ATE470442T1 - Verwendung von gamma-tocotrienol als diuretika - Google Patents

Verwendung von gamma-tocotrienol als diuretika

Info

Publication number: ATE470442T1
Authority: AT; Austria
Prior art keywords: medicament; preventing; treating; tocotrienol; diuretic
Prior art date: 2000-03-31

Application number

AT01915838T

Other languages

English (en)

Inventor

Osamu Igarashi

Chikako Kiyose

Hiroyuki Yoshimura

Shigehiro Yoshitake

Original Assignee

Eisai R&D Man Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-31

Filing date

2001-03-27

Publication date

2010-06-15

2001-03-27 Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd

2010-06-15 Application granted granted Critical

2010-06-15 Publication of ATE470442T1 publication Critical patent/ATE470442T1/de

Links

OTXNTMVVOOBZCV-UHFFFAOYSA-N 2R-gamma-tocotrienol Natural products OC1=C(C)C(C)=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 OTXNTMVVOOBZCV-UHFFFAOYSA-N 0.000 title abstract 2
RZFHLOLGZPDCHJ-DLQZEEBKSA-N alpha-Tocotrienol Natural products Oc1c(C)c(C)c2O[C@@](CC/C=C(/CC/C=C(\CC/C=C(\C)/C)/C)\C)(C)CCc2c1C RZFHLOLGZPDCHJ-DLQZEEBKSA-N 0.000 title abstract 2
239000002934 diuretic Substances 0.000 title abstract 2
230000001882 diuretic effect Effects 0.000 title abstract 2
OTXNTMVVOOBZCV-YMCDKREISA-N gamma-Tocotrienol Natural products Oc1c(C)c(C)c2O[C@@](CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)(C)CCc2c1 OTXNTMVVOOBZCV-YMCDKREISA-N 0.000 title abstract 2
239000011722 γ-tocotrienol Substances 0.000 title abstract 2
OTXNTMVVOOBZCV-WAZJVIJMSA-N γ-tocotrienol Chemical compound OC1=C(C)C(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 OTXNTMVVOOBZCV-WAZJVIJMSA-N 0.000 title abstract 2
235000019150 γ-tocotrienol Nutrition 0.000 title abstract 2
239000003814 drug Substances 0.000 abstract 4
206010019280 Heart failures Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
208000019622 heart disease Diseases 0.000 abstract 1
230000000302 ischemic effect Effects 0.000 abstract 1
208000017169 kidney disease Diseases 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT01915838T 2000-03-31 2001-03-27 Verwendung von gamma-tocotrienol als diuretika ATE470442T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2000097442		2000-03-31
PCT/JP2001/002479 WO2001074354A1 (en)	2000-03-31	2001-03-27	DIURETICS CONTAINING η-TOCOTRIENOL

Publications (1)

Publication Number	Publication Date
ATE470442T1 true ATE470442T1 (de)	2010-06-15

Family

ID=18612062

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01915838T ATE470442T1 (de)	2000-03-31	2001-03-27	Verwendung von gamma-tocotrienol als diuretika

Country Status (10)

Country	Link
US (1)	US6864280B2 (de)
EP (1)	EP1270004B1 (de)
KR (1)	KR100730338B1 (de)
AT (1)	ATE470442T1 (de)
AU (2)	AU4281101A (de)
CA (1)	CA2403977C (de)
DE (1)	DE60142330D1 (de)
ES (1)	ES2346181T3 (de)
MY (1)	MY131758A (de)
WO (1)	WO2001074354A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003291012A1 (en) *	2002-11-15	2004-06-15	Galileo Pharmaceuticals, Inc.	Chroman derivatives for the reduction of inflammation symptoms
US7989006B2 (en) *	2003-04-08	2011-08-02	American River Nutrition, Inc.	Annatto extract compositions, including geranyl geraniols and methods of use
US20050037102A1 (en) *	2003-07-18	2005-02-17	Barrie Tan	Annatto extract compositions including tocotrienols and tocopherols and methods of use
JP2007504136A (ja) *	2003-08-28	2007-03-01	ニトロメッドインコーポレーティッド	ニトロソ化およびニトロシル化利尿化合物、組成物、ならびに使用方法
CA2567963A1 (en) *	2004-05-26	2005-12-08	Kgk Synergize Inc.	Functional foods comprising flavonoids and tocotrienols and methods thereof
WO2006091716A2 (en) *	2005-02-24	2006-08-31	Nitromed, Inc.	Nitric oxide enhancing diuretic compounds, compositions and methods of use
RU2015120181A (ru) *	2012-11-13	2017-01-10	Гордаген Фармасьютикалз Пти Лтд	Чресслизистая доставка токотриенола
US9132117B2 (en)	2013-06-17	2015-09-15	Kgk Synergize, Inc	Compositions and methods for glycemic control of subjects with impaired fasting glucose

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR910007523A (ko) *	1989-10-04	1991-05-30	브리스톨-마이어즈 스퀴브 컴페니	과콜레스테린혈증, 과지방혈증 및 혈전색전증 질병 치료용 토코트리엔올
EP0669132A1 (de) *	1994-02-23	1995-08-30	van der Kraaij, Antonius Marinus Maria	Kombinationspräparat von Vitamine E und Acetylsalicylate zur Behandlung und Prophylaxis des Atherosclerosis
US6150402A (en)	1994-08-15	2000-11-21	Loma Linda University Medical Center	Natriuretic compounds
WO1999006040A1 (en) *	1997-08-04	1999-02-11	Berry Christopher J	Method of treating disease using a tocotrienol and alpha-lipoic acid or derivatives or an ester thereof
JP4271742B2 (ja)	1997-08-07	2009-06-03	エーザイ・アール・アンド・ディー・マネジメント株式会社	免疫機能改善剤
ID26335A (id) *	1997-11-17	2000-12-14	Lipogenic Inc	Metoda untuk mencegah restenosis dengan menggunakan tokotrienol
WO2000015201A2 (en) *	1998-09-10	2000-03-23	Forbes Medi-Tech Inc.	Compositions comprising one or more phytosterols, phytostanols or mixtures of both and one or more alpha, beta, delta, or gamma tocotrienols or derivatives thereof and use of the compositions in treating or preventing cardiovascular disease, its underlying conditions and other disorders

2001
- 2001-03-27 KR KR1020027012545A patent/KR100730338B1/ko not_active Expired - Fee Related
- 2001-03-27 AT AT01915838T patent/ATE470442T1/de not_active IP Right Cessation
- 2001-03-27 WO PCT/JP2001/002479 patent/WO2001074354A1/ja not_active Ceased
- 2001-03-27 DE DE60142330T patent/DE60142330D1/de not_active Expired - Lifetime
- 2001-03-27 EP EP01915838A patent/EP1270004B1/de not_active Expired - Lifetime
- 2001-03-27 CA CA002403977A patent/CA2403977C/en not_active Expired - Fee Related
- 2001-03-27 ES ES01915838T patent/ES2346181T3/es not_active Expired - Lifetime
- 2001-03-27 US US10/239,945 patent/US6864280B2/en not_active Expired - Fee Related
- 2001-03-27 AU AU4281101A patent/AU4281101A/xx active Pending
- 2001-03-27 AU AU2001242811A patent/AU2001242811B2/en not_active Ceased
- 2001-03-30 MY MYPI20011518A patent/MY131758A/en unknown

Also Published As

Publication number	Publication date
US20030139467A1 (en)	2003-07-24
ES2346181T3 (es)	2010-10-13
AU4281101A (en)	2001-10-15
KR20030019330A (ko)	2003-03-06
WO2001074354A1 (en)	2001-10-11
DE60142330D1 (de)	2010-07-22
CA2403977C (en)	2009-09-01
EP1270004A1 (de)	2003-01-02
MY131758A (en)	2007-08-30
KR100730338B1 (ko)	2007-06-19
US6864280B2 (en)	2005-03-08
EP1270004B1 (de)	2010-06-09
CA2403977A1 (en)	2002-09-25
AU2001242811B2 (en)	2005-07-14
EP1270004A4 (de)	2006-02-01

Legal Events

Date	Code	Title	Description
2010-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
BR9806752A (pt)	2000-03-14	Ftalazinonas.
ATE336248T1 (de)	2006-09-15	Verwendung von thiazolidinderivaten als antihyperglykämische mittel
NO20032831D0 (no)	2003-06-20	Pyrimidinaminer som angiogenese-modulatorer
DK1200418T3 (da)	2004-07-26	Nematodicide trifluorbutener
TR200000782T2 (tr)	2000-09-21	Resorsinol türevleri.
FI903331A0 (fi)	1990-07-02	Substituerade kinazolinoner, vilka aer anvaendbara som angiotensin-ii-antagonister.
DK5389A (da)	1989-07-08	Substituerede pyrroler, pyrazoler og triazoler, fremgangsmaader til deres fremstilling samt deres anvendelse som angiotensin ii-antagonister
DK1379239T3 (da)	2008-01-07	N(2-aryl-ethyl)-benzyl-aminer som antagonister af 5 HT6 receptoren
ATE302775T1 (de)	2005-09-15	Carbolinderivate
DE69803907D1 (de)	2002-03-28	Fungizide 2-Methoxybenzophenone
EA200300829A1 (ru)	2003-12-25	Производные 1-арил- или 1-алкилсульфонилбензазола в качестве лигандов 5-гидрокситриптамина-6
EA200301142A1 (ru)	2004-02-26	Производные гетероциклилокси-, -тиокси- и -аминобензазола в качестве лигандов 5-гидрокситриптамина-6
DE69919700D1 (de)	2004-09-30	Überbrückte indenopyrrolocarbazole
CO4940466A1 (es)	2000-07-24	Sales metanosulfonato de 5-(2-(4-(1,2-benzoisotiazol-3-il)- 1-piperazinil)etil)-6-cloro-1,3-dihidro-2h-indol-2-ona dihidratadas
BR0209149A (pt)	2004-07-13	Ftalazinonas
ATE346067T1 (de)	2006-12-15	Carbolinderivate
ATE300543T1 (de)	2005-08-15	Kondensierte pyrazindionderivate als pde5 inhibitore
TR200100885T2 (tr)	2001-08-21	2-Metil-tieno-benzodiazepin formülasyonu
TR200001452T2 (tr)	2004-12-21	Bifenilamidin türevleri.
DE60142330D1 (de)	2010-07-22	Verwendung von gamma-tocotrienol als diuretika
EA200400117A1 (ru)	2004-08-26	Производные 6-[2-(фосфонометокси)алкокси]пиримидинов, обладающие антивирусной активностью, способ их получения (варианты) и способ лечения вирусной инфекции
SV2003000981A (es)	2003-07-29	Fenil-heterociclil-eteres ref. pcs10973
BR9902084A (pt)	2000-04-11	Heterociclos.
TR200202195T2 (tr)	2002-12-23	5-Yer değiştirmiş 1-(4-florofenil)-1,3- dihidroizobenzofuran'ın adım adım alkillenmesi
MA26397A1 (fr)	2004-12-01	Protege-orteils, particulierement pour chaussures de securite.