ATE476434T1 - Thienopyridinderivate als kaliumkanalinhibitoren - Google Patents

Thienopyridinderivate als kaliumkanalinhibitoren

Info

Publication number: ATE476434T1
Authority: AT; Austria
Prior art keywords: sub; alkyl; halo; cycloalkyl; aryl
Prior art date: 2004-12-09

Application number

AT05818439T

Other languages

English (en)

Inventor

John Ford

David John Madge

Nicholas John Palmer

John Frederick Atherall

Derek John

Original Assignee

Xention Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-09

Filing date

2005-12-09

Publication date

2010-08-15

2004-12-09 Priority claimed from GB0427005A external-priority patent/GB0427005D0/en

2005-12-09 Application filed by Xention Ltd filed Critical Xention Ltd

2010-08-15 Application granted granted Critical

2010-08-15 Publication of ATE476434T1 publication Critical patent/ATE476434T1/de

Links

102000004257 Potassium Channel Human genes 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
108020001213 potassium channel Proteins 0.000 title abstract 2
DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical class C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 7
125000003118 aryl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 3
125000001072 heteroaryl group Chemical group 0.000 abstract 2
238000007254 oxidation reaction Methods 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
206010003119 arrhythmia Diseases 0.000 abstract 1
230000006793 arrhythmia Effects 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002825 nitriles Chemical class 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
-1 trifluromethyl Chemical group 0.000 abstract 1
208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Transplantation (AREA)
Endocrinology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

AT05818439T 2004-12-09 2005-12-09 Thienopyridinderivate als kaliumkanalinhibitoren ATE476434T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US63427104P	2004-12-09	2004-12-09
GB0427005A GB0427005D0 (en)	2004-12-09	2004-12-09	Compounds
PCT/GB2005/004753 WO2006061642A1 (en)	2004-12-09	2005-12-09	Compounds

Publications (1)

Publication Number	Publication Date
ATE476434T1 true ATE476434T1 (de)	2010-08-15

Family

ID=35922802

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05818439T ATE476434T1 (de)	2004-12-09	2005-12-09	Thienopyridinderivate als kaliumkanalinhibitoren

Country Status (4)

Country	Link
EP (1)	EP1879899B1 (de)
JP (1)	JP5173429B2 (de)
AT (1)	ATE476434T1 (de)
WO (1)	WO2006061642A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0315950D0 (en)	2003-06-11	2003-08-13	Xention Discovery Ltd	Compounds
GB0525164D0 (en) *	2005-12-09	2006-01-18	Xention Discovery Ltd	Compounds
WO2009041591A1 (ja) *	2007-09-28	2009-04-02	Kyowa Hakko Kirin Co., Ltd.	縮環ピリジン誘導体
GB0815781D0 (en) *	2008-08-29	2008-10-08	Xention Ltd	Novel potassium channel blockers
WO2010054285A2 (en) *	2008-11-10	2010-05-14	National Health Research Institutes	Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors
EP2473487B1 (de)	2009-09-03	2016-10-26	Bristol-Myers Squibb Company	Chinazoline als kaliumionenkanalhemmer
US20130317045A1 (en)	2010-09-01	2013-11-28	Ambit Biosciences Corporation	Thienopyridine and thienopyrimidine compounds and methods of use thereof
EP2611809A1 (de)	2010-09-01	2013-07-10	Ambit Biosciences Corporation	Azolopyridin- und azolopyrimidinverbindungen sowie verfahren zu ihrer verwendung
GB201105659D0 (en)	2011-04-01	2011-05-18	Xention Ltd	Compounds
AR090037A1 (es)	2011-11-15	2014-10-15	Xention Ltd	Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
EA201690089A1 (ru)	2013-06-11	2017-04-28	Латвийский Институт Органического Синтеза	ТИЕНО[2,3-b]ПИРИДИНЫ КАК МОДУЛЯТОРЫ СОСТОЯНИЯ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR960007566A (ko) *	1994-08-19	1996-03-22	김정규	신규한 퀴놀릴아민 유도체, 그의 제조방법 및 항부정맥제로서의 용도
EP0895994A3 (de) *	1997-08-05	1999-12-15	Hoechst Marion Roussel Deutschland GmbH	Sulfonamid-substituierte Pyranopyridine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
EP1240147A1 (de) *	1999-12-21	2002-09-18	Icagen, Inc.	Kaliumkanalblocker
AR035369A1 (es) *	2000-11-14	2004-05-12	Smithkline Beecham Plc	Derivados de tetrahidrobenzazepina composiciones farmaceuticas que los comprenden, el uso de dichos derivados en la fabricacion de medicamentos, e intermediarios utiles en la preparacion de dichos compuestos
GB0124848D0 (en) *	2001-10-16	2001-12-05	Celltech R&D Ltd	Chemical compounds
BR0311605A (pt) *	2002-06-06	2005-02-22	Boehringer Ingelheim Pharma	Compostos de amida de ácido 3-aminotieno[2,3-b]piridina-2-carboxìlico substituìdo e processos para preparação e seus usos

2005
- 2005-12-09 AT AT05818439T patent/ATE476434T1/de not_active IP Right Cessation
- 2005-12-09 JP JP2007544986A patent/JP5173429B2/ja not_active Expired - Fee Related
- 2005-12-09 EP EP05818439A patent/EP1879899B1/de not_active Expired - Lifetime
- 2005-12-09 WO PCT/GB2005/004753 patent/WO2006061642A1/en not_active Ceased

Also Published As

Publication number	Publication date
HK1109771A1 (en)	2008-06-20
EP1879899A1 (de)	2008-01-23
JP2008523042A (ja)	2008-07-03
EP1879899B1 (de)	2010-08-04
WO2006061642A1 (en)	2006-06-15
JP5173429B2 (ja)	2013-04-03

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Legal Events

Date	Code	Title	Description
2011-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties