ATE478084T1 - Verfahren zur herstellung von 4'- azidocytidinderivaten - Google Patents

Verfahren zur herstellung von 4'- azidocytidinderivaten

Info

Publication number
ATE478084T1
ATE478084T1 AT07847643T AT07847643T ATE478084T1 AT E478084 T1 ATE478084 T1 AT E478084T1 AT 07847643 T AT07847643 T AT 07847643T AT 07847643 T AT07847643 T AT 07847643T AT E478084 T1 ATE478084 T1 AT E478084T1
Authority
AT
Austria
Prior art keywords
azidocytidine
derivatives
producing
mediated diseases
treating
Prior art date
Application number
AT07847643T
Other languages
English (en)
Inventor
Peter John Harrington
Stefan Hildbrand
Keshab Sarma
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE478084T1 publication Critical patent/ATE478084T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT07847643T 2006-12-11 2007-12-03 Verfahren zur herstellung von 4'- azidocytidinderivaten ATE478084T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125768 2006-12-11
PCT/EP2007/063132 WO2008071571A1 (en) 2006-12-11 2007-12-03 Process for preparation of 4'-azido cytidine derivatives

Publications (1)

Publication Number Publication Date
ATE478084T1 true ATE478084T1 (de) 2010-09-15

Family

ID=39111615

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07847643T ATE478084T1 (de) 2006-12-11 2007-12-03 Verfahren zur herstellung von 4'- azidocytidinderivaten

Country Status (9)

Country Link
US (1) US7632940B2 (de)
EP (1) EP2102221B1 (de)
JP (1) JP2010512365A (de)
CN (1) CN101541818B (de)
AT (1) ATE478084T1 (de)
CA (1) CA2671306C (de)
DE (1) DE602007008616D1 (de)
ES (1) ES2348687T3 (de)
WO (1) WO2008071571A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2619215B1 (de) 2010-09-22 2018-09-05 Alios Biopharma, Inc. Azido-nukleoside und nukleotidanaloga
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
AR088441A1 (es) 2011-09-12 2014-06-11 Idenix Pharmaceuticals Inc Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales
CN102286047A (zh) * 2011-09-14 2011-12-21 郑州大学 2’-脱氧-2’-氟-4’-三氮唑取代-β-D胞苷类似物、其制备方法及其应用
US8507460B2 (en) 2011-10-14 2013-08-13 Idenix Pharmaceuticals, Inc. Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
AU2012357940B2 (en) * 2011-12-20 2017-02-16 Riboscience Llc 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
JP6165848B2 (ja) 2012-05-22 2017-07-19 イデニク ファーマシューティカルズ エルエルシー 肝疾患のためのｄ−アミノ酸化合物
WO2013177188A1 (en) 2012-05-22 2013-11-28 Idenix Pharmaceuticals, Inc. 3',5'-cyclic phosphoramidate prodrugs for hcv infection
US9296778B2 (en) 2012-05-22 2016-03-29 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphate prodrugs for HCV infection
MX2014014323A (es) 2012-05-25 2015-02-12 Janssen R & D Ireland Nucleosidos de espirooxetano de uracilo.
WO2014052638A1 (en) 2012-09-27 2014-04-03 Idenix Pharmaceuticals, Inc. Esters and malonates of sate prodrugs
EP2906579B1 (de) 2012-10-08 2018-04-18 Idenix Pharmaceuticals LLC. 2'-chlor-nukleosidanaloga für hcv-infektion
US10723754B2 (en) 2012-10-22 2020-07-28 Idenix Pharmaceuticals Llc 2′,4′-bridged nucleosides for HCV infection
EP2935304A1 (de) 2012-12-19 2015-10-28 IDENIX Pharmaceuticals, Inc. 4'-fluor-nukleoside zur behandlung von hcv
WO2014137930A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. Thiophosphate nucleosides for the treatment of hcv
WO2014137926A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. 3'-deoxy nucleosides for the treatment of hcv
WO2014160484A1 (en) 2013-03-13 2014-10-02 Idenix Pharmaceuticals, Inc. Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
EP2981542B1 (de) 2013-04-01 2021-09-15 Idenix Pharmaceuticals LLC 2',4'-fluor-nukleoside zur behandlung von hcv
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
WO2015017713A1 (en) 2013-08-01 2015-02-05 Idenix Pharmaceuticals, Inc. D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
US10202411B2 (en) 2014-04-16 2019-02-12 Idenix Pharmaceuticals Llc 3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV
US20240166680A1 (en) * 2021-04-15 2024-05-23 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Nucleoside analog and use thereof
CN114656512B (zh) * 2022-03-07 2022-12-06 安徽瑞拜药业有限公司 一种规模化寡核酸生产用氨解装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07103149B2 (ja) * 1987-11-30 1995-11-08 ヤマサ醤油株式会社 シトシン誘導体の製造法
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
WO2004013300A2 (en) * 2002-08-01 2004-02-12 Pharmasset Inc. Compounds with the bicyclo[4.2.1]nonane system for the treatment of flaviviridae infections
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
JP2006527719A (ja) * 2003-06-19 2006-12-07 エフ．ホフマン−ラ　ロシュ　アーゲー ４’−アジドヌクレオシド誘導体の調製方法

Also Published As

Publication number Publication date
WO2008071571A1 (en) 2008-06-19
EP2102221A1 (de) 2009-09-23
JP2010512365A (ja) 2010-04-22
DE602007008616D1 (de) 2010-09-30
US20080161550A1 (en) 2008-07-03
EP2102221B1 (de) 2010-08-18
CA2671306A1 (en) 2008-06-19
US7632940B2 (en) 2009-12-15
CN101541818A (zh) 2009-09-23
CN101541818B (zh) 2012-03-21
ES2348687T3 (es) 2010-12-10
CA2671306C (en) 2011-04-19

Similar Documents

Publication Publication Date Title
ATE478084T1 (de) Verfahren zur herstellung von 4'- azidocytidinderivaten
ATE475655T1 (de) Verfahren zur herstellung von (s)-4- fluormethyldihydrofuran-2-on
ATE459638T1 (de) Verfahren zur herstellung makrocyclischer dipeptide, die sich für die behandlung von hepatitis-c-virusinfektionen eignen
ATE547417T1 (de) Dihydropyrimidinverbindungen und ihre verwendungen bei der herstellung von medikamenten zur behandlung und prävention antiviraler krankheiten
EA200600621A1 (ru) Производные тетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
CY1111327T1 (el) Υποκατεστημενα παραγωγα κυκλοεξυλοξεικου οξεος
ATE548353T1 (de) Verfahren zur herstellung von substituierte n- aryl-n'-ä3-(1h-pyrazol-5-yl)phenylü-harnstoffe and intermediate davon.
DE602004019897D1 (de) Verfahren zur racematspaltung von 2,4-diamino-3,6-dihydro-1,3,5-triazinen, die sich zur behandlung vkrankungen eignen
DE60312029D1 (de) Verfahren zur herstellung c-7 substituierter 5-androstene
ATE407127T1 (de) Verfahren zur herstellung von beraprost und dessen salzen
BRPI0517032A (pt) compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento e/ou prevenção de enfermidades e utilização desses compostos
ATE250057T1 (de) Verfahren zur herstellung von 1-(1h)- benzoquinolizin-3-on derivaten
ATE542810T1 (de) Verfahren zur herstellung von 3,5-di-omikron-acyl-2-fluor-2-c-methyl-d-ribono gamma-lacton
TW200633977A (en) Novel process for the manufacture of 3-pyrrolidin-2-yl-propionic acid derivatives
ATE515496T1 (de) Verfahren zur herstellung von enantiomerenangereicherter indolin-2-carbonsäure
ES2333026T3 (es) Derivados de ciclohexil-1,4-diamina sustituidos.
ATE447567T1 (de) Verfahren zur herstellung von tryptase- inhibitoren
ATE415404T1 (de) Lösungsmittelfreies verfahren zur herstellung von diketopyrrolopyrrol-derivaten
ATE496038T1 (de) Verfahren zur herstellung von quetiapin
DE602007005077D1 (de) Verfahren zur Herstellung von Pyridinmethylsulphinylverbindungen
DE60107292D1 (de) Verfahren zur herstellung von (+)-trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidin
DE602004008486D1 (de) Verfahren zur herstellung von (1s,4r)-cis-4-ä2-amino-6-chlor-9h-purin-9-ylü-2-cyclopenten-1-methanol
ATE399757T1 (de) Neues verfahren zur herstellung von nitrooxyderivaten von paracetamol
ATE390400T1 (de) Verfahren zur herstellung von alpha'-chlorketonen
ATE515502T1 (de) Verfahren zur herstellung von tetranorlabdanderivaten

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties