ATE480525T1 - Neues verfahren zur synthese von 2- aminooxazolverbindungen - Google Patents
Neues verfahren zur synthese von 2- aminooxazolverbindungenInfo
- Publication number
- ATE480525T1 ATE480525T1 AT07729016T AT07729016T ATE480525T1 AT E480525 T1 ATE480525 T1 AT E480525T1 AT 07729016 T AT07729016 T AT 07729016T AT 07729016 T AT07729016 T AT 07729016T AT E480525 T1 ATE480525 T1 AT E480525T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- aminooxazole
- synthesis
- new method
- flt
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- ACTKAGSPIFDCMF-UHFFFAOYSA-N 1,3-oxazol-2-amine Chemical class NC1=NC=CO1 ACTKAGSPIFDCMF-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 abstract 1
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 abstract 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 abstract 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 abstract 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/48—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79967406P | 2006-05-12 | 2006-05-12 | |
| PCT/EP2007/054564 WO2007131953A1 (en) | 2006-05-12 | 2007-05-11 | A new process for the synthesis of 2-aminoxazole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE480525T1 true ATE480525T1 (de) | 2010-09-15 |
Family
ID=38268842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07729016T ATE480525T1 (de) | 2006-05-12 | 2007-05-11 | Neues verfahren zur synthese von 2- aminooxazolverbindungen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8080669B2 (de) |
| EP (1) | EP2019822B1 (de) |
| AT (1) | ATE480525T1 (de) |
| DE (1) | DE602007009085D1 (de) |
| ES (1) | ES2352320T3 (de) |
| WO (1) | WO2007131953A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0709031D0 (en) | 2007-05-10 | 2007-06-20 | Sareum Ltd | Pharmaceutical compounds |
| EP2573087A1 (de) | 2007-09-21 | 2013-03-27 | Array Biopharma, Inc. | Pyridin-2-yl-amino-1,2,4-thiadiazol Derivate als glucokinase Activatoren zur Behandlung von Diabetes Mellitus |
| JP5328816B2 (ja) | 2008-02-22 | 2013-10-30 | エフ．ホフマン−ラ ロシュ アーゲー | アミロイドβの調節薬 |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| WO2010040661A1 (en) | 2008-10-09 | 2010-04-15 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
| AU2009312856A1 (en) | 2008-11-10 | 2010-05-14 | F. Hoffmann-La Roche Ag | Heterocyclic gamma secretase modulators |
| GB0820819D0 (en) | 2008-11-13 | 2008-12-24 | Sareum Ltd | Pharmaceutical compounds |
| US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| JP5996532B2 (ja) | 2010-07-15 | 2016-09-21 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 有害生物防除剤としての新規複素環式化合物 |
| EP2714667B1 (de) | 2011-05-27 | 2020-11-25 | Laxman S. DESAI | Aminooxazolhemmer von cyclinabhängigen kinasen |
| CN103717591B (zh) | 2011-07-27 | 2016-08-24 | Ab科学有限公司 | 作为选择性蛋白激酶(c-kit)抑制剂的噁唑和噻唑衍生物 |
| GB201202027D0 (en) | 2012-02-06 | 2012-03-21 | Sareum Ltd | Pharmaceutical compounds |
| EP3040336B1 (de) | 2012-03-02 | 2020-04-08 | Sareum Limited | Verbindungen zur verwendung in der behandlung von tyk2 kinase vermittelten erkrankungen |
| ES2796276T3 (es) | 2015-02-05 | 2020-11-26 | Ab Science | Compuestos con actividad antitumoral |
| GB201617871D0 (en) | 2016-10-21 | 2016-12-07 | Sareum Limited | Pharmaceutical compounds |
| GB201816369D0 (en) | 2018-10-08 | 2018-11-28 | Sareum Ltd | Pharmaceutical compounds |
| CN110041285B (zh) * | 2019-04-29 | 2021-08-20 | 大连理工大学 | 一种2，4，5-三取代噁唑类化合物的制备方法 |
| GB202005114D0 (en) | 2020-04-07 | 2020-05-20 | Sareum Ltd | Crystalline Forms of a Pharmaceutical Compound |
| WO2022234069A1 (en) | 2021-05-07 | 2022-11-10 | Ab Science | Novel 2-aminooxazoles derivatives and use thereof for treating infectious diseases |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050228031A1 (en) | 2004-04-13 | 2005-10-13 | Bilodeau Mark T | Tyrosine kinase inhibitors |
-
2007
- 2007-05-11 ES ES07729016T patent/ES2352320T3/es active Active
- 2007-05-11 US US12/299,901 patent/US8080669B2/en not_active Expired - Fee Related
- 2007-05-11 DE DE602007009085T patent/DE602007009085D1/de active Active
- 2007-05-11 AT AT07729016T patent/ATE480525T1/de not_active IP Right Cessation
- 2007-05-11 WO PCT/EP2007/054564 patent/WO2007131953A1/en not_active Ceased
- 2007-05-11 EP EP07729016A patent/EP2019822B1/de not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| US8080669B2 (en) | 2011-12-20 |
| ES2352320T3 (es) | 2011-02-17 |
| WO2007131953A1 (en) | 2007-11-22 |
| EP2019822B1 (de) | 2010-09-08 |
| HK1126777A1 (en) | 2009-09-11 |
| EP2019822A1 (de) | 2009-02-04 |
| US20090192317A1 (en) | 2009-07-30 |
| DE602007009085D1 (de) | 2010-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |