ATE480524T1 - Pyridazinonderivate als schilddrüsenhormon- rezeptoragonisten - Google Patents

Pyridazinonderivate als schilddrüsenhormon- rezeptoragonisten

Info

Publication number
ATE480524T1
ATE480524T1 AT06792493T AT06792493T ATE480524T1 AT E480524 T1 ATE480524 T1 AT E480524T1 AT 06792493 T AT06792493 T AT 06792493T AT 06792493 T AT06792493 T AT 06792493T AT E480524 T1 ATE480524 T1 AT E480524T1
Authority
AT
Austria
Prior art keywords
receptor agonists
hormone receptor
thyroid hormone
pyridazinone derivatives
pyridazinone
Prior art date
Application number
AT06792493T
Other languages
English (en)
Inventor
Nancy-Ellen Haynes
Denis John Kertesz
Sherrie Lynn Pietranico-Cole
Yimin Qian
Nathan Robert Scott
Sung-Sau So
Kshitij Chhabilbhai Thakkar
Jefferson Wright Tilley
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE480524T1 publication Critical patent/ATE480524T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C07D237/16—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/18—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT06792493T 2005-07-21 2006-07-11 Pyridazinonderivate als schilddrüsenhormon- rezeptoragonisten ATE480524T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70121505P 2005-07-21 2005-07-21
PCT/EP2006/064093 WO2007009913A1 (en) 2005-07-21 2006-07-11 Pyridazinone derivatives as thyroid hormone receptor agonists

Publications (1)

Publication Number Publication Date
ATE480524T1 true ATE480524T1 (de) 2010-09-15

Family

ID=37114368

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06792493T ATE480524T1 (de) 2005-07-21 2006-07-11 Pyridazinonderivate als schilddrüsenhormon- rezeptoragonisten

Country Status (31)

Country Link
US (3) US7452882B2 (de)
EP (1) EP1919878B1 (de)
JP (1) JP5000649B2 (de)
KR (1) KR100965006B1 (de)
CN (1) CN101228135B (de)
AR (1) AR054848A1 (de)
AT (1) ATE480524T1 (de)
AU (1) AU2006271721C1 (de)
BR (1) BRPI0613754B8 (de)
CA (1) CA2614529C (de)
CR (1) CR9644A (de)
CY (1) CY1110929T1 (de)
DE (1) DE602006016821D1 (de)
DK (1) DK1919878T3 (de)
EC (1) ECSP088120A (de)
ES (1) ES2349131T3 (de)
HR (1) HRP20100633T1 (de)
IL (1) IL188476A (de)
MA (1) MA29731B1 (de)
MX (1) MX2008000818A (de)
MY (1) MY142861A (de)
NO (1) NO340679B1 (de)
NZ (1) NZ565190A (de)
PL (1) PL1919878T3 (de)
PT (1) PT1919878E (de)
RS (1) RS51639B (de)
RU (1) RU2379295C2 (de)
TW (1) TWI330636B (de)
UA (1) UA88104C2 (de)
WO (1) WO2007009913A1 (de)
ZA (1) ZA200800405B (de)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7829552B2 (en) 2003-11-19 2010-11-09 Metabasis Therapeutics, Inc. Phosphorus-containing thyromimetics
EP1604988A1 (de) * 2004-05-18 2005-12-14 Sanofi-Aventis Deutschland GmbH Pyridazinonderivate, Methoden, um selbige herzustellen, und ihre Verwendung als Pharmazeutika
JP2008542301A (ja) 2005-05-26 2008-11-27 メタバシス・セラピューティクス・インコーポレイテッド 脂肪性肝疾患の処置のための甲状腺ホルモン様薬剤
CA2614529C (en) 2005-07-21 2011-06-28 F. Hoffmann-La Roche Ag Pyridazinone derivatives as thyroid hormone receptor agonists
GB0610680D0 (en) * 2006-05-31 2006-07-12 Istituto Di Ricerche D Biolog Therapeutic compounds
AU2007283113A1 (en) 2006-08-08 2008-02-14 Sanofi-Aventis Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
JPWO2008133141A1 (ja) * 2007-04-24 2010-07-22 東洋紡績株式会社 オスモチン組換えタンパク質およびその製造方法、並びにその利用
JP5243537B2 (ja) * 2007-06-06 2013-07-24 トレント ファーマシューティカルズ リミテッド 新規化合物
US8076334B2 (en) * 2007-09-20 2011-12-13 Hoffmann-La Roche Inc. Prodrugs of thyroid hormone analogs
MX2010005070A (es) 2007-11-15 2010-05-24 Angeletti P Ist Richerche Bio Derivados de piridazinona como inhibidores de parp.
KR100981781B1 (ko) 2008-02-29 2010-09-10 재단법인 한국원자력의학원 방사선 치료용 콜리메이터 장치 및 그 장치를 이용한방사선 치료장치
UY31968A (es) 2008-07-09 2010-01-29 Sanofi Aventis Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
AU2010240200B2 (en) 2009-04-20 2014-03-13 Mitsubishi Tanabe Pharma Corporation Novel thyroid hormone beta receptor agonist
KR20120060207A (ko) 2009-08-26 2012-06-11 사노피 신규한 결정성 헤테로방향족 플루오로글리코시드 수화물, 이들 화합물을 포함하는 약제 및 이들의 용도
JP5847533B2 (ja) * 2010-10-19 2016-01-27 田辺三菱製薬株式会社 新規甲状腺ホルモンβ受容体作動薬
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP4023641B1 (de) * 2012-09-17 2024-05-01 Madrigal Pharmaceuticals, Inc. Verfahren zur synthese von schilddrüsenhormonanaloga und polymorphe davon
CN105272927A (zh) * 2015-11-17 2016-01-27 华中药业股份有限公司 一种制备氯氮卓的新方法
ES2924257T3 (es) 2016-10-18 2022-10-05 Madrigal Pharmaceuticals Inc Métodos de tratar trastornos hepáticos o trastornos lipídicos con un agonista de THR-beta
EP3541395A4 (de) 2016-11-21 2020-07-01 Viking Therapeutics, Inc. Verfahren zur behandlung einer glykogenspeicherkrankheit
EP3634426A4 (de) 2017-06-05 2021-04-07 Viking Therapeutics, Inc. Zusammensetzungen zur behandlung von fibrose
CN111094554A (zh) 2017-09-14 2020-05-01 国立研究开发法人理化学研究所 视网膜组织的制备方法
EP3725779A4 (de) * 2018-01-23 2021-02-24 Shenzhen TargetRx, Inc. Substituierte pyridazinonverbindung
CA3094167A1 (en) 2018-03-22 2019-09-26 Viking Therapeutics, Inc. Crystalline forms and methods of producing crystalline forms of a compound
JP7239604B2 (ja) 2018-04-16 2023-03-14 ツェティ，ユリア 甲状腺ホルモンを含む吸入用の薬学的乾燥粉末組成物
KR102531771B1 (ko) * 2018-06-12 2023-05-11 스촨 하이스코 파마수티컬 씨오., 엘티디 갑상선 호르몬 수용체 작용제 및 그 용도
US20210292304A1 (en) * 2018-06-22 2021-09-23 Hinova Pharmaceuticals Inc. Deuterated mgl-3196 compound and use thereof
TW202019914A (zh) * 2018-07-02 2020-06-01 美商瑪德瑞高製藥公司 ２-（３，５-二氯-４-（（５-異丙基-６-側氧基-１，６-二氫噠嗪-３-基）氧）苯基）-３，５-二側氧基-２，３，４，５-四氫-１，２，４-三嗪-６-腈之固體型式
US10800767B2 (en) 2018-08-24 2020-10-13 Terns, Inc. Thyroid hormone receptor beta agonist compounds
KR102876077B1 (ko) * 2018-09-06 2025-10-23 갈메드 리서치 앤드 디벨롭먼트 리미티드 간 질환을 치료하기 위한 병용 요법
TWI884745B (zh) * 2018-10-12 2025-05-21 美商拓臻股份有限公司 甲狀腺素受體β促效劑化合物
KR20210076932A (ko) * 2018-10-12 2021-06-24 인벤티스바이오 컴퍼니 리미티드 갑상선 호르몬 수용체 작용제
WO2020117962A1 (en) 2018-12-05 2020-06-11 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis and inflammation
CN121081472A (zh) * 2018-12-13 2025-12-09 拓臻股份有限公司 一种THRβ受体激动剂化合物及其制备方法和用途
CN111592528A (zh) * 2019-02-20 2020-08-28 苏州泽璟生物制药股份有限公司 氘代的哒嗪酮及其衍生物和药物组合物
CN119431265A (zh) * 2019-02-21 2025-02-14 南京瑞捷医药科技有限公司 一种作为甲状腺激素受体激动剂的化合物
SG11202109855PA (en) 2019-03-13 2021-10-28 Sumitomo Dainippon Pharma Co Ltd Method for evaluating quality of transplant neural retina, and transplant neural retina sheet
KR20220017917A (ko) * 2019-05-08 2022-02-14 알리고스 테라퓨틱스 인코포레이티드 Thr-베타의 조절제 및 이의 사용 방법
CN111909137B (zh) * 2019-05-10 2023-05-30 深圳微芯生物科技股份有限公司 一种哒嗪酮衍生物及其应用
CN114174282A (zh) * 2019-05-29 2022-03-11 南京明德新药研发有限公司 作为甲状腺素受体-β激动剂的哒嗪酮类衍生物及其应用
US12378268B2 (en) 2019-08-19 2025-08-05 Hepagene Therapeutics (HK) Limited Heterocyclic THR-β receptor agonist compound and preparation method and use therefor
CN112409340B (zh) * 2019-08-21 2022-03-18 海创药业股份有限公司 卤素取代的苯醚类化合物及其用途
EP4017875A4 (de) * 2019-08-23 2023-05-03 Terns Pharmaceuticals, Inc. Schilddrüsenhormon-rezeptor-beta-agonistenverbindungen
WO2021043185A1 (en) * 2019-09-04 2021-03-11 Sunshine Lake Pharma Co., Ltd. A compound as a thyroid hormone beta receptor agonist and use thereof
AU2020346057A1 (en) * 2019-09-12 2022-04-21 Terns Pharmaceuticals, Inc. Thyroid hormone receptor beta agonist compounds
EP4036090A4 (de) * 2019-09-24 2023-11-15 Sunshine Lake Pharma Co., Ltd. Chemische verbindung als thyroidhormon-beta-rezeptor-agonist und verwendung davon
CN112707892A (zh) * 2019-10-24 2021-04-27 苏州泽璟生物制药股份有限公司 哒嗪酮或哒嗪类化合物及其衍生物和药物组合物
CA3158379A1 (en) * 2019-11-26 2021-06-03 Hejun Lv 1,2,4-triazine-3,5-dione compound, preparation method therefor, and application thereof
CN114787153A (zh) 2019-12-26 2022-07-22 苏州科睿思制药有限公司 一种Resmetirom晶型及其制备方法和用途
CN113045551B (zh) * 2019-12-27 2024-07-09 广东东阳光药业股份有限公司 一种作为甲状腺激素β受体激动剂的化合物及其用途
EP4090652A1 (de) 2020-01-13 2022-11-23 Eccogene (Shanghai) Co., Ltd. Substituierte triazinone als schilddrüsenhormonrezeptoragonisten
CN113278013B (zh) * 2020-02-20 2022-09-23 昆药集团股份有限公司 2,6-二取代的1,2,4-三嗪-3,5-二酮化合物及其制备方法和应用
CN113698388B (zh) * 2020-05-20 2022-11-22 江苏恒瑞医药股份有限公司 6-氧代-1,6-二氢吡啶类衍生物、其制备方法及其在医药上的应用
KR20230048481A (ko) 2020-06-02 2023-04-11 쳉두 캉홍 파마슈티칼 코., 엘티디. 새로운 갑상선 호르몬 β 수용체 효능제
CN116056709A (zh) * 2020-08-27 2023-05-02 益方生物科技(上海)股份有限公司 哒嗪酮化合物
WO2022053028A1 (zh) * 2020-09-10 2022-03-17 南京明德新药研发有限公司 1,2,4-三嗪-3,5(2h,4h)-二酮类化合物及其应用
AU2021341182A1 (en) * 2020-09-10 2023-04-27 Crystal Pharmaceutical (Suzhou) Co., Ltd. Crystal form of resmetirom, preparation method therefor, and use thereof
WO2022054924A1 (ja) 2020-09-11 2022-03-17 大日本住友製薬株式会社 移植用組織のための媒体
EP4206321A4 (de) 2020-09-11 2024-05-01 Riken Komplex mit nervennetzhauthaltigen zellaggregaten und matrix sowie verfahren zur herstellung davon
WO2022068915A1 (zh) * 2020-09-30 2022-04-07 江苏恒瑞医药股份有限公司 6-氧代-1,6-二氢哒嗪类衍生物、其制备方法及其在医药上的应用
WO2022086894A1 (en) 2020-10-19 2022-04-28 Teva Pharmaceuticals International Gmbh Solid state forms of resmetirom
WO2022087141A1 (en) * 2020-10-23 2022-04-28 Madrigal Pharmaceuticals, Inc. Process for the preparation of 6-(4-nitro-phenoxy)-2h-pyridazin-3-one and 6-(4-amino-phenoxy)-2h-pyridazin-3-one derivatives as intermediates of thyroid hormone analogues
CN114437042A (zh) * 2020-11-03 2022-05-06 深圳微芯生物科技股份有限公司 酞嗪类化合物的晶型及其制备方法
AU2021374988A1 (en) * 2020-11-06 2023-06-15 Aligos Therapeutics, Inc. Bicyclic pyridazinones as thyroid hormone receptor beta (tr-beta) agonists
CA3197234A1 (en) * 2020-11-06 2022-05-12 David Craig Mcgowan Pyridazinone derivatives as thyroid receptor agonists and uses thereof
CN112645936B (zh) * 2020-12-17 2022-03-01 山东第一医科大学(山东省医学科学院) 取代的哒嗪酮类化合物及其用途
CN114685450A (zh) * 2020-12-30 2022-07-01 昆药集团股份有限公司 2-吡啶酮类衍生物及其制备方法和在医药上的应用
CN114907327A (zh) * 2021-02-10 2022-08-16 杭州领业医药科技有限公司 Resmetirom的晶型及其制备方法和用途
CN115073429A (zh) * 2021-03-15 2022-09-20 昆药集团股份有限公司 一种1，2，4-三嗪-3，5-二酮类化合物的盐型、晶型及其制备方法
CN116063296B (zh) * 2021-11-02 2025-08-19 凯思凯迪（上海）医药科技有限公司 一种作为甲状腺激素β受体激动剂的化合物及其用途
CA3238664A1 (en) 2021-11-19 2023-05-25 Riken Production method for sheet-like retinal tissue
KR20240163659A (ko) * 2022-03-10 2024-11-19 세키스이가가쿠 고교가부시키가이샤 바이러스 감염 저지제, 바이러스 감염 저지 제품, 바이러스 감염 저지 도료 및 수지 조성물
CN116836158A (zh) * 2022-03-23 2023-10-03 凯思凯迪（上海）医药科技有限公司 一种作为甲状腺激素β受体激动剂的化合物及其用途
WO2024084491A1 (en) * 2022-10-21 2024-04-25 Mehta Nilesh Vipinchandra Process for synthesis of res metirom and its intermediates thereof
CN118146217A (zh) 2022-12-07 2024-06-07 昆药集团股份有限公司 一种甲状腺激素β受体激动剂、晶型、制备方法和用途
CN115650928B (zh) * 2022-12-28 2023-03-31 凯思凯旭(上海)医药科技有限公司 一种多环类甲状腺激素β受体激动剂及其用途
WO2024141076A1 (en) * 2022-12-29 2024-07-04 Gannex Pharma Co., Ltd. Prodrugs to thyroid hormone analogs and method of making and use thereof
WO2024211898A1 (en) 2023-04-07 2024-10-10 Terns Pharmaceuticals, Inc. Combination comprising a thrbeta agonist anda glp-1r agonist for use in treating a liver disorder or a cardiometabolic disease
CN116768802B (zh) * 2023-05-25 2025-11-21 杭州科巢生物科技有限公司 一种瑞司美替罗的合成方法
WO2025011259A1 (zh) * 2023-07-07 2025-01-16 苏州科睿思制药有限公司 瑞司美替罗的晶型及其制备方法和用途
CN117263870B (zh) * 2023-09-21 2026-02-06 江西同和药业股份有限公司 一种Resmetirom关键中间体III的制备方法
WO2025083699A2 (en) 2023-10-16 2025-04-24 Cipla Limited Resmetirom polymorphs and process thereof
US12377104B1 (en) 2024-02-06 2025-08-05 Madrigal Pharmaceuticals, Inc. Methods for treating a fatty liver disease
WO2025171032A1 (en) 2024-02-06 2025-08-14 Madrigal Pharmaceuticals, Inc. Methods for treating a fatty liver disease
WO2025191457A1 (en) * 2024-03-13 2025-09-18 Morepen Laboratories Limited Process for the preparation of pyridazinone derivative
US20250340541A1 (en) 2024-05-03 2025-11-06 Aligos Therapeutics, Inc. Methods of preparing modulators of thr-beta
CN119798230B (zh) * 2025-03-13 2025-06-27 中国药科大学 吲哚酮类化合物及其在治疗急慢性肝病与促进组织修复中的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582842A (en) 1981-02-25 1986-04-15 Merck & Co., Inc. Anti-asthmatic 6H-dibenz-[b,e] [1,4]oxathiepin derivatives, compositions, and method of use therefor
GB8501372D0 (en) 1985-01-18 1985-02-20 Smith Kline French Lab Chemical compounds
US5284971A (en) * 1992-07-16 1994-02-08 Syntex (U.S.A.) Inc. 4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents
EP0728482A3 (de) 1995-02-10 1999-10-20 Smithkline Beecham Corporation Verwendung spezifischen HCP-Verbindungen zur Erhöhung der Erythropoyesis
CA2222204C (en) 1995-06-06 2002-02-19 Pfizer Inc. Process for converting 2,4-dichloropyridines into 2-aryloxy-4-chloropyridines
AU6480796A (en) 1995-06-30 1997-02-05 Smithkline Beecham Corporation Use of stat 6 sh2 domain specific compounds to treat allergic reactions
US5883294A (en) 1997-06-18 1999-03-16 The Regeants Of The University Of California Selective thyroid hormone analogs
GB9713739D0 (en) * 1997-06-27 1997-09-03 Karobio Ab Thyroid receptor ligands
KR100626605B1 (ko) * 1997-11-19 2006-09-22 코와 가부시키가이샤 신규 피리다진 유도체 및 이를 유효성분으로 하는 의약
AR023659A1 (es) 1998-09-18 2002-09-04 Vertex Pharma Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos
IL144765A0 (en) * 1999-03-01 2002-06-30 Pfizer Prod Inc Oxamic acids and derivatives as thyroid receptor ligands
WO2002051805A1 (de) * 2000-12-27 2002-07-04 Bayer Aktiengesellschaft Indol-derivate
AU2002237298B2 (en) * 2001-02-08 2006-08-03 Karo Bio Ab Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands
ES2240657T3 (es) * 2001-02-28 2005-10-16 Pfizer Products Inc. Compuestos de sulfonilpiridazinona utiles como inhibidores de aldosa reductasa.
EP1608629A1 (de) * 2003-03-24 2005-12-28 F. Hoffmann-La Roche Ag Benzylpyridazinone als inhibitoren der reversen transkriptase
US7829552B2 (en) 2003-11-19 2010-11-09 Metabasis Therapeutics, Inc. Phosphorus-containing thyromimetics
CA2559552A1 (en) * 2004-03-23 2005-09-29 F. Hoffmann-La Roche Ag Benzyl-pyridazinone derivatives as non-nucleoside reverse transcriptase inhibitors
CA2614529C (en) 2005-07-21 2011-06-28 F. Hoffmann-La Roche Ag Pyridazinone derivatives as thyroid hormone receptor agonists

Also Published As

Publication number Publication date
EP1919878B1 (de) 2010-09-08
RU2008106058A (ru) 2009-08-27
JP2009501759A (ja) 2009-01-22
KR20080019297A (ko) 2008-03-03
TW200745052A (en) 2007-12-16
US7807674B2 (en) 2010-10-05
USRE46024E1 (en) 2016-06-07
MY142861A (en) 2011-01-14
BRPI0613754B1 (pt) 2021-03-16
US7452882B2 (en) 2008-11-18
TWI330636B (en) 2010-09-21
UA88104C2 (ru) 2009-09-10
AR054848A1 (es) 2007-07-18
US20090005383A1 (en) 2009-01-01
RS51639B (sr) 2011-10-31
ES2349131T3 (es) 2010-12-28
CR9644A (es) 2008-02-20
AU2006271721B2 (en) 2010-06-17
JP5000649B2 (ja) 2012-08-15
US20070032494A1 (en) 2007-02-08
AU2006271721C1 (en) 2013-09-19
AU2006271721A1 (en) 2007-01-25
CY1110929T1 (el) 2015-06-10
EP1919878A1 (de) 2008-05-14
IL188476A (en) 2011-10-31
PT1919878E (pt) 2010-11-02
MX2008000818A (es) 2008-03-18
NO20080058L (no) 2008-04-18
KR100965006B1 (ko) 2010-06-21
ZA200800405B (en) 2008-12-31
NO340679B1 (no) 2017-05-29
BRPI0613754B8 (pt) 2021-05-25
ECSP088120A (es) 2008-02-20
HK1115129A1 (en) 2008-11-21
DK1919878T3 (da) 2010-10-25
IL188476A0 (en) 2008-04-13
MA29731B1 (fr) 2008-09-01
BRPI0613754A2 (pt) 2011-02-08
CN101228135A (zh) 2008-07-23
CA2614529A1 (en) 2007-01-25
PL1919878T3 (pl) 2011-03-31
NZ565190A (en) 2010-02-26
RU2379295C2 (ru) 2010-01-20
CA2614529C (en) 2011-06-28
WO2007009913A1 (en) 2007-01-25
CN101228135B (zh) 2011-08-31
HRP20100633T1 (hr) 2011-01-31
DE602006016821D1 (de) 2010-10-21

Similar Documents

Publication Publication Date Title
ATE480524T1 (de) Pyridazinonderivate als schilddrüsenhormon- rezeptoragonisten
ATE504559T1 (de) Arylanilinderivate als agonisten des beta2- adrenergen rezeptors
ATE502040T1 (de) Bisadenosinverbindungen als adenosin-a2a- rezeptoragonisten
ATE481404T1 (de) Adenosinderivate als agonisten am a2a-rezeptor
IL188550A0 (en) Heterocyclic compounds as agonists for the thyroid receptor
ATE509927T1 (de) Indolderivate als s1p1-rezeptor-agonisten
DE602006015607D1 (de) Thiazol-4-carboxamid-derivate als mglur5-antagonisten
ATE413874T1 (de) Neue thiophen-derivate als sphingosin-1-phosphat- 1-rezeptorantagonisten
ATE420088T1 (de) Chinolinoncarbonsäureamidverbindungen als 5-ht4- rezeptoragonisten
IS8842A (is) Kjarnviðtaka bindimiðlar.
ATE478064T1 (de) Als pi-3-kinaseinhibitoren verwendete pyrimidinderivate
ATE555111T1 (de) Chinuclidinol-derivate als muscarinrezeptor- antagonisten
ATE523195T1 (de) Neue thiophen-derivate als sphingosin-1-phosphat- 1-rezeptorantagonisten
NL1028624A1 (nl) Alfa-aryl- of -heteroarylmethyl-bèta-piperidinopropaan-zuurverbindingen als ORL1-receptorantagonisten.
ATE513827T1 (de) Oxyindol-derivate als 5ht4-rezeptor-agonisten
ATE549350T1 (de) Neuropeptid-2-rezeptor-agonisten
DE602006003628D1 (de) Purinderivate als a2a-rezeptoragonisten
ATE477243T1 (de) 2-aminochinoline als 5-ht(5a)- rezeptorantagonisten
DE602006020447D1 (de) Niacin-rezeptoragonisten, zusammensetzungen mit de
DK1973886T3 (da) Prokineticin-1-receptor-antagonister
ATE534628T1 (de) Urotensin ii-rezeptorantagonisten
DE602005004404D1 (de) Als histamin-3-rezeptorliganden einsetzbare naphthalene-derivate
ATE537144T1 (de) Nitrierte heterocyclische verbindungen als endothelinrezeptorantagonisten
NL2000241A1 (nl) Carboxamidederivaten als muscarine-receptorantagonisten.
ATE535523T1 (de) Benzimidazolcarbonsäureamid-verbindungen als 5- ht4 rezeptor-agonisten

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1919878

Country of ref document: EP