ATE470468T1 - Substrate für eine medikamentenverabreichungsvorrichtung und verfahren zur bereitung - Google Patents

Substrate für eine medikamentenverabreichungsvorrichtung und verfahren zur bereitung

Info

Publication number
ATE470468T1
ATE470468T1 AT04780193T AT04780193T ATE470468T1 AT E470468 T1 ATE470468 T1 AT E470468T1 AT 04780193 T AT04780193 T AT 04780193T AT 04780193 T AT04780193 T AT 04780193T AT E470468 T1 ATE470468 T1 AT E470468T1
Authority
AT
Austria
Prior art keywords
aerosol
film
exterior surface
drug composition
substrates
Prior art date
Application number
AT04780193T
Other languages
English (en)
Inventor
Bryson Bennett
Ron Hale
Amy Lu
Daniel Myers
Joshua Rabinowitz
Krishnamohan Sharma
Martin Wensley
Original Assignee
Alexza Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexza Pharmaceuticals Inc filed Critical Alexza Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE470468T1 publication Critical patent/ATE470468T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/047—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters by exothermic chemical reaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Other Surface Treatments For Metallic Materials (AREA)
  • Chemical Treatment Of Metals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT04780193T 2003-08-04 2004-08-04 Substrate für eine medikamentenverabreichungsvorrichtung und verfahren zur bereitung ATE470468T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49263003P 2003-08-04 2003-08-04
PCT/US2004/025313 WO2005016421A1 (en) 2003-08-04 2004-08-04 Substrates for drug delivery device and methods of preparing and use

Publications (1)

Publication Number Publication Date
ATE470468T1 true ATE470468T1 (de) 2010-06-15

Family

ID=34193141

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04780193T ATE470468T1 (de) 2003-08-04 2004-08-04 Substrate für eine medikamentenverabreichungsvorrichtung und verfahren zur bereitung

Country Status (8)

Country Link
US (4) US20050034723A1 (de)
EP (1) EP1656171B9 (de)
JP (1) JP4869927B2 (de)
AT (1) ATE470468T1 (de)
AU (1) AU2004264344B2 (de)
CA (1) CA2534566A1 (de)
DE (1) DE602004027638D1 (de)
WO (1) WO2005016421A1 (de)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
JP2005503425A (ja) 2001-05-24 2005-02-03 アレックザ モレキュラー デリヴァリー コーポレイション 所定の吸入ルートによる薬剤エステルの送出
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
WO2002094218A2 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
US7498019B2 (en) 2001-05-24 2009-03-03 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of headache through an inhalation route
US6805853B2 (en) 2001-11-09 2004-10-19 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
US7766013B2 (en) * 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7458374B2 (en) * 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
CA2460343A1 (en) * 2001-11-21 2003-07-17 Alexza Molecular Delivery Corporation Delivery of caffeine through an inhalation route
US8003080B2 (en) * 2002-05-13 2011-08-23 Alexza Pharmaceuticals, Inc. Delivery of drug amines through an inhalation route
US20040101481A1 (en) * 2002-11-26 2004-05-27 Alexza Molecular Delivery Corporation Acute treatment of headache with phenothiazine antipsychotics
US20060193788A1 (en) * 2002-11-26 2006-08-31 Hale Ron L Acute treatment of headache with phenothiazine antipsychotics
CA2507159A1 (en) * 2002-11-26 2004-06-10 Alexza Molecular Delivery Corporation Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7550133B2 (en) * 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
US20040234699A1 (en) * 2003-05-21 2004-11-25 Alexza Molecular Delivery Corporation Methods of controlling uniformity of substrate temperature and self-contained heating unit and drug-supply unit employing same
US7402777B2 (en) 2004-05-20 2008-07-22 Alexza Pharmaceuticals, Inc. Stable initiator compositions and igniters
US7540286B2 (en) * 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP2246086A3 (de) 2004-08-12 2012-11-21 Alexza Pharmaceuticals, Inc. Aerosolverabreichungsvorrichtung mit Schlag gezündete Heizeinheit
US20100006092A1 (en) * 2004-08-12 2010-01-14 Alexza Pharmaceuticals, Inc. Aerosol Drug Delivery Device Incorporating Percussively Activated Heat Packages
US9675109B2 (en) * 2005-07-19 2017-06-13 J. T. International Sa Method and system for vaporization of a substance
US10244793B2 (en) 2005-07-19 2019-04-02 Juul Labs, Inc. Devices for vaporization of a substance
WO2007083073A1 (en) * 2006-01-19 2007-07-26 Optinose As Nasal administration
WO2008080170A1 (en) * 2006-12-22 2008-07-03 Alexza Pharmaceuticals, Inc. Mixed drug aerosol compositiions
EP2121088B1 (de) 2007-03-09 2016-07-13 Alexza Pharmaceuticals, Inc. Erhitzungseinheit zur verwendung in einer arzneimittelabgabevorrichtung
GB2448183A (en) * 2007-04-05 2008-10-08 Optinose As Nasal powder delivery device
US8991402B2 (en) * 2007-12-18 2015-03-31 Pax Labs, Inc. Aerosol devices and methods for inhaling a substance and uses thereof
US20090226598A1 (en) * 2008-02-11 2009-09-10 Boston Scientific Scimed, Inc. Substrate Coating Apparatus Having a Solvent Vapor Emitter
US20100065052A1 (en) * 2008-09-16 2010-03-18 Alexza Pharmaceuticals, Inc. Heating Units
US7834295B2 (en) * 2008-09-16 2010-11-16 Alexza Pharmaceuticals, Inc. Printable igniters
EP2198972A1 (de) 2008-12-18 2010-06-23 Boehringer Ingelheim International GmbH Reservoir und Zerstäuber
US8277781B2 (en) 2009-03-13 2012-10-02 Luitpold Pharmaceuticals, Inc. Device for intranasal administration
US8551454B2 (en) * 2009-03-13 2013-10-08 Luitpold Pharmaceuticals, Inc. Device for intranasal administration
EP2408571B1 (de) 2009-03-17 2015-09-16 Boehringer Ingelheim International GmbH Reservoir und zerstäuber
EP2425224A1 (de) 2009-04-28 2012-03-07 Boehringer Ingelheim International GmbH Verfahren zur prüfung der dichtheit eines mit einem fluid befüllten behälters
US20100300433A1 (en) * 2009-05-28 2010-12-02 Alexza Pharmaceuticals, Inc. Substrates for Enhancing Purity or Yield of Compounds Forming a Condensation Aerosol
US20120048963A1 (en) 2010-08-26 2012-03-01 Alexza Pharmaceuticals, Inc. Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter
EP2618878A4 (de) * 2010-09-22 2016-03-30 Clovershield Inc Therapeutischer zerstäuber
US11577035B2 (en) 2010-09-22 2023-02-14 Robert Irving Pratt, JR. Therapeutic vaporizer
US20140158129A1 (en) 2010-09-22 2014-06-12 Clovershield, Inc. Transversely-activated valve for a therapeutic vaporizer bag attachment system
CA2845090C (en) 2011-08-16 2023-01-31 Ploom, Inc. Low temperature electronic vaporization device and methods
UA114306C2 (uk) 2011-12-30 2017-05-25 Філіп Морріс Продактс С.А. Пристрій для утворення аерозолю з виявленням потоку повітря
US10517530B2 (en) 2012-08-28 2019-12-31 Juul Labs, Inc. Methods and devices for delivering and monitoring of tobacco, nicotine, or other substances
US8881737B2 (en) * 2012-09-04 2014-11-11 R.J. Reynolds Tobacco Company Electronic smoking article comprising one or more microheaters
US10034988B2 (en) 2012-11-28 2018-07-31 Fontem Holdings I B.V. Methods and devices for compound delivery
US10279934B2 (en) 2013-03-15 2019-05-07 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
US11554229B2 (en) 2013-03-26 2023-01-17 OptiNose Inc. Nasal administration
JP6046547B2 (ja) * 2013-04-25 2016-12-14 株式会社Ihi ステンレス鋼部品の不動態化処理方法
KR102705152B1 (ko) 2013-05-06 2024-09-09 쥴 랩스, 인크. 에어로졸 장치를 위한 니코틴 염 제제 및 그 방법
EP2993997B1 (de) * 2013-05-10 2023-08-02 Fontem Ventures B.V. Geschmackswirbelvorrichtung
CN111642812A (zh) 2013-06-14 2020-09-11 尤尔实验室有限公司 电子汽化设备中的具有单独的可汽化材料的多个加热元件
CA3061122C (en) 2013-07-11 2023-10-17 Alexza Pharmaceuticals, Inc. Nicotine salt with meta-salicylic acid
HUE071661T2 (hu) * 2013-08-06 2025-09-28 Fontem Ventures Bv Elektronikus dohányzóeszköz és annak gyártási eljárása
AU2014310918B2 (en) 2013-08-20 2018-08-16 Boehringer Ingelheim Vetmedica Gmbh Inhaler
HUE064186T2 (hu) 2013-08-20 2024-03-28 Boehringer Ingelheim Vetmedica Gmbh Inhalátor
PL3035886T3 (pl) 2013-08-20 2021-05-31 Boehringer Ingelheim Vetmedica Gmbh Inhalator
US10194693B2 (en) 2013-09-20 2019-02-05 Fontem Holdings 1 B.V. Aerosol generating device
BR112016007023B1 (pt) 2013-10-10 2022-01-25 Carag Ag Oclusor para obstrução de uma passagem em um sistema circulatório
KR102957402B1 (ko) 2013-12-05 2026-04-24 쥴 랩스, 인크. 에어로졸 장치를 위한 니코틴 액제 및 그 방법
KR102721939B1 (ko) 2013-12-23 2024-10-25 쥴 랩스, 인크. 기화 디바이스 시스템 및 방법
US10058129B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Vaporization device systems and methods
USD842536S1 (en) 2016-07-28 2019-03-05 Juul Labs, Inc. Vaporizer cartridge
US10076139B2 (en) 2013-12-23 2018-09-18 Juul Labs, Inc. Vaporizer apparatus
US20160366947A1 (en) 2013-12-23 2016-12-22 James Monsees Vaporizer apparatus
US10159282B2 (en) 2013-12-23 2018-12-25 Juul Labs, Inc. Cartridge for use with a vaporizer device
USD825102S1 (en) 2016-07-28 2018-08-07 Juul Labs, Inc. Vaporizer device with cartridge
US9549573B2 (en) 2013-12-23 2017-01-24 Pax Labs, Inc. Vaporization device systems and methods
US9839238B2 (en) 2014-02-28 2017-12-12 Rai Strategic Holdings, Inc. Control body for an electronic smoking article
WO2015175979A1 (en) 2014-05-16 2015-11-19 Pax Labs, Inc. Systems and methods for aerosolizing a smokeable material
KR20250012730A (ko) 2014-12-05 2025-01-24 쥴 랩스, 인크. 교정된 투여량 제어
HRP20240104T1 (hr) 2015-03-11 2024-05-10 Alexza Pharmaceuticals, Inc. Uporaba antistatičkih materijala u dišnim putevima za proces kondenzacije toplinskog aerosola
WO2016160983A1 (en) 2015-03-30 2016-10-06 C. R. Bard, Inc. Application of antimicrobial agents to medical devices
CA2984161A1 (en) * 2015-04-29 2016-11-03 Poda Technologies Ltd. Vaporizer apparatus, device, and methods
EP3307097A1 (de) * 2015-06-10 2018-04-18 Philip Morris Products S.a.s. Elektrisches aerosolerzeugungssystem
CA3005687A1 (en) * 2015-12-22 2017-06-29 Philip Morris Products S.A. Aerosol-generating system with motor
MX388616B (es) 2016-02-11 2025-03-20 Juul Labs Inc Cartuchos de fijacion segura para dispositivos vaporizadores
MX377347B (es) 2016-02-11 2025-03-07 Juul Labs Inc Cartucho rellenable de vaporizador y metodo de relleno
US10405582B2 (en) 2016-03-10 2019-09-10 Pax Labs, Inc. Vaporization device with lip sensing
RU2731533C2 (ru) * 2016-05-31 2020-09-04 Филип Моррис Продактс С.А. Узел нагревателя и фитиля для системы, генерирующей аэрозоль
USD849996S1 (en) 2016-06-16 2019-05-28 Pax Labs, Inc. Vaporizer cartridge
USD851830S1 (en) 2016-06-23 2019-06-18 Pax Labs, Inc. Combined vaporizer tamp and pick tool
USD848057S1 (en) 2016-06-23 2019-05-07 Pax Labs, Inc. Lid for a vaporizer
USD836541S1 (en) 2016-06-23 2018-12-25 Pax Labs, Inc. Charging device
WO2018027189A2 (en) 2016-08-05 2018-02-08 Juul Labs, Inc. Anemometric-assisted control of a vaporizer
US11937647B2 (en) * 2016-09-09 2024-03-26 Rai Strategic Holdings, Inc. Fluidic control for an aerosol delivery device
US11660403B2 (en) 2016-09-22 2023-05-30 Juul Labs, Inc. Leak-resistant vaporizer device
US10524508B2 (en) 2016-11-15 2020-01-07 Rai Strategic Holdings, Inc. Induction-based aerosol delivery device
BR112019011291A2 (pt) * 2016-12-02 2019-10-08 Vmr Products Llc vaporizador de combinação
CN110267662A (zh) 2016-12-09 2019-09-20 艾利斯达医药品公司 治疗癫痫的方法
US10765148B2 (en) * 2016-12-27 2020-09-08 Altria Client Services Llc E-vaping device including e-vaping case with sliding mechanism for initiating vapor generation
EP3563698B1 (de) * 2017-04-24 2021-11-24 Japan Tobacco Inc. Aerosolerzeugungsvorrichtung
WO2019046315A1 (en) 2017-08-28 2019-03-07 Juul Labs, Inc. DRYER FOR SPRAY DEVICE
USD887632S1 (en) 2017-09-14 2020-06-16 Pax Labs, Inc. Vaporizer cartridge
US12214118B2 (en) 2018-02-02 2025-02-04 Alexza Pharmaceuticals, Inc. Electrical condensation aerosol device
CN120226799A (zh) 2018-06-07 2025-07-01 尤尔实验室有限公司 用于蒸发器装置的料盒
US11094993B2 (en) * 2018-08-10 2021-08-17 Rai Strategic Holdings, Inc. Charge circuitry for an aerosol delivery device
JP2020058236A (ja) * 2018-10-04 2020-04-16 日本たばこ産業株式会社 吸引成分生成装置、制御回路、吸引成分生成装置の制御方法および制御プログラム
US12117353B2 (en) 2018-10-22 2024-10-15 Juul Labs, Inc. Vaporizer heater and temperature sensing element
EP3886925A2 (de) * 2018-11-29 2021-10-06 Ethicon, Inc Applikator und verfahren zur beschichtung von operationssälen
CN113260399A (zh) 2018-12-31 2021-08-13 尤尔实验室有限公司 用于蒸发器装置的料盒
WO2022221530A1 (en) * 2021-04-14 2022-10-20 The University Of North Carolina At Chapel Hill Hot porous-solid metering systems and methods for generation of therapeutic aerosols by evaporation/condensation

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1514682A (en) * 1923-05-03 1924-11-11 Wilson Harold Electric vaporizer
US1759029A (en) * 1926-01-06 1930-05-20 Climax Engineering Company Stuffing-box packing
CA1107584A (en) * 1977-10-27 1981-08-25 William V. Youdelis Process for surface coating alloys to enhance corrosion resistance
US4935073A (en) * 1981-11-27 1990-06-19 Sri International Process for applying coatings of zirconium and/or titantuim and a less noble metal to metal substrates and for converting the zirconium and/or titanium to an oxide, nitride, carbide, boride or silicide
US4771795A (en) * 1986-05-15 1988-09-20 R. J. Reynolds Tobacco Company Smoking article with dual burn rate fuel element
US4735217A (en) * 1986-08-21 1988-04-05 The Procter & Gamble Company Dosing device to provide vaporized medicament to the lungs as a fine aerosol
US5397652A (en) * 1992-03-27 1995-03-14 The Louis Berkman Company Corrosion resistant, colored stainless steel and method of making same
WO1994009842A1 (en) * 1992-10-28 1994-05-11 Rosen Charles A Method and devices for delivering drugs by inhalation
ES2210313T3 (es) * 1994-09-26 2004-07-01 Steris, Inc. Tratamiento alcalino del acero inoxidable.
PL191745B1 (pl) * 1998-01-06 2006-06-30 Philip Morris Prod Artykuł do palenia o zredukowanym strumieniu bocznym dymu
US6228445B1 (en) * 1999-04-06 2001-05-08 Crucible Materials Corp. Austenitic stainless steel article having a passivated surface layer
US6315985B1 (en) * 1999-06-18 2001-11-13 3M Innovative Properties Company C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
MY136453A (en) * 2000-04-27 2008-10-31 Philip Morris Usa Inc "improved method and apparatus for generating an aerosol"
US6514482B1 (en) * 2000-09-19 2003-02-04 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US7594507B2 (en) * 2001-01-16 2009-09-29 Hewlett-Packard Development Company, L.P. Thermal generation of droplets for aerosol
US7585493B2 (en) * 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
WO2002094244A2 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of benzodiazepines through an inhalation route
US20030118512A1 (en) * 2001-10-30 2003-06-26 Shen William W. Volatilization of a drug from an inclusion complex
US6805853B2 (en) * 2001-11-09 2004-10-19 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
US20070122353A1 (en) * 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7766013B2 (en) * 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
WO2002094218A2 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
US20030138508A1 (en) * 2001-12-18 2003-07-24 Novack Gary D. Method for administering an analgesic
WO2002094232A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of antidepressants through an inhalation route
JP2005503425A (ja) * 2001-05-24 2005-02-03 アレックザ モレキュラー デリヴァリー コーポレイション 所定の吸入ルートによる薬剤エステルの送出
US7645442B2 (en) * 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US6759029B2 (en) * 2001-05-24 2004-07-06 Alexza Molecular Delivery Corporation Delivery of rizatriptan and zolmitriptan through an inhalation route
WO2003045484A2 (en) * 2001-11-21 2003-06-05 Alexza Molecular Delivery Corporation Open-celled substrates for drug delivery
CA2460343A1 (en) * 2001-11-21 2003-07-17 Alexza Molecular Delivery Corporation Delivery of caffeine through an inhalation route
US20030106551A1 (en) * 2001-12-06 2003-06-12 Sprinkel F. Murphy Resistive heater formed inside a fluid passage of a fluid vaporizing device
US8003080B2 (en) * 2002-05-13 2011-08-23 Alexza Pharmaceuticals, Inc. Delivery of drug amines through an inhalation route
US20060193788A1 (en) * 2002-11-26 2006-08-31 Hale Ron L Acute treatment of headache with phenothiazine antipsychotics
US20040101481A1 (en) * 2002-11-26 2004-05-27 Alexza Molecular Delivery Corporation Acute treatment of headache with phenothiazine antipsychotics
US7550133B2 (en) * 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
CA2507159A1 (en) * 2002-11-26 2004-06-10 Alexza Molecular Delivery Corporation Use of loxapine and amoxapine for the manufacture of a medicament for the treatment of pain
US20040105818A1 (en) * 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
US20050131739A1 (en) * 2003-12-16 2005-06-16 Alexza Molecular Delivery Corporation Methods for monitoring severity of panic attacks and other rapidly evolving medical events in real time
US7402777B2 (en) * 2004-05-20 2008-07-22 Alexza Pharmaceuticals, Inc. Stable initiator compositions and igniters
EP2246086A3 (de) * 2004-08-12 2012-11-21 Alexza Pharmaceuticals, Inc. Aerosolverabreichungsvorrichtung mit Schlag gezündete Heizeinheit
US20060032496A1 (en) * 2004-08-12 2006-02-16 Alexza Molecular Delivery Corporation Inhalation actuated percussive ignition system
WO2006044421A2 (en) * 2004-10-12 2006-04-27 Alexza Pharmaceuticals, Inc. Cardiac safe, rapid medication delivery
EP2121088B1 (de) * 2007-03-09 2016-07-13 Alexza Pharmaceuticals, Inc. Erhitzungseinheit zur verwendung in einer arzneimittelabgabevorrichtung

Also Published As

Publication number Publication date
DE602004027638D1 (de) 2010-07-22
US20050034723A1 (en) 2005-02-17
WO2005016421A1 (en) 2005-02-24
AU2004264344B2 (en) 2011-02-17
US20180296568A1 (en) 2018-10-18
JP2007501073A (ja) 2007-01-25
EP1656171B9 (de) 2010-10-20
EP1656171A1 (de) 2006-05-17
EP1656171B1 (de) 2010-06-09
US20140072605A1 (en) 2014-03-13
US20110240014A1 (en) 2011-10-06
CA2534566A1 (en) 2005-02-24
AU2004264344A1 (en) 2005-02-24
JP4869927B2 (ja) 2012-02-08

Similar Documents

Publication Publication Date Title
DE602004027638D1 (de) Substrate für eine medikamentenverabreichungsvorrichtung und verfahren zur bereitung
ES2813870T3 (es) Producto plano de acero con un revestimiento de Al, procedimiento para su fabricación y procedimiento para la fabricación de un elemento constructivo conformado en caliente
ATE468603T1 (de) Verfahren zur herstellung aufgerauhter platinschichten, und verfahren zur kondensatoren- herstellung, die diese aufgerauhten platinschichten enthalten
DE602004021957D1 (de) Wärmebehandelbarer beschichteter gegenstand mit beschichtung aus diamantähnlichem kohlenstoff (dlc)
MX2009012006A (es) Metodo para hacer un articulo recubierto tratado termicamente utilizando un recubrimiento de carbon tipo diamante (dlc) y una pelicula protectora.
DE60306817D1 (de) Metallkorrosionsschutz
MX2010005478A (es) Metodo para hacer un articulo recubierto que incluye el tratamiento con haz de iones de una pelicula protectora de oxido de metal.
BR0304718A (pt) Trilho de aço perlìtico excelente na resistência ao desgaste e ductilidade e método para fabricação do mesmo
SG123725A1 (en) Laser enhancements of cold sprayed deposits
Campos-Silva et al. Diffusion model for growth of Fe2B layer in pure iron
WO2002061164A1 (en) Surface treated steel plate and method for production thereof
DE60321435D1 (de) Zink-diffundierte Legierungsbeschichtung als Korrosions-/Wärmeschutz
BRPI0407236A (pt) Processo de fabricação de uma tira de aço bifásico de estrutura ferrito-martensìtica, laminada a frio e tira obtida
ATE535631T1 (de) Verfahren zum herstellen eines stahlbauteils durch warmformen und durch warmformen hergestelltes stahlbauteil
MX2009012983A (es) Metodo para hacer un articulo recubierto tratado termicamente utilizando un recubrimiento de carbon tipo diamante (dlc) y pelicula protectora con contenido de oxigeno de la pelicula protectora basado en las caracteristicas de doblamiento del articulo
BR0011605A (pt) Processos multi-estágios para revestir substratos com camada base lìquida e camada superior em pó
MX2021004446A (es) Lamina de acero recubierta a base de zinc electrolitico de alta resistencia y alta ductilidad y metodo para la produccion de la misma.
BRPI0408268A (pt) moléculas e métodos de prevenção ou inibição da atividade da malária in vivo e de tratamento de pessoas
BR0210147A (pt) Métodos para preparar um material de substrato, para preparar um substrato, para depositar um material sobre um substrato em um padrão definido pelo usuário através de uma reação catalìtica e para galvanizar metal sobre um substrato em um padrão definido pelo usuário através de um processo autocatalìtico, e, formulação de tinta
PT1204485E (pt) Processos de varios passos para revestir substratos com revestimento de base liquido e revestimento de superficie liquido
WO2008050071A3 (fr) Couche d ' alliage de nickel-titane comprenant des atomes d ' azote inseres, procede d ' implantation
BRPI0509222A (pt) tiras de aço inoxidável austenìtico com uma superfìcie de aparência fosca
BR112014030402A2 (pt) método de preparar artigo revestido tratado com calor usando revestimento à base de carbono e filme protetor
Sicard et al. Excimer laser induced surface nitriding of aluminium alloy
Francis et al. Investigating the effect of salicylate salt in enhancing the corrosion resistance of AZ91 magnesium alloy for biomedical applications

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties