ATE471369T1 - Assay-elektroden mit schichten aus immobilisiertem lipid/protein sowie verfahren zu deren herstellung und verwendung - Google Patents
Assay-elektroden mit schichten aus immobilisiertem lipid/protein sowie verfahren zu deren herstellung und verwendungInfo
- Publication number
- ATE471369T1 ATE471369T1 AT02803272T AT02803272T ATE471369T1 AT E471369 T1 ATE471369 T1 AT E471369T1 AT 02803272 T AT02803272 T AT 02803272T AT 02803272 T AT02803272 T AT 02803272T AT E471369 T1 ATE471369 T1 AT E471369T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- membrane
- layers
- production
- virion
- Prior art date
Links
- 150000002632 lipids Chemical class 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 238000003556 assay Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 3
- 239000012528 membrane Substances 0.000 abstract 3
- 210000003463 organelle Anatomy 0.000 abstract 3
- 210000002845 virion Anatomy 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- -1 cell membrane Substances 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 210000004379 membrane Anatomy 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
- G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Plasma & Fusion (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30876201P | 2001-07-30 | 2001-07-30 | |
| PCT/US2002/024029 WO2003068947A1 (en) | 2001-07-30 | 2002-07-30 | Assay electrodes having immobilized lipid/protein layers and methods of making and using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE471369T1 true ATE471369T1 (de) | 2010-07-15 |
Family
ID=27734195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02803272T ATE471369T1 (de) | 2001-07-30 | 2002-07-30 | Assay-elektroden mit schichten aus immobilisiertem lipid/protein sowie verfahren zu deren herstellung und verwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8815577B2 (de) |
| EP (3) | EP2135943A1 (de) |
| JP (1) | JP4355214B2 (de) |
| AT (1) | ATE471369T1 (de) |
| AU (1) | AU2002365119A1 (de) |
| CA (1) | CA2455932C (de) |
| DE (1) | DE60236732D1 (de) |
| DK (1) | DK1412487T3 (de) |
| WO (1) | WO2003068947A1 (de) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6808939B2 (en) * | 2001-06-29 | 2004-10-26 | Igen International, Inc. | ECL labels having improved non-specific binding properties, methods of using and kits containing the same |
| US20030113832A1 (en) * | 2001-12-14 | 2003-06-19 | Lauf Robert J. | Apparatus and method for assaying electrophysiological effects |
| US20040002064A1 (en) * | 2002-06-27 | 2004-01-01 | Ye Fang | Toxin detection and compound screening using biological membrane microarrays |
| AU2003258683A1 (en) * | 2002-09-03 | 2004-03-29 | Zeptosens Ag | Analytical platform and detection method with analytes which are to be detected in a sample in the form of immobilized specific binding partners |
| US7041401B2 (en) * | 2002-10-18 | 2006-05-09 | University Of Iowa Research Foundation | Magnetically modified electrodes containing at least one catalyst component that mediates a subatomic particle transfer process |
| WO2004042352A2 (en) | 2002-10-30 | 2004-05-21 | Meso Scale Technologies, Llc | Substrates of n-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrates |
| WO2005040403A1 (en) * | 2003-10-29 | 2005-05-06 | Agency For Science, Technology And Research | Method for detecting analytes by means of an analyte/polymeric activator bilayer arrangement |
| US7713508B2 (en) * | 2004-03-19 | 2010-05-11 | Arrowhead Center, Inc. | Thiation of carbon nanotubes and composite formation |
| WO2005103695A1 (ja) * | 2004-04-23 | 2005-11-03 | Matsushita Electric Industrial Co., Ltd. | 遺伝子検出方法及び遺伝子検出装置 |
| US7833406B2 (en) * | 2004-07-06 | 2010-11-16 | Panasonic Corporation | Gene detection method, and intercalator |
| WO2007040559A2 (en) * | 2004-11-17 | 2007-04-12 | Bioveris | Electrochemiluminescent assay |
| SE0403139D0 (sv) * | 2004-12-23 | 2004-12-23 | Nanoxis Ab | Device and use thereof |
| JP4583356B2 (ja) * | 2006-10-30 | 2010-11-17 | 株式会社アルバック | 結合素子、バイオセンサ及び生体物質間の相互作用測定方法 |
| US11339430B2 (en) | 2007-07-10 | 2022-05-24 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| EP2639578B1 (de) | 2006-12-14 | 2016-09-14 | Life Technologies Corporation | Vorrichtung zur Messung von Analyten mithilfe großer FET-Arrays |
| US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| US8349167B2 (en) | 2006-12-14 | 2013-01-08 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
| CN103900894A (zh) * | 2008-06-06 | 2014-07-02 | 华盛顿大学 | 用于从溶液浓缩颗粒的方法和系统 |
| CN102203282B (zh) | 2008-06-25 | 2014-04-30 | 生命技术公司 | 使用大规模fet阵列测量分析物的方法和装置 |
| DE102008047399A1 (de) * | 2008-09-16 | 2010-04-15 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Elektrodeneinrichtung, Generatoreinrichtung und Verfahren zur Stromerzeugung durch Membranpotential-Ableitung |
| US20100301398A1 (en) | 2009-05-29 | 2010-12-02 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
| US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
| US8940092B1 (en) | 2008-10-27 | 2015-01-27 | University Of Washington Through Its Center For Commercialization | Hybrid fibers, devices using hybrid fibers, and methods for making hybrid fibers |
| US20120261274A1 (en) | 2009-05-29 | 2012-10-18 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
| US8776573B2 (en) | 2009-05-29 | 2014-07-15 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
| EP2459696B1 (de) | 2009-08-02 | 2017-11-08 | Qvella Corporation | Zellkonzentrations-, erfassungs- und -lysevorrichtungen sowie verwendungsverfahren dafür |
| WO2012050646A2 (en) | 2010-06-29 | 2012-04-19 | The Trustees Of The University Of Pennsylvania | Biomimetic chemical sensors using nanoelectronic readout of olfactory receptors |
| TW201716791A (zh) | 2010-06-30 | 2017-05-16 | 生命技術公司 | 用於測試離子感測場效電晶體（ｉｓｆｅｔ）陣列之裝置及方法 |
| EP2598804B1 (de) | 2010-06-30 | 2021-10-20 | Life Technologies Corporation | Verfahren zur erzeugung eines ausgangssignals in einem isfet-array |
| WO2012003363A1 (en) | 2010-06-30 | 2012-01-05 | Life Technologies Corporation | Ion-sensing charge-accumulation circuits and methods |
| US11307166B2 (en) | 2010-07-01 | 2022-04-19 | Life Technologies Corporation | Column ADC |
| TWI527245B (zh) | 2010-07-03 | 2016-03-21 | 生命技術公司 | 具有微摻雜汲極之化學感測器 |
| EP2617061B1 (de) | 2010-09-15 | 2021-06-30 | Life Technologies Corporation | Verfahren und vorrichtung zur analytmessung |
| EP2619564B1 (de) | 2010-09-24 | 2016-03-16 | Life Technologies Corporation | Transistorschaltungen mit zusammengehörigen paaren |
| EP2628013B1 (de) | 2010-10-14 | 2019-06-12 | The Johns Hopkins University | Biomarker für gehirnverletzungen |
| KR101789356B1 (ko) | 2010-10-25 | 2017-10-23 | 에프. 호프만-라 로슈 아게 | 전기화학발광 검출에 있어서의 신호 증강 화합물의 용도 |
| US8845879B2 (en) | 2010-11-24 | 2014-09-30 | Saint Louis Univesrity | Organelle bioelectrodes and methods of making and using the same |
| US9055248B2 (en) | 2011-05-02 | 2015-06-09 | Sony Corporation | Infrared imaging system and method of operating |
| JP2014518624A (ja) | 2011-05-12 | 2014-08-07 | ザ・ジョンズ・ホプキンス・ユニバーシティー | ニューログラニン診断キットのためのアッセイ試薬 |
| US10983117B2 (en) | 2011-08-31 | 2021-04-20 | The Trustees Of The University Of Pennsylvania | Carbon nanotube biosensors and related methods |
| US9970984B2 (en) | 2011-12-01 | 2018-05-15 | Life Technologies Corporation | Method and apparatus for identifying defects in a chemical sensor array |
| US8786331B2 (en) | 2012-05-29 | 2014-07-22 | Life Technologies Corporation | System for reducing noise in a chemical sensor array |
| GB201212528D0 (en) * | 2012-07-13 | 2012-08-29 | Isis Innovation | Assay |
| US9080968B2 (en) | 2013-01-04 | 2015-07-14 | Life Technologies Corporation | Methods and systems for point of use removal of sacrificial material |
| US9841398B2 (en) | 2013-01-08 | 2017-12-12 | Life Technologies Corporation | Methods for manufacturing well structures for low-noise chemical sensors |
| US8962366B2 (en) | 2013-01-28 | 2015-02-24 | Life Technologies Corporation | Self-aligned well structures for low-noise chemical sensors |
| US8841217B1 (en) | 2013-03-13 | 2014-09-23 | Life Technologies Corporation | Chemical sensor with protruded sensor surface |
| US8963216B2 (en) | 2013-03-13 | 2015-02-24 | Life Technologies Corporation | Chemical sensor with sidewall spacer sensor surface |
| EP2972281B1 (de) | 2013-03-15 | 2023-07-26 | Life Technologies Corporation | Chemische vorrichtung mit dünnem leitenden element |
| US20140264472A1 (en) | 2013-03-15 | 2014-09-18 | Life Technologies Corporation | Chemical sensor with consistent sensor surface areas |
| US9116117B2 (en) | 2013-03-15 | 2015-08-25 | Life Technologies Corporation | Chemical sensor with sidewall sensor surface |
| WO2014149778A1 (en) | 2013-03-15 | 2014-09-25 | Life Technologies Corporation | Chemical sensors with consistent sensor surface areas |
| US9835585B2 (en) | 2013-03-15 | 2017-12-05 | Life Technologies Corporation | Chemical sensor with protruded sensor surface |
| US20140336063A1 (en) | 2013-05-09 | 2014-11-13 | Life Technologies Corporation | Windowed Sequencing |
| US10458942B2 (en) | 2013-06-10 | 2019-10-29 | Life Technologies Corporation | Chemical sensor array having multiple sensors per well |
| JP6715766B2 (ja) * | 2013-06-21 | 2020-07-01 | ザ ジョンズ ホプキンス ユニバーシティ | ヒト膜蛋白質の機能および相互作用をプロファイリングするためのビリオンディスプレイアレイ |
| WO2015009907A1 (en) | 2013-07-17 | 2015-01-22 | The Johns Hopkins University | A multi-protein biomarker assay for brain injury detection and outcome |
| US11415546B2 (en) | 2014-09-05 | 2022-08-16 | The Trustees Of The University Of Pennsylvania | Volatile organic compound-based diagnostic systems and methods |
| WO2016044697A1 (en) | 2014-09-19 | 2016-03-24 | The Johns Hopkins University | Biomarkers of cognitive dysfunction |
| US10077472B2 (en) | 2014-12-18 | 2018-09-18 | Life Technologies Corporation | High data rate integrated circuit with power management |
| EP3234576B1 (de) | 2014-12-18 | 2023-11-22 | Life Technologies Corporation | Integrierte schaltung mit hoher datenrate und mit transmitterkonfiguration |
| US10379079B2 (en) | 2014-12-18 | 2019-08-13 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| WO2016134365A1 (en) | 2015-02-20 | 2016-08-25 | The Johns Hopkins University | Biomarkers of myocardial injury |
| CN106754860A (zh) * | 2016-11-22 | 2017-05-31 | 上海纳米技术及应用国家工程研究中心有限公司 | 一种基于脂质体的对界面快速修饰亲和素的方法 |
| EP3791179A4 (de) | 2018-05-09 | 2022-01-26 | Arizona Board of Regents on behalf of Arizona State University | Verfahren zur elektronischen detektion und quantifizierung von antikörpern |
| IL278769B2 (en) * | 2018-05-17 | 2025-06-01 | Stuart Lindsay | Device, system and method for direct electrical measurement of enzyme activity |
| BR112020024715A2 (pt) | 2018-06-04 | 2021-03-23 | Avon Products. Inc. | biomarcadores proteicos para identificar e tratar o envelhecimento da pele e afecções cutâneas |
| CN109100400B (zh) * | 2018-07-17 | 2019-11-08 | 西南大学 | 用于检测刀豆蛋白a的传感器及其制备方法和应用 |
| AU2020214334A1 (en) | 2019-01-30 | 2021-08-12 | Arizona Board Of Regents On Behalf Of Arizona State University | Bioelectronic circuits, systems and methods for preparing and using them |
| CN115380120A (zh) | 2020-02-28 | 2022-11-22 | 代表亚利桑那大学的亚利桑那校董事会 | 用于对生物聚合物进行测序的方法 |
| CN115552030A (zh) | 2020-04-17 | 2022-12-30 | 代表亚利桑那大学的亚利桑那校董事会 | 单分子电子序列检测器及其使用方法 |
| AU2021263432A1 (en) | 2020-04-30 | 2022-12-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for sequencing biopolymers |
| US12276653B2 (en) | 2020-05-29 | 2025-04-15 | Arizona Board Of Regents On Behalf Of Arizona State University | Bioelectronic devices with programmable adaptors |
| US20230375552A1 (en) | 2020-09-29 | 2023-11-23 | The Johns Hopkins University | Integrated proteomic biomarkers for the detection of aggressive prostate cancer |
| US12624389B2 (en) | 2021-06-07 | 2026-05-12 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for sequencing biopolymers |
| CN114705742B (zh) * | 2022-02-21 | 2024-08-02 | 南京理工大学 | 一种基于锌卟啉有机笼的仿生膜结构及其应用 |
| CN119291178A (zh) * | 2024-12-12 | 2025-01-10 | 杭州禾帆生物科技有限公司 | 基于细胞膜定向重构技术的胰岛素亲和力测定装置、检测方法及应用 |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4024235A (en) * | 1975-07-21 | 1977-05-17 | Corning Glass Works | Detection and quantitation of viral antibodies |
| US5310687A (en) | 1984-10-31 | 1994-05-10 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5238808A (en) | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5171560A (en) | 1984-12-06 | 1992-12-15 | Hyperion Catalysis International | Carbon fibrils, method for producing same, and encapsulated catalyst |
| US4663230A (en) | 1984-12-06 | 1987-05-05 | Hyperion Catalysis International, Inc. | Carbon fibrils, method for producing same and compositions containing same |
| US5165909A (en) | 1984-12-06 | 1992-11-24 | Hyperion Catalysis Int'l., Inc. | Carbon fibrils and method for producing same |
| USH201H (en) * | 1985-08-23 | 1987-01-06 | United States Of America | Biosensors from membrane proteins reconstituted in polymerized lipid bilayers |
| US6271041B1 (en) * | 1986-04-30 | 2001-08-07 | Igen International, Inc. | Electrochemiluminescent reaction utilizing amine-derived reductant |
| US5591581A (en) | 1986-04-30 | 1997-01-07 | Igen, Inc. | Electrochemiluminescent rhenium moieties and methods for their use |
| US6165729A (en) | 1986-04-30 | 2000-12-26 | Hyperion Catalysis International, Inc. | Electrochemiluminescent reaction utilizing amine-derived reductant |
| CA1339465C (en) | 1986-04-30 | 1997-09-16 | Richard J. Massey | Electrochemiluminescent assays |
| US5147806A (en) * | 1988-04-29 | 1992-09-15 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescence measurements |
| US5766960A (en) | 1987-07-27 | 1998-06-16 | Australian Membrane And Biotechnology Research Institute | Receptor membranes |
| US5308754A (en) | 1988-03-21 | 1994-05-03 | Kankare Jouko J | Electrogenerated luminescence in solution |
| US5093268A (en) | 1988-04-28 | 1992-03-03 | Igen, Inc. | Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena |
| US6702986B1 (en) * | 1988-04-29 | 2004-03-09 | Igen International, Inc. | Electrochemiluminescent reaction utilizing amine-derived reductant |
| JPH03504975A (ja) * | 1988-06-14 | 1991-10-31 | セル―エスシーアイ コーポレイション | 異種官能性細胞免疫剤、それを含有するワクチン及びその使用方法 |
| US5705402A (en) | 1988-11-03 | 1998-01-06 | Igen International, Inc. | Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets |
| US5200051A (en) | 1988-11-14 | 1993-04-06 | I-Stat Corporation | Wholly microfabricated biosensors and process for the manufacture and use thereof |
| US5324457A (en) | 1989-10-02 | 1994-06-28 | Board Of Regents, The University Of Tx System | Devices and methods for generating electrogenerated chemiluminescence |
| US6165710A (en) | 1989-10-23 | 2000-12-26 | Robinson; James E. | Method for immobilizing viral glycoproteins for use in solid-phase immunoassays |
| IL93020A (en) * | 1990-01-09 | 1995-06-29 | Yeda Res & Dev | Biosensors comprising a lipid bilayer doped with ion channels anchored to a recording electrode by bridging molecules |
| US5545519A (en) * | 1990-09-13 | 1996-08-13 | Victoria University Of Manchester | Electrolytic analytical methods |
| US5776672A (en) | 1990-09-28 | 1998-07-07 | Kabushiki Kaisha Toshiba | Gene detection method |
| IT1252041B (it) | 1990-10-11 | 1995-05-29 | Enimont Anic Srl | Componente solido di catalizzatore per la (co)polimerizzazione dell'etilene |
| ZA92804B (en) | 1991-02-06 | 1992-12-30 | Igen Inc | Methods and apparatus for improved luminescence assays |
| JPH0534345A (ja) | 1991-02-19 | 1993-02-09 | Tdk Corp | 化学発光を利用する抗原・抗体の測定方法 |
| EP0639269B1 (de) | 1991-03-27 | 2002-06-12 | Ambri Limited | Ionisches reservoir an der oberfläche einer elektrode |
| EP0522677B1 (de) * | 1991-07-10 | 1996-12-18 | TDK Corporation | Verfahren zur Messung der Konzentration eines Immuno-Reaktanden unter Verwendung von Elektrochemilumineszenz |
| US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
| ZA929351B (en) | 1991-12-11 | 1993-06-04 | Igen Inc | Electrochemiluminescent label for DNA assays. |
| US5541061A (en) | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
| EP1130387A1 (de) | 1992-10-01 | 2001-09-05 | Australian Membrane And Biotechnology Research Institute | Linkerlipid zur Sensormembranen |
| US5565325A (en) | 1992-10-30 | 1996-10-15 | Bristol-Myers Squibb Company | Iterative methods for screening peptide libraries |
| US5393818A (en) * | 1993-04-06 | 1995-02-28 | Shell Oil Company | Solvent-free laminating adhesive composition from epoxidized block polymer |
| US5786141A (en) | 1994-08-26 | 1998-07-28 | Bard; Allen J. | Electrogenerated chemiluminescence labels for analysis and/or referencing |
| US5463564A (en) | 1994-09-16 | 1995-10-31 | 3-Dimensional Pharmaceuticals, Inc. | System and method of automatically generating chemical compounds with desired properties |
| US5866434A (en) | 1994-12-08 | 1999-02-02 | Meso Scale Technology | Graphitic nanotubes in luminescence assays |
| DE4444893A1 (de) * | 1994-12-16 | 1996-06-20 | Merck Patent Gmbh | Peptide und synthetische Zellmembranen |
| US5643713A (en) | 1995-06-07 | 1997-07-01 | Liang; Pam | Electrochemiluminescent monitoring of compounds |
| US5641623A (en) | 1995-01-04 | 1997-06-24 | Martin; Mark T. | Electrochemiluminescence assay |
| US6207369B1 (en) | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
| KR100449615B1 (ko) * | 1995-03-10 | 2004-12-08 | 메소 스케일 테크놀러지즈, 엘엘시 | 다-배열,다-특이적전기화학발광시험법 |
| US6319670B1 (en) * | 1995-05-09 | 2001-11-20 | Meso Scale Technology Llp | Methods and apparatus for improved luminescence assays using microparticles |
| US5679519A (en) | 1995-05-09 | 1997-10-21 | Oprandy; John J. | Multi-label complex for enhanced sensitivity in electrochemiluminescence assay |
| US5593135A (en) | 1995-05-12 | 1997-01-14 | Asahi/America, Inc. | Precise throttling ball valve |
| US5589136A (en) | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions |
| AU692107B2 (en) * | 1995-06-20 | 1998-05-28 | Ambri Limited | Detection of small analytes |
| US6143247A (en) | 1996-12-20 | 2000-11-07 | Gamera Bioscience Inc. | Affinity binding-based system for detecting particulates in a fluid |
| WO1997005477A1 (en) * | 1995-08-01 | 1997-02-13 | Australian Membrane And Biotechnology Research Institute | Composite membrane sensor |
| US5569588A (en) | 1995-08-09 | 1996-10-29 | The Regents Of The University Of California | Methods for drug screening |
| GB9606850D0 (en) | 1996-04-01 | 1996-06-05 | Univ Liverpool | An assay system and novel labelled compounds for use therwith |
| US5783431A (en) | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
| US5851531A (en) * | 1996-05-09 | 1998-12-22 | Lazarus; Douglas D. | Adult-onset diabetes treatment method |
| JP4663824B2 (ja) * | 1996-12-31 | 2011-04-06 | ハイ スループット ジェノミクス インコーポレイテッド | 多重化分子分析装置および方法 |
| FR2764381A1 (fr) | 1997-06-09 | 1998-12-11 | Univ De Neuchatel | Detecteur electrochimioluminescent |
| US6413783B1 (en) | 1997-09-18 | 2002-07-02 | Meso Scale Technologies, Llc | Assay sonication apparatus and methodology |
| US5919576A (en) * | 1997-11-21 | 1999-07-06 | Health Research Inc. | Immobilized biological membranes |
| DE19814775C2 (de) | 1998-04-02 | 2001-04-19 | Nimbus Biotechnologie Gmbh | Verfahren zur Bestimmung der Lipid-Bindungskonstanten von Substanzen in wässriger Lösung an Oberflächen aus amphiphilen Molekülen |
| US6200531B1 (en) | 1998-05-11 | 2001-03-13 | Igen International, Inc. | Apparatus for carrying out electrochemiluminescence test measurements |
| EP0962773A1 (de) * | 1998-06-03 | 1999-12-08 | Mark Howard Jones | Prüfverfahren, Vorrichtung und Markierungsmittel basierend auf Elektrochemie |
| US6214552B1 (en) * | 1998-09-17 | 2001-04-10 | Igen International, Inc. | Assays for measuring nucleic acid damaging activities |
| EP1055929A1 (de) * | 1999-05-26 | 2000-11-29 | Tibotec N.V. | Mittel und Verfahren für Medizinentdeckung und phenotypische Charakterisierung von Zellen |
| KR100303611B1 (ko) | 1999-07-07 | 2001-09-24 | 박호군 | 미생물의 전기화학적 농화배양 방법 및 유기물질 및 ｂｏｄ 분석용 바이오센서 |
| US6136268A (en) | 1999-08-17 | 2000-10-24 | Orion Diagnostica | Method for luminescence measurements |
| US6197881B1 (en) * | 1999-08-18 | 2001-03-06 | Biopixel Ltd. | Electrically conductive copolymers and their preparation |
| KR100348786B1 (ko) * | 1999-10-01 | 2002-08-17 | 엘지전자주식회사 | 핵산검출방법, 및 핵산검출기와 이의 제조방법 |
| US6219674B1 (en) | 1999-11-24 | 2001-04-17 | Classen Immunotherapies, Inc. | System for creating and managing proprietary product data |
| DE10112505C1 (de) * | 2001-03-15 | 2003-01-30 | Iongate Biosciences Gmbh | Sensoranordnung und Vorrichtung zur amperometrischen und/oder potentiometrischen, pharmakologischen Wirkort- und/oder Wirkstofftestung sowie Verfahren zur amperometrischen und/oder potentiometrischen, pharmakologischen Wirkort- und/oder Wirkstofftestung |
| EP1269993A1 (de) | 2001-06-21 | 2003-01-02 | Applied NanoSystems B.V. | Verabreichung von in Lipidvesikeln verpackten kleinen hydrophilen Molekülen |
| EP2420824B1 (de) * | 2001-06-29 | 2018-11-28 | Meso Scale Technologies LLC | Multiwell-Platte mit einer Reihe von Wells und Kit für den Einsatz bei der Durchführung eines ECL-Assays |
-
2002
- 2002-07-30 US US10/208,526 patent/US8815577B2/en not_active Expired - Lifetime
- 2002-07-30 EP EP20090010299 patent/EP2135943A1/de not_active Withdrawn
- 2002-07-30 JP JP2003568062A patent/JP4355214B2/ja not_active Expired - Lifetime
- 2002-07-30 DK DK02803272.0T patent/DK1412487T3/da active
- 2002-07-30 WO PCT/US2002/024029 patent/WO2003068947A1/en not_active Ceased
- 2002-07-30 CA CA2455932A patent/CA2455932C/en not_active Expired - Lifetime
- 2002-07-30 EP EP02803272A patent/EP1412487B1/de not_active Expired - Lifetime
- 2002-07-30 AT AT02803272T patent/ATE471369T1/de not_active IP Right Cessation
- 2002-07-30 DE DE60236732T patent/DE60236732D1/de not_active Expired - Lifetime
- 2002-07-30 EP EP15192728.2A patent/EP3021106B8/de not_active Expired - Lifetime
- 2002-07-30 AU AU2002365119A patent/AU2002365119A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DK1412487T3 (da) | 2010-08-30 |
| EP2135943A1 (de) | 2009-12-23 |
| EP1412487B1 (de) | 2010-06-16 |
| WO2003068947A1 (en) | 2003-08-21 |
| JP2005517905A (ja) | 2005-06-16 |
| JP4355214B2 (ja) | 2009-10-28 |
| US8815577B2 (en) | 2014-08-26 |
| AU2002365119A1 (en) | 2003-09-04 |
| EP1412487A1 (de) | 2004-04-28 |
| EP3021106B1 (de) | 2019-01-30 |
| EP1412487A4 (de) | 2004-09-29 |
| CA2455932C (en) | 2011-02-22 |
| EP3021106A2 (de) | 2016-05-18 |
| US20030124572A1 (en) | 2003-07-03 |
| EP3021106B8 (de) | 2019-03-27 |
| DE60236732D1 (de) | 2010-07-29 |
| WO2003068947A8 (en) | 2003-10-23 |
| EP3021106A3 (de) | 2016-07-27 |
| CA2455932A1 (en) | 2003-08-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60236732D1 (de) | Assay-elektroden mit schichten aus immobilisiertem lipid/protein sowie verfahren zu deren herstellung und verwendung | |
| EP1278260A4 (de) | Verfahren zur herstellung von verbundenen brennstoffzellen-elektrolyfilmelektroden | |
| DE60221752D1 (de) | Brennstoffzellenelektrode, Verfahren zur Herstellung und Brennstoffzelle mit solcher Elektrode | |
| JP2005517905A5 (de) | ||
| ATE242114T1 (de) | Elastische laminate und verfahren zu ihrer herstellung | |
| EP1117142A4 (de) | Brennstoffzelle und verfahren zu deren herstellung | |
| KR970707599A (ko) | 유기 연료 셀, 및 그 작동방법과 그를 위한 전극 제조방법(Organic fuel cell, and methods of operation theeof and manufacture of electrode therefor) | |
| DE69613030D1 (de) | Material zur Verwendung bei der Herstellung von katalytischen Elektroden | |
| BR0101612B1 (pt) | estrutura de difusão de gás, eletrodo de difusão de gás, conjunto de eletrodo de membrana, célula de combustìvel bem como processo para produção de estruturas de difusão de gás para células de combustìvel de eletrólito de polìmero. | |
| DE60130302D1 (de) | Vielfach gestapelte elektrochemische zelle und verfahren zu deren herstellung | |
| ATE298420T1 (de) | Mehrschichtenmembranen für enzymelektrode und verfahren zu ihrer herstellung | |
| MY120479A (en) | Method for producing a thin membrane and membrane structure so obtained. | |
| SG145703A1 (en) | Cell cultivation and breeding method | |
| DE69710787D1 (de) | Komposit-kathoden, elektrochemische zellen mit komposit-kathoden und verfahren zur herstellung | |
| EP1365455A4 (de) | Solarzelle und verfahren zu ihrer herstellung | |
| PL1710015T3 (pl) | Struktura typu plastra miodu | |
| DE60225803D1 (de) | Poröse folie, faserverbundfolie und verfahren zu deren herstellung | |
| DE60236614D1 (de) | Verahren zur herstellung einer elektrode für eine brennstoffzelle | |
| WO2002032589A3 (de) | Poröse schichten und ein verfahren zu deren herstellung mittels spin-coating | |
| DE69826053D1 (de) | Halbleitersubstrat und Verfahren zu dessen Herstellung | |
| DE60209127D1 (de) | Biegsame elektrochrome struktur und verfahren zu deren herstellung | |
| ATE345813T1 (de) | Virus mit membranmutationen für ein witsspektrum und deren verwendung als vakzinsubstrat | |
| DE69825252D1 (de) | Kapillarhohlmembranen, daraus hergestellte fluidbehandlungsmodulen und verfahren zu ihrer herstellung | |
| AU2003216459A1 (en) | Fuel cell membranes and catalytic layers | |
| ATE267464T1 (de) | Verfahren zur herstellung von elektroden, komponenten, halbzellen und zellen für elektrochmische energiewandler |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |