-biosynthesis related regulatory protein-regulatory region associations |
| US20100062137A1 (en) * | 2005-09-30 | 2010-03-11 | Steven Craig Bobzin | Modulating plant tocopherol levels |
| MX2008009220A (es) * | 2006-01-17 | 2008-10-10 | Biolex Therapeutics Inc | Composiciones y metodos para la humanizacion y optimizacion de n-glicanos en plantas. |
| US20090060921A1 (en) * | 2006-01-17 | 2009-03-05 | Biolex Therapeutics, Inc. | Glycan-optimized anti-cd20 antibodies |
| US20070199090A1 (en) * | 2006-02-22 | 2007-08-23 | Nestor Apuya | Modulating alkaloid biosynthesis |
| WO2007120989A2 (en) * | 2006-02-24 | 2007-10-25 | Ceres, Inc. | Shade regulatory regions |
| WO2007117693A2 (en) * | 2006-04-07 | 2007-10-18 | Ceres, Inc. | Regulatory protein-regulatory region associations related to alkaloid biosynthesis |
| US20100024070A1 (en) * | 2006-05-15 | 2010-01-28 | Steven Craig Bobzin | Modulation of oil levels in plants |
| WO2007147068A2 (en) * | 2006-06-14 | 2007-12-21 | Ceres, Inc. | Increasing uv-b tolerance in plants |
| WO2007149570A2 (en) * | 2006-06-21 | 2007-12-27 | Ceres, Inc. | Modulation of protein levels in plants |
| US20130191941A1 (en) | 2006-07-05 | 2013-07-25 | Shing Kwok | Modulating light response pathways in plants, increasing light-related tolerances in plants, and increasing biomass in plants |
| WO2008064128A2 (en) * | 2006-11-22 | 2008-05-29 | Ceres, Inc. | Broadly expressing regulatory regions |
| US20100151109A1 (en) * | 2006-12-15 | 2010-06-17 | Amr Saad Ragab | Modulation of plant protein levels |
| BRPI0701172B1 (pt) | 2007-02-05 | 2019-11-26 | Empresa Brasileira De Pesquisa Agropecuaria Embrapa | composições e métodos para modificar a expressão de genes usando o promotor do gene da proteína de conjugação à ubiquitina de plantas de soja |
| BRPI0701230B1 (pt) * | 2007-02-05 | 2018-06-26 | Empresa Brasileira De Pesquisa Agropecuária - Embrapa | Composições e métodos para modificar a expressão de genes usando o promotor do gene da proteína de conjugação à ubiquitina de plantas de algodoeiro |
| BRPI0701826B1 (pt) | 2007-03-16 | 2021-02-17 | Embrapa - Empresa Brasileira De Pesquisa Agropecuária | proteínas da teia de aranha nephilengys cruentata, avicularia juruensis e parawixia bistriata isoladas da biodiversidade brasileira |
| US8419145B2 (en) * | 2008-07-25 | 2013-04-16 | Eastman Kodak Company | Inkjet printhead and method of printing with multiple drop volumes |
| US8298794B2 (en) * | 2008-10-09 | 2012-10-30 | Ceres, Inc. | Cinnamyl-alcohol dehydrogenases |
| US20100257634A1 (en) * | 2009-04-03 | 2010-10-07 | Venganza Inc. | Bioassay for gene silencing constructs |
| EA036343B1 (ru) | 2009-07-20 | 2020-10-29 | Серес, Инк. | Увеличение биомассы трансгенных растений |
| WO2011009182A2 (pt) | 2009-07-24 | 2011-01-27 | Embrapa - Empresa Brasileira De Pesquisa Agropecuária | Molécula de ácido nucléico isolada, construção gênica, vetor, célula transgênica, método para obtenção de uma célula e de uma planta transgênica, polipeptídeo isolado e purificado, composição pesticida biodegradável, método para o controle de uma praga, método de obtenção de linhagens transgênicas resistentes a um inseto praga |
| WO2011140329A1 (en) | 2010-05-06 | 2011-11-10 | Ceres, Inc. | Transgenic plants having increased biomass |
| BR112013010278B1 (pt) | 2010-10-27 | 2020-12-29 | Ceres, Inc | método para produzir uma planta, método para modular a composição de biomassa em uma planta, ácido nucleico isolado e método para alterar a composição de biomassa em uma planta |
| US20120107355A1 (en) | 2010-10-27 | 2012-05-03 | Harrisvaccines, Inc. | Method of rapidly producing improved vaccines for animals |
| US8822427B2 (en) | 2010-10-27 | 2014-09-02 | Harrisvaccines | Methods and compositions to protect aquatic invertebrates from disease |
| US10004797B2 (en) | 2010-10-27 | 2018-06-26 | Harrisvaccines, Inc. | Method of rapidly producing improved vaccines for animals |
| DK2718442T3 (en) | 2011-06-10 | 2017-08-14 | Temasek Life Sciences Laboratory Ltd | GENETIC MANIPULATION AND EXPRESSION SYSTEMS FOR SUBPHYLA OF PUCCINIOMYCOTINA AND USTILAGINOMYCOTINA |
| WO2013067128A1 (en) | 2011-11-02 | 2013-05-10 | Ceres, Inc. | Transgenic plants having increased tolerance to aluminum |
| BR112014013853A2 (pt) | 2011-12-09 | 2020-01-14 | Ceres, Inc. | uso de um ácido nucleico isolado, método de obtenção de uma célula vegetal transgênica, método de obtenção de uma planta transgênica, método de produção de uma planta, método de produção de biomassa, método de processamento de biomassa, método de alteração da composição de biomassa, método de modulação de composição de biomassa, método de produção de um produto de forragem |
| EP2839007B1 (de) | 2012-04-19 | 2017-12-27 | Temasek Life Sciences Laboratory Limited | Verfahren zur erhöhung der faserlänge von baumwolle |
| WO2014004458A2 (en) * | 2012-06-25 | 2014-01-03 | Dow Agrosciences Llc | Insect resistant and herbicide tolerant soybean event pdab9582.816.15.1 |
| US9101100B1 (en) | 2014-04-30 | 2015-08-11 | Ceres, Inc. | Methods and materials for high throughput testing of transgene combinations |
| AU2015289691B2 (en) | 2014-07-15 | 2020-12-24 | Ceres, Inc. | Methods of increasing crop yield under abiotic stress |
| WO2016064347A1 (en) | 2014-10-22 | 2016-04-28 | Temasek Life Sciences Laboratory Limited | Terpene synthases from ylang ylang (cananga odorata var. fruticosa) |
| US11525140B2 (en) | 2016-03-24 | 2022-12-13 | Universiteit Leiden | Methods for transfecting plants and for reducing random integration events |
| PL3458074T3 (pl) * | 2016-05-16 | 2024-11-12 | Board Of Regents Of The University Of Texas System | KOMPOZYCJA DO DOSTARCZANIA tRNA W POSTACI NANOCZĄSTEK I SPOSOBY ICH STOSOWANIA |
| CN119506283A (zh) | 2017-09-15 | 2025-02-25 | 联邦科学技术研究组织 | Rna分子 |
| EP3502259A1 (de) | 2017-12-19 | 2019-06-26 | Universiteit Leiden | Kombinatorische strategie zur reduzierung von zufälligen integrationsereignissen bei der transfektion von pflanzen |
| EP3744849A1 (de) | 2019-05-31 | 2020-12-02 | Consejo Superior de Investigaciones Cientificas (CSIC) | Verfahren zur modulation des durch trans-agierende, kleine interferierende rnas induzierten gen-silencing-grades |
| US11473086B2 (en) | 2019-06-19 | 2022-10-18 | Ut-Battelle, Llc | Loss of function alleles of PtEPSP-TF and its regulatory targets in rice |
| EP4007813A4 (de) * | 2019-08-02 | 2023-08-30 | Commonwealth Scientific and Industrial Research Organisation | Rna-moleküle zur modulation der blüte bei pflanzen |
| NL2035852B1 (en) | 2023-09-21 | 2025-03-28 | Academisch Ziekenhuis Leiden | Enhancement of t cell mediated therapies |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5037745A (en) * | 1986-04-01 | 1991-08-06 | University Of Medicine And Dentistry Of New Jersey | Plasmid for the overproduction of bacteriophage T3 RNA polymerase, transcription vectors that carry a promoter recognized by its polymerase, gene coding for T3 RNA polymerase and application of these plasmids |
| GB9210273D0 (en) * | 1992-05-13 | 1992-07-01 | Ici Plc | Dna |
| CN101818145A (zh) | 1998-03-20 | 2010-09-01 | 联邦科学和工业研究组织 | 控制基因表达 |
| AR020078A1 (es) * | 1998-05-26 | 2002-04-10 | Syngenta Participations Ag | Metodo para alterar la expresion de un gen objetivo en una celula de planta |
| CA2408326A1 (en) * | 2000-06-23 | 2002-01-03 | E.I. Dupont De Nemours And Company | Recombinant constructs and their use in reducing gene expression |
| AU2001281024A1 (en) | 2000-08-02 | 2002-02-13 | The Board Of Regents Of The University Of Nebraska | Down-regulation of single genes and simultaneous down-regulation of multiple genes by nuclear localization of rna transcripts |
| CA2427347C (en) * | 2000-10-31 | 2011-01-18 | Commonwealth Scientific And Industrial Research Organisation | Method and means for producing barley yellow dwarf virus resistant cereal plants |
-
2003
- 2003-03-12 ES ES03707900T patent/ES2346645T3/es not_active Expired - Lifetime
- 2003-03-12 US US10/385,546 patent/US20030175783A1/en not_active Abandoned
- 2003-03-12 DE DE60332820T patent/DE60332820D1/de not_active Expired - Lifetime
- 2003-03-12 JP JP2003574824A patent/JP2006503548A/ja active Pending
- 2003-03-12 AU AU2003212089A patent/AU2003212089B2/en not_active Expired
- 2003-03-12 EP EP03707900A patent/EP1490489B1/de not_active Expired - Lifetime
- 2003-03-12 CN CN038060388A patent/CN1643147B/zh not_active Expired - Lifetime
- 2003-03-12 WO PCT/AU2003/000293 patent/WO2003076620A1/en not_active Ceased
- 2003-03-12 AT AT03707900T patent/ATE469968T1/de not_active IP Right Cessation
- 2003-03-12 CA CA2478910A patent/CA2478910C/en not_active Expired - Lifetime
-
2013
- 2013-12-09 US US14/100,272 patent/US20140196160A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003212089B2 (en) | 2008-08-21 |
| WO2003076620A1 (en) | 2003-09-18 |
| EP1490489A1 (de) | 2004-12-29 |
| AU2003212089A1 (en) | 2003-09-22 |
| DE60332820D1 (de) | 2010-07-15 |
| US20030175783A1 (en) | 2003-09-18 |
| EP1490489B1 (de) | 2010-06-02 |
| CN1643147B (zh) | 2010-04-14 |
| ES2346645T3 (es) | 2010-10-19 |
| JP2006503548A (ja) | 2006-02-02 |
| EP1490489A4 (de) | 2006-06-14 |
| US20140196160A1 (en) | 2014-07-10 |
| CN1643147A (zh) | 2005-07-20 |
| CA2478910A1 (en) | 2003-09-18 |
| CA2478910C (en) | 2012-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |