ATE473214T1 - 2-(4-oxo-4h-chinazolin-3-yl)acetamide und ihre verwendung als vasopressin-v3-antagonisten - Google Patents
2-(4-oxo-4h-chinazolin-3-yl)acetamide und ihre verwendung als vasopressin-v3-antagonistenInfo
- Publication number
- ATE473214T1 ATE473214T1 AT06725007T AT06725007T ATE473214T1 AT E473214 T1 ATE473214 T1 AT E473214T1 AT 06725007 T AT06725007 T AT 06725007T AT 06725007 T AT06725007 T AT 06725007T AT E473214 T1 ATE473214 T1 AT E473214T1
- Authority
- AT
- Austria
- Prior art keywords
- chinazoline
- vasopressin
- acetamide
- antagonists
- oxo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66092605P | 2005-03-11 | 2005-03-11 | |
| US71587505P | 2005-09-09 | 2005-09-09 | |
| PCT/EP2006/060612 WO2006095014A1 (en) | 2005-03-11 | 2006-03-10 | 2- (4-0x0-4h-quinaz0lin-3-yl) acetamides and their use as vasopressin v3 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE473214T1 true ATE473214T1 (de) | 2010-07-15 |
Family
ID=36579595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06725007T ATE473214T1 (de) | 2005-03-11 | 2006-03-10 | 2-(4-oxo-4h-chinazolin-3-yl)acetamide und ihre verwendung als vasopressin-v3-antagonisten |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7807686B2 (de) |
| EP (1) | EP1861380B1 (de) |
| JP (1) | JP4997391B2 (de) |
| KR (1) | KR20080009076A (de) |
| AR (1) | AR052943A1 (de) |
| AT (1) | ATE473214T1 (de) |
| AU (1) | AU2006221962A1 (de) |
| CA (1) | CA2599511C (de) |
| DE (1) | DE602006015293D1 (de) |
| ES (1) | ES2346790T3 (de) |
| IL (1) | IL185343A0 (de) |
| MX (1) | MX2007011023A (de) |
| NO (1) | NO20074275L (de) |
| NZ (1) | NZ560958A (de) |
| PE (1) | PE20061106A1 (de) |
| RU (1) | RU2007137649A (de) |
| TW (1) | TW200643015A (de) |
| WO (1) | WO2006095014A1 (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200643015A (en) | 2005-03-11 | 2006-12-16 | Akzo Nobel Nv | 2-(4-oxo-4H-quinazolin-3-yl)acetamide derivatives |
| WO2008033757A2 (en) | 2006-09-11 | 2008-03-20 | N.V. Organon | 2-(1-oxo-1h-isoquinolin-2-yl) acetamide derivatives |
| JP5256202B2 (ja) | 2006-09-11 | 2013-08-07 | エム・エス・ディー・オス・ベー・フェー | キナゾリノンおよびイソキノリノンアセトアミド誘導体 |
| WO2008071779A1 (en) | 2006-12-13 | 2008-06-19 | N.V. Organon | V3 antagonists for the treatment or prevention of chronic pain |
| JP2010229035A (ja) * | 2007-08-01 | 2010-10-14 | Taisho Pharmaceutical Co Ltd | ピリドピリミジン−4−オン誘導体 |
| JP5369721B2 (ja) * | 2009-01-30 | 2013-12-18 | 大正製薬株式会社 | ピリドピリミジン−4−オン誘導体 |
| ME02847B (de) | 2009-07-27 | 2018-01-20 | Gilead Sciences Inc | Kondensierte heterocyclische verbindungen als ionenkanalmodulatoren |
| WO2011091407A1 (en) * | 2010-01-25 | 2011-07-28 | Glaxosmithkline Llp | Trpv4 antagonists |
| BR112012033402A2 (pt) | 2010-07-02 | 2017-01-24 | Gilead Sciences Inc | moduladores de canais de íons conforme os compostos heterocíclicos fundidos |
| JP5859010B2 (ja) * | 2010-09-27 | 2016-02-10 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company | 2−アミノ−n−(2,2,2−トリフルオロエチル)アセトアミドの調製方法 |
| EP2623499B1 (de) | 2010-10-01 | 2015-04-22 | Taisho Pharmaceutical Co., Ltd | 1,2,4-Triazolonderivat |
| ES2648820T3 (es) * | 2011-05-10 | 2018-01-08 | Gilead Sciences, Inc. | Compuestos heterocíclicos condensados como moduladores de los canales de sodio |
| NO3175985T3 (de) | 2011-07-01 | 2018-04-28 | ||
| TWI478908B (zh) | 2011-07-01 | 2015-04-01 | Gilead Sciences Inc | 作為離子通道調節劑之稠合雜環化合物 |
| PT2772482E (pt) | 2011-10-27 | 2016-06-03 | Taisho Pharmaceutical Co Ltd | Derivados de azole |
| RU2014143794A (ru) * | 2012-03-30 | 2016-05-27 | Тайсо Фармасьютикал Ко., Лтд. | Производное конденсированного азола |
| EP2847193B1 (de) * | 2012-05-09 | 2019-08-07 | Sunovion Pharmaceuticals Inc. | Heteroarylverbindungen und verfahren zur verwendung davon |
| US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
| JO3805B1 (ar) | 2013-10-10 | 2021-01-31 | Araxes Pharma Llc | مثبطات كراس جي12سي |
| EP3191459A1 (de) | 2014-09-05 | 2017-07-19 | AbbVie Deutschland GmbH & Co. KG | Kondensierte heterocyclischen oder carbocyclischen verbindungen mit substituierten cycloaliphatischen rest und verwendung zur behandlung von vasopressin-erkrankungen |
| CA2993013A1 (en) * | 2015-07-22 | 2017-01-26 | Araxes Pharma Llc | Substituted quinazoline compounds and their use as inhibitors of g12c mutant kras, hras and/or nras proteins |
| US10975071B2 (en) | 2015-09-28 | 2021-04-13 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| US10414757B2 (en) | 2015-11-16 | 2019-09-17 | Araxes Pharma Llc | 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof |
| ES2950348T3 (es) | 2015-12-09 | 2023-10-09 | Novartis Ag | Moduladores de receptores NMDA de tienopirimidinona y usos de los mismos |
| PL3386591T3 (pl) | 2015-12-09 | 2021-02-22 | Novartis Ag | Heteroaromatyczne modulatory receptorów nmda i ich zastosowania |
| EP3558318B1 (de) | 2016-12-22 | 2023-12-20 | Novartis AG | Nmda-rezeptor-modulatoren und verwendungen davon |
| WO2018140599A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| EP3573954A1 (de) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Fusionierte bicyclische benzoheteroaromatische verbindungen und verfahren zur verwendung davon |
| WO2018140600A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Fused hetero-hetero bicyclic compounds and methods of use thereof |
| US11136308B2 (en) | 2017-01-26 | 2021-10-05 | Araxes Pharma Llc | Substituted quinazoline and quinazolinone compounds and methods of use thereof |
| EP3573971A1 (de) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-on-derivate und ähnliche verbindungen als kras-g12c-modulatoren zur behandlung von krebs |
| KR20200010306A (ko) | 2017-05-25 | 2020-01-30 | 아락세스 파마 엘엘씨 | Kras의 공유적 억제제 |
| WO2018218069A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant kras, hras or nras |
| CA3107168A1 (en) | 2018-08-01 | 2020-02-06 | Araxes Pharma Llc | Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer |
| RS64359B1 (sr) | 2018-08-03 | 2023-08-31 | Novartis Ag | Heteroaromatični modulatori nmda receptora i njihove upotrebe |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2506767A1 (fr) * | 1981-05-26 | 1982-12-03 | Synthelabo | Derives heterocycliques d'amidoximes, leur preparation et leur application en therapeutique |
| FR2804114B1 (fr) * | 2000-01-25 | 2002-03-08 | Sanofi Synthelabo | Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
| FR2842527B1 (fr) | 2002-07-19 | 2005-01-28 | Sanofi Synthelabo | Derives d'acyloxypyrolidine, leur preparation et leur application en therapeutique |
| TW200643015A (en) | 2005-03-11 | 2006-12-16 | Akzo Nobel Nv | 2-(4-oxo-4H-quinazolin-3-yl)acetamide derivatives |
-
2006
- 2006-03-02 TW TW095107055A patent/TW200643015A/zh unknown
- 2006-03-09 PE PE2006000270A patent/PE20061106A1/es not_active Application Discontinuation
- 2006-03-10 EP EP06725007A patent/EP1861380B1/de not_active Expired - Lifetime
- 2006-03-10 MX MX2007011023A patent/MX2007011023A/es active IP Right Grant
- 2006-03-10 NZ NZ560958A patent/NZ560958A/en not_active IP Right Cessation
- 2006-03-10 US US11/908,221 patent/US7807686B2/en not_active Expired - Lifetime
- 2006-03-10 AR ARP060100908A patent/AR052943A1/es unknown
- 2006-03-10 WO PCT/EP2006/060612 patent/WO2006095014A1/en not_active Ceased
- 2006-03-10 AT AT06725007T patent/ATE473214T1/de not_active IP Right Cessation
- 2006-03-10 RU RU2007137649/04A patent/RU2007137649A/ru not_active Application Discontinuation
- 2006-03-10 KR KR1020077023214A patent/KR20080009076A/ko not_active Withdrawn
- 2006-03-10 ES ES06725007T patent/ES2346790T3/es not_active Expired - Lifetime
- 2006-03-10 AU AU2006221962A patent/AU2006221962A1/en not_active Abandoned
- 2006-03-10 JP JP2008500206A patent/JP4997391B2/ja not_active Expired - Lifetime
- 2006-03-10 CA CA2599511A patent/CA2599511C/en not_active Expired - Fee Related
- 2006-03-10 DE DE602006015293T patent/DE602006015293D1/de not_active Expired - Lifetime
-
2007
- 2007-08-16 IL IL185343A patent/IL185343A0/en unknown
- 2007-08-22 NO NO20074275A patent/NO20074275L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006221962A1 (en) | 2006-09-14 |
| IL185343A0 (en) | 2008-02-09 |
| KR20080009076A (ko) | 2008-01-24 |
| NO20074275L (no) | 2007-09-27 |
| CA2599511C (en) | 2013-12-10 |
| ES2346790T3 (es) | 2010-10-20 |
| TW200643015A (en) | 2006-12-16 |
| CA2599511A1 (en) | 2006-09-14 |
| NZ560958A (en) | 2009-09-25 |
| MX2007011023A (es) | 2008-03-12 |
| EP1861380A1 (de) | 2007-12-05 |
| JP4997391B2 (ja) | 2012-08-08 |
| WO2006095014A1 (en) | 2006-09-14 |
| AR052943A1 (es) | 2007-04-11 |
| US20080214553A1 (en) | 2008-09-04 |
| JP2008532981A (ja) | 2008-08-21 |
| PE20061106A1 (es) | 2006-10-13 |
| US7807686B2 (en) | 2010-10-05 |
| RU2007137649A (ru) | 2009-04-20 |
| EP1861380B1 (de) | 2010-07-07 |
| DE602006015293D1 (de) | 2010-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |