ATE476436T1 - Synthese von combretastatin a-4 prodrugs - Google Patents

Synthese von combretastatin a-4 prodrugs

Info

Publication number: ATE476436T1
Authority: AT; Austria
Prior art keywords: combretastatin; prodrugs; synthesis; water soluble; derivatives
Prior art date: 1998-01-09

Application number

AT99902121T

Other languages

English (en)

Inventor

George Pettit

Monte Rhodes

Original Assignee

Univ Arizona

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-09

Filing date

1999-01-08

Publication date

2010-08-15

1999-01-08 Application filed by Univ Arizona filed Critical Univ Arizona

2010-08-15 Application granted granted Critical

2010-08-15 Publication of ATE476436T1 publication Critical patent/ATE476436T1/de

Links

HVXBOLULGPECHP-WAYWQWQTSA-N Combretastatin A4 Chemical compound C1=C(O)C(OC)=CC=C1\C=C/C1=CC(OC)=C(OC)C(OC)=C1 HVXBOLULGPECHP-WAYWQWQTSA-N 0.000 title abstract 5
229960005537 combretastatin A-4 Drugs 0.000 title abstract 3
HVXBOLULGPECHP-UHFFFAOYSA-N combretastatin A4 Natural products C1=C(O)C(OC)=CC=C1C=CC1=CC(OC)=C(OC)C(OC)=C1 HVXBOLULGPECHP-UHFFFAOYSA-N 0.000 title abstract 3
229940002612 prodrug Drugs 0.000 title abstract 2
239000000651 prodrug Substances 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
229940034982 antineoplastic agent Drugs 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000012910 preclinical development Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT99902121T 1998-01-09 1999-01-08 Synthese von combretastatin a-4 prodrugs ATE476436T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US7107098P	1998-01-09	1998-01-09
US11153198P	1998-12-09	1998-12-09
PCT/US1999/000419 WO1999035150A1 (en)	1998-01-09	1999-01-08	Synthesis of combretastatin a-4 prodrugs and trans-isomers thereo f

Publications (1)

Publication Number	Publication Date
ATE476436T1 true ATE476436T1 (de)	2010-08-15

Family

ID=26751799

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99902121T ATE476436T1 (de)	1998-01-09	1999-01-08	Synthese von combretastatin a-4 prodrugs

Country Status (7)

Country	Link
US (3)	US7018987B1 (de)
EP (1)	EP1045853B1 (de)
JP (1)	JP2002500227A (de)
AT (1)	ATE476436T1 (de)
CA (1)	CA2314238C (de)
DE (1)	DE69942645D1 (de)
WO (1)	WO1999035150A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7018987B1 (en) *	1998-01-09	2006-03-28	Arizona Broad of Regents acting for and on behalf of Arizona State University	Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof
WO2000009101A2 (en) *	1998-08-11	2000-02-24	Entremed, Inc.	Use of estrogenic compounds as anti-fungal agents
US7087592B1 (en)	1999-08-23	2006-08-08	Entre Med, Inc.	Compositions comprising purified 2-methoxyestradiol and methods of producing same
PT1278758E (pt)	2000-04-27	2011-12-22	Univ Arizona	Pró-fármacos de fosfato de combretastatina a-1 e fosfato de combretastatina b-1
US6743937B2 (en)	2000-07-17	2004-06-01	Oxigene, Inc.	Efficient method of synthesizing combretastatin A-4 prodrugs
GB0019944D0 (en) *	2000-08-15	2000-09-27	Angiogene Pharm Ltd	Compositions with vascular damaging activity
US7135581B2 (en)	2000-08-18	2006-11-14	Entremed, Inc.	Antiangiogenic agents
US20050153939A1 (en)	2003-09-10	2005-07-14	Bristol-Myers Squibb Company	Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts
DK1320534T3 (da) *	2000-09-14	2005-08-22	Bristol Myers Squibb Co	Combrestatin A-4-phosphat-prodrugsalte med nitrogenholdige forbindelser
US6670344B2 (en) *	2000-09-14	2003-12-30	Bristol-Myers Squibb Company	Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts
CA2432640A1 (en) *	2000-12-21	2002-06-27	Cancer Research Technology Limited	Substituted stilbenes, their reactions and anticancer activity
JP2004523517A (ja)	2000-12-22	2004-08-05	ブリストル−マイヤーズスクイブカンパニー	腫瘍増殖および転移を調節するための方法
AU2002246756A1 (en)	2000-12-26	2002-08-06	Bristol-Myers Squibb Company	Use of combretastatin a4 and its prodrugs as an immune enhancing therapy
EP1395265A4 (de)	2001-06-15	2005-08-10	Univ Arizona	Combretastatin a-3 pro-arzneimittel
CA2453442C (en) *	2001-07-13	2011-02-01	Oxigene, Inc.	Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases
JP2005507912A (ja) *	2001-10-26	2005-03-24	オキシジーン，インコーポレイテッド	改良型血管標的化剤としての官能化スチルベン誘導体
WO2003059855A1 (en) *	2001-12-21	2003-07-24	Arizona Board Of Regents	Synthesis of combretastatin a-2 prodrugs
US20040127467A1 (en) *	2002-04-17	2004-07-01	Pettit George R	Synthesis of pancratistatin prodrugs
US7358236B1 (en) *	2002-06-21	2008-04-15	Oxigene, Inc.	Control of acute hypertension and cardiotoxicity in patients treated with vascular targeting agents
US20090137687A1 (en) *	2003-02-28	2009-05-28	Oxigene, Inc.	Compositions and Methods With Enhanced Therapeutic Activity
CN1907989B (zh) *	2005-08-02	2011-08-17	浙江天皇药业有限公司	毛兰素盐及其制备方法和包含其的药物组合物
EP1933848A2 (de) *	2005-10-06	2008-06-25	Innate Pharma	Phosphoantigen-salze von organischen basen und verfahren zu ihrer kristallisation
CN101085743B (zh)	2006-06-06	2012-02-15	浙江大德药业集团有限公司	含氟烷氧基康普立停衍生物及制法和用途
US20080214509A1 (en) *	2007-03-02	2008-09-04	Robert Kerbel	Methods for enhancing the efficacy of vascular disrupting agents
US20090192098A1 (en) *	2007-11-21	2009-07-30	Oxigene, Inc.	Method for treating hematopoietic neoplasms
US9353150B2 (en)	2012-12-04	2016-05-31	Massachusetts Institute Of Technology	Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
US10201623B2 (en)	2013-03-15	2019-02-12	Memorial Sloan Kettering Cancer Center	HSP90-targeted cardiac imaging and therapy
WO2016130969A1 (en)	2015-02-13	2016-08-18	George Robert Pettit	Silstatin compounds
WO2017031157A1 (en)	2015-08-18	2017-02-23	Mateon Therapeutics, Inc.	Use of vdas to enhance immunomodulating therapies against tumors
WO2017197045A1 (en)	2016-05-11	2017-11-16	Movassaghi Mohammad	Convergent and enantioselective total synthesis of communesin analogs
US12552763B2 (en)	2017-02-02	2026-02-17	Bioventures, Llc	Methods of protecting against neurodegeneration
WO2018209239A1 (en)	2017-05-11	2018-11-15	Massachusetts Institute Of Technology	Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en)	2017-10-13	2020-05-05	Massachusetts Institute Of Technology	Diazene directed modular synthesis of compounds with quaternary carbon centers
US11629167B2 (en)	2017-11-09	2023-04-18	Arizona Board Of Regents On Behalf Of Arizona State University	Betulastatin compounds
WO2020247054A1 (en)	2019-06-05	2020-12-10	Massachusetts Institute Of Technology	Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
WO2022182415A1 (en)	2021-02-24	2022-09-01	Massachusetts Institute Of Technology	Himastatin derivatives, and processes of preparation thereof, and uses thereof
CN113520995B (zh) *	2021-08-16	2023-03-10	海南鑫开源医药科技有限公司	一种离子敏感型眼用原位凝胶、其制备方法及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4996237A (en) *	1987-01-06	1991-02-26	Arizona Board Of Regents	Combretastatin A-4
GB9106177D0 (en) *	1991-03-22	1991-05-08	Aston Molecules Ltd	Substituted diphenylethylenes and analogues or derivatives thereof
US5484799A (en) *	1993-12-09	1996-01-16	Abbott Laboratories	Antifungal dorrigocin derivatives
US5561122A (en) *	1994-12-22	1996-10-01	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Combretastatin A-4 prodrug
US7018987B1 (en) *	1998-01-09	2006-03-28	Arizona Broad of Regents acting for and on behalf of Arizona State University	Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof

1999
- 1999-01-08 US US09/582,950 patent/US7018987B1/en not_active Expired - Fee Related
- 1999-01-08 WO PCT/US1999/000419 patent/WO1999035150A1/en not_active Ceased
- 1999-01-08 CA CA002314238A patent/CA2314238C/en not_active Expired - Fee Related
- 1999-01-08 AT AT99902121T patent/ATE476436T1/de not_active IP Right Cessation
- 1999-01-08 JP JP2000527548A patent/JP2002500227A/ja not_active Ceased
- 1999-01-08 DE DE69942645T patent/DE69942645D1/de not_active Expired - Lifetime
- 1999-01-08 EP EP99902121A patent/EP1045853B1/de not_active Expired - Lifetime
2006
- 2006-02-27 US US11/364,733 patent/US7279466B2/en not_active Expired - Fee Related
2007
- 2007-10-08 US US11/868,913 patent/US7557096B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1045853A4 (de)	2002-04-17
JP2002500227A (ja)	2002-01-08
US7557096B2 (en)	2009-07-07
EP1045853A1 (de)	2000-10-25
DE69942645D1 (en)	2010-09-16
WO1999035150A1 (en)	1999-07-15
US7018987B1 (en)	2006-03-28
CA2314238C (en)	2008-09-02
EP1045853B1 (de)	2010-08-04
US20080146528A1 (en)	2008-06-19
US20070073077A1 (en)	2007-03-29
US7279466B2 (en)	2007-10-09
CA2314238A1 (en)	1999-07-15

Legal Events

Date	Code	Title	Description
2011-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE476436T1 (de)	2010-08-15	Synthese von combretastatin a-4 prodrugs
EA199900937A1 (ru)	2000-08-28	Фармацевтические композиции, содержащие вориконазол
ATE270817T1 (de)	2004-07-15	Fungizide
GT199900019A (es)	2000-08-04	Formulas farmaceuticamente estables de solucion de oxaliplatino.
TNSN00200A1 (fr)	2002-05-30	Derives d'ethers de biaryle nouveaux, compositions les contenant et leur utilisation
DE69830504D1 (de)	2005-07-14	Antithrombotische mitteln
PT94085A (pt)	1991-01-08	Processo para a preparacao de derivados de amino-fenol anti-inflamatorios
GT199900040A (es)	2000-09-06	Biciclo [2.2.1] heptanos y compuestos relacionados.
PL309197A1 (en)	1995-09-18	Novel compositions based on taxoides
PT831837E (pt)	2003-09-30	Utilizacao de esqualamina no fabrico de um medicamento para inibicao de nhe
EP0999834A4 (de)	2001-04-04	Antithrombosemittel
ATE260237T1 (de)	2004-03-15	Racemisch sertralin synthese
DK1124842T3 (da)	2003-09-22	Betulinsyrederivater anvendelige til behandling af neuroektodermale tumorer
ES2097174T3 (es)	1997-04-01	Derivados de la 2-ciclohexan-1-il amina.
DK1100789T3 (da)	2005-05-23	Substituerede benzoylcyclohexandioner
ES2121993T3 (es)	1998-12-16	Derivados de 4-oxo-2-tioxoimidazolidina como sustancias inhibidoras de la agregacion de plaquetas sanguineas.
ATE345349T1 (de)	2006-12-15	Purinderivate
UA66866C2 (uk)	2004-06-15	Синтез морфолінових похідних
BR0114380A (pt)	2003-12-30	Derivados-1-aminobutan-3-ol-substituìdos
ES2019244A6 (es)	1991-06-01	Procedimiento para preparar nuevos derivados sulfonilicos de tieno-triazolo-diazepina>
ES2185196T3 (es)	2003-04-16	Un procedimiento para la preparacion de tetraazamacrociclos.
TR200400293T4 (tr)	2004-04-21	9-dihidro-13-asetilbasatin III'e ait suda çözünebilir 9-dihidro-paklitaksel türevlerinin sentezi.
IT1318547B1 (it)	2003-08-27	Impiego dell'aloe-emodin nel trattamento di patologie neoplastiche diorigine neuroectodermica.
DE59910585D1 (en)	2004-10-28	3,4-dihydrochinolin-derivative als stickstoffmonoxid-synthase (nos) inhibitoren
ES2138367T3 (es)	2000-01-01	Procedimiento para la fabricacion de agentes de contraste yodados.