CL2011002925A1 - Compuestos derivados de isoquinolin-1(2h)-ona, inhibidores selectivos de la actividad de poli (adp-ribosa) polimerasa parp-1; proceso para prepararlos; composicion farmaceutica; y su uso para tratar una enfermedad mediada por la proteina parp-1. - Google Patents

Compuestos derivados de isoquinolin-1(2h)-ona, inhibidores selectivos de la actividad de poli (adp-ribosa) polimerasa parp-1; proceso para prepararlos; composicion farmaceutica; y su uso para tratar una enfermedad mediada por la proteina parp-1.

Info

Publication number
CL2011002925A1
CL2011002925A1 CL2011002925A CL2011002925A CL2011002925A1 CL 2011002925 A1 CL2011002925 A1 CL 2011002925A1 CL 2011002925 A CL2011002925 A CL 2011002925A CL 2011002925 A CL2011002925 A CL 2011002925A CL 2011002925 A1 CL2011002925 A1 CL 2011002925A1
Authority
CL
Chile
Prior art keywords
parp
treat
pharmaceutical composition
isoquinolin
adp
Prior art date
Application number
CL2011002925A
Other languages
English (en)
Inventor
Gianluca Mariano Enrico Papeo
Jay Aaron Bertrand
Giovanni Cervi
Barbara Forte
Rosita Lupi
Montagnoli
Alessia
Alessandra Scolaro
Fabio Zuccotto
Paolo: Posteri Helena Orsini
Original Assignee
Nerviano Medical Sciences Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42372343&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2011002925(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl
Publication of CL2011002925A1 publication Critical patent/CL2011002925A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN COMPUESTO QUE TIENE LA FÓRMULA (1): DONDE L, R, R 1 , R 2 , R3 Y R4 SE DEFINEN EN LA MEMORIA DESCRIPTIVA. UN PROCESO PARA LA PREPARACIÓN DE COMPUESTOS DE FÓRMULA (1), UNA COMPOSICIÓN FARMACÉUTICA Y USO DE UN COMPUESTO DE FÓRMULA (1) PARA LA PREPARACIÓN DE UN MEDICAMENTO ÚTIL PARA TRATAR UNA ENFERMEDAD MEDIADA POR LA PROTEÍNA PARP-1.
CL2011002925A 2009-05-21 2011-11-18 Compuestos derivados de isoquinolin-1(2h)-ona, inhibidores selectivos de la actividad de poli (adp-ribosa) polimerasa parp-1; proceso para prepararlos; composicion farmaceutica; y su uso para tratar una enfermedad mediada por la proteina parp-1. CL2011002925A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09160869 2009-05-21

Publications (1)

Publication Number Publication Date
CL2011002925A1 true CL2011002925A1 (es) 2012-04-13

Family

ID=42372343

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011002925A CL2011002925A1 (es) 2009-05-21 2011-11-18 Compuestos derivados de isoquinolin-1(2h)-ona, inhibidores selectivos de la actividad de poli (adp-ribosa) polimerasa parp-1; proceso para prepararlos; composicion farmaceutica; y su uso para tratar una enfermedad mediada por la proteina parp-1.

Country Status (15)

Country Link
US (2) US8592416B2 (es)
EP (1) EP2432765B1 (es)
JP (1) JP5731486B2 (es)
CN (1) CN102438986B (es)
AR (1) AR076688A1 (es)
AU (1) AU2010251112B2 (es)
BR (1) BRPI1011046B1 (es)
CA (1) CA2762226C (es)
CL (1) CL2011002925A1 (es)
DK (1) DK2432765T3 (es)
EA (1) EA023112B1 (es)
ES (1) ES2568936T3 (es)
MX (1) MX2011012187A (es)
TW (1) TWI499418B (es)
WO (1) WO2010133647A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI499418B (zh) 2009-05-21 2015-09-11 Nerviano Medical Sciences Srl 異喹啉－１（２ｈ）－酮衍生物
FR2956816B1 (fr) * 2010-03-01 2012-05-18 Univ Joseph Fourier Utilisation de quinolones pour la preparation de medicaments, nouvelles quinolones et leur procede de synthese
WO2013014038A1 (en) 2011-07-26 2013-01-31 Nerviano Medical Sciences S.R.L. 3-oxo-2,3-dihydro-1h-indazole-4-carboxamide derivatives as parp-1 inhibitors
IN2014CN04671A (es) * 2011-11-25 2015-09-18 Nerviano Medical Sciences Srl
CA2865511A1 (en) 2012-03-07 2013-09-12 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
EP2882714B1 (en) 2012-08-08 2019-11-13 Merck Patent GmbH (aza-)isoquinolinone derivatives
JP6276769B2 (ja) 2012-09-26 2018-02-07 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｐａｒｐインヒビターとしてのキナゾリノン誘導体
EP2922539B1 (en) 2012-10-01 2020-01-15 Merck Sharp & Dohme Corp. Substituted isoquinolines as crth2 receptor modulators
HUE051078T2 (hu) 2012-10-26 2021-03-01 Nerviano Medical Sciences Srl 4-karboxamido-izoindolinone származék mint szelektív parp-1 inhibitor
US9611223B2 (en) 2013-09-11 2017-04-04 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
JP6871169B2 (ja) 2015-03-02 2021-05-12 シナイ ヘルス システム 相同組換え因子
EP3440052B1 (en) 2016-04-06 2023-10-25 University Of Oulu Compounds for use in the treatment of cancer
CN106083716B (zh) * 2016-06-07 2018-10-30 温州医科大学仁济学院 一种3-芳基异喹啉化合物的制备方法
US9891509B2 (en) 2016-06-17 2018-02-13 Mimono LLC Projector holder
US10899733B2 (en) 2017-08-23 2021-01-26 Oregon Health & Science University Inhibitors of PARPs that catalyze mono-ADP-ribosylation
US12030867B2 (en) 2018-05-30 2024-07-09 University Of Notre Dame Du Lac Hsp90β selective inhibitors
CN113549044B (zh) * 2021-07-23 2024-01-23 中国药科大学 8-氮杂环取代色酮类衍生物及其制备方法与制药用途
IL317573A (en) 2022-06-15 2025-02-01 Astrazeneca Ab Combination therapy for cancer treatment
EP4709386A1 (en) 2023-05-11 2026-03-18 Astrazeneca AB Combination of a parp1 inhibitor and a selective estrogen degrader for treating cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59116269A (ja) * 1982-12-24 1984-07-05 Nisshin Flour Milling Co Ltd イソカルボスチリル誘導体
JPS60237070A (ja) * 1984-05-08 1985-11-25 Nisshin Flour Milling Co Ltd 光学活性イソカルボスチリル誘導体の製法
EP0389995B1 (en) 1989-03-28 1995-05-31 Nisshin Flour Milling Co., Ltd. Isoquinoline derivatives for the treatment of glaucoma or ocular hypertension
JP3141051B2 (ja) 1992-10-09 2001-03-05 日清製粉株式会社 抗動脈硬化剤
SE9902268D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
DE60218458T2 (de) * 2001-05-08 2007-11-15 Kudos Pharmaceuticals Ltd. Isochinolinon derivate als parp inhibitoren
JP4520406B2 (ja) * 2002-10-01 2010-08-04 田辺三菱製薬株式会社 イソキノリン化合物及びその医薬用途
US7501412B2 (en) * 2002-11-22 2009-03-10 Mitsubishi Tanabe Pharma Corporation Isoquinoline compounds and medicinal use thereof
DE102004028973A1 (de) * 2004-06-16 2006-01-05 Sanofi-Aventis Deutschland Gmbh Substituierte Tetrahydro-2H-isochinolin-1-on-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
WO2008092292A1 (en) 2007-01-17 2008-08-07 The Hong Kong University Of Science And Technology Isoquinolone compounds as subtype-selective agonists for melatonin receptors mt1 and mt2
TWI499418B (zh) 2009-05-21 2015-09-11 Nerviano Medical Sciences Srl 異喹啉－１（２ｈ）－酮衍生物

Also Published As

Publication number Publication date
CA2762226C (en) 2017-12-05
DK2432765T3 (en) 2016-04-25
AU2010251112A1 (en) 2012-01-19
JP5731486B2 (ja) 2015-06-10
JP2012527428A (ja) 2012-11-08
HK1166076A1 (en) 2012-10-19
MX2011012187A (es) 2012-01-27
ES2568936T3 (es) 2016-05-05
CN102438986B (zh) 2015-07-01
AU2010251112B2 (en) 2015-11-12
EP2432765B1 (en) 2016-03-02
EP2432765A1 (en) 2012-03-28
AU2010251112A2 (en) 2012-02-02
CN102438986A (zh) 2012-05-02
EA201171448A1 (ru) 2012-06-29
AR076688A1 (es) 2011-06-29
WO2010133647A1 (en) 2010-11-25
EA023112B1 (ru) 2016-04-29
CA2762226A1 (en) 2010-11-25
TWI499418B (zh) 2015-09-11
TW201043232A (en) 2010-12-16
US20120157454A1 (en) 2012-06-21
US8993594B2 (en) 2015-03-31
BRPI1011046B1 (pt) 2020-02-27
BRPI1011046A2 (pt) 2016-03-15
US20140045846A1 (en) 2014-02-13
US8592416B2 (en) 2013-11-26

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