DK1124842T3 - Betulinsyrederivater anvendelige til behandling af neuroektodermale tumorer - Google Patents

Betulinsyrederivater anvendelige til behandling af neuroektodermale tumorer

Info

Publication number: DK1124842T3
Authority: DK; Denmark
Prior art keywords: treatment; neuroectodermal tumors; betulinic acid; acid derivatives; derivatives useful
Prior art date: 1998-10-28

Application number

DK99955899T

Other languages

English (en)

Inventor

Klaus Michael Debatin

Simone Fulda

Manfred Wiessler

Marek Los

Walter Mier

Original Assignee

Deutsches Krebsforsch

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-28

Filing date

1999-10-28

Publication date

2003-09-22

1999-10-28 Application filed by Deutsches Krebsforsch filed Critical Deutsches Krebsforsch

2003-09-22 Application granted granted Critical

2003-09-22 Publication of DK1124842T3 publication Critical patent/DK1124842T3/da

Links

208000009277 Neuroectodermal Tumors Diseases 0.000 title abstract 5
QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical class C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 title abstract 4
QGJZLNKBHJESQX-UHFFFAOYSA-N 3-Epi-Betulin-Saeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(=C)C)C5C4CCC3C21C QGJZLNKBHJESQX-UHFFFAOYSA-N 0.000 abstract 3
CLOUCVRNYSHRCF-UHFFFAOYSA-N 3beta-Hydroxy-20(29)-Lupen-3,27-oic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C(O)=O)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C CLOUCVRNYSHRCF-UHFFFAOYSA-N 0.000 abstract 3
DIZWSDNSTNAYHK-XGWVBXMLSA-N Betulinic acid Natural products CC(=C)[C@@H]1C[C@H]([C@H]2CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(=O)O DIZWSDNSTNAYHK-XGWVBXMLSA-N 0.000 abstract 3
PZXJOHSZQAEJFE-UHFFFAOYSA-N dihydrobetulinic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(C)C)C5C4CCC3C21C PZXJOHSZQAEJFE-UHFFFAOYSA-N 0.000 abstract 3
MQYXUWHLBZFQQO-UHFFFAOYSA-N nepehinol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C MQYXUWHLBZFQQO-UHFFFAOYSA-N 0.000 abstract 3
239000003795 chemical substances by application Substances 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000000973 chemotherapeutic effect Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)

DK99955899T 1998-10-28 1999-10-28 Betulinsyrederivater anvendelige til behandling af neuroektodermale tumorer DK1124842T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/182,588 US6369109B1 (en)	1998-10-28	1998-10-28	Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumor
PCT/EP1999/008196 WO2000024762A1 (en)	1998-10-28	1999-10-28	Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumors

Publications (1)

Publication Number	Publication Date
DK1124842T3 true DK1124842T3 (da)	2003-09-22

Family

ID=22669114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99955899T DK1124842T3 (da)	1998-10-28	1999-10-28	Betulinsyrederivater anvendelige til behandling af neuroektodermale tumorer

Country Status (9)

Country	Link
US (1)	US6369109B1 (da)
EP (1)	EP1124842B1 (da)
AT (1)	ATE241641T1 (da)
AU (1)	AU1266900A (da)
DE (1)	DE69908397T2 (da)
DK (1)	DK1124842T3 (da)
ES (1)	ES2201800T3 (da)
PT (1)	PT1124842E (da)
WO (1)	WO2000024762A1 (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1292562A1 (en) *	2000-05-23	2003-03-19	Univerzita palackeho V Olomouci	Triterpenoid derivatives
GB2362649A (en) *	2000-05-25	2001-11-28	Univerzita Palackeho V Olomouc	Triterpenoid derivatives
GB0012528D0 (en)	2000-05-23	2000-07-12	Univ Palackeho	Triterpenoid derivatives
JP2004509972A (ja) *	2000-09-29	2004-04-02	リージェンツ　オブ　ザ　ユニバーシティ　オブ　ミネソタ	酵母に対する殺真菌活性を有するトリテルペン
US6689767B2 (en)	2000-09-29	2004-02-10	Regents Of The University Of Minnesota	Triterpenes having antibacterial activity
US6951847B2 (en)	2000-09-29	2005-10-04	Regents Of The University Of Minnesota	Methods of treating fungal infections using lupeol
EP1476031A1 (en) *	2001-05-11	2004-11-17	University of Ottawa	Anxiolytic marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods
AU2002367429A1 (en) *	2001-12-28	2003-07-24	The Nisshin Oillio, Ltd.	Apoptosis inductor
US7041309B2 (en) *	2002-06-13	2006-05-09	Neuropro Technologies, Inc.	Spinal fusion using an HMG-CoA reductase inhibitor
EP1594885B8 (de)	2003-02-11	2009-03-25	Novelix Pharmaceuticals, Inc.	Medikament zur wachstumsinhibierung von tumoren
US7026305B2 (en) *	2003-04-14	2006-04-11	Meharry Medical College	Anti-HIV agents with dual sites of action
WO2005112929A2 (en) *	2004-05-20	2005-12-01	Cornell Research Foundation, Inc.	Anti-hiv-1 activity of betulinol derivatives
US7282521B2 (en) *	2004-05-24	2007-10-16	University Of North Carolina At Chapel Hill	Anti-retroviral moronic acid derivatives
WO2006081371A2 (en) *	2005-01-27	2006-08-03	Research Development Foundation	Combination therapy with triterpenoid compounds and proteasome inhibitors
US20070232577A1 (en) *	2006-03-23	2007-10-04	Advanced Life Sciences, Inc.	Synthetic pentacyclic triterpenoids and derivatives of betulinic acid and betulin
CA2586614A1 (en) *	2006-10-27	2008-04-27	Universite Du Quebec A Chicoutimi	Triterpenes derivatives and uses thereof as antitumor agents or anti-inflammatory agents
RU2317996C1 (ru) *	2006-10-30	2008-02-27	Институт нефтехимии и катализа РАН	N'-{n-[3-оксо-лупан-28-оил]-9-аминононаноил}-3-амино-3-фенил-пропионовая кислота и ее соли как противовирусные и иммуностимулирующие агенты
CZ200851A3 (cs) *	2008-01-30	2009-10-21	Institut Of Organic Chemistry, Polish Academy Of Sciences	Sacharidové deriváty lupanu, jejich použití a farmaceutické prípravky obsahující tyto deriváty
SG193860A1 (en)	2008-06-04	2013-10-30	Amgen Inc	Fgf21 mutants and uses thereof
WO2010028487A1 (en) *	2008-09-10	2010-03-18	Université Du Québec À Chicoutimi	Bidesmosidic betulin and betulinic acid derivatives and uses thereof as antitumor agents
WO2010053817A1 (en) *	2008-11-04	2010-05-14	Trustees Of Dartmouth College	Betulinic acid derivatives and methods of use thereof
CZ2008723A3 (cs) *	2008-11-13	2010-01-13	Univerzita Palackého v Olomouci	2-Deoxyglykosidy triterpenoidu, zpusob jejich prípravy a jejich použití jako lécivo
WO2011077253A2 (en)	2009-12-23	2011-06-30	Marvel World Trade Ltd	Start-up supply
JP6109817B2 (ja)	2011-05-16	2017-04-05	マーベルワールドトレードリミテッド	高電圧スタートアップ回路を用いたシステムおよび方法
US8742735B2 (en)	2011-05-16	2014-06-03	Marvell World Trade Ltd.	High-voltage startup circuit
RU2468031C1 (ru) *	2011-11-02	2012-11-27	Учреждение Российской академии наук Институт химии и химической технологии Сибирского отделения РАН (ИХХТ СО РАН)	Способ получения 3,28-дисульфата бетулина
RU2477285C1 (ru) *	2012-03-23	2013-03-10	Федеральное Государственное Бюджетное Учреждение Науки Институт Химии И Химической Технологии Сибирского Отделения Российской Академии Наук (Иххт Со Ран)	Способ получения 3-ацетата-28-сульфата бетулина
CN103768078B (zh)	2012-10-22	2019-02-05	北京大学	三萜衍生物及其抗流感用途
CN104910239B (zh) *	2014-03-14	2018-12-07	中国科学院上海药物研究所	五环三萜类化合物及其制备方法、药物组合物和用途
CN114133424B (zh) *	2020-09-03	2023-07-18	沈阳药科大学	三萜类化合物及其制备方法和应用
EP4472994A4 (en) *	2022-02-02	2026-04-08	Sang Hyun Pyo	NEW BETULIN DERIVATIVES, THEIR MANUFACTURING PROCESS AND THEIR USE AS SURFACTANTS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5658947A (en)	1995-03-21	1997-08-19	Board Of Trustees Of The University Of Illinois	Method and composition for selectively inhibiting melanoma using betalinic acid
US5962527A (en) *	1995-03-21	1999-10-05	The Board Of Trustees Of The University Of Illinois	Method and composition for treating cancers
US5869535A (en)	1995-03-21	1999-02-09	The Board Of Trustees Of The University Of Illinois	Method and composition for selectively inhibiting melanoma
KR100205045B1 (ko)	1996-12-05	1999-06-15	김송배	신규한 트리테르펜 글리코사이드 화합물, 그의 제조방법 및 그를 함유하는 항암제 조성물

1998
- 1998-10-28 US US09/182,588 patent/US6369109B1/en not_active Expired - Lifetime
1999
- 1999-10-28 EP EP99955899A patent/EP1124842B1/en not_active Expired - Lifetime
- 1999-10-28 PT PT99955899T patent/PT1124842E/pt unknown
- 1999-10-28 AU AU12669/00A patent/AU1266900A/en not_active Abandoned
- 1999-10-28 DK DK99955899T patent/DK1124842T3/da active
- 1999-10-28 ES ES99955899T patent/ES2201800T3/es not_active Expired - Lifetime
- 1999-10-28 AT AT99955899T patent/ATE241641T1/de not_active IP Right Cessation
- 1999-10-28 DE DE69908397T patent/DE69908397T2/de not_active Expired - Lifetime
- 1999-10-28 WO PCT/EP1999/008196 patent/WO2000024762A1/en not_active Ceased

Also Published As

Publication number	Publication date
DE69908397T2 (de)	2004-04-01
DE69908397D1 (de)	2003-07-03
ES2201800T3 (es)	2004-03-16
AU1266900A (en)	2000-05-15
PT1124842E (pt)	2003-10-31
WO2000024762A1 (en)	2000-05-04
EP1124842A1 (en)	2001-08-22
EP1124842B1 (en)	2003-05-28
ATE241641T1 (de)	2003-06-15
US6369109B1 (en)	2002-04-09

Publication	Publication Date	Title
DE69908397D1 (de)	2003-07-03	Betulinsäure derivate zur behandlung von neuroektodermalen tumoren
DE60118003D1 (de)	2006-05-11	Harnstoffderivate und ihre verwendung
DE69830504D1 (de)	2005-07-14	Antithrombotische mitteln
PT896533E (pt)	2004-02-27	Pentafluorobenzenosulfonamidas e analogos
ATE366721T1 (de)	2007-08-15	Indolinderivate als progesteron antagonisten
EA200300293A1 (ru)	2003-08-28	Противовоспалительные конденсированные пирролокарбазолы
ATE306261T1 (de)	2005-10-15	Antithrombosemittel
ATE309237T1 (de)	2005-11-15	Aromatische heterozyklische verbindungen als antientzündungwirkstoffe
HK1056181A1 (zh)	2004-02-06	作為抗炎劑的17β-硫代羧酸酯17α-芳基羰氧基氧雄甾烷衍生物
ATE263157T1 (de)	2004-04-15	Nematizide trifluorbutene
BG66084B1 (bg)	2011-03-31	Циклопентаноиндоли, състави,съдържащи такива съединения и използването им
DK0939627T3 (da)	2003-10-13	Pentaflourbenzensulfonamider og analoger
ATE277929T1 (de)	2004-10-15	Immunsuppressive wirkungen von pteridinderivaten
ES2243579T3 (es)	2005-12-01	Derivados de pirazolopirideno.
DE60121461D1 (de)	2006-08-24	Kondensierte pyridoindolderivate
ATE404552T1 (de)	2008-08-15	Substituierte isochinolinderivate und anwendungsverfahren
EA200300716A1 (ru)	2003-12-25	Гетероциклилалкилиндольные или -азаиндольные соединения в качестве лиганд 5-гидрокситриптамина-6
SE9804212D0 (sv)	1998-12-04	Compounds
UY26426A1 (es)	2001-05-31	Nuevos compuestos
BR0212899A (pt)	2004-11-03	Compostos orgânicos
TR199902094T2 (xx)	1999-12-21	3-Heteroareil-4(3H)-kinazolinonlar�n atropizomerleri.
ATE266029T1 (de)	2004-05-15	Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung
SE9604582D0 (sv)	1996-12-13	Novel compounds
TR199900523T2 (xx)	1999-05-21	Vir�s k�kenli hastal�klar�n tedavisi i�in farmas�tik bile�imler.
DE60204014D1 (de)	2005-06-09	Chlormethylierung von thiophene