ATE473446T1 - Verfahren und testvorrichtungen zur unterscheidung verschiedener formen von krankheiten und leiden, die durch thrombocytopenia und/oder durch spontane interaktionen zwischen dem von-willebrand-faktor und plättchen gekennzeichnet sind - Google Patents
Verfahren und testvorrichtungen zur unterscheidung verschiedener formen von krankheiten und leiden, die durch thrombocytopenia und/oder durch spontane interaktionen zwischen dem von-willebrand-faktor und plättchen gekennzeichnet sindInfo
- Publication number
- ATE473446T1 ATE473446T1 AT06701801T AT06701801T ATE473446T1 AT E473446 T1 ATE473446 T1 AT E473446T1 AT 06701801 T AT06701801 T AT 06701801T AT 06701801 T AT06701801 T AT 06701801T AT E473446 T1 ATE473446 T1 AT E473446T1
- Authority
- AT
- Austria
- Prior art keywords
- diseases
- thrombocytopenia
- von willebrand
- willebrand factor
- vwf
- Prior art date
Links
- 108010047303 von Willebrand Factor Proteins 0.000 title abstract 10
- 102100036537 von Willebrand factor Human genes 0.000 title abstract 10
- 229960001134 von willebrand factor Drugs 0.000 title abstract 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 8
- 201000010099 disease Diseases 0.000 title abstract 5
- 230000003993 interaction Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 230000002269 spontaneous effect Effects 0.000 title abstract 3
- 206010043554 thrombocytopenia Diseases 0.000 title abstract 3
- 238000012360 testing method Methods 0.000 title 1
- 208000035475 disorder Diseases 0.000 abstract 3
- 239000012472 biological sample Substances 0.000 abstract 2
- 239000000523 sample Substances 0.000 abstract 2
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/22—Haematology
- G01N2800/222—Platelet disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64441405P | 2005-01-14 | 2005-01-14 | |
| PCT/EP2006/000273 WO2006074947A2 (en) | 2005-01-14 | 2006-01-13 | METHODS AND ASSAYS FOR DISTINGUISHING BETWEEN DIFFERENT FORMS OF DISEASES AND DISORDERS CHARACTERIZED BY THROMBOCYTOPENIA AND/OR BY SPONTANEOUS INTERACTION BETWEEN VON WILLEBRAND FACTOR (vWF) AND PLATELETS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE473446T1 true ATE473446T1 (de) | 2010-07-15 |
Family
ID=36593150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06701801T ATE473446T1 (de) | 2005-01-14 | 2006-01-13 | Verfahren und testvorrichtungen zur unterscheidung verschiedener formen von krankheiten und leiden, die durch thrombocytopenia und/oder durch spontane interaktionen zwischen dem von-willebrand-faktor und plättchen gekennzeichnet sind |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7939277B2 (de) |
| EP (1) | EP1836500B1 (de) |
| JP (1) | JP4829897B2 (de) |
| AT (1) | ATE473446T1 (de) |
| AU (1) | AU2006205900B8 (de) |
| CA (1) | CA2593328C (de) |
| DE (1) | DE602006015281D1 (de) |
| DK (1) | DK1836500T3 (de) |
| ES (1) | ES2347908T3 (de) |
| PL (1) | PL1836500T3 (de) |
| PT (1) | PT1836500E (de) |
| SI (1) | SI1836500T1 (de) |
| WO (1) | WO2006074947A2 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003251238A1 (en) * | 2002-08-07 | 2004-02-25 | Umc Utrecht Holding B.V. | Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha |
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| EP1587838B1 (de) | 2003-01-10 | 2015-04-15 | Ablynx N.V. | Therapeutische polypeptide, deren homologe, deren fragmente und deren verwendung bei der modulierung der thrombozytenvermittelten aggregation |
| US8603824B2 (en) | 2004-07-26 | 2013-12-10 | Pfenex, Inc. | Process for improved protein expression by strain engineering |
| JP2008512097A (ja) | 2004-09-07 | 2008-04-24 | アーケミックス コーポレイション | アプタマー医薬品化学 |
| US7566701B2 (en) | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
| DK1836500T3 (da) | 2005-01-14 | 2010-11-01 | Ablynx Nv | Fremgangsmåde og assays til at skelne mellem forskellige former af sygdomme og lidelser, der er kendetegnet ved thrombocytopeni og/eller ved spantan interaktion mellem von Willbrandfaktor 8vWF) og blodplader |
| ES2852423T3 (es) | 2005-05-20 | 2021-09-13 | Ablynx Nv | NanobodiesTM mejorados para el tratamiento de trastornos mediados por agregación |
| WO2008049881A2 (en) * | 2006-10-25 | 2008-05-02 | Umc Utrecht Holding Bv | Polypeptides and pharmaceutical compositions comprising the same for the prevention and treatment of complications associated with infectious diseases |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| JP5444553B2 (ja) | 2007-04-27 | 2014-03-19 | フェネックス インコーポレイテッド | 微生物宿主を迅速にスクリーニングして、異種タンパク質発現の収率および／または質が改善されている特定の株を同定する方法 |
| EP2252303A2 (de) * | 2008-03-21 | 2010-11-24 | Ablynx NV | Von-willebrand-faktor-spezifische bindemittel und verfahren zu ihrer verwendung |
| GB0809069D0 (en) | 2008-05-19 | 2008-06-25 | Univ Leuven Kath | Gene signatures |
| US8444976B2 (en) | 2008-07-02 | 2013-05-21 | Argen-X B.V. | Antigen binding polypeptides |
| ES2569610T3 (es) * | 2008-12-04 | 2016-05-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Método para producir plaquetas |
| WO2010100135A1 (en) | 2009-03-05 | 2010-09-10 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
| WO2011026948A1 (en) | 2009-09-03 | 2011-03-10 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
| US9265834B2 (en) | 2009-03-05 | 2016-02-23 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
| KR101808751B1 (ko) | 2009-11-13 | 2017-12-13 | 그리폴스 테라퓨틱스 인코포레이티드 | 폰 빌레브란트 인자(ｖＷＦ)-함유 제제, 및 그와 관련된 방법, 키트 및 용도 |
| NL1040254C2 (en) | 2013-05-17 | 2014-11-24 | Ablynx Nv | Stable formulations of immunoglobulin single variable domains and uses thereof. |
| NL2013007B1 (en) | 2014-06-16 | 2016-07-05 | Ablynx Nv | Methods of treating TTP with immunoglobulin single variable domains and uses thereof. |
| CN117138060A (zh) | 2014-10-07 | 2023-12-01 | 免疫医疗公司 | 抗体-药物缀合物的新辅助剂用途 |
| WO2016172427A1 (en) | 2015-04-22 | 2016-10-27 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells |
| PL3316885T3 (pl) | 2015-07-01 | 2021-12-06 | Immunomedics, Inc. | Immunokoniugaty przeciwciało-sn-38 z linkerem cl2a |
| RU2599021C1 (ru) * | 2015-07-27 | 2016-10-10 | Федеральное государственное бюджетное учреждение науки "Кировский научно-исследовательский институт гематологии и переливания крови Федерального медико-биологического агентства" | Способ прогнозирования течения иммунной тромбоцитопении после спленэктомии по массе cd4+ т-лимфоцитов селезенки |
| WO2019154867A1 (en) | 2018-02-06 | 2019-08-15 | Ablynx Nv | Methods of treating initial episode of ttp with immunoglobulin single variable domains |
| EP4172214A4 (de) * | 2020-06-26 | 2024-10-30 | Monash University | Anti-vwf-antikörper und verwendungen davon |
| WO2026017728A1 (en) | 2024-07-16 | 2026-01-22 | Synapse Research Institute | Polypeptide for treatment of microvascular thrombosis |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5238919A (en) * | 1986-05-30 | 1993-08-24 | Scipps Clinic And Research Foundation | Peptides that inhibit von Willebrand Factor binding to the platelet SPIB receptor |
| US5200510A (en) | 1987-06-16 | 1993-04-06 | Zymogenetics, Inc. | Method for purifying factor viii:c, von willebrand factor and complexes thereof |
| US5770198A (en) * | 1988-05-18 | 1998-06-23 | The Research Foundation Of The State Of New York | Platelet-specific chimeric 7E3 immunoglobulin |
| EP0368684B2 (de) | 1988-11-11 | 2004-09-29 | Medical Research Council | Klonierung von Immunglobulin sequenzen aus den variabelen Domänen. |
| GB8905400D0 (en) | 1989-03-09 | 1989-04-19 | Jonker Margreet | Medicaments |
| DE69232137T2 (de) | 1991-11-25 | 2002-05-29 | Enzon Inc | Multivalente antigen-bindende proteine |
| AU701578B2 (en) | 1992-08-21 | 1999-02-04 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| WO1994013806A1 (en) | 1992-12-11 | 1994-06-23 | The Dow Chemical Company | Multivalent single chain antibodies |
| WO1994025591A1 (en) | 1993-04-29 | 1994-11-10 | Unilever N.V. | PRODUCTION OF ANTIBODIES OR (FUNCTIONALIZED) FRAGMENTS THEREOF DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF $i(CAMELIDAE) |
| US5670132A (en) * | 1994-09-20 | 1997-09-23 | Immunomedics, Inc. | Modified radioantibody fragments for reduced renal uptake |
| CN1254275C (zh) * | 1994-11-30 | 2006-05-03 | 味之素株式会社 | 抗血栓药剂和抗维勒布兰德因子单克隆抗体 |
| EP0739981A1 (de) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable Fragmente von Immunglobulinen-Verwendung zur therapeutischen oder veterinären Zwecken |
| ES2225961T3 (es) | 1996-04-04 | 2005-03-16 | Unilever N.V. | Proteina de union a antigeno multivalente y multiespecifica. |
| ES2294799T3 (es) | 1996-06-27 | 2008-04-01 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Moleculas de anticuerpos que interactuan especificamente con el sitio activo o hendidura de una molecula diana. |
| AU9262598A (en) | 1997-08-18 | 1999-03-08 | Innogenetics N.V. | Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders |
| BR9813276A (pt) * | 1997-10-27 | 2000-08-22 | Unilever Nv | Proteìna multivalente de ligação de antìgeno, sequências de nucleotìdeos, vetor de expressão, célula hospedeira, processo para preparação de proteìna multivalente de ligação de antìgeno, e, uso da mesma |
| ATE535154T1 (de) * | 1998-03-12 | 2011-12-15 | Vhsquared Ltd | Produkten die inaktivierte hefen oder schimmel enthalten, die auf ihrer aussenoberfläche aktive antikörper haben |
| HUP9900956A2 (hu) | 1998-04-09 | 2002-04-29 | Aventis Pharma Deutschland Gmbh. | Egyláncú, több antigéntkötőhely kialakítására képes molekulák, előállításuk és alkalmazásuk |
| US6228360B1 (en) * | 1998-08-19 | 2001-05-08 | Ajinomoto Co., Inc. | Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody |
| EP1124856A1 (de) * | 1998-10-23 | 2001-08-22 | The Brigham And Women's Hospital, Inc. | Konformationspezifische anti-von willebrand faktor antikörper |
| EP1002861A1 (de) | 1998-10-26 | 2000-05-24 | Unilever Plc | Antigenbindungsproteine mit einer Kopplung, die die strukturelle Beweglichkeit einschränkt |
| DE60013767T3 (de) | 1999-01-19 | 2009-07-09 | Unilever N.V. | Verfahren zur herstellung von antikörperfragmenten |
| US6419934B1 (en) * | 1999-02-24 | 2002-07-16 | Edward L. Tobinick | TNF modulators for treating neurological disorders associated with viral infection |
| DE60045577D1 (de) * | 1999-07-05 | 2011-03-10 | Leuven K U Res & Dev | Von willebrand-faktor-aktivitätsnachweis |
| US7943129B2 (en) | 2000-05-26 | 2011-05-17 | National Research Council Of Canada | Single-domain brain-targeting antibody fragments derived from llama antibodies |
| WO2001090190A2 (en) | 2000-05-26 | 2001-11-29 | National Research Council Of Canada | Single-domain antigen-binding antibody fragments derived from llama antibodies |
| US6699473B2 (en) * | 2000-10-13 | 2004-03-02 | Uab Research Foundation | Human anti-epidermal growth factor receptor single-chain antibodies |
| GB0031448D0 (en) | 2000-12-22 | 2001-02-07 | Leuven K U Res & Dev | Inhibition of the vWF-collagen interaction by anti-human vWF monoclonal antibody (82D6A3) results in abolition of in vivo arterial platelet thrombus formation |
| EP1433793A4 (de) | 2001-09-13 | 2006-01-25 | Inst Antibodies Co Ltd | Verfahren zum erstellen einer kamel-antikörperbibliothek |
| ES2263984T3 (es) | 2002-06-28 | 2006-12-16 | Domantis Limited | Ligandos doble-especificos con una vida media serica aumentada. |
| US20050136056A1 (en) * | 2002-07-29 | 2005-06-23 | Shunsuke Kageyama | Pharmaceutical composition for the treatment of thrombocytopenia |
| AU2003251238A1 (en) * | 2002-08-07 | 2004-02-25 | Umc Utrecht Holding B.V. | Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha |
| WO2005044858A1 (en) | 2003-11-07 | 2005-05-19 | Ablynx N.V. | Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor |
| WO2004041867A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Camelidae antibodies against imminoglobulin e and use thereof for the treatment of allergic disorders |
| CA2505316C (en) | 2002-11-08 | 2014-08-05 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| EP1587838B1 (de) * | 2003-01-10 | 2015-04-15 | Ablynx N.V. | Therapeutische polypeptide, deren homologe, deren fragmente und deren verwendung bei der modulierung der thrombozytenvermittelten aggregation |
| CN1845938B (zh) * | 2003-06-30 | 2010-05-26 | 杜门蒂斯有限公司 | 多肽 |
| DK1836500T3 (da) | 2005-01-14 | 2010-11-01 | Ablynx Nv | Fremgangsmåde og assays til at skelne mellem forskellige former af sygdomme og lidelser, der er kendetegnet ved thrombocytopeni og/eller ved spantan interaktion mellem von Willbrandfaktor 8vWF) og blodplader |
| ES2852423T3 (es) | 2005-05-20 | 2021-09-13 | Ablynx Nv | NanobodiesTM mejorados para el tratamiento de trastornos mediados por agregación |
| WO2008049881A2 (en) | 2006-10-25 | 2008-05-02 | Umc Utrecht Holding Bv | Polypeptides and pharmaceutical compositions comprising the same for the prevention and treatment of complications associated with infectious diseases |
-
2006
- 2006-01-13 DK DK06701801.0T patent/DK1836500T3/da active
- 2006-01-13 AT AT06701801T patent/ATE473446T1/de active
- 2006-01-13 SI SI200630783T patent/SI1836500T1/sl unknown
- 2006-01-13 JP JP2007550764A patent/JP4829897B2/ja not_active Expired - Lifetime
- 2006-01-13 EP EP06701801A patent/EP1836500B1/de not_active Expired - Lifetime
- 2006-01-13 CA CA2593328A patent/CA2593328C/en not_active Expired - Fee Related
- 2006-01-13 US US11/795,162 patent/US7939277B2/en active Active
- 2006-01-13 ES ES06701801T patent/ES2347908T3/es not_active Expired - Lifetime
- 2006-01-13 WO PCT/EP2006/000273 patent/WO2006074947A2/en not_active Ceased
- 2006-01-13 DE DE602006015281T patent/DE602006015281D1/de not_active Expired - Lifetime
- 2006-01-13 AU AU2006205900A patent/AU2006205900B8/en not_active Expired
- 2006-01-13 PL PL06701801T patent/PL1836500T3/pl unknown
- 2006-01-13 PT PT06701801T patent/PT1836500E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI1836500T1 (sl) | 2010-11-30 |
| AU2006205900B8 (en) | 2012-04-05 |
| US7939277B2 (en) | 2011-05-10 |
| CA2593328A1 (en) | 2006-07-20 |
| WO2006074947A3 (en) | 2006-09-14 |
| US20080096223A1 (en) | 2008-04-24 |
| PL1836500T3 (pl) | 2010-12-31 |
| AU2006205900A8 (en) | 2012-04-05 |
| AU2006205900A1 (en) | 2006-07-20 |
| EP1836500B1 (de) | 2010-07-07 |
| CA2593328C (en) | 2018-02-06 |
| PT1836500E (pt) | 2010-09-28 |
| AU2006205900B2 (en) | 2011-12-08 |
| EP1836500A2 (de) | 2007-09-26 |
| ES2347908T3 (es) | 2010-11-25 |
| WO2006074947A2 (en) | 2006-07-20 |
| DE602006015281D1 (de) | 2010-08-19 |
| DK1836500T3 (da) | 2010-11-01 |
| JP4829897B2 (ja) | 2011-12-07 |
| JP2008527358A (ja) | 2008-07-24 |
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