ATE473757T1 - Stabile glucoseoxidase-formulierungen und verfahren zur herstellung und verwendung davon - Google Patents
Stabile glucoseoxidase-formulierungen und verfahren zur herstellung und verwendung davonInfo
- Publication number
- ATE473757T1 ATE473757T1 AT06718158T AT06718158T ATE473757T1 AT E473757 T1 ATE473757 T1 AT E473757T1 AT 06718158 T AT06718158 T AT 06718158T AT 06718158 T AT06718158 T AT 06718158T AT E473757 T1 ATE473757 T1 AT E473757T1
- Authority
- AT
- Austria
- Prior art keywords
- formulations
- methods
- glucose oxidase
- production
- stable glucose
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 108010015776 Glucose oxidase Proteins 0.000 title abstract 2
- 239000004366 Glucose oxidase Substances 0.000 title abstract 2
- 229940116332 glucose oxidase Drugs 0.000 title abstract 2
- 235000019420 glucose oxidase Nutrition 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 abstract 5
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/904—Oxidoreductases (1.) acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/060,255 US7241586B2 (en) | 2005-02-17 | 2005-02-17 | Polypeptide formulations and methods for making, using and characterizing them |
| PCT/US2006/001048 WO2006088576A2 (en) | 2005-02-17 | 2006-01-12 | Polypeptide formulations and methods for making, using and characterizing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE473757T1 true ATE473757T1 (de) | 2010-07-15 |
Family
ID=36423621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06718158T ATE473757T1 (de) | 2005-02-17 | 2006-01-12 | Stabile glucoseoxidase-formulierungen und verfahren zur herstellung und verwendung davon |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7241586B2 (de) |
| EP (1) | EP1851536B1 (de) |
| JP (1) | JP4948424B2 (de) |
| AT (1) | ATE473757T1 (de) |
| CA (1) | CA2597367C (de) |
| DE (1) | DE602006015427D1 (de) |
| DK (1) | DK1851536T3 (de) |
| WO (1) | WO2006088576A2 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
| US8527026B2 (en) | 1997-03-04 | 2013-09-03 | Dexcom, Inc. | Device and method for determining analyte levels |
| US20030032874A1 (en) | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
| US7828728B2 (en) | 2003-07-25 | 2010-11-09 | Dexcom, Inc. | Analyte sensor |
| US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
| JP4708342B2 (ja) | 2003-07-25 | 2011-06-22 | デックスコム・インコーポレーテッド | 埋設可能な装置に用いる酸素増大膜システム |
| US9763609B2 (en) | 2003-07-25 | 2017-09-19 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| US8277713B2 (en) | 2004-05-03 | 2012-10-02 | Dexcom, Inc. | Implantable analyte sensor |
| US7857760B2 (en) | 2004-07-13 | 2010-12-28 | Dexcom, Inc. | Analyte sensor |
| US8989833B2 (en) | 2004-07-13 | 2015-03-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
| WO2006127694A2 (en) | 2004-07-13 | 2006-11-30 | Dexcom, Inc. | Analyte sensor |
| US8744546B2 (en) | 2005-05-05 | 2014-06-03 | Dexcom, Inc. | Cellulosic-based resistance domain for an analyte sensor |
| US20200037874A1 (en) | 2007-05-18 | 2020-02-06 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| US8512731B2 (en) * | 2007-11-13 | 2013-08-20 | Medtronic Minimed, Inc. | Antimicrobial coatings for medical devices and methods for making and using them |
| US20090275815A1 (en) * | 2008-03-21 | 2009-11-05 | Nova Biomedical Corporation | Temperature-compensated in-vivo sensor |
| US11730407B2 (en) | 2008-03-28 | 2023-08-22 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US8682408B2 (en) | 2008-03-28 | 2014-03-25 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US8583204B2 (en) | 2008-03-28 | 2013-11-12 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| EP4227675B1 (de) | 2008-09-19 | 2024-12-11 | DexCom, Inc. | Partikelhaltige membran und partikelelektrode für analytsensoren |
| CN102438517B (zh) * | 2009-02-26 | 2015-03-25 | 雅培糖尿病护理公司 | 改进的分析物传感器及其制造和使用方法 |
| US8828201B2 (en) | 2009-07-02 | 2014-09-09 | Dexcom, Inc. | Analyte sensors and methods of manufacturing same |
| CN102749408B (zh) * | 2011-04-21 | 2015-08-19 | 天士力金纳生物技术（天津）有限公司 | 一种亚单位流感疫苗中裂解剂含量的检测方法 |
| CN104458969B (zh) * | 2014-12-31 | 2016-05-11 | 深圳康泰生物制品股份有限公司 | 重组酿酒酵母表达的HBsAg原液中Triton X-100残留量的测定方法 |
| JP7286536B2 (ja) * | 2016-08-15 | 2023-06-05 | ジェネンテック， インコーポレイテッド | 非イオン性サーファクタント及びポリペプチドを含む組成物中の非イオン性サーファクタントを定量するためのクロマトグラフィー法 |
| CN109406698B (zh) * | 2018-11-30 | 2020-12-25 | 广州中科检测技术服务有限公司 | 一种hplc测定单链取代二甲基苄基氯化铵含量的方法 |
| IL296330A (en) * | 2020-03-20 | 2022-11-01 | Glaxosmithkline Ip Dev Ltd | Method for detecting polysorbates |
| CN112710751A (zh) * | 2020-12-19 | 2021-04-27 | 无锡济煜山禾药业股份有限公司 | 一种醒脑静注射液中吐温80含量测定方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2308013A1 (de) * | 1973-02-17 | 1974-09-12 | Behringwerke Ag | Katalasearme glucoseoxidase und verfahren zu ihrer gewinnung |
| US4045343A (en) | 1975-11-10 | 1977-08-30 | Varian Associates, Inc. | High pressure liquid chromatography system |
| US4116837A (en) | 1978-01-12 | 1978-09-26 | The Upjohn Company | High pressure liquid chromatography apparatus |
| EP0021817B1 (de) * | 1979-06-22 | 1985-10-02 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Füllmaterial für Flüssigkeits-Chromatographie, Verfahren zur Trennung wasserlöslicher Substanzen mit diesem Füllstoff und Verwendung dieses Füllstoffes bei der Trennung wasserlöslicher biochemischer Substanzen |
| US4729959A (en) * | 1986-02-24 | 1988-03-08 | Streck Laboratories, Inc. | Glucose reference control for glucose test strips |
| US4952321A (en) | 1988-10-07 | 1990-08-28 | Brigham Young University | Process of removing and concentrating desired ions from solutions |
| ZA938555B (en) | 1992-11-23 | 1994-08-02 | Lilly Co Eli | Technique to improve the performance of electrochemical sensors |
| DK0641859T3 (da) * | 1993-09-01 | 2004-03-29 | Genencor Int | Fremgangsmåde til fremstilling af immobiliserede enzymkonjugater og immobiliserede enzymkonjugater fremstillet derved |
| US5447556A (en) | 1994-03-04 | 1995-09-05 | Graseby-Anderson, Inc. | Sample injection apparatus and method |
| US5670054A (en) | 1996-04-04 | 1997-09-23 | Warner Lambert Company | Method and system for identification, purification, and quantitation of reaction components |
| GB9618428D0 (en) | 1996-09-04 | 1996-10-16 | Polymer Lab Ltd | ELSD diffuser |
| DE19652713C2 (de) | 1996-12-18 | 2001-11-22 | Aventis Pharma Gmbh | Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher |
| US5938932A (en) | 1997-11-14 | 1999-08-17 | Pharmacopeia, Inc. | High-throughput method and apparatus for identifying, quantitating and determining the purity of chemical compounds in mixtures |
| JP3694424B2 (ja) * | 1998-09-29 | 2005-09-14 | 松下電器産業株式会社 | グルコースセンサ |
| US6280623B1 (en) | 1999-03-23 | 2001-08-28 | Hsien-Chih Ma | Differential and continuous separation apparatus with controlled parameters for solids and liquids |
| US6541273B1 (en) | 1999-11-12 | 2003-04-01 | Aventis Cropscience, S.A. | Multiple sorbent cartridges for solid phase extraction |
| US6229605B1 (en) * | 2000-03-10 | 2001-05-08 | Alltech Associates, Inc. | Evaporative light scattering device |
| US6759442B2 (en) | 2000-06-02 | 2004-07-06 | Showa Denko Kabushiki Kaisha | Packing material for solid phase extraction and solid phase extraction method |
| US6602928B2 (en) | 2000-08-21 | 2003-08-05 | Showa Denko Kabushiki Kaisha | Packing material and cartridge for solid phase extraction |
| US6465411B2 (en) * | 2000-12-21 | 2002-10-15 | Clariant International Ltd. | Pine oil cleaning composition |
| US6679989B2 (en) | 2001-06-01 | 2004-01-20 | Agilent Technologies, Inc. | Integral, thru-bore, direct coupled high pressure liquid chromatography guard column |
| US6737401B2 (en) | 2001-06-28 | 2004-05-18 | Metronic Minimed, Inc. | Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom |
| US20030077702A1 (en) * | 2001-10-23 | 2003-04-24 | Rajiv Shah | Method for formulating a glucose oxidase enzyme with a desired property or properties and a glucose oxidase enzyme with the desired property |
| US6723236B2 (en) | 2002-03-19 | 2004-04-20 | Waters Investments Limited | Device for solid phase extraction and method for purifying samples prior to analysis |
| US20040074785A1 (en) | 2002-10-18 | 2004-04-22 | Holker James D. | Analyte sensors and methods for making them |
| JP2004212393A (ja) * | 2002-12-20 | 2004-07-29 | Matsushita Electric Ind Co Ltd | バイオセンサ |
| EP1439220B1 (de) * | 2003-01-16 | 2007-08-22 | Adorkem Technology SpA | Immobilisierte Biokatalysatoren für die Herstellung von natürlichen Nukleosiden und modifizierten Analogen durch enzymatische Transglykosylierungsreaktionen |
-
2005
- 2005-02-17 US US11/060,255 patent/US7241586B2/en not_active Expired - Lifetime
-
2006
- 2006-01-12 AT AT06718158T patent/ATE473757T1/de not_active IP Right Cessation
- 2006-01-12 DE DE602006015427T patent/DE602006015427D1/de not_active Expired - Lifetime
- 2006-01-12 WO PCT/US2006/001048 patent/WO2006088576A2/en not_active Ceased
- 2006-01-12 EP EP06718158A patent/EP1851536B1/de not_active Expired - Lifetime
- 2006-01-12 DK DK06718158.6T patent/DK1851536T3/da active
- 2006-01-12 JP JP2007556142A patent/JP4948424B2/ja not_active Expired - Fee Related
- 2006-01-12 CA CA2597367A patent/CA2597367C/en not_active Expired - Lifetime
-
2007
- 2007-05-25 US US11/807,073 patent/US20080113443A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE602006015427D1 (de) | 2010-08-26 |
| WO2006088576A2 (en) | 2006-08-24 |
| CA2597367C (en) | 2013-06-25 |
| CA2597367A1 (en) | 2006-08-24 |
| JP2008536097A (ja) | 2008-09-04 |
| EP1851536A2 (de) | 2007-11-07 |
| WO2006088576A3 (en) | 2007-02-08 |
| JP4948424B2 (ja) | 2012-06-06 |
| US20060183178A1 (en) | 2006-08-17 |
| US20080113443A1 (en) | 2008-05-15 |
| DK1851536T3 (da) | 2010-10-25 |
| US7241586B2 (en) | 2007-07-10 |
| EP1851536B1 (de) | 2010-07-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602006015427D1 (de) | Stabile glucoseoxidase-formulierungen und verfahren zur herstellung und verwendung davon | |
| DK1751302T3 (da) | Analytsensorer og fremgangsmåder til fremstilling og anvendelse heraf | |
| ATE549039T1 (de) | Verfahren zur herstellung einer sterilen vorrichtung | |
| DK1805518T3 (da) | Fiberoptik til afføling af analytter og fremgangsmåde til fremstilling heraf | |
| DE602005022859D1 (de) | Heteroarylbenzamidderivate zur verwendung als glk-aktivatoren bei der behandlung von diabetes | |
| DE602004031134D1 (de) | Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopa | |
| DK1969359T3 (da) | Biosensorer og fremgangsmåde til fremstilling og anvendelse heraf | |
| WO2008027420A3 (en) | Implantable devices for producing insulin | |
| ATE514755T1 (de) | Fluoreszenzfarbstoffe zur verwendung bei der glukoseerfassung | |
| DE602005022471D1 (de) | Zusammensetzungen enthaltend lipase, protease und amylase zur behandlung von pankreasinsuffizienz | |
| BRPI0813699A2 (pt) | Formulações de proteína de fusão glp-1-fc | |
| WO2007067743A3 (en) | Optical determination of glucose utilizing boronic acid adducts-ii | |
| SG162788A1 (en) | Self-buffering protein formulations | |
| WO2008046003A3 (en) | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases | |
| ATE518010T1 (de) | Aktive oberflächengekoppelte polymerasen | |
| DE102005001078A8 (de) | Glaspulver, insbesondere biologisch aktives Glaspulver und Verfahren zur Herstellung von Glaspulver, insbesondere biologisch aktivem Glaspulver | |
| CY1110860T1 (el) | Αναστροφη μεταγραφαση τελομερασης πτηνου | |
| BRPI0507680A (pt) | partìculas de fosfato de cálcio terapêuticas e métodos de fabricação e uso das mesmas | |
| GT200600112A (es) | Composiciiones de tigeciclina y metodos de preparacion | |
| DE502006006107D1 (de) | Amid substituierte 8-n-benzimidazole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
| ATE525648T1 (de) | Testelement mit nanofasern | |
| WO2008014135A3 (en) | Non-invasive analyte measurement glasses and method of use | |
| DE602005001688D1 (de) | Aufbereitung von Aldesleukin zur pharmazeutischen Verwendung | |
| WO2012012742A3 (en) | Crystal structure of human alpha-n-acetylglucosaminidase | |
| EA200970597A1 (ru) | Новые бис(диалкиламиды), способ получения и применения |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |