ATE482275T1 - Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden - Google Patents
Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden bindenInfo
- Publication number
- ATE482275T1 ATE482275T1 AT00947904T AT00947904T ATE482275T1 AT E482275 T1 ATE482275 T1 AT E482275T1 AT 00947904 T AT00947904 T AT 00947904T AT 00947904 T AT00947904 T AT 00947904T AT E482275 T1 ATE482275 T1 AT E482275T1
- Authority
- AT
- Austria
- Prior art keywords
- poly
- binding partners
- ests
- genomic dna
- dna fragments
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—RNA viruses
- C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99112815 | 1999-07-02 | ||
| PCT/EP2000/006137 WO2001002588A2 (en) | 1999-07-02 | 2000-06-30 | Generation of specific binding partners binding to (poly)peptides encoded by genomic dna fragments or ests |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE482275T1 true ATE482275T1 (de) | 2010-10-15 |
Family
ID=8238496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00947904T ATE482275T1 (de) | 1999-07-02 | 2000-06-30 | Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6653068B2 (de) |
| EP (1) | EP1133565B1 (de) |
| JP (1) | JP4794789B2 (de) |
| AT (1) | ATE482275T1 (de) |
| CA (1) | CA2339889C (de) |
| DE (1) | DE60044997D1 (de) |
| DK (1) | DK1133565T3 (de) |
| ES (1) | ES2353268T3 (de) |
| WO (1) | WO2001002588A2 (de) |
Families Citing this family (69)
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|---|---|---|---|---|
| US6696251B1 (en) * | 1996-05-31 | 2004-02-24 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| US6759243B2 (en) * | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
| WO2001077365A2 (en) | 2000-04-06 | 2001-10-18 | Pharmacia & Upjohn Company | Antimicrobial methods and materials |
| WO2003029484A2 (en) * | 2001-09-28 | 2003-04-10 | Pharmacia & Upjohn Company | Antimicrobial methods and materials |
| US20030235814A1 (en) * | 2002-06-19 | 2003-12-25 | Los Alamos National Laboratory | Compositions and methods for selecting open reading frames |
| DOP2006000277A (es) | 2005-12-12 | 2007-08-31 | Bayer Pharmaceuticals Corp | Anticuerpos anti mn y métodos para su utilización |
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| US9044461B2 (en) | 2006-04-07 | 2015-06-02 | The Research Foundation Of State University Of New York | Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency |
| JP5675109B2 (ja) | 2007-02-20 | 2015-02-25 | アナプティスバイオ インコーポレイティッド | ライブラリーの生成方法及びその使用 |
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| US8832581B2 (en) * | 2009-03-05 | 2014-09-09 | Ming Zhang | Gene expression browser for web-based search and visualization of characteristics of gene expression |
| AR076284A1 (es) | 2009-04-29 | 2011-06-01 | Bayer Schering Pharma Ag | Inmunoconjugados de antimesotelina y usos de los mismos |
| MX2012008085A (es) | 2010-01-13 | 2012-09-12 | Oncomed Pharm Inc | Agentes de union notch1 y metodos de uso de los mismos. |
| KR20120117931A (ko) | 2010-02-12 | 2012-10-24 | 온코메드 파마슈티칼스, 인크. | 폴리펩타이드를 발현하는 세포를 확인 및 분리하는 방법 |
| EP3178846B1 (de) | 2010-02-17 | 2018-08-22 | Cedars-Sinai Medical Center | Neuartige phosphorylierung von kardialem troponin i als ein monitor einer kardialen verletzung |
| CN105777907B (zh) | 2010-02-24 | 2020-03-17 | 伊缪诺金公司 | 叶酸受体1抗体与免疫缀合物以及其用途 |
| LT2544719T (lt) | 2010-03-12 | 2019-10-25 | Debiopharm Int Sa | Cd37 surišančios molekulės, ir jų imunokonjugatai |
| WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
| WO2012019024A2 (en) | 2010-08-04 | 2012-02-09 | Immunogen, Inc. | Her3-binding molecules and immunoconjugates thereof |
| DK2714738T3 (en) | 2011-05-24 | 2019-01-28 | Zyngenia Inc | MULTIVALENT AND MONOVALENT MULTISPECIFIC COMPLEXES AND THEIR APPLICATIONS |
| WO2013012747A1 (en) | 2011-07-15 | 2013-01-24 | Oncomed Pharmaceuticals, Inc. | Rspo binding agents and uses thereof |
| US9120858B2 (en) | 2011-07-22 | 2015-09-01 | The Research Foundation Of State University Of New York | Antibodies to the B12-transcobalamin receptor |
| TWI583699B (zh) | 2011-09-23 | 2017-05-21 | 安可美德藥物股份有限公司 | Vegf/dll4結合劑類及彼等之用途 |
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| CN108424456B (zh) | 2011-11-23 | 2022-04-26 | 医学免疫有限责任公司 | 特异于her3的结合分子及其用途 |
| MX2014014951A (es) | 2012-06-06 | 2015-03-13 | Oncomed Pharm Inc | Agentes aglutinantes que modulan la trayectoria hippo y sus usos. |
| SG11201500938XA (en) | 2012-08-31 | 2015-04-29 | Immunogen Inc | Diagnostic assays and kits for detection of folate receptor 1 |
| HK1214521A1 (zh) | 2012-11-05 | 2016-07-29 | Genzyme Corporation | 用於治療蛋白質病的組合物和方法 |
| MX2015013163A (es) | 2013-03-15 | 2016-04-04 | Zyngenia Inc | Complejos multiespecificos multivalente y monovalentes y sus usos. |
| KR20240122922A (ko) | 2013-03-27 | 2024-08-13 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전 |
| DE102013106462B3 (de) * | 2013-06-20 | 2014-10-09 | Airbus Defence and Space GmbH | Detektionsverfahren zur Detektion von Bakterien, Verfahren zur Herstellung von Fusionsproteinen und Fusionsprotein |
| EP3022295A4 (de) | 2013-07-19 | 2017-03-01 | Cedars-Sinai Medical Center | Signatur des tl1a (tnfsf15)-signalweges |
| NZ717140A (en) | 2013-08-30 | 2022-05-27 | Immunogen Inc | Antibodies and assays for detection of folate receptor 1 |
| JP6463744B2 (ja) | 2013-10-08 | 2019-02-06 | イミュノジェン, インコーポレイテッド | 抗folr1免疫抱合体投薬レジメン |
| AU2015244025B2 (en) | 2014-04-08 | 2019-03-21 | Boston Pharmaceuticals Inc. | Binding molecules specific for IL-21 and uses thereof |
| CA2943299A1 (en) | 2014-04-11 | 2015-10-15 | Medimmune, Llc | Bispecific her2 antibodies |
| RS62003B2 (sr) | 2014-11-10 | 2025-01-31 | Medimmune Ltd | Vezujući molekuli specifični za cd73 i njihove upotrebe |
| EP3789403A1 (de) | 2014-11-11 | 2021-03-10 | MedImmune Limited | Therapeutische kombinationen mit anti-cd73-antikörpern und a2a-rezeptorinhibitoren sowie verwendungen davon |
| MX387295B (es) | 2015-03-31 | 2025-03-18 | Medimmune Ltd | Nueva forma de interleucina-33 (il33), formas mutadas de interleucina-33 (il33), anticuerpos, ensayos y métodos para usar los mismos. |
| SMT202100092T1 (it) | 2015-06-29 | 2021-03-15 | Immunogen Inc | Anticorpi anti-cd123 e loro coniugati e derivati |
| CN122075735A (zh) | 2015-09-17 | 2026-05-26 | 伊缪诺金公司 | 包含抗folr1免疫缀合物的治疗组合 |
| PL3374398T3 (pl) | 2015-11-10 | 2020-08-24 | Medimmune, Llc | Cząsteczki wiążące swoiste dla ASCT2 i ich zastosowanie |
| CA3015277A1 (en) | 2016-03-10 | 2017-09-14 | Acceleron Pharma Inc. | Activin type 2 receptor binding proteins and uses thereof |
| JP6979976B2 (ja) | 2016-03-10 | 2021-12-15 | ヴィエラ バイオ,インコーポレーテッド | Ilt7結合分子及びその使用方法 |
| CN109462996A (zh) | 2016-03-17 | 2019-03-12 | 西达-赛奈医疗中心 | 通过rnaset2诊断炎性肠病的方法 |
| JP7103950B2 (ja) | 2016-04-22 | 2022-07-20 | アクセレロン ファーマ インコーポレーテッド | Alk7結合性タンパク質及びその使用 |
| RS62040B1 (sr) | 2016-06-02 | 2021-07-30 | Abbvie Inc | Agonist receptora glukokortikoida i njegovi imunokonjugati |
| BR112019002039A2 (pt) | 2016-08-05 | 2019-05-07 | Medimmune, Llc | anticorpos anti-o2 e uso dos mesmos |
| CA3039686A1 (en) | 2016-10-19 | 2018-04-26 | Medimmune, Llc | Anti-o1 antibodies and uses thereof |
| MY191324A (en) | 2016-10-26 | 2022-06-15 | Cedars Sinai Medical Center | Neutralizing anti-tl1a monoclonal antibodies |
| AU2017363309A1 (en) | 2016-11-23 | 2019-07-11 | Bioverativ Therapeutics Inc. | Mono- and bispecific antibodies binding to coagulation factor IX and coagulation factor X |
| EP3752195A4 (de) | 2018-02-14 | 2021-11-17 | Viela Bio, Inc. | Antikörper gegen felinen mcdonough-sarkom(fms)-ähnlichen tyrosinkinase-3-rezeptorliganden (flt3l) und verwendungen davon zur behandlung von autoimmun- und entzündungskrankheiten |
| CN119735681A (zh) | 2018-04-25 | 2025-04-01 | 普罗米修斯生物科学公司 | 优化的抗tl1a抗体 |
| JP7463366B2 (ja) | 2018-11-20 | 2024-04-08 | タケダ ワクチン,インコーポレイテッド | 新規の抗ジカウイルス抗体及びその使用 |
| US11447551B2 (en) | 2018-12-28 | 2022-09-20 | Sparx Bioscience Limited | Binding molecules specific for claudin 18.2, compositions and methods thereof, for the treatment of cancer and other diseases |
| TW202600603A (zh) | 2019-10-24 | 2026-01-01 | 美商普羅米修斯生物科學股份有限公司 | 針對類-tnf配體1a (tl1a)之人類化抗體及其用途 |
| WO2021203013A2 (en) | 2020-04-03 | 2021-10-07 | Viela Bio, Inc. | Methods of treating immune mediated pulmonary injury |
| TW202216744A (zh) | 2020-07-20 | 2022-05-01 | 美商維埃拉生物股份有限公司 | 用於治療自體免疫性病症和炎性病症之免疫細胞介素 |
| CN116829592A (zh) | 2020-09-11 | 2023-09-29 | 免疫医疗有限公司 | 治疗性b7-h4结合分子 |
| KR20230066095A (ko) | 2020-09-12 | 2023-05-12 | 메디뮨 리미티드 | 항-b7h4 항체-약물 접합체 요법에 대한 점수산정 방법 |
| US11452757B2 (en) * | 2021-02-25 | 2022-09-27 | Intron Biotechnology, Inc. | Antibacterial composition effective in treating gram negative bacterial infections and method for preparing the same |
| EP4308607A2 (de) | 2021-03-18 | 2024-01-24 | MedImmune Limited | An ccr9 bindendes therapeutisches bindungsmolekül |
| US11807685B2 (en) | 2021-08-05 | 2023-11-07 | The Uab Research Foundation | Anti-CD47 antibody and uses thereof |
| TW202348252A (zh) | 2022-02-16 | 2023-12-16 | 英商梅迪繆思有限公司 | 用治療性結合分子治療癌症的組合療法 |
| WO2024169990A1 (zh) | 2023-02-13 | 2024-08-22 | 浙江大学绍兴研究院 | 双特异性抗体及其应用 |
| KR20260048598A (ko) | 2023-07-31 | 2026-04-10 | 아스트라제네카 아베 | Cd123 항체-약물 접합체 및 이의 사용 방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5601823A (en) * | 1989-10-31 | 1997-02-11 | Ophidian Pharmaceuticals, Inc. | Avian antitoxins to clostridium difficle toxin A |
| US6069230A (en) * | 1994-11-10 | 2000-05-30 | Promega Corporation | High level expression and facile purification of proteins, peptides and conjugates for immunization, purification and detection applications |
| US5895651A (en) * | 1996-06-27 | 1999-04-20 | The United States Of America As Represented By The Secretary Of The Navy | Recombinant dengue virus envelope protein/maltose-binding protein antigens and subunit vaccine compositions containing said antigens |
| JP2001512306A (ja) * | 1997-01-08 | 2001-08-21 | ライフ テクノロジーズ,インコーポレイテッド | タンパク質の産生方法 |
-
2000
- 2000-06-30 AT AT00947904T patent/ATE482275T1/de active
- 2000-06-30 WO PCT/EP2000/006137 patent/WO2001002588A2/en not_active Ceased
- 2000-06-30 JP JP2001508360A patent/JP4794789B2/ja not_active Expired - Lifetime
- 2000-06-30 DE DE60044997T patent/DE60044997D1/de not_active Expired - Lifetime
- 2000-06-30 DK DK00947904.9T patent/DK1133565T3/da active
- 2000-06-30 ES ES00947904T patent/ES2353268T3/es not_active Expired - Lifetime
- 2000-06-30 CA CA2339889A patent/CA2339889C/en not_active Expired - Lifetime
- 2000-06-30 EP EP00947904A patent/EP1133565B1/de not_active Expired - Lifetime
-
2001
- 2001-02-28 US US09/795,872 patent/US6653068B2/en not_active Expired - Lifetime
-
2003
- 2003-09-16 US US10/662,824 patent/US20040157291A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003504031A (ja) | 2003-02-04 |
| DK1133565T3 (da) | 2011-01-24 |
| CA2339889A1 (en) | 2001-01-11 |
| WO2001002588A3 (en) | 2001-07-12 |
| US20030170622A1 (en) | 2003-09-11 |
| JP4794789B2 (ja) | 2011-10-19 |
| WO2001002588A2 (en) | 2001-01-11 |
| DE60044997D1 (de) | 2010-11-04 |
| US6653068B2 (en) | 2003-11-25 |
| US20040157291A1 (en) | 2004-08-12 |
| EP1133565A2 (de) | 2001-09-19 |
| CA2339889C (en) | 2012-01-31 |
| ES2353268T3 (es) | 2011-02-28 |
| EP1133565B1 (de) | 2010-09-22 |
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| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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