ATE473299T1 - M. tb offener leserahmen rv2659c, und deren verwendung - Google Patents

M. tb offener leserahmen rv2659c, und deren verwendung

Info

Publication number
ATE473299T1
ATE473299T1 AT08017907T AT08017907T ATE473299T1 AT E473299 T1 ATE473299 T1 AT E473299T1 AT 08017907 T AT08017907 T AT 08017907T AT 08017907 T AT08017907 T AT 08017907T AT E473299 T1 ATE473299 T1 AT E473299T1
Authority
AT
Austria
Prior art keywords
deletions
bcg
isolates
tuberculosis
rv2659c
Prior art date
Application number
AT08017907T
Other languages
English (en)
Inventor
Marcel Behr
Peter Small
Gary Schoolnik
Michael A Wilson
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of ATE473299T1 publication Critical patent/ATE473299T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Multicomponent Fibers (AREA)
  • Door And Window Frames Mounted To Openings (AREA)
  • Data Exchanges In Wide-Area Networks (AREA)
  • Load-Bearing And Curtain Walls (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT08017907T 1998-08-25 1999-08-10 M. tb offener leserahmen rv2659c, und deren verwendung ATE473299T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9793698P 1998-08-25 1998-08-25
US09/318,191 US6291190B1 (en) 1998-08-25 1999-05-25 Molecular differences between species of the M. tuberculosis complex

Publications (1)

Publication Number Publication Date
ATE473299T1 true ATE473299T1 (de) 2010-07-15

Family

ID=26793800

Family Applications (3)

Application Number Title Priority Date Filing Date
AT08017907T ATE473299T1 (de) 1998-08-25 1999-08-10 M. tb offener leserahmen rv2659c, und deren verwendung
AT08015511T ATE507308T1 (de) 1998-08-25 1999-08-10 M. tuberculosis offener leserahmen rv2660c und deren verwendung
AT99939702T ATE466100T1 (de) 1998-08-25 1999-08-10 Molekulare unterschiede innerhalb von spezies des m. tuberculosis-komplexes

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT08015511T ATE507308T1 (de) 1998-08-25 1999-08-10 M. tuberculosis offener leserahmen rv2660c und deren verwendung
AT99939702T ATE466100T1 (de) 1998-08-25 1999-08-10 Molekulare unterschiede innerhalb von spezies des m. tuberculosis-komplexes

Country Status (9)

Country Link
US (6) US6291190B1 (de)
EP (3) EP1108060B1 (de)
AT (3) ATE473299T1 (de)
AU (1) AU5394699A (de)
DE (3) DE69942569D1 (de)
DK (3) DK2006395T3 (de)
ES (1) ES2343927T3 (de)
PT (2) PT2006395E (de)
WO (1) WO2000011214A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291190B1 (en) 1998-08-25 2001-09-18 The Board Of Trustees Of The Leland Stanford Junior University Molecular differences between species of the M. tuberculosis complex
US20040018574A1 (en) * 1998-08-25 2004-01-29 Marcel Behr Molecular differences between species of the M. tuberculosis complex
FR2791067B1 (fr) * 1999-03-16 2003-01-31 Pasteur Institut Sequence deletees chez m.bovis bcg/m.ou m.tuberculosis, procede de detection des mycobacteries utilisant ces sequences et vaccins
ES2326257T3 (es) 1999-05-04 2009-10-06 The University Of Medicine And Dentistry Of New Jersey Proteinas expresadas por mycobacterium tuberculosis y no por bcg y su utilizacion como reactivos diagnosticos y vacunas.
EP1377827A2 (de) * 2001-04-10 2004-01-07 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen in Reutlingen Stiftung Bürgerlichen Rechts Methode zur bestimmung von analytmolekülen in einer probe
US7722861B2 (en) * 2002-02-19 2010-05-25 Svetoslav Bardarov, legal representative Attenuated Mycobacterium tuberculosis vaccines
US7758874B2 (en) * 2002-02-19 2010-07-20 Albert Einstein College Of Medicine Of Yeshiva University Attenuated Mycobacterium tuberculosis vaccines
ES2286212T3 (es) * 2002-02-25 2007-12-01 Pasteur Institut Secuencias suprimidas especificamente del genoma de mycobacterium tuberculosis, y su uso en el diagnostico y como vacunas.
CN100572540C (zh) * 2002-04-16 2009-12-23 成都永安制药有限公司 包括表达丙氨酸脱氢酶、丝氨酸脱水酶和/或谷氨酰胺合成酶的重组卡介苗菌株的结核病疫苗
WO2003093307A2 (en) * 2002-04-27 2003-11-13 The Secretary Of State For Environment, Food And Rural Affairs Mycobacterial antigens and uses thereof
US20070105100A1 (en) * 2003-04-28 2007-05-10 Canon Kabushiki Kaisha Process for assay of nucleic acids by competitive hybridization using a dna microarray
ITRM20030411A1 (it) * 2003-08-29 2005-02-28 Consiglio Nazionale Ricerche Uso di sequenze geniche specifiche di mycobacterium tubercolosis ecorrispondenti proteine per la diagnosi e la prevenzione di infezione tubercolare.
WO2006060484A2 (en) * 2004-12-01 2006-06-08 Gene Therapy Systems, Inc. Tuberculosis nucleic acids, polypeptides and immunogenic compositions
US8475803B2 (en) * 2005-04-29 2013-07-02 Fusion Antibodies Limited Assays for diagnosis of tuberculosis and uses thereof
ES2534428T3 (es) 2005-07-26 2015-04-22 Rutgers, The State University Of New Jersey Perfiles de anticuerpos específicos de un estado tuberculoso
US20080206776A1 (en) * 2005-09-05 2008-08-28 Bio-Rad Pasteur Use of Both Rd9 and Is6110 as Nucleic Acid Targets for the Diagnosis of Tuberculosis, and Provision of Multiplex-Compliant Is6110 and Rd9 Targets
EP2021018A4 (de) * 2006-05-18 2009-06-03 Daniel G Ericson Rascher nachweis von mykobakteriumtuberkulose und resistenz gegen antimikrobika
BRPI0604958B1 (pt) * 2006-11-23 2022-05-17 Fundação Oswaldo Cruz Kit para distinção de mycobacterium tuberculosis, m. bovis, m. bovis bcg em uma amostra, e, método para distinguir mycobacterium tuberculosis, m. bovis, m. bovis bcg
CN101661044B (zh) * 2008-08-27 2013-10-16 复旦大学附属华山医院 一种结核病诊断试剂及试剂盒
WO2010030049A1 (en) * 2008-09-12 2010-03-18 Lg Life Sciences, Ltd. Composition for detection of m. tuberculosis complex or mycobacteria genus and simultaneous detection method for m. tuberculosis complex and mycobacteria genus with multiplex real time pcr using the same
GB0903168D0 (en) 2009-02-25 2009-04-08 Fusion Antibodies Ltd Diagnostic method and kit
EP3360566B1 (de) 2009-11-20 2019-12-25 Oregon Health&Science University Verfahren zum erkennen einer infektion mit dem mycobakterium tuberculosis
KR101158647B1 (ko) * 2010-05-27 2012-06-26 울산대학교 산학협력단 이중 실시간 중합효소연쇄반응법과 융해곡선분석을 이용하는 결핵균과 항산성비결핵균의 검출 방법
US9663758B2 (en) 2013-03-12 2017-05-30 Wisconsin Alumni Research Foundation Global gene regulators (GGR) as vaccine candidates against paratuberculosis
EP4257976A3 (de) * 2016-09-22 2024-01-24 Pace Diagnostics, Inc Mycobacterium-tuberculosis-proteine in diagnostischen tests und vorrichtungen zur erkennung und diagnose von tuberkulose
KR102247643B1 (ko) * 2019-11-01 2021-05-03 바이오파크진단 주식회사 결핵균 및 비결핵항산균을 검출하기 위한 2단계 진단방법 및 키트

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591632A (en) 1987-03-02 1997-01-07 Beth Israel Hospital Recombinant BCG
EP0347425B1 (de) * 1987-03-02 1995-12-27 Whitehead Institute For Biomedical Research Rekombinant-mykobakterielle impfstoffe
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
EP0499003A1 (de) * 1991-02-14 1992-08-19 N.V. Innogenetics S.A. Polypeptide und Peptide, insbesondere rekombinante Polypeptide und Peptide, dafür kodierende Nukleinsäuren und Verwendung dieser Polypeptide und Peptide in der Tuberkulosediagnose
DK79793D0 (da) * 1993-07-02 1993-07-02 Statens Seruminstitut Diagnostic test
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5700683A (en) 1995-02-17 1997-12-23 Pathogenesis Corporation Virulence-attenuating genetic deletions deleted from mycobacterium BCG
AU4996796A (en) 1995-02-28 1996-09-18 Joel R.L. Ehrenkranz Rapid, self-performing tsh immunoassay
US5686597A (en) 1995-06-06 1997-11-11 Incyte Pharmaceuticals, Inc. Thrombin receptor homolog
EP0952849A4 (de) * 1996-12-31 2004-09-08 Univ New York Frühe erkennung von mycobakteriellen erkrankungen
WO2001004151A2 (en) * 1999-07-13 2001-01-18 Statens Serum Institut TUBERCULOSIS VACCINE AND DIAGNOSTICS BASED ON THE MYCOBACTERIUM TUBERCULOSIS esat-6 GENE FAMILY
US20040013685A1 (en) * 1997-11-10 2004-01-22 Peter Andersen Nucleic acid fragments and polypeptide fragments derived from M. tuberculosis
US6291190B1 (en) * 1998-08-25 2001-09-18 The Board Of Trustees Of The Leland Stanford Junior University Molecular differences between species of the M. tuberculosis complex

Also Published As

Publication number Publication date
PT1108060E (pt) 2010-08-04
US20040063923A1 (en) 2004-04-01
US7700118B2 (en) 2010-04-20
DE69942569D1 (de) 2010-08-19
PT2006395E (pt) 2011-07-13
US6686166B2 (en) 2004-02-03
US7364740B2 (en) 2008-04-29
EP1108060B1 (de) 2010-04-28
DK2031075T3 (da) 2010-10-18
DE69943401D1 (de) 2011-06-09
US20060002953A1 (en) 2006-01-05
US20110206715A1 (en) 2011-08-25
DK2006395T3 (da) 2011-07-18
AU5394699A (en) 2000-03-14
EP2031075A1 (de) 2009-03-04
ATE507308T1 (de) 2011-05-15
EP1108060A1 (de) 2001-06-20
US6291190B1 (en) 2001-09-18
US20080254052A1 (en) 2008-10-16
WO2000011214B1 (en) 2000-04-13
EP2006395A1 (de) 2008-12-24
US20020176873A1 (en) 2002-11-28
EP2006395B1 (de) 2011-04-27
WO2000011214A1 (en) 2000-03-02
DE69942310D1 (de) 2010-06-10
DK1108060T3 (da) 2010-08-16
ES2343927T3 (es) 2010-08-12
ATE466100T1 (de) 2010-05-15
EP2031075B1 (de) 2010-07-07

Similar Documents

Publication Publication Date Title
DE69942569D1 (de) M. tb offener Leserahmen Rv2659c, und deren Verwendung
Kaufmann et al. Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64‐kDa protein
Turnbull Anthrax vaccines: past, present and future
DK79893D0 (da) New vaccine
Allison et al. Electrophoretic separation and molecular weight characterization of Pseudomonas aeruginosa H-antigen flagellins
ATE526994T1 (de) Mtb32a antigen aus mycobakterium tuberculosis mit inaktivierter protease aktivität und fusionsproteine die das antigen enthalten
FI895050A0 (fi) Diagnostiska preparat och vaccin foer mykobakterier i folkhaelso-, medicinsk och veterinaermedicinsk praxis.
Singh et al. Resistance to intravenous inoculation of Mycobacterium tuberculosis H37Rv in mice of different inbred strains following immunization with a leprosy vaccine based on Mycobacterium w
CY1107950T1 (el) Νεϊσσεριακες συνθεσεις εμβολιου και μεθοδοι
Blander et al. Vaccination with Legionella pneumophila membranes induces cell-mediated and protective immunity in a guinea pig model of Legionnaires' disease. Protective immunity independent of the major secretory protein of Legionella pneumophila.
CY1109210T1 (el) Διαγραφεισες αλληλουχιες στο μ. bovis bcg/m. bovis ΄η μ. tuberculosis, μεθοδος ανιχνευσεως μυκοβακτηριων που χρησιμοποιουν αυτες τις αλληλουχιες και εμβολια
ATE414761T1 (de) Verringerung der virulenz von mycobacterium tuberculosis und tuberkuloseschutz mittels inaktivierung des phop-gens
DE60218327D1 (de) Inaktivierte immunogene bakterielle ganzzell-zusammensetzungen
Nel Mycobacterium avium-intracellulare complex serovars isolated in South Africa from humans, swine, and the environment
Kingsley et al. TonB-dependent iron supply in Salmonella by α-ketoacids and α-hydroxyacids
ATE366583T1 (de) Identifizierung von spezifischen differenziell exprimierten antigenen aus mycobacterium und medizinische verwendung der mycobakteriumproteine rv0068 und rv3407
Rhodes et al. Bordetella bronchiseptica and toxigenic type D Pasteurella multocida as agents of severe atrophic rhinitis of swine
Khattak et al. A comparison of the DNA fragment patterns of the mouse-virulent challenge strains and clinical isolates of Bordetella pertussis
DE60032293D1 (de) Lebende attenuierte bakterien zur verwendung als impfstoff
Amutha et al. Immunoreactive outer membrane proteins of Leptospira interrogans serovar Canicola strain Hond Utrecht IV
Bonifacio da Silva et al. An epidemiological study of Haemophilus influenzae at a Brazilian day care center
O’Neill et al. Population-based analysis of Actinobacillus pleuropneumoniae ApxIVA for use as a DIVA antigen
Bergmans Cat scratch disease: studies on diagnosis and identification of reservoirs and vectors
Kumar et al. Identification of a 25-kilodalton protein of Mycobacterium bovis BCG to distinguish BCG strains from Mycobacterium tuberculosis
Angelety et al. Agar diffusion method for the differentiation of Bacillus anthracis

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties