ATE478687T1 - Zur mutation geeignete einzelsträngige oligonukleotid vektoren - Google Patents

Zur mutation geeignete einzelsträngige oligonukleotid vektoren

Info

Publication number: ATE478687T1
Authority: AT; Austria
Prior art keywords: effective; oligodeoxynucleotides; mutation; single stranded; stranded oligonucleotide
Prior art date: 1999-08-27

Application number

AT00959442T

Other languages

English (en)

Inventor

Richard Metz

Bruce Frank

Debra Walther

Original Assignee

Valigen Us Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-27

Filing date

2000-08-25

Publication date

2010-09-15

2000-08-25 Application filed by Valigen Us Inc filed Critical Valigen Us Inc

2010-09-15 Application granted granted Critical

2010-09-15 Publication of ATE478687T1 publication Critical patent/ATE478687T1/de

Links

108091034117 Oligonucleotide Proteins 0.000 title abstract 2
230000035772 mutation Effects 0.000 title 1
239000013598 vector Substances 0.000 title 1
229940046166 oligodeoxynucleotide Drugs 0.000 abstract 4
210000004027 cell Anatomy 0.000 abstract 2
241000894006 Bacteria Species 0.000 abstract 1
108091028664 Ribonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
230000001580 bacterial effect Effects 0.000 abstract 1
230000002068 genetic effect Effects 0.000 abstract 1
210000003494 hepatocyte Anatomy 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
210000004962 mammalian cell Anatomy 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
239000002336 ribonucleotide Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Crystallography & Structural Chemistry (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

AT00959442T 1999-08-27 2000-08-25 Zur mutation geeignete einzelsträngige oligonukleotid vektoren ATE478687T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/384,960 US6271360B1 (en)	1999-08-27	1999-08-27	Single-stranded oligodeoxynucleotide mutational vectors
PCT/US2000/023457 WO2001015740A1 (en)	1999-08-27	2000-08-25	Single-stranded oligodeoxynucleotide mutational vectors

Publications (1)

Publication Number	Publication Date
ATE478687T1 true ATE478687T1 (de)	2010-09-15

Family

ID=23519459

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00959442T ATE478687T1 (de)	1999-08-27	2000-08-25	Zur mutation geeignete einzelsträngige oligonukleotid vektoren

Country Status (15)

Country	Link
US (3)	US6271360B1 (de)
EP (3)	EP1210123B1 (de)
JP (2)	JP5697187B2 (de)
CN (1)	CN1384759B (de)
AT (1)	ATE478687T1 (de)
AU (2)	AU773242C (de)
BR (1)	BR0013590A (de)
CA (1)	CA2382120C (de)
DE (1)	DE60044876D1 (de)
DK (3)	DK2324856T3 (de)
ES (3)	ES2544727T3 (de)
NZ (1)	NZ517942A (de)
PT (3)	PT1210123E (de)
WO (1)	WO2001015740A1 (de)
ZA (1)	ZA200201228B (de)

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ES2531882T3 (es)	2006-01-12	2015-03-20	Cibus Europe B.V.	EPSPS mutantes
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US9102948B2 (en)	2006-11-17	2015-08-11	22Nd Century Limited, Llc	Regulating alkaloids
BR122018070228B1 (pt) *	2007-10-05	2023-01-10	Cibus Europe B.V.	Método para produção de planta brassica resistente à herbicida
KR20170010072A (ko) *	2008-05-23	2017-01-25	누셀리스 인크.	효모를 사용한 스쿠알렌 생산
NZ592464A (en)	2008-09-26	2013-05-31	Basf Agrochemical Products Bv	Herbicide resistant acetohydroxyacid synthase large subunit (AHAS) mutants and methods of use thereof
AU2009326129B2 (en)	2008-12-12	2016-05-12	Basf Plant Science Gmbh	Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms
HUE034245T2 (en)	2009-11-23	2018-02-28	Nucelis Llc	Methods and preparations for the preparation of squalene using yeast
US20120122223A1 (en)	2010-08-03	2012-05-17	Cibus Us Llc	Mutated protoporphyrinogen ix oxidase (ppx) genes
UA112969C2 (uk)	2010-08-03	2016-11-25	Сібас Юс Ллс	Рослина, стійка до одного або більше ррх-інгібуючих гербіцидів, яка містить мутантний ген протопорфіриноген ix оксидази (ррх)
WO2012028673A1 (en)	2010-09-02	2012-03-08	Ludwig-Maximilians-Universitaet Muenchen	Spontaneous organogenesis in plants
EP2426204A1 (de)	2010-09-02	2012-03-07	Ludwig-Maximilians-Universität München	Spontane Knöllchenorganogenese in Pflanzen
KR101137285B1 (ko)	2010-10-28	2012-04-20	위월드 주식회사	초소형 광대역 송수신 안테나 피더
WO2014028295A2 (en)	2012-08-17	2014-02-20	Dow Agrosciences Llc	Use of a maize untranslated region for transgene expression in plants
CN105358696A (zh)	2013-03-14	2016-02-24	希博斯美国有限公司	突变的丙二烯氧合酶2(aos2)基因
AU2014233465A1 (en)	2013-03-15	2015-09-03	Cibus Europe B.V.	Targeted gene modification using oligonucleotide-mediated gene repair
US9957515B2 (en)	2013-03-15	2018-05-01	Cibus Us Llc	Methods and compositions for targeted gene modification
US12331303B2 (en)	2013-03-15	2025-06-17	Cibus Us Llc	Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
IL290273B2 (en)	2013-03-15	2024-03-01	Cibus Us Llc	Methods and compositions for increasing efficiency of increased efficiency of targeted gene modification using oligonucleotide-mediated gene repair
CA3208184A1 (en)	2014-03-14	2015-09-17	Cibus Us Llc	Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
CN109072248A (zh)	2016-02-09	2018-12-21	希博斯美国有限公司	采用寡核苷酸介导的基因修复提高靶向基因修饰的效率的方法和组合物
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1999
- 1999-08-27 US US09/384,960 patent/US6271360B1/en not_active Expired - Lifetime
2000
- 2000-08-25 EP EP00959442A patent/EP1210123B1/de not_active Expired - Lifetime
- 2000-08-25 ES ES10183960.3T patent/ES2544727T3/es not_active Expired - Lifetime
- 2000-08-25 US US09/645,889 patent/US6479292B1/en not_active Expired - Lifetime
- 2000-08-25 DE DE60044876T patent/DE60044876D1/de not_active Expired - Lifetime
- 2000-08-25 CN CN008149968A patent/CN1384759B/zh not_active Expired - Lifetime
- 2000-08-25 EP EP20100183960 patent/EP2324856B1/de not_active Expired - Lifetime
- 2000-08-25 AU AU70767/00A patent/AU773242C/en not_active Expired
- 2000-08-25 PT PT00959442T patent/PT1210123E/pt unknown
- 2000-08-25 DK DK10183960.3T patent/DK2324856T3/en active
- 2000-08-25 AT AT00959442T patent/ATE478687T1/de active
- 2000-08-25 BR BR0013590-9A patent/BR0013590A/pt not_active Application Discontinuation
- 2000-08-25 PT PT100086024T patent/PT2266627E/pt unknown
- 2000-08-25 NZ NZ517942A patent/NZ517942A/en not_active IP Right Cessation
- 2000-08-25 DK DK00959442.5T patent/DK1210123T3/da active
- 2000-08-25 JP JP2001520151A patent/JP5697187B2/ja not_active Expired - Lifetime
- 2000-08-25 PT PT101839603T patent/PT2324856E/pt unknown
- 2000-08-25 EP EP20100008602 patent/EP2266627B1/de not_active Expired - Lifetime
- 2000-08-25 DK DK10008602.4T patent/DK2266627T3/da active
- 2000-08-25 ES ES00959442T patent/ES2358292T3/es not_active Expired - Lifetime
- 2000-08-25 CA CA2382120A patent/CA2382120C/en not_active Expired - Lifetime
- 2000-08-25 WO PCT/US2000/023457 patent/WO2001015740A1/en not_active Ceased
- 2000-08-25 ES ES10008602.4T patent/ES2542530T3/es not_active Expired - Lifetime
2002
- 2002-02-13 ZA ZA200201228A patent/ZA200201228B/en unknown
- 2002-11-12 US US10/292,856 patent/US7060500B2/en not_active Expired - Lifetime
2004
- 2004-08-19 AU AU2004205139A patent/AU2004205139B2/en not_active Expired
2012
- 2012-05-10 JP JP2012108528A patent/JP5813571B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60044876D1 (de)	2010-10-07
EP2266627B1 (de)	2015-04-22
PT2266627E (pt)	2015-08-25
ES2358292T3 (es)	2011-05-09
AU773242C (en)	2005-04-07
EP2324856A1 (de)	2011-05-25
CN1384759A (zh)	2002-12-11
DK2266627T3 (da)	2015-06-15
JP5697187B2 (ja)	2015-04-08
PT1210123E (pt)	2010-11-30
WO2001015740A1 (en)	2001-03-08
PT2324856E (pt)	2015-09-03
US20040023392A1 (en)	2004-02-05
EP2324856B1 (de)	2015-05-06
ES2544727T3 (es)	2015-09-03
AU2004205139A1 (en)	2004-09-16
AU2004205139B2 (en)	2008-01-10
JP2003508451A (ja)	2003-03-04
DK2324856T3 (en)	2015-08-03
US7060500B2 (en)	2006-06-13
EP1210123B1 (de)	2010-08-25
BR0013590A (pt)	2002-05-07
EP1210123A1 (de)	2002-06-05
CA2382120A1 (en)	2001-03-08
JP5813571B2 (ja)	2015-11-17
NZ517942A (en)	2004-07-30
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