ATE486070T1 - Piperidinylaminopyridazine und ihre verwendung als schnelldissoziierende antagonisten des dopamin-2-rezeptors - Google Patents

Piperidinylaminopyridazine und ihre verwendung als schnelldissoziierende antagonisten des dopamin-2-rezeptors

Info

Publication number
ATE486070T1
ATE486070T1 AT07847833T AT07847833T ATE486070T1 AT E486070 T1 ATE486070 T1 AT E486070T1 AT 07847833 T AT07847833 T AT 07847833T AT 07847833 T AT07847833 T AT 07847833T AT E486070 T1 ATE486070 T1 AT E486070T1
Authority
AT
Austria
Prior art keywords
piperidinylaminopyridazine
dopamine
antagonists
receptor
rapid dissociation
Prior art date
Application number
AT07847833T
Other languages
English (en)
Inventor
Gregor James Macdonald
Jose Ignacio Andres-Gil
Den Keybus Frans Alfons Maria Van
Jose Manuel Bartolome-Nebreda
Gool Michiel Luc Maria Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37964744&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE486070(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE486070T1 publication Critical patent/ATE486070T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT07847833T 2006-12-08 2007-12-05 Piperidinylaminopyridazine und ihre verwendung als schnelldissoziierende antagonisten des dopamin-2-rezeptors ATE486070T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125685 2006-12-08
PCT/EP2007/063338 WO2008068277A1 (en) 2006-12-08 2007-12-05 Piperidinylamino-pyridazines and their use as fast dissociating dopamine 2 receptor antagonists

Publications (1)

Publication Number Publication Date
ATE486070T1 true ATE486070T1 (de) 2010-11-15

Family

ID=37964744

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07847833T ATE486070T1 (de) 2006-12-08 2007-12-05 Piperidinylaminopyridazine und ihre verwendung als schnelldissoziierende antagonisten des dopamin-2-rezeptors

Country Status (28)

Country Link
US (1) US8466153B2 (de)
EP (1) EP2091938B1 (de)
JP (1) JP5255568B2 (de)
KR (1) KR101468384B1 (de)
CN (1) CN101547915B (de)
AR (1) AR064198A1 (de)
AT (1) ATE486070T1 (de)
AU (1) AU2007328897B2 (de)
BR (1) BRPI0720247A2 (de)
CA (1) CA2665924C (de)
CL (1) CL2007003556A1 (de)
CY (1) CY1112227T1 (de)
DE (1) DE602007010179D1 (de)
DK (1) DK2091938T3 (de)
EA (1) EA016654B1 (de)
ES (1) ES2354756T3 (de)
IL (1) IL199076A (de)
JO (1) JO2642B1 (de)
MX (1) MX2009005983A (de)
MY (1) MY148772A (de)
NO (1) NO20092574L (de)
NZ (1) NZ576484A (de)
PL (1) PL2091938T3 (de)
PT (1) PT2091938E (de)
SI (1) SI2091938T1 (de)
TW (1) TWI433676B (de)
UA (1) UA98940C2 (de)
WO (1) WO2008068277A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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JO2769B1 (en) 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
JO2849B1 (en) * 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
RU2489431C2 (ru) * 2007-04-23 2013-08-10 Янссен Фармацевтика Н.В. Тиа(диа)золы как быстро диссоциирующие антагонисты рецептора допамина 2
JP5431305B2 (ja) * 2007-04-23 2014-03-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体
AU2008240727C1 (en) * 2007-04-23 2013-10-03 Janssen Pharmaceutica N.V. Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists
JP5417439B2 (ja) * 2008-07-03 2014-02-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ５−ｈｔ６受容体アンタゴニストとしての置換された６−（１−ピペラジニル）−ピリダジン類
EA019048B1 (ru) * 2008-07-31 2013-12-30 Янссен Фармацевтика Нв Пиперазин-1-илтрифторметилзамещенные пиридины в качестве быстро диссоциирующихся антагонистов d-рецепторов дофамина
EP4574152A1 (de) * 2023-12-22 2025-06-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Kaliumkanalaktivatoren zur behandlung von epileptischen erkrankungen

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JO2769B1 (en) * 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
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JO2849B1 (en) 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
EA019048B1 (ru) * 2008-07-31 2013-12-30 Янссен Фармацевтика Нв Пиперазин-1-илтрифторметилзамещенные пиридины в качестве быстро диссоциирующихся антагонистов d-рецепторов дофамина

Also Published As

Publication number Publication date
BRPI0720247A2 (pt) 2013-12-31
CA2665924A1 (en) 2008-06-12
CA2665924C (en) 2014-08-12
TW200831098A (en) 2008-08-01
EA016654B1 (ru) 2012-06-29
JP2010511673A (ja) 2010-04-15
PL2091938T3 (pl) 2011-04-29
PT2091938E (pt) 2011-01-20
CN101547915A (zh) 2009-09-30
EP2091938A1 (de) 2009-08-26
JP5255568B2 (ja) 2013-08-07
CN101547915B (zh) 2013-08-21
ES2354756T3 (es) 2011-03-17
HK1137434A1 (en) 2010-07-30
JO2642B1 (en) 2012-06-17
WO2008068277A1 (en) 2008-06-12
TWI433676B (zh) 2014-04-11
US20100076187A1 (en) 2010-03-25
EP2091938B1 (de) 2010-10-27
US8466153B2 (en) 2013-06-18
CY1112227T1 (el) 2015-12-09
NO20092574L (no) 2009-09-08
MX2009005983A (es) 2009-06-16
EA200970553A1 (ru) 2009-10-30
AU2007328897A1 (en) 2008-06-12
CL2007003556A1 (es) 2008-06-13
DE602007010179D1 (de) 2010-12-09
AR064198A1 (es) 2009-03-18
KR20090089858A (ko) 2009-08-24
SI2091938T1 (sl) 2011-02-28
DK2091938T3 (da) 2011-02-07
IL199076A (en) 2012-12-31
NZ576484A (en) 2010-10-29
MY148772A (en) 2013-05-31
AU2007328897B2 (en) 2013-01-10
KR101468384B1 (ko) 2014-12-03
UA98940C2 (ru) 2012-07-10

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