ATE519757T1 - 3 hydroxyflavon-derivate zur erkennung und quantifizierung von zell-apoptosen - Google Patents
3 hydroxyflavon-derivate zur erkennung und quantifizierung von zell-apoptosenInfo
- Publication number
- ATE519757T1 ATE519757T1 AT06842347T AT06842347T ATE519757T1 AT E519757 T1 ATE519757 T1 AT E519757T1 AT 06842347 T AT06842347 T AT 06842347T AT 06842347 T AT06842347 T AT 06842347T AT E519757 T1 ATE519757 T1 AT E519757T1
- Authority
- AT
- Austria
- Prior art keywords
- cell apoptosis
- quantification
- derivatives
- detection
- hydroxyflavone
- Prior art date
Links
- 230000006907 apoptotic process Effects 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title abstract 2
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Chemical class O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 title abstract 2
- 238000011002 quantification Methods 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000007850 fluorescent dye Substances 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72477205P | 2005-10-11 | 2005-10-11 | |
| PCT/IB2006/003911 WO2007057782A2 (en) | 2005-10-11 | 2006-10-11 | 3 -hydroxyflavone derivatives for the detection and the quantification of cell apoptosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE519757T1 true ATE519757T1 (de) | 2011-08-15 |
Family
ID=38008234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06842347T ATE519757T1 (de) | 2005-10-11 | 2006-10-11 | 3 hydroxyflavon-derivate zur erkennung und quantifizierung von zell-apoptosen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7880021B2 (de) |
| EP (1) | EP1948633B1 (de) |
| JP (1) | JP5030961B2 (de) |
| AT (1) | ATE519757T1 (de) |
| CA (1) | CA2624772C (de) |
| WO (1) | WO2007057782A2 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6262229A (ja) * | 1985-09-13 | 1987-03-18 | Minolta Camera Co Ltd | 多分割測光装置を有するカメラ |
| SI2350075T1 (sl) | 2008-09-22 | 2014-06-30 | Array Biopharma, Inc. | Substituirane imidazo (1,2b)piridazinske spojine kot Trk kinazni inhibitorji |
| CN102264736B (zh) | 2008-10-22 | 2013-08-14 | 阵列生物制药公司 | 作为TRK激酶抑制剂的取代的吡唑并[1,5-a]嘧啶化合物 |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| BR122019024201B1 (pt) | 2010-05-20 | 2021-08-03 | Array Biopharma Inc | Composto macrocíclico como inibidores de trk quinase, seu uso, e composição farmacêutica |
| US8852274B2 (en) | 2011-06-24 | 2014-10-07 | Advanced Vision Science, Inc. | Composite ophthalmic devices and methods with incident light modifying properties |
| UA105278C2 (ru) | 2012-09-06 | 2014-04-25 | Інститут Біології Клітини Нан України | Способ получения каталитически активных антител (абзимов) с сиалидазной активностью |
| JP6322702B2 (ja) * | 2013-10-10 | 2018-05-09 | チュビタック （ターキー ビリムセル ヴィ テクノロジク アラスティルマ クルム）Ｔｕｂｉｔａｋ （Ｔｕｒｋｉｙｅ Ｂｉｌｉｍｓｅｌ Ｖｅ Ｔｅｋｎｏｌｏｊｉｋ Ａｒａｓｔｉｒｍａ Ｋｕｒｕｍｕ） | 蛍光色素分子である３−ヒドロキシフラボン |
| US9868715B2 (en) * | 2014-04-19 | 2018-01-16 | The Board Of Regents Of The University Of Texas Systems | Apigenin analogs, compositions, and methods related thereto |
| TWI746426B (zh) | 2014-11-16 | 2021-11-21 | 美商亞雷生物製藥股份有限公司 | (S)-N-(5-((R)-2-(2,5-二氟苯基)-吡咯啶-1-基)-吡唑并[1,5-a]嘧啶-3-基)-3-羥基吡咯啶-1-甲醯胺硫酸氫鹽結晶型 |
| EP3368039A1 (de) | 2015-10-26 | 2018-09-05 | The Regents of The University of Colorado, A Body Corporate | Punktmutationen bei trk-inhibitor-resistentem krebs und zugehörige verfahren |
| UA125026C2 (uk) | 2016-04-04 | 2021-12-29 | Локсо Онколоджі, Інк. | РІДКІ КОМПОЗИЦІЇ (S)-N-(5-((R)-2-(2,5-ДИФТОРФЕНІЛ)ПІРОЛІДИН-1-ІЛ)ПІРАЗОЛО[1,5-a]ПІРИМІДИН-3-ІЛ)-3-ГІДРОКСИПІРОЛІДИН-1-КАРБОКСАМІДУ |
| UA125025C2 (uk) | 2016-04-04 | 2021-12-29 | Локсо Онколоджі, Інк. | Способи лікування дитячих ракових захворювань |
| MX392604B (es) | 2016-05-18 | 2025-03-24 | Array Biopharma Inc | Procesos para la preparacion de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidin-1-carboxamida y sales del mismo. |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| AU2021342568B2 (en) | 2020-09-21 | 2025-04-03 | Landos Biopharma, Inc. | Nlrx1 ligands |
| KR20240032892A (ko) * | 2021-07-01 | 2024-03-12 | 나노템퍼 테크놀로지스 게엠베하 | 형광 입자의 비율계량 특성화 방법 및 장치 |
| CN114957299B (zh) * | 2022-02-24 | 2024-04-09 | 川北医学院 | 用于检测凋亡细胞的荧光探针及其制备方法 |
| CN115028652B (zh) * | 2022-02-24 | 2024-04-05 | 川北医学院 | 用于卵巢癌光动力诊疗的高光敏性荧光探针 |
| JP2025513455A (ja) | 2022-04-22 | 2025-04-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | 疼痛の治療のためのヘテロアリール化合物 |
| CN119080688B (zh) * | 2024-10-31 | 2025-03-14 | 山东第一医科大学第三附属医院(山东省医学科学院附属医院) | 一种利用极性响应比率型检测细胞膜完整性的荧光探针及其应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040022731A1 (en) * | 2002-04-26 | 2004-02-05 | Alexei Bogdanov | In vivo imaging of apoptosis |
-
2006
- 2006-10-11 AT AT06842347T patent/ATE519757T1/de not_active IP Right Cessation
- 2006-10-11 WO PCT/IB2006/003911 patent/WO2007057782A2/en not_active Ceased
- 2006-10-11 US US11/992,387 patent/US7880021B2/en active Active
- 2006-10-11 JP JP2008535133A patent/JP5030961B2/ja not_active Expired - Fee Related
- 2006-10-11 EP EP06842347A patent/EP1948633B1/de active Active
- 2006-10-11 CA CA2624772A patent/CA2624772C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2624772A1 (en) | 2007-05-24 |
| WO2007057782A3 (en) | 2007-08-30 |
| US7880021B2 (en) | 2011-02-01 |
| JP2009511566A (ja) | 2009-03-19 |
| WO2007057782A2 (en) | 2007-05-24 |
| CA2624772C (en) | 2011-11-29 |
| JP5030961B2 (ja) | 2012-09-19 |
| US20090269793A1 (en) | 2009-10-29 |
| EP1948633B1 (de) | 2011-08-10 |
| EP1948633A2 (de) | 2008-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |