ATE478559T1 - Nachweis von protease und protease-aktivität mithilfe einer einzel-nanosteigerungs-sers-sonde - Google Patents

Nachweis von protease und protease-aktivität mithilfe einer einzel-nanosteigerungs-sers-sonde

Info

Publication number
ATE478559T1
ATE478559T1 AT07835744T AT07835744T ATE478559T1 AT E478559 T1 ATE478559 T1 AT E478559T1 AT 07835744 T AT07835744 T AT 07835744T AT 07835744 T AT07835744 T AT 07835744T AT E478559 T1 ATE478559 T1 AT E478559T1
Authority
AT
Austria
Prior art keywords
protease
detection
peptide
single nano
sers probe
Prior art date
Application number
AT07835744T
Other languages
English (en)
Inventor
Gang Liu
Jonathan Ellman
Luke Lee
Fanqing Chen
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE478559T1 publication Critical patent/ATE478559T1/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96466—Cysteine endopeptidases (3.4.22)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nanotechnology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Detergent Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT07835744T 2006-05-03 2007-05-02 Nachweis von protease und protease-aktivität mithilfe einer einzel-nanosteigerungs-sers-sonde ATE478559T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79752506P 2006-05-03 2006-05-03
PCT/US2007/010722 WO2008018933A2 (en) 2006-05-03 2007-05-02 Detection of protease and protease activity using a single nanocrescent sers probe

Publications (1)

Publication Number Publication Date
ATE478559T1 true ATE478559T1 (de) 2010-09-15

Family

ID=39033446

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07835744T ATE478559T1 (de) 2006-05-03 2007-05-02 Nachweis von protease und protease-aktivität mithilfe einer einzel-nanosteigerungs-sers-sonde

Country Status (10)

Country Link
US (2) US8361932B2 (de)
EP (1) EP2019587B1 (de)
JP (1) JP2009535060A (de)
KR (1) KR20090009302A (de)
CN (1) CN101484002B (de)
AT (1) ATE478559T1 (de)
AU (1) AU2007282164A1 (de)
CA (1) CA2679707A1 (de)
DE (1) DE602007008716D1 (de)
WO (1) WO2008018933A2 (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7947437B2 (en) 2005-10-17 2011-05-24 Sword Diagnostics, Inc. Methods for detecting organisms and enzymatic reactions using raman spectroscopy
ATE511636T1 (de) 2005-10-17 2011-06-15 Sword Diagnostics Inc Verfahren zum nachweis biologischer organismen mittels raman-streuung
US20100041016A1 (en) 2005-10-17 2010-02-18 Sword Diagnostics, Inc. Methods for detecting organisms and enzymatic reactions using raman spectroscopy and aromatic compounds comprising phosphate
WO2008018933A2 (en) 2006-05-03 2008-02-14 The Regents Of The University Of California Detection of protease and protease activity using a single nanocrescent sers probe
KR100857770B1 (ko) * 2007-04-11 2008-09-09 한국과학기술연구원 단백질 분해효소 검출 및 생체 내 영상화를 위한 금속 나노입자 및 그것의 용도
EP2210072A4 (de) * 2007-11-02 2014-04-16 Univ California Einstufiges echtzeit-bioassay unter verwendung von nanoplasmonischem resonator mit ultrahoher sensibilität
JP5620154B2 (ja) * 2009-10-15 2014-11-05 公益財団法人神奈川科学技術アカデミー 中空微小体およびその作製方法
BR112012013999B1 (pt) * 2009-12-11 2020-12-01 Korea Research Institute Of Chemical Technology nanoestrutura dimérica de casca-núcleo marcada com molécula raman ativa localizada na junção de interpartículas e método para preparação do mesmo e para a detecção de um analito
US9190099B2 (en) * 2010-03-15 2015-11-17 Purdue Research Foundation Higher order structured dyes with enhanced optical features
CN102175705B (zh) * 2011-03-11 2012-08-22 中国科学院半导体研究所 双新月对结构的化学传感系统
WO2012165837A2 (ko) * 2011-05-29 2012-12-06 한국화학연구원 라만 분석 기반 고속 다중 약물 고속 스크리닝 장치
CN102590509A (zh) * 2012-03-20 2012-07-18 湖南大学 基于无修饰抗体介导纳米金组装检测组蛋白修饰酶活性及筛选其抑制剂的生物传感方法
US9599590B2 (en) 2012-10-12 2017-03-21 Sage Science, Inc. Side-eluting molecular fractionator
WO2014080519A1 (ja) * 2012-11-26 2014-05-30 独立行政法人産業技術総合研究所 ナノカーボンを用いた臨床検査
EP2980585B1 (de) * 2013-03-29 2019-11-20 Mie University Vitalfärbung
CN105021819B (zh) * 2014-04-28 2017-05-03 中国科学院苏州纳米技术与纳米仿生研究所 荧光纳米磁性粒子‑多肽底物复合体及其制备方法
CN104122248A (zh) * 2014-07-03 2014-10-29 上海师范大学 一种具有表面增强拉曼效应的Fe3+的拉曼探针及其制备方法和应用
US10131901B2 (en) 2014-10-15 2018-11-20 Sage Science, Inc. Apparatuses, methods and systems for automated processing of nucleic acids and electrophoretic sample preparation
CN104892541A (zh) * 2015-05-28 2015-09-09 中国科学院化学研究所 一种用于γ-谷氨酰转肽酶检测的荧光探针及其制备方法与应用
CN105199422B (zh) * 2015-10-20 2017-05-10 北京科技大学 含巯基基团的联噻吩苯并吲哚盐染料及其制备方法和应用
US11826344B2 (en) * 2015-11-19 2023-11-28 Howard University Composition, method of manufacture, and use of site-specific delivery of bruceolides for treatment of cancer and other diseases
US11542495B2 (en) 2015-11-20 2023-01-03 Sage Science, Inc. Preparative electrophoretic method for targeted purification of genomic DNA fragments
FR3044415B1 (fr) * 2015-11-27 2017-12-01 Biomerieux Sa Procede de determination de la reaction d'un microorganisme a son exposition a un antibiotique
WO2017139669A1 (en) * 2016-02-11 2017-08-17 Sage Science, Inc. Workflows for enzymatic nucleic acid modification
CN106290873B (zh) * 2016-07-28 2018-03-30 江南大学 一种基于具有拉曼和荧光双重信号的金‑上转换空间四面体结构的制备及应用
CN106290898B (zh) * 2016-07-29 2017-11-28 江南大学 一种金‑上转换纳米粒子三聚体的制备方法及其应用
EP3519583A4 (de) * 2016-09-28 2020-06-03 Georgia Tech Research Corporation Verfahren und zusammensetzungen zur nichtinvasiven detektion von organtransplantatabstossung
JP2017032580A (ja) * 2016-10-05 2017-02-09 ヒューレット−パッカード デベロップメント カンパニー エル.ピー.Hewlett‐Packard Development Company, L.P. 化学的な検知器
CN110506203A (zh) 2017-04-07 2019-11-26 塞奇科学股份有限公司 用于通过使用集成电泳dna纯化来检测遗传结构变异的系统和方法
US10156658B1 (en) * 2017-06-06 2018-12-18 Saudi Arabian Oil Company Detecting a tracer in a hydrocarbon reservoir
GB201710401D0 (en) * 2017-06-29 2017-08-16 Vib Vzw Label free detection of protease activity
CN107727632B (zh) * 2017-08-22 2020-08-04 陕西专壹知识产权运营有限公司 一种sers增强的可控链状组装体检测凝血酶的方法
EP3460472B1 (de) 2017-09-22 2024-09-18 Nokia Technologies Oy Funktionalisierte partikel
EP3593708B1 (de) 2018-07-13 2024-08-28 Nokia Technologies Oy Künstliche haut
CN119264211A (zh) 2018-08-27 2025-01-07 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
US12338483B2 (en) 2019-02-28 2025-06-24 Georgia Tech Research Corporation Compositions and methods for logic-gated profiling of biologic activity
KR102230533B1 (ko) * 2019-03-05 2021-03-19 서강대학교산학협력단 전도성 고분자 나노 구조체 및 금속 나노입자 복합체를 이용한 표면증강 라만분광 기반 단백질 분해 효소 검출용 센서
JP7479051B2 (ja) * 2019-09-27 2024-05-08 国立大学法人広島大学 プラスチック粒子の検出方法およびプラスチック粒子の検出キット
CN110726710A (zh) * 2019-10-28 2020-01-24 山东师范大学 基于Au-Se界面的SERS传感器用于超灵敏高保真生物分子定量检测
US11785734B2 (en) * 2020-05-04 2023-10-10 Panduit Corp. Data center cabinet and top caps for a data center cabinet
JP7638478B2 (ja) * 2020-07-30 2025-03-04 国立研究開発法人産業技術総合研究所 微小構造体と分子検出法
JP2023542867A (ja) 2020-09-11 2023-10-12 グリンプス バイオ， インコーポレイテッド 疾患の検出／診断、病期分類、モニタリング及び処置のための生体外でのプロテアーゼ活性検出
US11796517B2 (en) 2021-11-09 2023-10-24 Saudi Arabian Oil Company Multifunctional magnetic tags for mud logging
US12140582B2 (en) 2021-11-09 2024-11-12 Saudi Arabian Oil Company Multifunctional polysaccharide-based mud logging barcode tracers
US12110448B2 (en) 2021-11-09 2024-10-08 Saudi Arabian Oil Company Multifunctional fluorescent tags for subterranean applications
US12253467B2 (en) 2021-12-13 2025-03-18 Saudi Arabian Oil Company Determining partition coefficients of tracer analytes
US11725139B2 (en) 2021-12-13 2023-08-15 Saudi Arabian Oil Company Manipulating hydrophilicity of conventional dye molecules for water tracer applications
US11999855B2 (en) 2021-12-13 2024-06-04 Saudi Arabian Oil Company Fluorescent dye molecules having hydrophilicity and hydrophobicity for tracer applications
US12440821B2 (en) 2021-12-13 2025-10-14 Saudi Arabian Oil Company Method for tracing subterranean formations with oil-soluble organic molecular tracers and extracting them of from oil phases
US12000278B2 (en) 2021-12-16 2024-06-04 Saudi Arabian Oil Company Determining oil and water production rates in multiple production zones from a single production well
CN114384032B (zh) * 2022-01-17 2023-07-14 云南大学 诺如病毒检测探针和非诊断目的检测诺如病毒的方法
US12188350B2 (en) 2022-06-08 2025-01-07 Saudi Arabian Oil Company Fluorescent dye oil tracer compositions
CN115746091B (zh) * 2022-07-29 2024-10-01 胶原蛋白(武汉)生物科技有限公司 一种高稳定性的胶原蛋白靶向sers多肽探针及其在肝纤维化诊断中的应用
KR102925354B1 (ko) * 2022-12-02 2026-02-09 한국화학연구원 금 나노갭입자를 포함하는 사스 코로나바이러스 2 검출용 조성물, 이를 포함하는 진단키트 및 이의 검출방법
CN118755098B (zh) * 2024-06-17 2025-09-09 浙江工业大学 一种基于Zr-MOF荧光探针快速检测水中重铬酸根离子的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5306403A (en) * 1992-08-24 1994-04-26 Martin Marietta Energy Systems, Inc. Raman-based system for DNA sequencing-mapping and other separations
CA2459136A1 (en) * 2001-09-04 2003-03-13 Yeda Research And Development Co. Ltd. A caspase-8 binding protein, its preparation and use
US8697029B2 (en) * 2002-04-18 2014-04-15 The Regents Of The University Of Michigan Modulated physical and chemical sensors
US7429472B2 (en) 2003-01-31 2008-09-30 Promega Corporation Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule
US20050148100A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Methods and devices for using Raman-active probe constructs to assay biological samples
US7425436B2 (en) * 2004-07-30 2008-09-16 Promega Corporation Covalent tethering of functional groups to proteins and substrates therefor
WO2008018933A2 (en) 2006-05-03 2008-02-14 The Regents Of The University Of California Detection of protease and protease activity using a single nanocrescent sers probe
EP2210072A4 (de) * 2007-11-02 2014-04-16 Univ California Einstufiges echtzeit-bioassay unter verwendung von nanoplasmonischem resonator mit ultrahoher sensibilität
US20110046018A1 (en) * 2007-12-31 2011-02-24 Fanqing Frank Chen Sers-based, single step, real-time detection of protein kinase and/or phosphatase activity

Also Published As

Publication number Publication date
CN101484002B (zh) 2014-04-30
US9145575B2 (en) 2015-09-29
EP2019587A2 (de) 2009-02-04
CN101484002A (zh) 2009-07-15
US20140011705A1 (en) 2014-01-09
CA2679707A1 (en) 2008-02-14
WO2008018933A3 (en) 2008-10-09
EP2019587A4 (de) 2009-06-10
JP2009535060A (ja) 2009-10-01
AU2007282164A1 (en) 2008-02-14
US8361932B2 (en) 2013-01-29
WO2008018933A2 (en) 2008-02-14
EP2019587B1 (de) 2010-08-25
DE602007008716D1 (de) 2010-10-07
KR20090009302A (ko) 2009-01-22
US20100048412A1 (en) 2010-02-25

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