ATE483688T1 - Neues auflösungsverfahren von enantiomeren von (3,4-dimethoxy-bicycloä4.2.0üocta-1,3,5-trien-7 yl)nitril und anwendung für die synthese von ivabradin - Google Patents

Neues auflösungsverfahren von enantiomeren von (3,4-dimethoxy-bicycloä4.2.0üocta-1,3,5-trien-7 yl)nitril und anwendung für die synthese von ivabradin

Info

Publication number
ATE483688T1
ATE483688T1 AT09290646T AT09290646T ATE483688T1 AT E483688 T1 ATE483688 T1 AT E483688T1 AT 09290646 T AT09290646 T AT 09290646T AT 09290646 T AT09290646 T AT 09290646T AT E483688 T1 ATE483688 T1 AT E483688T1
Authority
AT
Austria
Prior art keywords
ivabradine
trien
enantiomers
dimethoxy
nitrile
Prior art date
Application number
AT09290646T
Other languages
English (en)
Inventor
Jean-Michel Lerestif
Jean-Pierre Lecouve
Daniel Dron
Eric Gojon
Maryse Phan
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40431490&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE483688(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of ATE483688T1 publication Critical patent/ATE483688T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/48—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT09290646T 2008-08-29 2009-08-27 Neues auflösungsverfahren von enantiomeren von (3,4-dimethoxy-bicycloä4.2.0üocta-1,3,5-trien-7 yl)nitril und anwendung für die synthese von ivabradin ATE483688T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0804755A FR2935381B1 (fr) 2008-08-29 2008-08-29 Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine

Publications (1)

Publication Number Publication Date
ATE483688T1 true ATE483688T1 (de) 2010-10-15

Family

ID=40431490

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09290646T ATE483688T1 (de) 2008-08-29 2009-08-27 Neues auflösungsverfahren von enantiomeren von (3,4-dimethoxy-bicycloä4.2.0üocta-1,3,5-trien-7 yl)nitril und anwendung für die synthese von ivabradin

Country Status (38)

Country Link
US (3) US8536365B2 (de)
EP (1) EP2166004B1 (de)
JP (2) JP5663154B2 (de)
KR (1) KR101119309B1 (de)
CN (1) CN101659631B (de)
AR (1) AR073147A1 (de)
AT (1) ATE483688T1 (de)
AU (1) AU2009208068B2 (de)
BR (1) BRPI0903051A2 (de)
CA (1) CA2676712C (de)
CL (1) CL2009001758A1 (de)
CY (1) CY1110943T1 (de)
DE (1) DE602009000256D1 (de)
DK (1) DK2166004T3 (de)
EA (1) EA015777B1 (de)
ES (1) ES2353251T3 (de)
FR (1) FR2935381B1 (de)
GE (1) GEP20125409B (de)
HR (1) HRP20100679T1 (de)
JO (1) JO2786B1 (de)
MA (1) MA31228B1 (de)
ME (1) ME00835B (de)
MX (1) MX2009008443A (de)
MY (1) MY145992A (de)
NZ (1) NZ579270A (de)
PA (1) PA8840901A1 (de)
PE (1) PE20100234A1 (de)
PL (1) PL2166004T3 (de)
PT (1) PT2166004E (de)
RS (1) RS51554B (de)
SA (1) SA109300533B1 (de)
SG (1) SG159454A1 (de)
SI (1) SI2166004T1 (de)
TW (1) TWI404705B (de)
UA (1) UA105890C2 (de)
UY (1) UY32034A (de)
WO (1) WO2010023383A1 (de)
ZA (1) ZA200905566B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2528026T3 (es) 2007-05-30 2015-02-03 Ind-Swift Laboratories Limited Sales de oxalato de ivabridina cristalino y polimorfos de los mismos
FR2935381B1 (fr) * 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
CN101774969B (zh) * 2009-01-13 2012-07-04 江苏恒瑞医药股份有限公司 硫酸伊伐布雷定及其i型结晶的制备方法
HUP1000245A2 (en) * 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
EP2522647B1 (de) * 2011-05-10 2014-04-30 DSM IP Assets B.V. Verfahren zum Trennen von chiralen Isomeren von Chromverbindungen und ihre Derivate und Vorläufer
FR2984320B1 (fr) * 2011-12-20 2013-11-29 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2984319B1 (fr) * 2011-12-20 2013-12-27 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2986804A1 (fr) * 2012-02-09 2013-08-16 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels
FR2993561B1 (fr) * 2012-07-17 2014-10-31 Servier Lab Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels
FR3002542B1 (fr) * 2013-02-28 2016-01-22 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique et application a la synthese de l'ivabradine et de ses sels
EP3101010A1 (de) 2015-06-03 2016-12-07 Urquima S.A. Neues verfahren zur herstellung von hochreinem ivabradine und dessen salzen
CN106390519A (zh) * 2016-09-12 2017-02-15 华东理工大学 多柱模拟移动床色谱技术连续分离氨鲁米特外消旋体的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5246948B2 (de) * 1972-04-26 1977-11-29
IE52768B1 (en) * 1981-04-06 1988-02-17 Boots Co Ltd 1-arylcyclobutylalkylamine compounds useful as therapeutic agents
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
FR2539415B1 (fr) * 1983-01-14 1985-09-13 Adir Derives de la d-2 imidazoline, leur preparation et leur application en therapeutique
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
US5269482A (en) * 1991-09-30 1993-12-14 Shearing Ernest J Protective enclosure apparatus for magnetic propulsion space vehicle
US6312603B1 (en) * 1997-04-15 2001-11-06 Hideyuki Nishizawa Solid-liquid countercurrent extraction continuously separating apparatus
GB0325055D0 (en) * 2003-10-27 2003-12-03 Smithkline Beecham Corp New process
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
CN101568380B (zh) * 2006-09-29 2013-08-28 科学与工业研究委员会 有机-无机杂化手性吸附剂及其制备方法
FR2935381B1 (fr) * 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine

Also Published As

Publication number Publication date
CN101659631A (zh) 2010-03-03
FR2935381B1 (fr) 2010-12-17
EP2166004B1 (de) 2010-10-06
ZA200905566B (en) 2010-05-26
JO2786B1 (en) 2014-03-15
HK1141511A1 (en) 2010-11-12
US20130211070A1 (en) 2013-08-15
CA2676712C (fr) 2012-09-18
US20130204032A1 (en) 2013-08-08
NZ579270A (en) 2010-12-24
JP2013237675A (ja) 2013-11-28
MA31228B1 (fr) 2010-03-01
US20100056778A1 (en) 2010-03-04
WO2010023383A1 (fr) 2010-03-04
DE602009000256D1 (de) 2010-11-18
PL2166004T3 (pl) 2011-03-31
EA200901051A1 (ru) 2010-04-30
AR073147A1 (es) 2010-10-13
UY32034A (es) 2010-01-29
US8536365B2 (en) 2013-09-17
ME00835B (me) 2012-03-20
PA8840901A1 (es) 2010-04-21
CL2009001758A1 (es) 2010-12-24
MY145992A (en) 2012-06-08
US8778930B2 (en) 2014-07-15
SA109300533B1 (ar) 2013-07-04
GEP20125409B (en) 2012-02-27
RS51554B (sr) 2011-06-30
TWI404705B (zh) 2013-08-11
SG159454A1 (en) 2010-03-30
KR20100027025A (ko) 2010-03-10
CY1110943T1 (el) 2015-06-10
US8927758B2 (en) 2015-01-06
JP2010065032A (ja) 2010-03-25
UA105890C2 (uk) 2014-07-10
TW201010980A (en) 2010-03-16
JP5746733B2 (ja) 2015-07-08
DK2166004T3 (da) 2011-01-10
MX2009008443A (es) 2010-03-23
AU2009208068A1 (en) 2010-03-18
PE20100234A1 (es) 2010-03-27
AU2009208068B2 (en) 2013-09-05
JP5663154B2 (ja) 2015-02-04
PT2166004E (pt) 2010-10-27
HRP20100679T1 (hr) 2011-01-31
FR2935381A1 (fr) 2010-03-05
KR101119309B1 (ko) 2012-03-19
SI2166004T1 (sl) 2010-12-31
ES2353251T3 (es) 2011-02-28
CN101659631B (zh) 2013-08-28
EA015777B1 (ru) 2011-12-30
CA2676712A1 (fr) 2010-02-28
BRPI0903051A2 (pt) 2010-05-25
EP2166004A1 (de) 2010-03-24

Similar Documents

Publication Publication Date Title
DE602009000256D1 (de) Neues Auflösungsverfahren von Enantiomeren von (3,4-Dimethoxy-bicycloÄ4.2.0Üocta-1,3,5-trien-7-yl)Nitril und Anwendung für die Synthese von Ivabradin
FR2935389B1 (fr) Procede d'hydrogenation selective mettant en oeuvre un catalyseur sulfure de composition specifique
EP2334800A4 (de) Mikroorganismen zur herstellung von 1,4-butandiol
HUE061093T2 (hu) Eljárás katalitikus anyagok elõállítására
EP2338927A4 (de) Katalysator zur herstellung von polyalkylenglycol sowie verfahren zur herstellung von polyalkylenglycol damit
BRPI0715480A2 (pt) Liga a base de níquel, peça fundida equiaxial, processo de tratamento térmico de solução de uma liga a base de níquel, e, método para produzir uma peça fundida e artigo tratado termicamente a partir de uma liga a base de níquel
CL2009001684A1 (es) Procedimiento de sintesis de agomelatina por reduccion de un grupo nitrilo en presencia de anhidrido acetico.
IT1392456B1 (it) Processo per la sintesi di di- o oligosaccaridi l-fucosilati e loro nuovi intermedi 2,3,4-tribenzil-fucosil-derivati.
ATE447564T1 (de) Zwischenprodukte für die herstellung von trans-5- chlor-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenzä , 3:6,7üoxepinoä4,5-cüpyrrol
CL2011002925A1 (es) Compuestos derivados de isoquinolin-1(2h)-ona, inhibidores selectivos de la actividad de poli (adp-ribosa) polimerasa parp-1; proceso para prepararlos; composicion farmaceutica; y su uso para tratar una enfermedad mediada por la proteina parp-1.
ATE461699T1 (de) Verbesserte biologische wirkungen von zusammensetzungen, die rosmarinsäure enthalten
EP2351612A4 (de) Poröser gegenstand aus raney-nickel, herstellungsverfahren dafür und katalysator
EP2517789A4 (de) Hydrierungskatalysator, herstellungsverfahren dafür und verwendung davon
DE602006014558D1 (de) Verbessertes verfahren für die herstellung von tee
EP2452985A4 (de) Metallpigment, herstellungsverfahren dafür und wässrige metall/harz-zusammensetzung damit
DE602007011930D1 (de) Prepreg-anordnung zur herstellung von strukturen, zum beispiel welche, die sich durch aufblasen entfalten
EP2194087A4 (de) Verfahren zur herstellung von wässrigen harzmikropartikeldispersionen und nach diesem verfahren hergestellte wässrige mikropartikeldispersionen und harzmikropartikel
EP2487211A4 (de) Harzzusammensetzung für farbe und aus der zusammensetzung hergestelltes produkt
FR2925485B1 (fr) Produit en matiere ceramique fondue, procede de fabrication et utilisations.
EP2128872A4 (de) Hydraulische abbindezusammensetzung mit niedriger aktivierung, zement mit niedriger aktivierung und herstellungsverfahren dafür
DK2100871T3 (da) Katalytisk fremgangsmåde til fremstilling af mælkesyre af genanvendelige råmaterialer
DE602006021504D1 (de) Verfahren um die Trocknung von wässrigen Arbeitsfluiden zu beschleunigen
EP2444427A4 (de) Polychloropren, herstellungsverfahren dafür und dies enthaltende haftmittel
NL2000380A1 (nl) 3-aminocyclopentaancarboxamiden als modulatoren van chemokine-receptoren.
DK2054363T3 (da) Asymmetrisk hydrogenering af 1,1,1-trifluoracetone

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 2166004

Country of ref document: EP