ATE47998T1 - Antiinflammatorische phthalazinone. - Google Patents

Antiinflammatorische phthalazinone.

Info

Publication number
ATE47998T1
ATE47998T1 AT85105873T AT85105873T ATE47998T1 AT E47998 T1 ATE47998 T1 AT E47998T1 AT 85105873 T AT85105873 T AT 85105873T AT 85105873 T AT85105873 T AT 85105873T AT E47998 T1 ATE47998 T1 AT E47998T1
Authority
AT
Austria
Prior art keywords
class
alkyl
hydrogen
hydroxyl
alkylaminoalkylene
Prior art date
Application number
AT85105873T
Other languages
English (en)
Inventor
Telfer Lawson Thomas
Lesley Ann Radov
Original Assignee
Fisons Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Corp filed Critical Fisons Corp
Application granted granted Critical
Publication of ATE47998T1 publication Critical patent/ATE47998T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT85105873T 1984-05-17 1985-05-13 Antiinflammatorische phthalazinone. ATE47998T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/611,310 US4665181A (en) 1984-05-17 1984-05-17 Anti-inflammatory phthalazinones
EP85105873A EP0164593B1 (de) 1984-05-17 1985-05-13 Antiinflammatorische Phthalazinone

Publications (1)

Publication Number Publication Date
ATE47998T1 true ATE47998T1 (de) 1989-12-15

Family

ID=24448523

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85105873T ATE47998T1 (de) 1984-05-17 1985-05-13 Antiinflammatorische phthalazinone.

Country Status (14)

Country Link
US (1) US4665181A (de)
EP (1) EP0164593B1 (de)
JP (1) JPS60255777A (de)
KR (1) KR850008668A (de)
AT (1) ATE47998T1 (de)
AU (1) AU570549B2 (de)
DE (2) DE164593T1 (de)
DK (1) DK215485A (de)
FI (1) FI851959A7 (de)
IL (1) IL74805A (de)
NO (1) NO851938L (de)
NZ (1) NZ211589A (de)
PH (1) PH23246A (de)
ZA (1) ZA852387B (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0174464B1 (de) * 1984-09-14 1990-01-03 ASTA Pharma AG Substituierte Benzylphthalazinon-Derivate
US4769369A (en) * 1986-11-14 1988-09-06 Pennwalt Corporation Anti-allergy 1(2H)-phthalazinones
EP0309765A3 (de) * 1987-09-30 1990-09-26 Fisons Corporation 1(2H)-Phthalazinone als zytoprotektive Arzneimittel
DE4103405A1 (de) * 1991-02-05 1992-08-06 Basf Ag 3-amino-benzol-1,2,4,5-tetracarbonsaeuredihydrazide und ihre verwendung als chemilumineszenz-faehige verbindugnen sowie 3-amino-benzol-1,2,4,5-tetracarbonsaeuredianhydride
DE4207234A1 (de) * 1992-03-07 1993-09-09 Asta Medica Ag Neue aminocarbonsaeure-derivate mit antiallergischer/antiasthmatischer wirkung und verfahren zu deren herstellung
CH683965A5 (it) * 1993-02-19 1994-06-30 Limad Marketing Exp & Imp Composti della classe dei ftalidrazidici come sostanza attiva in agenti antinfiammatori ed antitossici.
EP0934933A1 (de) * 1998-02-06 1999-08-11 Byk Gulden Lomberg Chemische Fabrik GmbH Phthalazinone
CN1660840A (zh) * 1999-03-30 2005-08-31 诺瓦提斯公司 治疗炎性疾病的酞嗪衍生物
PT1246813E (pt) * 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
US7151102B2 (en) * 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0111078D0 (en) * 2001-05-04 2001-06-27 Novartis Ag Organic compounds
DE60335359D1 (de) * 2002-04-30 2011-01-27 Kudos Pharm Ltd Phthalazinonderivate
GB0223341D0 (en) * 2002-10-08 2002-11-13 Groningen Acad Ziekenhuis Organic compounds
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
US7449464B2 (en) * 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0419072D0 (en) * 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
US8758816B2 (en) 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
US20070020330A1 (en) 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
JP5607291B2 (ja) 2004-11-24 2014-10-15 メダ ファーマシューティカルズ インコーポレイテッド アゼラスチンを含む組成物およびその使用方法
GB0428111D0 (en) * 2004-12-22 2005-01-26 Kudos Pharm Ltd Pthalazinone derivatives
US7759337B2 (en) * 2005-03-03 2010-07-20 Amgen Inc. Phthalazine compounds and methods of use
WO2006103550A1 (en) * 2005-03-31 2006-10-05 Ranbaxy Laboratories Limited Processes for the preparation of citalopram and its intermediate 5-aminophthalide
GB0521373D0 (en) * 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
WO2007144639A1 (en) * 2006-06-15 2007-12-21 Kudos Pharmaceuticals Limited 2 -oxybenzamide derivatives as parp inhibitors
US20090181951A1 (en) * 2006-06-15 2009-07-16 Kudos Pharmaceuticals Limited Parp inhibitors
US20090281086A1 (en) * 2006-06-15 2009-11-12 Kudos Pharmaceuticals Limited 2 -oxyheteroarylamide derivatives as parp inhibitors
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
UY30639A1 (es) * 2006-10-17 2008-05-31 Kudos Pharm Ltd Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
US20080280910A1 (en) * 2007-03-22 2008-11-13 Keith Allan Menear Phthalazinone derivatives
TW200900396A (en) * 2007-04-10 2009-01-01 Kudos Pharm Ltd Phthalazinone derivatives
US20090023727A1 (en) * 2007-07-05 2009-01-22 Muhammad Hashim Javaid Phthalazinone derivatives
MX2010002749A (es) 2007-09-14 2010-06-25 Astrazeneca Ab Derivados de ftalazinona.
CA2702429A1 (en) * 2007-10-17 2009-04-23 Kudos Pharmaceuticals Limited Crystalline form l 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h-phthalazin-1-one
UY31603A1 (es) 2008-01-23 2009-08-31 Derivados de ftalazinona
CA2737400C (en) * 2008-10-07 2016-11-22 Astrazeneca Uk Limited Pharmaceutical formulation 514
US20110015393A1 (en) * 2009-07-15 2011-01-20 Astrazeneca Ab Phthalazinone compound
KR20140033377A (ko) * 2011-05-10 2014-03-18 길리애드 사이언시즈, 인코포레이티드 나트륨 채널 조절제로서의 융합된 헤테로시클릭 화합물
EP2968323A4 (de) 2013-03-13 2016-12-14 Flatley Discovery Lab Pyridazinonverbindungen und verfahren zur behandlung von zystischer fibrose

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB808636A (en) * 1955-08-02 1959-02-11 Cassella Farbwerke Mainkur Ag Basically substituted heterocyclic compounds
GB1126669A (en) * 1967-04-28 1968-09-11 Deutsches Hydrierwerke Rodlebe Process for production of basically substituted phthalazones
DE2114884A1 (de) * 1971-03-27 1972-10-12 Cassella Farbwerke Mainkur Ag, 6000 Frankfurt Basisch substituierte Derivate des 1(2H)-Phthalazinons
JPS4931683A (de) * 1972-07-27 1974-03-22
JPS5214788A (en) * 1975-07-21 1977-02-03 Fuji Photo Film Co Ltd Process for preparing phthalazinone and its derivatives
US4134880A (en) * 1978-01-19 1979-01-16 Mitsui Toatsu Chemicals, Incorporated Process for producing an aromatic urethane from nitro compounds, hydroxyl compounds and carbon monoxide using metal-Lewis acid-ammonia catalyst systems
US4334069A (en) * 1978-07-24 1982-06-08 Miles Laboratories, Inc. Chemiluminescent phthalhydrazide-labeled hapten conjugates
US4293553A (en) * 1978-08-11 1981-10-06 Masayuki Ishikawa 1-Phthalazone derivatives, and use thereof
CA1143733A (en) * 1979-07-31 1983-03-29 Masao Yoshida Producing 7-alkoxycarbonyl-6,8-dimethyl-4- hydroxymethyl-1-phthalazone and intermediates

Also Published As

Publication number Publication date
DE3574253D1 (de) 1989-12-21
KR850008668A (ko) 1985-12-21
FI851959L (fi) 1985-11-18
DK215485A (da) 1985-11-18
IL74805A0 (en) 1985-07-31
US4665181A (en) 1987-05-12
FI851959A7 (fi) 1985-11-18
FI851959A0 (fi) 1985-05-16
ZA852387B (en) 1986-04-30
PH23246A (en) 1989-06-16
IL74805A (en) 1988-07-31
DE164593T1 (de) 1986-06-12
NZ211589A (en) 1988-06-30
NO851938L (no) 1985-11-18
AU570549B2 (en) 1988-03-17
AU4087385A (en) 1985-11-21
EP0164593B1 (de) 1989-11-15
EP0164593A1 (de) 1985-12-18
JPS60255777A (ja) 1985-12-17
DK215485D0 (da) 1985-05-15

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee