CL2011002925A1 - Compuestos derivados de isoquinolin-1(2h)-ona, inhibidores selectivos de la actividad de poli (adp-ribosa) polimerasa parp-1; proceso para prepararlos; composicion farmaceutica; y su uso para tratar una enfermedad mediada por la proteina parp-1. - Google Patents
Compuestos derivados de isoquinolin-1(2h)-ona, inhibidores selectivos de la actividad de poli (adp-ribosa) polimerasa parp-1; proceso para prepararlos; composicion farmaceutica; y su uso para tratar una enfermedad mediada por la proteina parp-1.Info
- Publication number
- CL2011002925A1 CL2011002925A1 CL2011002925A CL2011002925A CL2011002925A1 CL 2011002925 A1 CL2011002925 A1 CL 2011002925A1 CL 2011002925 A CL2011002925 A CL 2011002925A CL 2011002925 A CL2011002925 A CL 2011002925A CL 2011002925 A1 CL2011002925 A1 CL 2011002925A1
- Authority
- CL
- Chile
- Prior art keywords
- parp
- treat
- pharmaceutical composition
- isoquinolin
- adp
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 230000001404 mediated effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 101100407073 Caenorhabditis elegans parp-1 gene Proteins 0.000 title 2
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 title 1
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 title 1
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 title 1
- 229940124639 Selective inhibitor Drugs 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- VDBNYAPERZTOOF-UHFFFAOYSA-N isoquinolin-1(2H)-one Chemical compound C1=CC=C2C(=O)NC=CC2=C1 VDBNYAPERZTOOF-UHFFFAOYSA-N 0.000 title 1
- 108010064218 Poly (ADP-Ribose) Polymerase-1 Proteins 0.000 abstract 1
- 102100023712 Poly [ADP-ribose] polymerase 1 Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
UN COMPUESTO QUE TIENE LA FÓRMULA (1): DONDE L, R, R 1 , R 2 , R3 Y R4 SE DEFINEN EN LA MEMORIA DESCRIPTIVA. UN PROCESO PARA LA PREPARACIÓN DE COMPUESTOS DE FÓRMULA (1), UNA COMPOSICIÓN FARMACÉUTICA Y USO DE UN COMPUESTO DE FÓRMULA (1) PARA LA PREPARACIÓN DE UN MEDICAMENTO ÚTIL PARA TRATAR UNA ENFERMEDAD MEDIADA POR LA PROTEÍNA PARP-1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09160869 | 2009-05-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2011002925A1 true CL2011002925A1 (es) | 2012-04-13 |
Family
ID=42372343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2011002925A CL2011002925A1 (es) | 2009-05-21 | 2011-11-18 | Compuestos derivados de isoquinolin-1(2h)-ona, inhibidores selectivos de la actividad de poli (adp-ribosa) polimerasa parp-1; proceso para prepararlos; composicion farmaceutica; y su uso para tratar una enfermedad mediada por la proteina parp-1. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8592416B2 (es) |
| EP (1) | EP2432765B1 (es) |
| JP (1) | JP5731486B2 (es) |
| CN (1) | CN102438986B (es) |
| AR (1) | AR076688A1 (es) |
| AU (1) | AU2010251112B2 (es) |
| BR (1) | BRPI1011046B1 (es) |
| CA (1) | CA2762226C (es) |
| CL (1) | CL2011002925A1 (es) |
| DK (1) | DK2432765T3 (es) |
| EA (1) | EA023112B1 (es) |
| ES (1) | ES2568936T3 (es) |
| MX (1) | MX2011012187A (es) |
| TW (1) | TWI499418B (es) |
| WO (1) | WO2010133647A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI499418B (zh) | 2009-05-21 | 2015-09-11 | Nerviano Medical Sciences Srl | 異喹啉－１（２ｈ）－酮衍生物 |
| FR2956816B1 (fr) * | 2010-03-01 | 2012-05-18 | Univ Joseph Fourier | Utilisation de quinolones pour la preparation de medicaments, nouvelles quinolones et leur procede de synthese |
| JP5902299B2 (ja) | 2011-07-26 | 2016-04-13 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | Ｐａｒｐ−１阻害剤としての３−オキソ−２，３−ジヒドロ−１ｈ−インダゾール−４−カルボキサミド誘導体 |
| AU2012342562B2 (en) * | 2011-11-25 | 2017-02-23 | Nerviano Medical Sciences S.R.L. | 3-phenyl-isoquinolin-1(2H)-one derivatives as PARP-1 inhibitors |
| WO2013132253A1 (en) | 2012-03-07 | 2013-09-12 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| KR102083154B1 (ko) | 2012-08-08 | 2020-03-02 | 메르크 파텐트 게엠베하 | （아자―）이소퀴놀리논 유도체 |
| RU2650107C2 (ru) | 2012-09-26 | 2018-04-09 | Мерк Патент Гмбх | Производные хиназолинона в качестве ингибиторов parp |
| EP2922539B1 (en) * | 2012-10-01 | 2020-01-15 | Merck Sharp & Dohme Corp. | Substituted isoquinolines as crth2 receptor modulators |
| CN104768948B (zh) | 2012-10-26 | 2018-11-27 | 内尔维阿诺医学科学有限公司 | 作为选择性parp-1抑制剂的4-甲酰氨基-异二氢吲哚酮衍生物 |
| EP3044221B1 (en) | 2013-09-11 | 2018-02-21 | Institute of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
| JP6871169B2 (ja) | 2015-03-02 | 2021-05-12 | シナイ ヘルス システム | 相同組換え因子 |
| EP3440052B1 (en) | 2016-04-06 | 2023-10-25 | University Of Oulu | Compounds for use in the treatment of cancer |
| CN106083716B (zh) * | 2016-06-07 | 2018-10-30 | 温州医科大学仁济学院 | 一种3-芳基异喹啉化合物的制备方法 |
| US9891509B2 (en) | 2016-06-17 | 2018-02-13 | Mimono LLC | Projector holder |
| US10899733B2 (en) | 2017-08-23 | 2021-01-26 | Oregon Health & Science University | Inhibitors of PARPs that catalyze mono-ADP-ribosylation |
| WO2019232223A1 (en) | 2018-05-30 | 2019-12-05 | University Of Notre Dame Du Lac | Hsp90 beta selective inhibitors |
| CN113549044B (zh) * | 2021-07-23 | 2024-01-23 | 中国药科大学 | 8-氮杂环取代色酮类衍生物及其制备方法与制药用途 |
| US20250352539A1 (en) | 2022-06-15 | 2025-11-20 | Astrazeneca Ab | Combination therapy for treating cancer |
| KR20260010420A (ko) | 2023-05-11 | 2026-01-20 | 아스트라제네카 아베 | 암 치료를 위한 parp1 억제제 및 선택적 에스트로겐 분해제의 병용 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59116269A (ja) * | 1982-12-24 | 1984-07-05 | Nisshin Flour Milling Co Ltd | イソカルボスチリル誘導体 |
| JPS60237070A (ja) * | 1984-05-08 | 1985-11-25 | Nisshin Flour Milling Co Ltd | 光学活性イソカルボスチリル誘導体の製法 |
| EP0389995B1 (en) | 1989-03-28 | 1995-05-31 | Nisshin Flour Milling Co., Ltd. | Isoquinoline derivatives for the treatment of glaucoma or ocular hypertension |
| JP3141051B2 (ja) | 1992-10-09 | 2001-03-05 | 日清製粉株式会社 | 抗動脈硬化剤 |
| SE9902268D0 (sv) * | 1999-06-16 | 1999-06-16 | Astra Ab | Pharmaceutically active compounds |
| DE60218458T2 (de) * | 2001-05-08 | 2007-11-15 | Kudos Pharmaceuticals Ltd. | Isochinolinon derivate als parp inhibitoren |
| CN100390164C (zh) * | 2002-10-01 | 2008-05-28 | 三菱制药株式会社 | 异喹啉化合物及其医药用途 |
| CA2507027C (en) * | 2002-11-22 | 2012-05-08 | Mitsubishi Pharma Corporation | Isoquinoline compounds and medicinal use thereof |
| DE102004028973A1 (de) * | 2004-06-16 | 2006-01-05 | Sanofi-Aventis Deutschland Gmbh | Substituierte Tetrahydro-2H-isochinolin-1-on-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| US8389544B2 (en) | 2007-01-17 | 2013-03-05 | The Hong Kong University Of Science And Technology | Isoquinolone compounds as subtype-selective agonists for melatonin receptors MT1 and MT2 |
| TWI499418B (zh) | 2009-05-21 | 2015-09-11 | Nerviano Medical Sciences Srl | 異喹啉－１（２ｈ）－酮衍生物 |
-
2010
- 2010-05-17 TW TW099115650A patent/TWI499418B/zh active
- 2010-05-18 AR ARP100101720A patent/AR076688A1/es active IP Right Grant
- 2010-05-19 ES ES10723046.8T patent/ES2568936T3/es active Active
- 2010-05-19 JP JP2012511282A patent/JP5731486B2/ja active Active
- 2010-05-19 EA EA201171448A patent/EA023112B1/ru not_active IP Right Cessation
- 2010-05-19 BR BRPI1011046-1A patent/BRPI1011046B1/pt active IP Right Grant
- 2010-05-19 WO PCT/EP2010/056921 patent/WO2010133647A1/en not_active Ceased
- 2010-05-19 US US13/320,969 patent/US8592416B2/en active Active
- 2010-05-19 EP EP10723046.8A patent/EP2432765B1/en active Active
- 2010-05-19 AU AU2010251112A patent/AU2010251112B2/en active Active
- 2010-05-19 DK DK10723046.8T patent/DK2432765T3/en active
- 2010-05-19 CA CA2762226A patent/CA2762226C/en active Active
- 2010-05-19 MX MX2011012187A patent/MX2011012187A/es active IP Right Grant
- 2010-05-19 CN CN201080021942.8A patent/CN102438986B/zh active Active
-
2011
- 2011-11-18 CL CL2011002925A patent/CL2011002925A1/es unknown
-
2013
- 2013-10-23 US US14/061,100 patent/US8993594B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI1011046A2 (pt) | 2016-03-15 |
| HK1166076A1 (en) | 2012-10-19 |
| US8993594B2 (en) | 2015-03-31 |
| EP2432765B1 (en) | 2016-03-02 |
| ES2568936T3 (es) | 2016-05-05 |
| AU2010251112A1 (en) | 2012-01-19 |
| AU2010251112A2 (en) | 2012-02-02 |
| TW201043232A (en) | 2010-12-16 |
| JP5731486B2 (ja) | 2015-06-10 |
| CN102438986B (zh) | 2015-07-01 |
| CA2762226C (en) | 2017-12-05 |
| US20140045846A1 (en) | 2014-02-13 |
| TWI499418B (zh) | 2015-09-11 |
| JP2012527428A (ja) | 2012-11-08 |
| CN102438986A (zh) | 2012-05-02 |
| CA2762226A1 (en) | 2010-11-25 |
| MX2011012187A (es) | 2012-01-27 |
| AU2010251112B2 (en) | 2015-11-12 |
| EP2432765A1 (en) | 2012-03-28 |
| DK2432765T3 (en) | 2016-04-25 |
| EA023112B1 (ru) | 2016-04-29 |
| EA201171448A1 (ru) | 2012-06-29 |
| US20120157454A1 (en) | 2012-06-21 |
| BRPI1011046B1 (pt) | 2020-02-27 |
| WO2010133647A1 (en) | 2010-11-25 |
| US8592416B2 (en) | 2013-11-26 |
| AR076688A1 (es) | 2011-06-29 |
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