ATE513827T1 - Oxyindol-derivate als 5ht4-rezeptor-agonisten - Google Patents

Oxyindol-derivate als 5ht4-rezeptor-agonisten

Info

Publication number: ATE513827T1
Authority: AT; Austria
Prior art keywords: receptor agonists; oxyindole derivatives; oxyindole; derivatives; agonists
Prior art date: 2005-02-22

Application number

AT06710525T

Other languages

English (en)

Inventor

Kiyoshi Kawamura

Hiroki Sone

Chikara Uchida

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-02-22

Filing date

2006-02-10

Publication date

2011-07-15

2006-02-10 Application filed by Pfizer filed Critical Pfizer

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE513827T1 publication Critical patent/ATE513827T1/de

Links

PTXVSDKCUJCCLC-UHFFFAOYSA-N 1-hydroxyindole Chemical class C1=CC=C2N(O)C=CC2=C1 PTXVSDKCUJCCLC-UHFFFAOYSA-N 0.000 title 1
108091005482 5-HT4 receptors Proteins 0.000 title 1
239000000018 receptor agonist Substances 0.000 title 1
229940044601 receptor agonist Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hematology (AREA)
Pulmonology (AREA)
Nutrition Science (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

AT06710525T 2005-02-22 2006-02-10 Oxyindol-derivate als 5ht4-rezeptor-agonisten ATE513827T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US65527605P	2005-02-22	2005-02-22
PCT/IB2006/000519 WO2006090279A1 (en)	2005-02-22	2006-02-10	Oxyindole derivatives as 5ht4 receptor agonists

Publications (1)

Publication Number	Publication Date
ATE513827T1 true ATE513827T1 (de)	2011-07-15

Family

ID=36579484

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06710525T ATE513827T1 (de)	2005-02-22	2006-02-10	Oxyindol-derivate als 5ht4-rezeptor-agonisten

Country Status (31)

Country	Link
US (2)	US7589109B2 (de)
EP (1)	EP1856110B1 (de)
JP (1)	JP4130220B1 (de)
KR (1)	KR100908547B1 (de)
CN (1)	CN101522668B (de)
AP (1)	AP2007004067A0 (de)
AR (1)	AR053548A1 (de)
AT (1)	ATE513827T1 (de)
AU (1)	AU2006217534B8 (de)
BR (1)	BRPI0607456A2 (de)
CA (1)	CA2598536C (de)
DK (1)	DK1856110T3 (de)
DO (1)	DOP2006000046A (de)
EA (1)	EA012615B1 (de)
ES (1)	ES2366375T3 (de)
GE (1)	GEP20094727B (de)
GT (1)	GT200600083A (de)
HN (1)	HN2006007884A (de)
IL (1)	IL184505A0 (de)
MA (1)	MA29260B1 (de)
MX (1)	MX2007010139A (de)
NL (1)	NL1031218C2 (de)
NO (1)	NO20073566L (de)
NZ (1)	NZ556627A (de)
PE (1)	PE20061096A1 (de)
TN (1)	TNSN07319A1 (de)
TW (1)	TW200640915A (de)
UA (1)	UA86301C2 (de)
UY (1)	UY29389A1 (de)
WO (1)	WO2006090279A1 (de)
ZA (1)	ZA200706420B (de)

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EA201792205A1 (ru)	2015-04-03	2018-02-28	Инсайт Корпорейшн	Гетероциклические соединения как ингибиторы lsd1
DK3334709T3 (da)	2015-08-12	2025-02-03	Incyte Holdings Corp	Salte af en lsd1-hæmmer
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2006
- 2006-02-10 AU AU2006217534A patent/AU2006217534B8/en not_active Ceased
- 2006-02-10 CA CA2598536A patent/CA2598536C/en not_active Expired - Fee Related
- 2006-02-10 AT AT06710525T patent/ATE513827T1/de not_active IP Right Cessation
- 2006-02-10 EA EA200701552A patent/EA012615B1/ru not_active IP Right Cessation
- 2006-02-10 CN CN200680005786XA patent/CN101522668B/zh not_active Expired - Fee Related
- 2006-02-10 BR BRPI0607456-1A patent/BRPI0607456A2/pt not_active IP Right Cessation
- 2006-02-10 GE GEAP200610234A patent/GEP20094727B/en unknown
- 2006-02-10 NZ NZ556627A patent/NZ556627A/en not_active IP Right Cessation
- 2006-02-10 KR KR1020077019124A patent/KR100908547B1/ko not_active Expired - Fee Related
- 2006-02-10 WO PCT/IB2006/000519 patent/WO2006090279A1/en not_active Ceased
- 2006-02-10 ES ES06710525T patent/ES2366375T3/es not_active Expired - Lifetime
- 2006-02-10 EP EP06710525A patent/EP1856110B1/de not_active Expired - Lifetime
- 2006-02-10 DK DK06710525.4T patent/DK1856110T3/da active
- 2006-02-10 MX MX2007010139A patent/MX2007010139A/es active IP Right Grant
- 2006-02-10 JP JP2007556683A patent/JP4130220B1/ja not_active Expired - Fee Related
- 2006-02-10 AP AP2007004067A patent/AP2007004067A0/xx unknown
- 2006-02-20 AR ARP060100601A patent/AR053548A1/es unknown
- 2006-02-20 PE PE2006000207A patent/PE20061096A1/es not_active Application Discontinuation
- 2006-02-20 DO DO2006000046A patent/DOP2006000046A/es unknown
- 2006-02-21 TW TW095105776A patent/TW200640915A/zh unknown
- 2006-02-21 HN HN2006007884A patent/HN2006007884A/es unknown
- 2006-02-21 GT GT200600083A patent/GT200600083A/es unknown
- 2006-02-22 NL NL1031218A patent/NL1031218C2/nl not_active IP Right Cessation
- 2006-02-22 UY UY29389A patent/UY29389A1/es not_active Application Discontinuation
- 2006-02-22 US US11/360,095 patent/US7589109B2/en not_active Expired - Fee Related
- 2006-10-02 UA UAA200709522A patent/UA86301C2/uk unknown
2007
- 2007-07-09 IL IL184505A patent/IL184505A0/en unknown
- 2007-07-10 NO NO20073566A patent/NO20073566L/no not_active Application Discontinuation
- 2007-08-01 ZA ZA200706420A patent/ZA200706420B/xx unknown
- 2007-08-21 TN TNP2007000319A patent/TNSN07319A1/fr unknown
- 2007-08-22 MA MA30153A patent/MA29260B1/fr unknown
2009
- 2009-06-24 US US12/490,451 patent/US20100173925A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN101522668A (zh)	2009-09-02
MX2007010139A (es)	2007-09-27
EA200701552A1 (ru)	2007-12-28
US20060194842A1 (en)	2006-08-31
GEP20094727B (en)	2009-07-10
AU2006217534B2 (en)	2011-08-11
PE20061096A1 (es)	2006-11-09
US20100173925A1 (en)	2010-07-08
TW200640915A (en)	2006-12-01
MA29260B1 (fr)	2008-02-01
WO2006090279A1 (en)	2006-08-31
NO20073566L (no)	2007-08-08
HN2006007884A (es)	2010-01-18
IL184505A0 (en)	2007-10-31
AU2006217534A8 (en)	2011-12-08
US7589109B2 (en)	2009-09-15
NL1031218A1 (nl)	2006-08-23
EA012615B1 (ru)	2009-10-30
NZ556627A (en)	2010-09-30
BRPI0607456A2 (pt)	2009-09-08
CN101522668B (zh)	2012-06-06
HK1135966A1 (en)	2010-06-18
AP2007004067A0 (en)	2007-08-31
DK1856110T3 (da)	2011-08-15
GT200600083A (es)	2006-11-07
AU2006217534B8 (en)	2011-12-08
CA2598536A1 (en)	2006-08-31
JP2008531543A (ja)	2008-08-14
CA2598536C (en)	2011-04-05
UA86301C2 (en)	2009-04-10
DOP2006000046A (es)	2006-08-31
UY29389A1 (es)	2006-10-02
KR20070098936A (ko)	2007-10-05
KR100908547B1 (ko)	2009-07-20
ES2366375T3 (es)	2011-10-19
AR053548A1 (es)	2007-05-09
NL1031218C2 (nl)	2007-01-23
EP1856110B1 (de)	2011-06-22
JP4130220B1 (ja)	2008-08-06
TNSN07319A1 (fr)	2008-12-31
AU2006217534A1 (en)	2006-08-31
ZA200706420B (en)	2009-04-29
EP1856110A1 (de)	2007-11-21

Legal Events

Date	Code	Title	Description
2011-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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