ATE478085T1 - Modifizierte oligonukleotide zur unterscheidung von fehlpaarungen - Google Patents
Modifizierte oligonukleotide zur unterscheidung von fehlpaarungenInfo
- Publication number
- ATE478085T1 ATE478085T1 AT01916372T AT01916372T ATE478085T1 AT E478085 T1 ATE478085 T1 AT E478085T1 AT 01916372 T AT01916372 T AT 01916372T AT 01916372 T AT01916372 T AT 01916372T AT E478085 T1 ATE478085 T1 AT E478085T1
- Authority
- AT
- Austria
- Prior art keywords
- modified oligonucleotides
- mismatches
- distinction
- pyrimidines
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18604600P | 2000-03-01 | 2000-03-01 | |
| US09/724,959 US6949367B1 (en) | 1998-04-03 | 2000-11-28 | Modified oligonucleotides for mismatch discrimination |
| PCT/US2001/006900 WO2001064958A2 (en) | 2000-03-01 | 2001-03-01 | Modified oligonucleotides for mismatch discrimination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE478085T1 true ATE478085T1 (de) | 2010-09-15 |
Family
ID=26881723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01916372T ATE478085T1 (de) | 2000-03-01 | 2001-03-01 | Modifizierte oligonukleotide zur unterscheidung von fehlpaarungen |
Country Status (8)
| Country | Link |
|---|---|
| EP (3) | EP1975256B1 (de) |
| JP (1) | JP2003525292A (de) |
| AT (1) | ATE478085T1 (de) |
| AU (1) | AU2001243403A1 (de) |
| CA (1) | CA2401781A1 (de) |
| DE (1) | DE60142828D1 (de) |
| ES (1) | ES2391213T3 (de) |
| WO (1) | WO2001064958A2 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4777401A (en) | 2000-03-27 | 2001-10-08 | Applera Corp | Improved invasion assay |
| WO2002012263A1 (en) * | 2000-08-03 | 2002-02-14 | Roche Diagnostics Gmbh | Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses |
| US6972339B2 (en) | 2001-09-07 | 2005-12-06 | Epoch Biosciences, Inc. | Compounds and methods for fluorescent labeling |
| US8569516B2 (en) | 2001-09-07 | 2013-10-29 | Elitech Holding B.V. | Compounds and methods for fluorescent labeling |
| US6818420B2 (en) | 2002-02-27 | 2004-11-16 | Biosource International, Inc. | Methods of using FET labeled oligonucleotides that include a 3′-5′ exonuclease resistant quencher domain and compositions for practicing the same |
| US7541454B2 (en) | 2003-10-24 | 2009-06-02 | Epoch Biosciences, Inc. | Compounds and methods for fluorescent labeling |
| ES2529256T3 (es) * | 2003-10-28 | 2015-02-18 | Epoch Biosciences, Inc. | Sondas fluorescentes para la detección de ADN mediante hibridación con una sensibilidad mejorada y baja señal de fondo |
| EP2087133A4 (de) * | 2006-11-22 | 2010-07-21 | Commw Scient Ind Res Org | Verbesserte hybridisierung von nukleinsäuren |
| WO2009048928A1 (en) * | 2007-10-09 | 2009-04-16 | Igor Vassily Kutyavin | Methods, compositions and kits for the improved detection of small rna molecules |
| EP3216874A1 (de) | 2008-09-05 | 2017-09-13 | TOMA Biosciences, Inc. | Verfahren zum stratifizieren und annotieren der behandlungsoptionen eines krebsmedikaments |
| WO2010078430A1 (en) | 2008-12-30 | 2010-07-08 | Arqule, Inc. | Substituted 1h-pyrazolo[3,4-d]pyrimidine-6-amine compounds |
| TW201100427A (en) | 2009-03-31 | 2011-01-01 | Arqule Inc | Substituted heterocyclic compounds |
| WO2011087707A1 (en) | 2009-12-22 | 2011-07-21 | Elitech Holding B.V. | Hypertheromostable endonuclease iv substrate probe |
| EP3572528A1 (de) | 2010-09-24 | 2019-11-27 | The Board of Trustees of the Leland Stanford Junior University | Direkte erfassung, amplifikation und sequenzierung einer ziel-dna unter verwendung immobilisierter primer |
| US8362023B2 (en) | 2011-01-19 | 2013-01-29 | Hoffmann-La Roche Inc. | Pyrazolo pyrimidines |
| ES2570591T3 (es) * | 2011-05-24 | 2016-05-19 | Elitechgroup B V | Detección de Staphylococcus aureus resistente a meticilina |
| US10590474B2 (en) | 2013-03-11 | 2020-03-17 | Elitechgroup B.V. | Methods for true isothermal strand displacement amplification |
| US20140255928A1 (en) | 2013-03-11 | 2014-09-11 | Elitech Holding B.V. | Methods for true isothermal strand displacement amplification |
| US10975423B2 (en) | 2013-03-11 | 2021-04-13 | Elitechgroup, Inc. | Methods for true isothermal strand displacement amplification |
| WO2014175974A2 (en) | 2013-03-13 | 2014-10-30 | Elitech Holding B.V. | Artificial nucleic acids |
| US10738346B2 (en) | 2017-03-09 | 2020-08-11 | Elitechgroup, Inc. | Nitrodiarylethenes as fluorescence quenchers for nucleic acid probes |
| WO2019036225A1 (en) | 2017-08-17 | 2019-02-21 | Elitechgroup, Inc. | FLUORESCENCE EXTINGUISHERS STABILIZING DUPLEX FOR NUCLEIC PROBES |
| EP3553182A1 (de) | 2018-04-11 | 2019-10-16 | Université de Bourgogne | Verfahren zum nachweis von somatischen genetischen anomalien, kombination von fangsonden und nachweiskit |
| US11155713B2 (en) | 2018-05-29 | 2021-10-26 | Elitechgroup, Inc. | Carborhodamine compounds and methods of preparation thereof |
| WO2021080629A1 (en) | 2019-10-23 | 2021-04-29 | Elitechgroup, Inc. | Methods for true isothermal strand displacement amplification |
| WO2022040027A1 (en) * | 2020-08-17 | 2022-02-24 | University Of Washington | Long-term dry storage of enzyme-based reagents in a porous matrix |
| JP7712517B1 (ja) * | 2024-03-19 | 2025-07-24 | 防衛装備庁長官 | ミスマッチ認識分子、ミスマッチ検出方法、疾病診断方法及びミスマッチ認識分子の製造方法 |
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| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4351760A (en) | 1979-09-07 | 1982-09-28 | Syva Company | Novel alkyl substituted fluorescent compounds and polyamino acid conjugates |
| US4358535A (en) | 1980-12-08 | 1982-11-09 | Board Of Regents Of The University Of Washington | Specific DNA probes in diagnostic microbiology |
| US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4868105A (en) | 1985-12-11 | 1989-09-19 | Chiron Corporation | Solution phase nucleic acid sandwich assay |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US6270961B1 (en) | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
| US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
| US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| US5585481A (en) | 1987-09-21 | 1996-12-17 | Gen-Probe Incorporated | Linking reagents for nucleotide probes |
| US5124246A (en) | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| US5824796A (en) | 1988-09-28 | 1998-10-20 | Epoch Pharmaceuticals, Inc. | Cross-linking oligonucleotides |
| WO1990003370A1 (en) * | 1988-09-28 | 1990-04-05 | Microprobe Corporation | DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE |
| US5849482A (en) * | 1988-09-28 | 1998-12-15 | Epoch Pharmaceuticals, Inc. | Crosslinking oligonucleotides |
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| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5177196A (en) | 1990-08-16 | 1993-01-05 | Microprobe Corporation | Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof |
| US5512667A (en) | 1990-08-28 | 1996-04-30 | Reed; Michael W. | Trifunctional intermediates for preparing 3'-tailed oligonucleotides |
| DE69132905T2 (de) | 1990-12-06 | 2002-08-01 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Detektion von Nukleinsäuresequenzen |
| US5766855A (en) | 1991-05-24 | 1998-06-16 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity and sequence specificity |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5419966A (en) | 1991-06-10 | 1995-05-30 | Microprobe Corporation | Solid support for synthesis of 3'-tailed oligonucleotides |
| US5512677A (en) | 1991-08-13 | 1996-04-30 | National Science Council | 3-substituted methyl-2,3-dihydroimidazo 1,2-c!quinazoline derivatives, the preparation and use thereof |
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| JPH11113571A (ja) * | 1997-10-14 | 1999-04-27 | Mitsubishi Chemical Corp | オリゴヌクレオチド及びその利用 |
| WO1999037085A2 (en) | 1998-01-16 | 1999-07-22 | Comsat Corporation | Arithmetic coding-based facsimile compression with error detection |
| US6127121A (en) * | 1998-04-03 | 2000-10-03 | Epoch Pharmaceuticals, Inc. | Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination |
| US6339147B1 (en) | 1999-07-29 | 2002-01-15 | Epoch Biosciences, Inc. | Attachment of oligonucleotides to solid supports through Schiff base type linkages for capture and detection of nucleic acids |
| US6727356B1 (en) | 1999-12-08 | 2004-04-27 | Epoch Pharmaceuticals, Inc. | Fluorescent quenching detection reagents and methods |
-
2001
- 2001-03-01 ES ES08075235T patent/ES2391213T3/es not_active Expired - Lifetime
- 2001-03-01 WO PCT/US2001/006900 patent/WO2001064958A2/en not_active Ceased
- 2001-03-01 AT AT01916372T patent/ATE478085T1/de not_active IP Right Cessation
- 2001-03-01 JP JP2001563645A patent/JP2003525292A/ja active Pending
- 2001-03-01 EP EP08075235A patent/EP1975256B1/de not_active Expired - Lifetime
- 2001-03-01 CA CA002401781A patent/CA2401781A1/en not_active Abandoned
- 2001-03-01 AU AU2001243403A patent/AU2001243403A1/en not_active Abandoned
- 2001-03-01 EP EP08075233A patent/EP1995330A1/de not_active Withdrawn
- 2001-03-01 EP EP01916372A patent/EP1261616B1/de not_active Expired - Lifetime
- 2001-03-01 DE DE60142828T patent/DE60142828D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1975256B1 (de) | 2012-07-11 |
| ES2391213T3 (es) | 2012-11-22 |
| WO2001064958A3 (en) | 2002-03-28 |
| EP1975256A1 (de) | 2008-10-01 |
| EP1261616A2 (de) | 2002-12-04 |
| CA2401781A1 (en) | 2001-09-07 |
| AU2001243403A1 (en) | 2001-09-12 |
| DE60142828D1 (de) | 2010-09-30 |
| JP2003525292A (ja) | 2003-08-26 |
| EP1995330A1 (de) | 2008-11-26 |
| EP1261616B1 (de) | 2010-08-18 |
| WO2001064958A2 (en) | 2001-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |