ATE471320T1 - 4-aminopiperidinderivate als inhibitoren der monoamin-aufnahme - Google Patents
4-aminopiperidinderivate als inhibitoren der monoamin-aufnahmeInfo
- Publication number
- ATE471320T1 ATE471320T1 AT05722890T AT05722890T ATE471320T1 AT E471320 T1 ATE471320 T1 AT E471320T1 AT 05722890 T AT05722890 T AT 05722890T AT 05722890 T AT05722890 T AT 05722890T AT E471320 T1 ATE471320 T1 AT E471320T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- aminopiperidine derivatives
- monoamine absorption
- monoamine
- absorption
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 238000010521 absorption reaction Methods 0.000 title 1
- BCIIMDOZSUCSEN-UHFFFAOYSA-N piperidin-4-amine Chemical class NC1CCNCC1 BCIIMDOZSUCSEN-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229960002748 norepinephrine Drugs 0.000 abstract 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 1
- 210000001428 peripheral nervous system Anatomy 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54867904P | 2004-02-27 | 2004-02-27 | |
| PCT/US2005/004174 WO2005092885A1 (en) | 2004-02-27 | 2005-02-11 | 4-amino-piperidine derivatives as monoamine uptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE471320T1 true ATE471320T1 (de) | 2010-07-15 |
Family
ID=34961148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05722890T ATE471320T1 (de) | 2004-02-27 | 2005-02-11 | 4-aminopiperidinderivate als inhibitoren der monoamin-aufnahme |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7521462B2 (de) |
| EP (1) | EP1735302B1 (de) |
| AT (1) | ATE471320T1 (de) |
| DE (1) | DE602005021871D1 (de) |
| ES (1) | ES2345261T3 (de) |
| WO (1) | WO2005092885A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0716532A2 (pt) * | 2006-09-11 | 2013-09-24 | Glaxo Group Ltd | compostos azabicÍclios como inidores de reabsorÇço de monoaminas |
| WO2008103615A1 (en) * | 2007-02-21 | 2008-08-28 | Kalypsys, Inc. | Isoquinolines useful as inducible nitric oxide synthase inhibitors |
| EP2008996A1 (de) | 2007-06-27 | 2008-12-31 | Syngeta Participations AG | Verfahren zur Herstellung von Pyrazolen |
| BRPI0819883A2 (pt) | 2007-11-28 | 2017-05-23 | Sequoia Pharmaceuticals Inc | composições e métodos para inibir citocromo p450 2d6 |
| BR112018069438B1 (pt) | 2016-03-31 | 2022-07-05 | Fujifilm Corporation | Método para produzir 5- (bromometil) -1-benzotiofeno |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2334358A1 (fr) | 1975-12-12 | 1977-07-08 | Sogeras | Nouveaux medicaments derives de l'indole |
| US4861785A (en) * | 1984-12-03 | 1989-08-29 | Janssen Pharmaceutica N.V. | Benzoxazol-and benzothiazolamine derivatives, useful as anti-anoxic agents |
| GB9226111D0 (en) | 1992-12-15 | 1993-02-10 | Smithkline Beecham Plc | Madicaments |
| US6303627B1 (en) | 1998-06-19 | 2001-10-16 | Eli Lilly And Company | Inhibitors of serotonin reuptake |
| ES2157148B1 (es) * | 1998-11-18 | 2002-03-01 | Faes Fabrica Espanola De Produ | Nuevas piperidinas 4-sustituidas. |
| US6498161B1 (en) | 1999-04-06 | 2002-12-24 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| CA2381252A1 (en) | 1999-09-14 | 2001-03-22 | Abbott Laboratories | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
| GB0011838D0 (en) | 2000-05-17 | 2000-07-05 | Astrazeneca Ab | Chemical compounds |
| AU2001291830A1 (en) | 2000-09-25 | 2002-04-02 | Actelion Pharmaceuticals Ltd. | Substituted amino-aza-cycloalkanes useful against malaria |
| AU2002360561A1 (en) | 2001-12-11 | 2003-06-23 | Sepracor, Inc. | 4-substituted piperidines, and methods of use thereof |
| CA2468413A1 (en) | 2001-12-14 | 2003-06-26 | Novo Nordisk A/S | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase |
| MY134200A (en) | 2002-04-12 | 2007-11-30 | Kowa Co | Method for treating cancer |
| EP1569905A2 (de) | 2002-12-06 | 2005-09-07 | Eli Lilly And Company | Monoamin-uptake inhibitoren |
| DE602004011221T2 (de) | 2003-06-11 | 2009-01-02 | Eli Lilly And Co., Indianapolis | 3-amino-pyrrolidine als inhibitoren der monoamin-wiederaufnahme |
| EP1638560A1 (de) | 2003-06-20 | 2006-03-29 | Eli Lilly And Company | 3-aminopiperidine und 3-aminochinuclidine als hemmer der monoamin-aufname |
-
2005
- 2005-02-11 EP EP05722890A patent/EP1735302B1/de not_active Expired - Lifetime
- 2005-02-11 WO PCT/US2005/004174 patent/WO2005092885A1/en not_active Ceased
- 2005-02-11 DE DE602005021871T patent/DE602005021871D1/de not_active Expired - Lifetime
- 2005-02-11 ES ES05722890T patent/ES2345261T3/es not_active Expired - Lifetime
- 2005-02-11 US US10/597,795 patent/US7521462B2/en not_active Expired - Fee Related
- 2005-02-11 AT AT05722890T patent/ATE471320T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2345261T3 (es) | 2010-09-20 |
| DE602005021871D1 (de) | 2010-07-29 |
| EP1735302A1 (de) | 2006-12-27 |
| US20070093526A1 (en) | 2007-04-26 |
| WO2005092885A1 (en) | 2005-10-06 |
| US7521462B2 (en) | 2009-04-21 |
| EP1735302B1 (de) | 2010-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |