ATE481398T1 - Verfahren zur herstellung von imatinib-base - Google Patents

Verfahren zur herstellung von imatinib-base

Info

Publication number
ATE481398T1
ATE481398T1 AT05822030T AT05822030T ATE481398T1 AT E481398 T1 ATE481398 T1 AT E481398T1 AT 05822030 T AT05822030 T AT 05822030T AT 05822030 T AT05822030 T AT 05822030T AT E481398 T1 ATE481398 T1 AT E481398T1
Authority
AT
Austria
Prior art keywords
methyl
pyridinyl
nitrophenyl
methylphenyl
condensing
Prior art date
Application number
AT05822030T
Other languages
English (en)
Inventor
Wojciech Szczepek
Wojciech Luniewski
Lukasz Kaczmarek
Bogdan Zagrodzki
Dorota Samson-Lazinska
Wieslaw Szelejewski
Maciej Skarzynski
Original Assignee
Inst Farmaceutyczny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PL372016A external-priority patent/PL372016A1/pl
Priority claimed from PL376691A external-priority patent/PL376691A1/pl
Priority claimed from PL377984A external-priority patent/PL377984A1/pl
Application filed by Inst Farmaceutyczny filed Critical Inst Farmaceutyczny
Application granted granted Critical
Publication of ATE481398T1 publication Critical patent/ATE481398T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT05822030T 2004-12-30 2005-12-30 Verfahren zur herstellung von imatinib-base ATE481398T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PL372016A PL372016A1 (pl) 2004-12-30 2004-12-30 Sposób wytwarzania pochodnych N-fenylo-2-pirymidynoamin
PL376691A PL376691A1 (pl) 2005-08-19 2005-08-19 Sposób wytwarzania pochodnych N-fenylo-2- pirymidynoamin
PL377984A PL377984A1 (pl) 2005-11-08 2005-11-08 Sposób wytwarzania N-(5-amino-2-metylofenylo)-4-(3-pirydylo)-2-pirymidynoaminy
PCT/PL2005/000088 WO2006071130A2 (en) 2004-12-30 2005-12-30 A process for preparation of imatinib base

Publications (1)

Publication Number Publication Date
ATE481398T1 true ATE481398T1 (de) 2010-10-15

Family

ID=36203912

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05822030T ATE481398T1 (de) 2004-12-30 2005-12-30 Verfahren zur herstellung von imatinib-base

Country Status (7)

Country Link
US (1) US7674901B2 (de)
EP (1) EP1833815B1 (de)
AT (1) ATE481398T1 (de)
DE (1) DE602005023658D1 (de)
PL (1) PL1833815T3 (de)
SI (1) SI1833815T1 (de)
WO (1) WO2006071130A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7977348B2 (en) 2006-04-27 2011-07-12 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
US8067421B2 (en) 2006-04-27 2011-11-29 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
EP2009008A1 (de) 2006-10-26 2008-12-31 Sicor, Inc. Imatinib-Base und Imatinib-Mesylat und Herstellungsverfahren dafür
US8168787B2 (en) 2006-11-16 2012-05-01 F.I.S. Fabbrica Italiana Sintetici S.P.A. Process for the preparation of imatinib and intermediates thereof
KR101012134B1 (ko) 2008-09-03 2011-02-07 주식회사 대희화학 이마티니브 및 이마티니브 메실레이트염의 제조방법
US20100330130A1 (en) 2009-05-22 2010-12-30 Actavis Group Ptc Ehf Substantially pure imatinib or a pharmaceutically acceptable salt thereof
CN102070604B (zh) * 2009-11-20 2014-06-25 成都弘达药业有限公司 一种伊马替尼游离碱的制备方法
WO2011095835A1 (en) 2010-02-02 2011-08-11 Actavis Group Ptc Ehf Highly pure imatinib or a pharmaceutically acceptable salt thereof
US20130060030A1 (en) * 2010-03-15 2013-03-07 Natco Pharma Limited Process for the preparation of highly pure crystalline imatinib base
EA024088B1 (ru) 2010-06-18 2016-08-31 КРКА, д.д., НОВО МЕСТО α-ФОРМА МЕЗИЛАТА ИМАТИНИБА, СПОСОБЫ ЕЕ ПОЛУЧЕНИЯ И СОДЕРЖАЩАЯ ЕЁ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ
TR201007005A2 (tr) 2010-08-23 2011-09-21 Mustafa Nevzat İlaç Sanayi̇i̇ A.Ş. İmatinib baz üretim yöntemi
CN102731474B (zh) * 2011-04-13 2014-12-03 石药集团中奇制药技术（石家庄）有限公司 一种伊马替尼的制备方法
JP6799201B2 (ja) 2013-07-31 2020-12-16 アヴァリン ファーマ インク． エアロゾルチロシンキナーゼ阻害剤の化合物、及びその使用
CN106854199A (zh) * 2015-12-08 2017-06-16 湖南华腾制药有限公司 一种伊马替尼的合成方法
EP3333162A1 (de) 2016-12-12 2018-06-13 Silesian Catalysts sp. z o.o. Verfahren zur herstellung von n-(2-methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine
DE102017004596B4 (de) 2017-05-13 2021-02-11 Alzchem Trostberg Gmbh Verfahren zur Herstellung von Phenylguanidinen oder deren Salze
WO2020232238A1 (en) 2019-05-16 2020-11-19 Aerovate Therapeutics, Inc. Inhalable formulations for kinase inhibition
US11464776B2 (en) 2019-05-16 2022-10-11 Aerovate Therapeutics, Inc. Inhalable imatinib formulations, manufacture, and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW225528B (de) * 1992-04-03 1994-06-21 Ciba Geigy Ag
HU224435B1 (hu) * 1995-02-09 2005-10-28 EGIS Gyógyszergyár Rt. Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények
AU2003232650A1 (en) * 2003-05-06 2004-11-26 Il Yang Pharm Co., Ltd. N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof
AU2003242988A1 (en) * 2003-06-06 2005-01-04 Adibhatla Kali Sathya Bhujanga Rao Process for the preparation of the anti-cancer drug imatinib and its analogues
WO2006021458A2 (en) * 2004-08-27 2006-03-02 Gpc Biotech Ag Pyrimidine derivatives

Also Published As

Publication number Publication date
EP1833815B1 (de) 2010-09-15
DE602005023658D1 (de) 2010-10-28
US7674901B2 (en) 2010-03-09
WO2006071130A2 (en) 2006-07-06
EP1833815A2 (de) 2007-09-19
WO2006071130A3 (en) 2006-09-28
WO2006071130A8 (en) 2007-02-22
PL1833815T3 (pl) 2011-03-31
SI1833815T1 (sl) 2011-01-31
WO2006071130B1 (en) 2006-11-16
US20080194819A1 (en) 2008-08-14

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