ATE483689T1 - Pyrazolderivate als modulatoren von proteinkinase - Google Patents

Pyrazolderivate als modulatoren von proteinkinase

Info

Publication number: ATE483689T1
Authority: AT; Austria
Prior art keywords: group; carbon atoms; compounds; protein kinase; atoms
Prior art date: 2003-12-23

Application number

AT04806258T

Other languages

German (de)

English (en)

Inventor

Valerio Berdini

Gordon Saxty

Marinus Verdonk

Steven Woodhead

Paul Wyatt

Robert Boyle

Hannah Sore

David Walker

Ian Collins

Robert Downham

Robin Carr

Original Assignee

Astex Therapeutics Ltd

Cancer Rec Tech Ltd

Cancer Res Inst Royal

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-23

Filing date

2004-12-23

Publication date

2010-10-15

2004-12-23 Application filed by Astex Therapeutics Ltd, Cancer Rec Tech Ltd, Cancer Res Inst Royal filed Critical Astex Therapeutics Ltd

2004-12-23 Priority claimed from PCT/GB2004/005464 external-priority patent/WO2005061463A1/en

2010-10-15 Application granted granted Critical

2010-10-15 Publication of ATE483689T1 publication Critical patent/ATE483689T1/de

Links

102000001253 Protein Kinase Human genes 0.000 title 1
WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 title 1
108060006633 protein kinase Proteins 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 3
125000005647 linker group Chemical group 0.000 abstract 3
125000004429 atom Chemical group 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000004043 oxo group Chemical group O=* 0.000 abstract 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
108091008611 Protein Kinase B Proteins 0.000 abstract 1
102000005765 Proto-Oncogene Proteins c-akt Human genes 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000002527 bicyclic carbocyclic group Chemical group 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT04806258T 2003-12-23 2004-12-23 Pyrazolderivate als modulatoren von proteinkinase ATE483689T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US53219903P	2003-12-23	2003-12-23
GB0329617A GB0329617D0 (en)	2003-12-23	2003-12-23	Pharmaceutical compounds
US57784304P	2004-06-08	2004-06-08
PCT/GB2004/005464 WO2005061463A1 (en)	2003-12-23	2004-12-23	Pyrazole derivatives as protein kinase modulators

Publications (1)

Publication Number	Publication Date
ATE483689T1 true ATE483689T1 (de)	2010-10-15

Family

ID=30776233

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04806258T ATE483689T1 (de)	2003-12-23	2004-12-23	Pyrazolderivate als modulatoren von proteinkinase

Country Status (11)

Country	Link
CN (1)	CN1922148B (sr)
AT (1)	ATE483689T1 (sr)
DE (1)	DE602004029501D1 (sr)
DK (1)	DK1706385T3 (sr)
GB (1)	GB0329617D0 (sr)
ME (1)	ME01934B (sr)
PT (1)	PT1706385E (sr)
RS (1)	RS51546B (sr)
SI (1)	SI1706385T1 (sr)
UA (1)	UA90461C2 (sr)
ZA (1)	ZA200605127B (sr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0704932D0 (en) *	2007-03-14	2007-04-25	Astex Therapeutics Ltd	Pharmaceutical compounds
CN108339121A (zh) *	2017-01-25	2018-07-31	苏州大学	蛋白激酶a抑制剂在制备治疗血小板数量增多相关疾病药物中的用途
CN111056990B (zh) *	2019-12-16	2022-06-17	爱斯特（成都）生物制药股份有限公司	一种合成1-叔丁氧羰基-4-(4-羧基苯基)哌啶的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9804734D0 (en) *	1998-03-05	1998-04-29	Pfizer Ltd	Compounds
AU6388900A (en) *	1999-07-30	2001-02-19	Abbott Gmbh & Co. Kg	2-pyrazolin-5-ones

2003
- 2003-12-23 GB GB0329617A patent/GB0329617D0/en not_active Ceased
2004
- 2004-12-23 RS RSP-2010/0532A patent/RS51546B/sr unknown
- 2004-12-23 SI SI200431571T patent/SI1706385T1/sl unknown
- 2004-12-23 UA UAA200608166A patent/UA90461C2/ru unknown
- 2004-12-23 DK DK04806258.2T patent/DK1706385T3/da active
- 2004-12-23 AT AT04806258T patent/ATE483689T1/de active
- 2004-12-23 ME MEP-2010-532A patent/ME01934B/me unknown
- 2004-12-23 PT PT04806258T patent/PT1706385E/pt unknown
- 2004-12-23 DE DE602004029501T patent/DE602004029501D1/de not_active Expired - Lifetime
- 2004-12-23 CN CN2004800420375A patent/CN1922148B/zh not_active Expired - Fee Related
2006
- 2006-06-21 ZA ZA200605127A patent/ZA200605127B/xx unknown

Also Published As

Publication number	Publication date
CN1922148A (zh)	2007-02-28
DK1706385T3 (da)	2011-01-10
DE602004029501D1 (de)	2010-11-18
PT1706385E (pt)	2010-12-22
SI1706385T1 (sl)	2011-01-31
GB0329617D0 (en)	2004-01-28
ZA200605127B (en)	2010-07-28
RS51546B (sr)	2011-06-30
CN1922148B (zh)	2012-03-21
ME01934B (me)	2011-06-30
UA90461C2 (en)	2010-05-11

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2011-04-15

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