ATE542810T1 - Verfahren zur herstellung von 3,5-di-omikron-acyl-2-fluor-2-c-methyl-d-ribono gamma-lacton - Google Patents

Verfahren zur herstellung von 3,5-di-omikron-acyl-2-fluor-2-c-methyl-d-ribono gamma-lacton

Info

Publication number: ATE542810T1
Authority: AT; Austria
Prior art keywords: methyl; ribono; lactone; acyl; omikron
Prior art date: 2006-12-18

Application number

AT07857390T

Other languages

English (en)

Inventor

Miall Cedilote

Thomas P Cleary

Hans Iding

Pingsheng Zhang

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-18

Filing date

2007-12-11

Publication date

2012-02-15

2007-12-11 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2012-02-15 Application granted granted Critical

2012-02-15 Publication of ATE542810T1 publication Critical patent/ATE542810T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
NYPIRLYMDJMKGW-VPCXQMTMSA-N 4-amino-1-[(2r,3r,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one Chemical compound C[C@@]1(F)[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)N=C(N)C=C1 NYPIRLYMDJMKGW-VPCXQMTMSA-N 0.000 abstract 1
208000005176 Hepatitis C Diseases 0.000 abstract 1
241000700605 Viruses Species 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT07857390T 2006-12-18 2007-12-11 Verfahren zur herstellung von 3,5-di-omikron-acyl-2-fluor-2-c-methyl-d-ribono gamma-lacton ATE542810T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US87561706P	2006-12-18	2006-12-18
PCT/EP2007/063703 WO2008074693A2 (en)	2006-12-18	2007-12-11	Process for preparing 3,5-di-omicron-acyl-2-fluoro-2-c-methyl-d-ribono-gamma-lactone

Publications (1)

Publication Number	Publication Date
ATE542810T1 true ATE542810T1 (de)	2012-02-15

Family

ID=39433788

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07857390T ATE542810T1 (de)	2006-12-18	2007-12-11	Verfahren zur herstellung von 3,5-di-omikron-acyl-2-fluor-2-c-methyl-d-ribono gamma-lacton

Country Status (13)

Country	Link
US (1)	US7838693B2 (de)
EP (1)	EP2094679B1 (de)
JP (1)	JP5148627B2 (de)
KR (1)	KR101118413B1 (de)
CN (1)	CN101573349B (de)
AT (1)	ATE542810T1 (de)
AU (1)	AU2007336365B2 (de)
BR (1)	BRPI0720835A2 (de)
CA (1)	CA2671856C (de)
ES (1)	ES2379696T3 (de)
IL (1)	IL198801A (de)
MX (1)	MX2009006156A (de)
WO (1)	WO2008074693A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN103724301A (zh)	2012-10-10	2014-04-16	上海特化医药科技有限公司	(2r)-2-脱氧-2,2-二取代-1,4-核糖内酯及其制备方法和用途
AR094466A1 (es) *	2013-01-14	2015-08-05	Hoffmann La Roche	Proceso para la obtención de un derivado de fluorlactona
CN104918924B (zh) *	2013-01-14	2018-05-11	吉利德制药有限责任公司	制备氟代内酯衍生物的方法
CN105026382B (zh) *	2013-02-28	2016-10-19	中央硝子株式会社	(2R)-2-氟-2-C-甲基-D-核糖酸-γ-内酯的制造方法
JP6476591B2 (ja) *	2013-06-05	2019-03-06	セントラル硝子株式会社	（２Ｒ）−２−フルオロ−２−Ｃ−メチル−Ｄ−リボノ−γ−ラクトン類の製造方法
CN105085445B (zh) *	2015-08-11	2016-09-07	海门慧聚药业有限公司	索非布韦中间体的制备

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20030005167A (ko) *	2000-11-30	2003-01-17	다이셀 가가꾸 고교 가부시끼가이샤	전사 시트
US7799827B2 (en) *	2002-03-08	2010-09-21	Eisai Co., Ltd.	Macrocyclic compounds useful as pharmaceuticals
BRPI0419345B8 (pt) *	2003-05-30	2021-05-25	Gilead Pharmasset Llc	uso do (2r)-2-desoxi-2-flúor-2-c-metil nucleosídeo e de uma composição farmacêutica que o compreende
PT1773856E (pt) *	2004-07-21	2012-05-14	Gilead Pharmasset Llc	Preparação de 2-desoxi-2-fluoro-d-ribofuranosilo pirimidinas e purinas substituídas com alquilo e seus derivados
MX2007003085A (es) *	2004-09-14	2007-08-02	Pharmasset Inc	Preparacion de 2'-fluoro-2'-alquilo sustituido u otras ribofuranosil pirimidinas y purinas opcionalmente sustituidas y sus derivados.

2007
- 2007-12-11 MX MX2009006156A patent/MX2009006156A/es active IP Right Grant
- 2007-12-11 CA CA2671856A patent/CA2671856C/en not_active Expired - Fee Related
- 2007-12-11 JP JP2009541984A patent/JP5148627B2/ja not_active Expired - Fee Related
- 2007-12-11 AT AT07857390T patent/ATE542810T1/de active
- 2007-12-11 US US11/953,900 patent/US7838693B2/en not_active Expired - Fee Related
- 2007-12-11 ES ES07857390T patent/ES2379696T3/es active Active
- 2007-12-11 CN CN2007800467888A patent/CN101573349B/zh not_active Expired - Fee Related
- 2007-12-11 EP EP07857390A patent/EP2094679B1/de not_active Not-in-force
- 2007-12-11 WO PCT/EP2007/063703 patent/WO2008074693A2/en not_active Ceased
- 2007-12-11 BR BRPI0720835A patent/BRPI0720835A2/pt not_active IP Right Cessation
- 2007-12-11 AU AU2007336365A patent/AU2007336365B2/en not_active Ceased
- 2007-12-11 KR KR1020097012519A patent/KR101118413B1/ko not_active Expired - Fee Related
2009
- 2009-05-18 IL IL198801A patent/IL198801A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2379696T3 (es)	2012-04-30
IL198801A (en)	2013-08-29
IL198801A0 (en)	2010-02-17
JP2010513377A (ja)	2010-04-30
MX2009006156A (es)	2009-06-19
CN101573349B (zh)	2013-07-10
CN101573349A (zh)	2009-11-04
JP5148627B2 (ja)	2013-02-20
AU2007336365A1 (en)	2008-06-26
CA2671856A1 (en)	2008-06-26
EP2094679B1 (de)	2012-01-25
US20080145901A1 (en)	2008-06-19
EP2094679A2 (de)	2009-09-02
CA2671856C (en)	2015-02-10
WO2008074693A2 (en)	2008-06-26
WO2008074693A3 (en)	2008-10-30
BRPI0720835A2 (pt)	2015-09-29
KR101118413B1 (ko)	2012-03-07
AU2007336365B2 (en)	2013-03-07
KR20090080562A (ko)	2009-07-24
US7838693B2 (en)	2010-11-23

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